Correlation between cerebral neurotransmitters levels by proton magnetic resonance spectroscopy and HbA1c in patients with type 2 diabetes

作     者：Xiang-Yu Gao Chen-Xia Zhou Hong-Mei Li Min Cheng Da Chen Zi-Yi Li Bo Feng Jun Song 

作者机构：Department of EndocrinologyEast HospitalTongji University School of MedicineShanghai 200120China Department of EndocrinologyQilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdao 266000Shandong ProvinceChina Department of Immunization ProgramHuangdao District Center for Disease Prevention and ControlQingdao 266400Shandong ProvinceChina 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2024年第15卷第6期

页      面：1263-1271页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by the Academic Leaders Training Program of Pudong Health Bureau of Shanghai,No.PWRd2023-03 Clinical Research Fund of Shanghai Municipal Commission of Health,No.202040136 National Natural Science Foundation of China,No.82070842 Jiangxi Health Commission Science and Technology Plan Project,No.202212838 and No.202212852 

主　　题：Type 2 diabetes mellitus Hemoglobin A1c Proton magnetic resonance spectroscopy Neurotransmitters Central neuropathy 

摘      要：BACKGROUND Cognitive dysfunction is the main manifestation of central *** cognitive impairments tend to be overlooked in patients with diabetes mellitus(DM),there is a growing body of evidence linking DM to cognitive *** is closely related to neurological abnormalities,while often disregarded in clinical *** in cerebral neurotransmitter levels are associated with a variety of neurological abnormalities and may be closely related to blood glucose control in patients with type 2 DM(T2DM).AIM To evaluate the concentrations of cerebral neurotransmitters in T2DM patients exhibiting different hemoglobin A1c(HbA1c)*** A total of 130 T2DM patients were enrolled at the Department of Endocrinology of Shanghai East *** participants were divided into four groups according to their HbA1c levels using the interquartile method,namely Q1(7.875%),Q2(7.875%-9.050%),Q3(9.050%-11.200%)and Q4(≥11.200%).Clinical data were collected and measured,including age,height,weight,neck/waist/hip circumferences,blood pressure,comorbidities,duration of DM,and biochemical ***,neurotransmitters in the left hippocampus and left brainstem area were detected by proton magnetic resonance *** The HbA1c level was significantly associated with urinary microalbumin(mALB),triglyceride,low-density lipoprotein cholesterol(LDL-C),homeostasis model assessment of insulin resistance(HOMA-IR),and beta cell function(HOMA-β),N-acetylaspartate/creatine(NAA/Cr),and NAA/choline(NAA/Cho).Spearman correlation analysis showed that mALB,LDL-C,HOMA-IR and NAA/Cr in the left brainstem area were positively correlated with the level of HbA1c(P0.05),whereas HOMA-βwas negatively correlated with the HbA1c level(P0.05).Ordered multiple logistic regression analysis showed that NAA/Cho[Odds ratio(OR):1.608,95%confidence interval(95%CI):1.004-2.578,P0.05],LDL-C(OR:1.627,95%CI:1.119-2.370,P0.05),and HOMA-IR(OR:1.107,95%CI:1.031-