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Ratchet motion and current motors in pulsating reversal of coupled Brownian symmetric potentials

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Frontiers of physics 2017年第4期12卷 197-206页

作者： chen-Pu Li hong-bin chen Zhi-Gang Zheng Department of Physics Beijing Normal University Beijing 100875 China College of Science Hebei University of Architecture Zhangjiakou 075000 China Institute of Systems Science (ISS) Huaqiao University Xiamen 361021 China College of Information Science and Engineering Huaqiao University Xiamen 361021 China

In this study, we investigate the collective directed transport of coupled Brownian particles in spatially symmetric periodic potentials under time-periodic pulsating modulations. We find that the coupling between two particles can induce symmetry breaking and consequently collective directed motion. Moreover, the direction of motion can be reversed under certain conditions. The dependence of directed current on various parameters is systematically studied, reverse motion can be achieved by modulating the coupling free length and the phase shift of tile pulsating potential. The dynamical mechanism of these transport properties is understood in terms of the effective-potential theory and the space-time transformation invariance. The directed transport of coupled Brownian motors can be maniplflated and optimized by adjusting the coupling strength, pulsating frequency, or noise intensity.

关键词： coupled Brownian motors ratchet effective potential symmetric periodic potential noise

MiR-24-3p Attenuates Doxorubicin-induced Cardiotoxicity via the Nrf2 Pathway in Mice

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Current Medical Science 2022年第1期42卷 48-55页

作者： Di FAN hong-bin chen Yan LENG Shi-jun YANG Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430060China Department of Pulmonary and Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Anesthesiology Renmin Hospital of Wuhan UniversityWuhan 430060China.

Objective:The nuclear factor erythroid 2(NFE2)-related factor 2(Nrf2)is associated with doxorubicin(DOX)-induced cardiac *** has been reported that microRNA-24-3p(miR-24-3p)may regulate the Keapl by mRNA degradation,whereas Keapl can suppress the activation of ***,the role of miR-24-3p in DOX-related cardiotoxicity remains unclear.

关键词： miR-24-3p Ros doxorubicin nuclear factor erythroid 2-related factor 2 apoptosis

Misdiagnosis of unroofed coronary sinus syndrome as an ostium primum atrial septal defect by echocardiography:A case report

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World Journal of Clinical Cases 2022年第5期10卷 1592-1597页

作者： Jin-Ling chen Cai-Gui Yu Dai-Jiao Wang hong-bin chen Department of Echocardiography Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Department of Pulmonary and Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

BACKGROUND Unroofed coronary sinus syndrome(UCSS)is a rare congenital heart disease,which has variable morphologic features and is strongly associated with persistent left superior vena cava(PLSVC).However,it is often difficult to visualize the left-to-right shunt pathway through the CS by transthoracic echocardiography(TTE).CASE SUMMARY A 37-year-old female was admitted to the hepatological surgery department of a hospital with complaint of subxiphoid pain that had started 1 wk *** examination revealed a grade 3/6 systolic murmur at the left margin of the sternum,between the 2nd and 3rd intercostal *** patient underwent echocardiography and was diagnosed with ostium primum atrial septal defect(ASD);thus,she was subsequently transferred to the cardiovascular surgery department.A second TTE evaluation before surgery showed type IV UCSS with secundum ***-heart contrast echocardiography(RHCE)showed that the right atrium and right ventricle were immediately filled with microbubbles,but no microbubble was observed in the ***,negative filling was observed at the right atrium orifice of the CS and right atrium side of the secundum atrial *** identified UCSS combined with secundum ASD but without PLSVC in this *** This rare case of UCSS highlights the value of TTE combined with RHCE in confirming UCSS with ASD or PLSVC.

关键词： Congenital heart disease Coronary sinus Atrial septal defect Persistent left superior vena cava Echocardiography Right heart contrast echocardiography Case report

Treadmill exercise exerts a synergistic effect with bone marrow mesenchymal stem cell-derived exosomes on neuronal apoptosis and synaptic-axonal remodeling

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Neural Regeneration Research 2023年第6期18卷 1293-1299页

作者： Xin-hong Jiang Hang-Feng Li Man-Li chen Yi-Xian Zhang hong-bin chen Rong-Hua chen Ying-Chun Xiao Nan Liu Department of Rehabilitation Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian Institute of Cerebrovascular Disease FuzhouFujian ProvinceChina Key Laboratory of Brain Aging and Neurodegenerative Diseases Fujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Longyan First Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina Department of Neurology Fujian Medical University Union HospitalFuzhouFujian ProvinceChina

Treadmill exercise and mesenchymal stem cell transplantation are both practical and effective methods for the treatment of cerebral ***,whether there is a synergistic effect between the two remains *** this study,we established rat models of ischemia/reperfusion injury by occlusion of the middle cerebral artery for 2 hours and reperfusion for 24 *** models were perfused with bone marrow mesenchymal stem cell-derived exosomes(MSC-exos)via the tail vein and underwent 14 successive days of treadmill *** assessment,histopathology,and immunohistochemistry results revealed decreased neuronal apoptosis and cerebral infarct volume,evident synaptic formation and axonal regeneration,and remarkably recovered neurological function in rats subjected to treadmill exercise and MSC-exos *** effects were superior to those in rats subjected to treadmill exercise or MSC-exos treatment ***,further investigation revealed that the activation of JNK1/c-Jun signaling pathways regulated neuronal apoptosis and synaptic-axonal *** findings suggest that treadmill exercise may exhibit a synergistic effect with MSC-exos treatment,which may be related to activation of the JNK1/c-Jun signaling *** study provides novel theoretical evidence for the clinical application of treadmill exercise combined with MSC-exos treatment for ischemic cerebrovascular disease.

关键词： apoptosis axonal regeneration c-Jun exosomes functional remodeling ischemic stroke JNK1 mesenchymal stem cells synaptic formation treadmill exercise

Order parameter analysis of synchronization transitions on star networks

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Frontiers of physics 2017年第6期12卷 11-20页

作者： hong-bin chen Yu-Ting Sun Jian Gao Can Xu Zhi-Gang Zheng Institute of Systems Science Huaqiao University Xiamen 361021 China CoUege of Information Science and Engineering Huaqiao University Xiamen 361021 China Department of Physics and the Beijing-hong Kong-Singapore Joint Centre for Nonlinear and Complex Systems (Beijing) Beijing Normal University Beijing 100875 China

The collective behaviors of populations of coupled oscillators have attracted significant attention in recent years. In this paper, an order parameter approach is proposed to study the low-dimensional dynamical mechanism of collective synchronizations, by adopting the star-topology of coupled oscil- lators as a prototype system. The order parameter equation of star-linked phase oscillators can be obtained in terms of the Watanabe--Strogatz transformation, Ott--Antonsen ansatz, and the ensem- ble order parameter approach. Different solutions of the order parameter equation correspond to the diverse collective states, and different bifurcations reveal various transitions among these collective states. The properties of various transitions in the star-network model are revealed by using tools of nonlinear dynamics such as time reversibility analysis and linear stability analysis.

关键词： Kuramoto model synchronization order parameter Ott-Antonsen ansatz star network

Tuberous sclerosis complex-lymphangioleiomyomatosis involving several visceral organs:A case report

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World Journal of Clinical Cases 2021年第24期9卷 7085-7091页

作者： hong-bin chen Xiao-hong Xu Cai-Gui Yu Meng-Ting Wan Chuang-Li Feng Zhi-Yu Zhao Dan-E Mei Jin-Ling chen Department of Pulmonary and Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Department of Pulmonary and Critical Care Medicine People's Hospital of HanchuanHanchuan 431600Hubei ProvinceChina Department of Echocardiography Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

BACKGROUND Lymphangioleiomyomatosis(LAM)is a rare cystic lung disease characterized by the proliferation,metastasis,and infiltration of smooth muscle cells in the lung and other tissues,which can be associated with tuberous sclerosis complex(TSC).The disorder of TSC has a variable expression,and there is great phenotypic *** SUMMARY A 32-year-old Chinese woman with a history of multiple renal angioleiomyolipoma presented with a productive cough persisting for over 2 *** chest computed tomography revealed interstitial changes,multiple pulmonary bullae,bilateral pulmonary nodules,and multiple fat density areas of the inferior *** and contrast ultrasonography revealed multiple high echogenic masses of the liver,kidneys,retroperitoneum,and inferior *** masses were diagnosed as *** through thoracoscopic lung biopsy confirmed ***,high-throughput genome sequencing of peripheral blood DNA confirmed the presence of a heterozygous mutation,c.1831C>T(***611Trp),of the TSC2 *** patient was diagnosed with *** We highlight a rare case of TSC-LAM and the first report of a mediastinum lymphangioleiomyoma associated with TSC-LAM.

关键词： Tuberous sclerosis complex Lymphangioleiomyomatosis Angioleiomyolipoma High-resolution chest computed tomography Contrast ultrasonography Case report

contrast enhanced computed tomography and reconstruction of hepatic vascular system for transjugular intrahepatic portal systemic shunt puncture path planning

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World Journal of Gastroenterology 2015年第32期21卷 9623-9629页

作者： Jian-Ping Qin Shan-hong Tang Ming-De Jiang Qian-Wen He hong-bin chen Xin Yao Wei-Zheng Zeng Ming Gu Department of Digestion General Hospital of Chengdu Military Command Disease Preventive and Control Center Chengdu Military Command Department of Radiology General Hospital of Chengdu Military Command

AIM: To describe a method for the transjugular intrahepatic portal systemic shunt(TIPS) placement performed with the aid of contrast-enhanced computed tomography(CECT) and three-dimensional reconstructed vascular images(3D RVIs), and to assess its safety and effectiveness. METHODS: Four hundred and ninety patients were treated with TIPS between January 2005 and December 2012. All patients underwent liver CECT and reconstruction of 3D RVIs of the right hepatic vein to portal vein(PV) prior to the operation. The 3D RVIs were carefully reviewed to plan the puncture path fromthe start to target points for needle pass through the PV in the TIPS procedure. R E S U LTS :The improved TIPS procedure was successful in 483(98.6%) of the 490 patients. The number of punctures attempted was one in 294(60%) patients, 2 to 3 in 147(30%) patients, 4 to 6 in 25(5.1%) patients and more than 6 in 17(3.5%) patients. Seven patients failed. Of the 490 patients, 12 had punctures into the artery, 15 into the bile duct, eight into the gallbladder, and 18 through the liver capsule. Analysis of the portograms from the 483 successful cases indicated that the puncture points were all located distally to the PV bifurcation on anteroposterior images, while the points were located proximally to the bifurcation in the three cases with intraabdominal bleeding. The complications included three cases of bleeding, of whom one died and two needed surgery. CONCLUSION: Use of CECT and 3D RVIs to plan the puncture path for TIPS procedure is safe, simple and effective for clinical use.

关键词： Transjugular intrahepatic portal systemic shunt Co

Severe acute pancreatitis in the elderly: Etiology and clinical characteristics

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World Journal of Gastroenterology 2008年第16期14卷 2517-2521页

作者： Ming-Jun Xin hong chen bin Luo Jia-Bang Sun Department of General Surgery Xuanwu Hospital Capital Medical University Beijing 100053 China

AIM: To investigate the etiology and clinical characteristics of severe acute pancreatitis (SAP) in elderly patients (≥ 60 years of age). METHODS: We reviewed retrospectively all the SAP cases treated in Xuanwu Hospital in Beijing between 2000 and 2007. RESULTS: In 169 patients with SAP, 94 were elderly and 16 died. Biliary and idiopathic etiologies were the first two causes that accounted for over 90% of SAP in the elderly. Biliary, hyperlipemic and alcoholic etiologies were the first three causes in the young. The proportion of co- morbidity of cholelithiasis, biliary infection, hypertension and coronary heart disease in the aged was significantly higher than that in their young partners. The scores of APACHE Ⅱ and Ranson were also significantly higher in the elderly except the CT score. Organ failures were more common in the elderly, but the local pancreatic complications were not different between the two groups. Mortality of the aged was correlated with the severity of SAP, multiple co-morbidity and incidence of multiple organ dysfunction syndrome (MODS). MODS was the main cause of death. CONCLUSION: The etiology of SAP in the elderly is quite different from that in the young. Biliary and unknown factors are main causes in the aged. The elderly are subject to major organ failures but there is no difference in the occurrence of local pancreatic complications between the elderly and the young. It is crucial to monitor and improve the functions of major organs so as to prevent MODS in the aged with SAP.

关键词： Severe acute pancreatitis Elderly Etiology Mortality Complication

Exploring a new chapter in traditional Chinese medicine:The potential of Calculus bovis in liver cancer treatment

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World Journal of Clinical Oncology 2024年第12期15卷 1520-1527页

作者： Huang Du hong-bin chen Yu Zhao Department of Gastroenterology Minqing County General HospitalFuzhou 350800Fujian ProvinceChina Department of Gastroenterology I Sanming First HospitalFujian Medical UniversitySanming 365000Fujian ProvinceChina Department of Gastroenterology Hannover Medical SchoolCarl-Neuberg-Straße 1Hannover 30625Lower SaxonyGermany

In the ongoing quest for new treatments in medicine,traditional Chinese medicine offers unique insights and ***,studies on the ability of Calculus bovis to inhibit M2-type tumour-associated macrophage polarisation by modulating the Wnt/β-catenin signalling pathway to suppress liver cancer have undoubtedly revealed new benefits and hope for this field of *** purpose of this article is to comment on this study and explore its strengths and weaknesses,thereby providing ideas for the future treatment of liver cancer.

关键词： Calculus bovis M2 tumor-associated macrophage polarization Liver cancer Wnt/β-catenin pathway The tumor microenvironment