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Correlation between cerebral neurotransmitters levels by proton magnetic resonance spectroscopy and HbA1c in patients with type 2 diabetes

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World Journal of Diabetes 2024年第6期15卷 1263-1271页

作者： Xiang-Yu Gao Chen-Xia Zhou hong-mei li Min Cheng Da Chen Zi-Yi li Bo Feng Jun Song Department of Endocrinology East HospitalTongji University School of MedicineShanghai 200120China Department of Endocrinology Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266000Shandong ProvinceChina Department of Immunization Program Huangdao District Center for Disease Prevention and ControlQingdao 266400Shandong ProvinceChina

BACKGROUND Cognitive dysfunction is the main manifestation of central *** cognitive impairments tend to be overlooked in patients with diabetes mellitus(DM),there is a growing body of evidence linking DM to cognitive *** is closely related to neurological abnormalities,while often disregarded in clinical *** in cerebral neurotransmitter levels are associated with a variety of neurological abnormalities and may be closely related to blood glucose control in patients with type 2 DM(T2DM).AIM To evaluate the concentrations of cerebral neurotransmitters in T2DM patients exhibiting different hemoglobin A1c(HbA1c)*** A total of 130 T2DM patients were enrolled at the Department of Endocrinology of Shanghai East *** participants were divided into four groups according to their HbA1c levels using the interquartile method,namely Q1(linical data were collected and measured,including age,height,weight,neck/waist/hip circumferences,blood pressure,comorbidities,duration of DM,and biochemical ***,neurotransmitters in the left hippocampus and left brainstem area were detected by proton magnetic resonance *** The HbA1c level was significantly associated with urinary microalbumin(mALB),triglyceride,low-density lipoprotein cholesterol(LDL-C),homeostasis model assessment of insulin resistance(HOMA-IR),and beta cell function(HOMA-β),N-acetylaspartate/creatine(NAA/Cr),and NAA/choline(NAA/Cho).Spearman correlation analysis showed that mALB,LDL-C,HOMA-IR and NAA/Cr in the left brainstem area were positively correlated with the level of HbA1c(P<0.05),whereas HOMA-βwas negatively correlated with the HbA1c level(P<0.05).Ordered multiple logistic regression analysis showed that NAA/Cho[Odds ratio(OR):1.608,95%confidence interval(95%CI):1.004-2.578,P<0.05],LDL-C(OR:1.627,95%CI:1.119-2.370,P<0.05),and HOMA-IR(OR:1.107,95%CI:1.031-

关键词： Type 2 diabetes mellitus Hemoglobin A1c Proton magnetic resonance spectroscopy Neurotransmitters Central neuropathy

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Application of prostate resectoscope in the treatment of massive rectal bleeding after transrectal prostate puncture

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World Journal of Clinical Cases 2024年第18期12卷 3438-3443页

作者： hong-mei li Fa-Ying Yang Song Tu Peng Yan Jun Qian Jia-Xi Yao Department of Urology Hexi University Affiliated Zhangye People’s HospitalHexi UniversityZhangye 734000Gansu ProvinceChina Department of General Surgery II Hexi UniversityZhangye 734000Gansu ProvinceChina

BACKGROUND Ultrasound-guided prostate biopsy is a reliable diagnostic procedure for prostate cancer diagnosis with minimal procedure-related ***,complications,such as massive rectal bleeding may occur after the *** hypothesized that using a transrectal resectoscope could help treat massive rectal bleeding after transrectal prostate *** To identify a simple and effective treatment for massive rectal bleeding after transrectal prostate *** Patients requiring treatment for massive rectal bleeding after transrectal prostate punctures were included.A SIMAI resectoscope was inserted through the *** electrocoagulation was performed for superficial bleeding *** of the rectal mucosa or surface muscle layer was removed to expose deep bleeding points,followed by *** electric cutting ring was used to compress and stop the bleeding for jet-like points before *** fluid color in the drainage tube was monitored postoperatively for continuous *** Eight patients were included from 2012 to *** of the patients with massive rectal bleeding after the transrectal prostate punctures improved with conventional conservative and blood transfusion *** patients had an inferior artery embolism,and digital subtraction angiography was *** patients received emergency transanal prostate resection,which immediately stopped the *** days after the procedure,the patients had recovered and were *** Using a transanal prostate resection instrument is a simple,safe,and effective method for treating massive rectal bleeding after transrectal prostate punctures.

关键词： Electrocoagulation Hemostasis Transanal prostate resection instrumentation Prostate puncture

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A Weakly-Supervised Crowd Density Estimation Method Based on Two-Stage linear Feature Calibration

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 965-981页

作者： Yong-Chao li Rui-Sheng Jia Ying-Xiang Hu hong-mei Sun the College of Computer Science and Engineering Shandong University of Science and TechnologyQingdao 266590 the Faculty of Information Science and Engineering Ocean University of ChinaQingdao 266000China the College of Computer Science and Engineering Shandong University of Science and TechnologyQingdao 266590China the College of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing 210000China

In a crowd density estimation dataset,the annotation of crowd locations is an extremely laborious task,and they are not taken into the evaluation *** this paper,we aim to reduce the annotation cost of crowd datasets,and propose a crowd density estimation method based on weakly-supervised learning,in the absence of crowd position supervision information,which directly reduces the number of crowds by using the number of pedestrians in the image as the supervised *** this purpose,we design a new training method,which exploits the correlation between global and local image features by incremental learning to train the ***,we design a parent-child network(PC-Net)focusing on the global and local image respectively,and propose a linear feature calibration structure to train the PC-Net simultaneously,and the child network learns feature transfer factors and feature bias weights,and uses the transfer factors and bias weights to linearly feature calibrate the features extracted from the Parent network,to improve the convergence of the network by using local features hidden in the crowd *** addition,we use the pyramid vision transformer as the backbone of the PC-Net to extract crowd features at different levels,and design a global-local feature loss function(L2).We combine it with a crowd counting loss(LC)to enhance the sensitivity of the network to crowd features during the training process,which effectively improves the accuracy of crowd density *** experimental results show that the PC-Net significantly reduces the gap between fullysupervised and weakly-supervised crowd density estimation,and outperforms the comparison methods on five datasets of Shanghai Tech Part A,ShanghaiTech Part B,UCF_CC_50,UCF_QNRF and JHU-CROWD++.

关键词： Crowd density estimation linear feature calibration vision transformer weakly-supervision learning

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Effect of Sc on Al_(3)Fe phase and mechanical properties of as-cast AA5052 aluminum alloy

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China Foundry 2024年第3期21卷 257-264页

作者： Yang li Qing Yu Feng-feng Chen Jia-wen He hong-mei Yang Meng-nie li Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China

The AA5052 aluminum alloy is widely used in automobile and aerospace manufacturing,and with the development of light-weight alloys,it is required that these materials exhibit better mechanical *** studies have demonstrated that the addition of Sc to aluminum alloys can improve both the microstructure and properties of the *** this study,the effect of Sc on the Fe-rich phase and properties of the AA5052 aluminum alloy was studied by adding 0%,0.05%,0.2%,and 0.3%*** results show that with the increase of Sc,the coarse needle-like Fe-rich phase gradually transforms into Chinese-script and then nearly spherical particles,reduce the size of Fe-rich phase,and refine the grain with increase of high angle grain boundaries(HAGBs).These microstructure changes enhance the strength of the AA5052 alloy through Sc *** ductility of the alloy is obviously improved because the addition of a lower amount of Sc changes the morphology of Fe-rich phase from needle-like into a Chinese-script,and it is subsequently reduced as a result of significant increase in HAGBs with increasing Sc content.

关键词： AA5052 aluminum alloy Al3Fe phase mechanical properties grain boundary

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Femtosecond laser fabrication of 3D vertically aligned micro-pore network on thick-film li_(4)Ti_(5)O_(12)electrode for high-performance lithium storage

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Journal of Energy Chemistry 2024年第8期95卷 250-262,I0006页

作者： Quansheng li Xiaofei Sun Xuesong mei lingzhi Wang Minxing Yang Jianlei Cui Wenjun Wang State Key Laboratory for Manufacturing System Engineering Xi'an Jiaotong UniversityXi'an 710049ShaanxiChina Shaanxi Key Laboratory of Intelligent Robots Xi'an Jiaotong UniversityXi'an 710049ShaanxiChina School of Mechanical Engineering Xi'an Jiaotong UniversityXi'an 710049ShaanxiChina

The development of energy storage devices with high energy density relies heavily on thick film electrodes,but it is challenging due to the limited ion transport kinetics inherent in thick ***,we report on the preparation of a directional vertical array of micro-porous transport networks on LTO electrodes using a femtosecond laser processing strategy,enabling directional ion rapid transport and achieving good electrochemical performance in thick film *** three-dimensional(3D)vertically aligned micro-pore networks are innovatively designed,and the structure,kinetics characteristics,and electrochemical performance of the prepared ion transport channels are analyzed and discussed by multiple characterization and testing ***,the rational mechanisms of electrode performance improvement are studied experimentally and simulated from two aspects of structural mechanics and transmission *** ion diffusion coefficient,rate performance at 60 C,and electrode interface area of the laser-optimized 60-15%micro-porous transport network electrodes increase by 25.2 times,2.2 times,and 2.15 times,respectively than those of untreated ***,the preparation of 3D micro-porous transport networks by femtosecond laser on ultra-thick electrodes is a feasible way to develop high-energy *** addition,the unique micro-porous transport network structure can be widely extended to design and explore other high-performance energy materials.

关键词： Femtosecond laser Micro-porous transport networks Laser processing Thick film electrodes Ion transport kinetics

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Identification of an immune-related gene signature for predicting prognosis and immunotherapy efficacy in liver cancer via cell-cell communication

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World Journal of Gastroenterology 2024年第11期30卷 1609-1620页

作者： Jun-Tao li hong-mei Zhang Wei Wang Dong-Qing Wei College of Mathematics and Information Science Henan Normal UniversityXinxiang 453007Henan ProvinceChina College of Computer and Information Engineering Henan Normal UniversityXinxiang 453007Henan ProvinceChina State Key Laboratory of Microbial Metabolism and School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai 200240China

BACKGROUND liver cancer is one of the deadliest malignant tumors *** has provided hope to patients with advanced liver cancer,but only a small fraction of patients benefit from this treatment due to individual *** immune-related gene signatures in liver cancer patients not only aids physicians in cancer diagnosis but also offers personalized treatment strategies,thereby improving patient survival *** several methods have been developed to predict the prognosis and immunotherapeutic efficacy in patients with liver cancer,the impact of cell-cell interactions in the tumor microenvir-onment has not been adequately *** To identify immune-related gene signals for predicting liver cancer prognosis and immunotherapy *** Cell grouping and cell-cell communication analysis were performed on single-cell RNA-sequencing data to identify highly active cell groups in immune-related *** active immune cells were identified by intersecting the highly active cell groups with B cells and T *** significantly differentially expressed genes between highly active immune cells and other cells were subsequently selected as features,and a least absolute shrinkage and selection operator(LASSO)regression model was constructed to screen for diagnostic-related *** genes that were selected more than 5 times in 10 LASSO regression experiments were included in a multivariable Cox regression ***,3 genes(stathmin 1,cofilin 1,and C-C chemokine ligand 5)significantly associated with survival were identified and used to construct an immune-related gene *** The immune-related gene signature composed of stathmin 1,cofilin 1,and C-C chemokine ligand 5 was identified through cell-cell *** effectiveness of the identified gene signature was validated based on experi-mental results of predictive immunotherapy response,tumor mutation burden analysis,immune cell infiltrat

关键词： liver cancer Cell-cell communication Gene signature Prognosis Immunotherapy Single-cell RNA sequencing

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Real value oftheoocyteswith smooth endoplasmic reticulum aggregates in in vitro fertilization/intracytoplasmic sperm injection cycle: a retrospective cohort study

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Reproductive and Developmental Medicine 2023年第3期7卷 142-148页

作者： Zheng Zhang Xiao-Na liu Ying Wang Xue-Yao Bai Tao Shangguan hong-mei li lin Zhu Yu-Yan li Wei He Departments of Obstetrics and Gynecology Center of Reproductive medicineFirst Affiliated Hospital of Army Medical UniversityChongqingChina

objective:The management of oocytes affected by smooth endoplasmic reticulum aggregates(SERa)remains *** understand how to manage SERa+oocytes and cycles,we performed a retrospective cohort study and analyzed the impact of SERa+cycles and oocytes on clinical and neonatal ***:We included 4856 cycles(149 SERa+and 4707 SERa-)from 4201 women(age:21-42 years)who received in vitro fertilization/intracytoplasmic sperm injection(IVF/ICSl)treatments at the Center of Reproductive Medicine,First Affliated Hospital of Army Military University,from 2016 to ***+cycles had at least one SERa oocyte in the oocyte *** 1722 oocytes in the SERa+cycle were divided into SERa+(405)and SERa-(1317)***:The rates of two pronuclei(2PN)and high-quality embryos were lower in SERa+cycles than in SERa-cycles,regardless of IVF or ICSI(Plity embryos declined gradually(Plinical pregnancy rate and spontaneous abortion rate were observed between SERa+and SERa-cycles or between SERa+and SERa-oocytes(P>0.05).conclusion:Normal fertilization with SERa+cycles and oocytes was substantially reduced,regardless of the insemination *** originating from SERa+oocytes can be transferred when there are no other options,but fully informed consent and strict follow-up of fetal development are mandatory.

关键词： Smooth endoplasmic reticulum aggregates In vitro fertilization Intracytoplasmic sperm injection Outcome

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Maternal weight and its association with risk of overweight in offspring:a trajectory analysis from a birth cohort in China

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World Journal of Pediatrics 2024年第5期20卷 496-505页

作者： Rui Deng Wei-Qin li Xing-Xiu li liu-mei Wei Jie Hu Jun-hong Leng Bin Dong Institute of Child and Adolescent Health School of Public HealthPeking University Health Science CenterNo.38 Xueyuan RdHaidian DistrictBeijing100191China Tianjin Women and Children’s Health Center No.96 Guizhou RdHeping DistrictTianjin300070China Menzies Health Institute Queensland Griffith UniversityNathanQLD4111Australia

Background Most studies on the association of maternal pregnancy weight with offspring weight trajectory have a short follow-up *** study aimed to explore the associations of maternal prepregnancy body mass index(BMI)and gestational weight gain(GWG)with childhood weight trajectories in a 7-year birth *** A total of 946 mother–child pairs(467 boys and 479 girls)from a longitudinal birth cohort in Tianjin City,China,were included in this study,ranging from pregnancy to offspring at 7 *** outcome variable was defined as overweight or not overweight in offspring at the last round.A group-based trajectory model was applied to identify childhood BMI trajectory *** Five discrete BMI trajectory groups were identified and characterized as constant underweight(25.2%),constant normal weight(42.8%),and high or increasing trajectory[at risk of overweight(16.9%),progressive overweight(11.0%)and progressive obesity(4.1%)].Maternal prepregnancy overweight was associated with 1.72(95%CI 1.14–2.60,P=0.01)to 4.02(95%CI 1.94–8.36,P<0.001)times the risk of all high or increasing trajectory groups,and excessive GWG was related to groups at risk of overweight[relative risk ratio(RRR)2.09,95%CI 1.27–3.46,P=0.004]and progressive obesity(RRR 3.33,95%CI 1.13–9.79,P=0.029).Children in all high or increasing trajectory groups were associated with greater overweight risk at the last round[risk ratios(RRs)ranged from 3.54(95%CI 2.53–4.95,P<0.001)to 6.18(95%CI 4.05–9.42,P<0.001)].Conclusion Maternal prepregnancy overweight and excessive gestational weight gain were associated with increasing or high-level childhood body mass index trajectories as well as a greater risk of overweight at 7 years.

关键词： Body-weight trajectory Child Gestational weight gain Overweight Pregnancy

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Boosting reversible charging of li-ion batteries at low temperatures by a synergy of propylene carbonate-based electrolyte and defective graphite

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Nano Research 2024年第3期17卷 1491-1499页

作者： Yingqiang Wu Jiao Zhang Jinli liu li Sheng Bo Zhang limin Wang Siqi Shi li Wang hong Xu Xiangming He Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of Sciences(CAS)Changchun 130022China China National Quality Supervision and Inspection Center for Industrial Explosive Materials Nanjing University of Science and TechnologyNanjing 210094China School of Materials Science and Engineering Materials Genome InstituteShanghai UniversityShanghai 200444China

Propylene carbonate(PC)-based electrolytes have exhibited significant advantages in boosting the low-temperature discharging of graphite-based li-ion ***,it is still unclear whether they can improve the charging property and suppress lithium *** this topic is challenging due to the problem of electrochemical *** overcome this issue,we introduced graphite with phase *** results show that the pouch-type full batteries using PC-based electrolyte exhibit steady performance over 500 cycles and can be reversibly charged over 30 times at-20℃ with an average Coulombic efficiency of 99.95%,while the corresponding value for the conventional ethylene carbonate(EC)-based electrolyte sample is only 31.20%.This indicates that the use of PC-based electrolyte significantly suppresses lithium plating during low-temperature *** further demonstrate that the improved performance is mainly attributed to the unique solvation structure,where PF-6more anions participate in solvation,leading to the formation of a stable F-rich solid state electrolyte interface on the graphite surface and a lower reduction tendency of li+*** work inspires new ideas for the design of PC-based electrolytes for low-temperature charging and fast-charging batteries.

关键词： lithium-ion batteries graphite propylene carbonate low-temperature charging

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Multiple factors influencing high-purity indium electrolytic refining

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Chinese Journal of Chemical Engineering 2024年第7期71卷 148-160页

作者： hong-Qiang Fan Fei li hong-Xing Zheng Wu-ji Pan mei-Zhen Wu Yashar Behnamian Ju-Bo Peng Dong-Hai lin State Key Laboratory of Advanced Special Steel&School of Materials Science and Engineering Shanghai UniversityShanghai 200444China Shanghai Engineering Research Center for Integrated Circuits and Advanced Display Materials Shanghai UniversityShanghai 200444China Research&Development Center Yunnan Tin Group(Holding)Limited CompanyKunming 650032China Department of Chemical and Materials Engineering University of AlbertaEdmonton T6G 2V4AlbertaCanada School of Energy and Materials Shanghai Key Laboratory of Engineering Materials Application and EvaluationShanghai Polytechnic UniversityShanghai 201209China

The effects of various contaminants in the electrolytic refinement of indium were investigated using a glow discharge mass spectrometer(GDMS).The effects of several factors such as the indium ion(In3+)concentration,the sodium chloride(NaCl)concentration,the current density,the gelatin concentration,the pH,and the electrode distance,were *** variations in impurity levels concerning gelatin concentration were *** the gelatin and In3+concentration were moderately positively correlated with the Pb *** Sb concentration was associated positively with the NaCl concentration,while the Ti concentration had an adverse correlation with the NaCl *** Bi element content was positively linked to the electrode *** the current density increased,Cu,Pb,and Bi impurities initially rose and then eventually ***,a critical current density of 45 A·m^(-2) was identified in this behavior.

关键词： High-purity indium Electrolysis Multiple factors Electrochemistry Purification

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