MiR-24-3p Attenuates Doxorubicin-induced Cardiotoxicity via the Nrf2 Pathway in Mice

作     者：Di FAN Hong-bin CHEN Yan LENG Shi-jun YANG Di FAN;Hong-bin CHEN;Yan LENG;Shi-jun YANG

作者机构：Department of CardiologyRenmin Hospital of Wuhan UniversityWuhan 430060China Department of CardiologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430060China Department of Pulmonary and Critical Care MedicineRenmin Hospital of Wuhan UniversityWuhan 430060China Department of AnesthesiologyRenmin Hospital of Wuhan UniversityWuhan 430060China. 

出 版 物：《Current Medical Science》 (当代医学科学（英文）)

年 卷 期：2022年第42卷第1期

页      面：48-55页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：This project was supported by National Natural Science Foundation of China(No.80700289)and Medical Research Foundation of Wuhan Municipal Health Commission(No.WX19Q15) 

主　　题：miR-24-3p Ros doxorubicin nuclear factor erythroid 2-related factor 2 apoptosis 

摘      要：Objective:The nuclear factor erythroid 2(NFE2)-related factor 2(Nrf2)is associated with doxorubicin(DOX)-induced cardiac *** has been reported that microRNA-24-3p(miR-24-3p)may regulate the Keapl by mRNA degradation,whereas Keapl can suppress the activation of ***,the role of miR-24-3p in DOX-related cardiotoxicity remains unclear.