Treadmill exercise exerts a synergistic effect with bone marrow mesenchymal stem cell-derived exosomes on neuronal apoptosis and synaptic-axonal remodeling

作     者：Xin-Hong Jiang Hang-Feng Li Man-Li Chen Yi-Xian Zhang Hong-Bin Chen Rong-Hua Chen Ying-Chun Xiao Nan Liu Xin-Hong Jiang;Hang-Feng Li;Man-Li Chen;Yi-Xian Zhang;Hong-Bin Chen;Rong-Hua Chen;Ying-Chun Xiao;Nan Liu

作者机构：Department of RehabilitationFujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian Institute of Cerebrovascular DiseaseFuzhouFujian ProvinceChina Key Laboratory of Brain Aging and Neurodegenerative DiseasesFujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian ProvinceChina Department of NeurologyLongyan First Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina Department of NeurologyFujian Medical University Union HospitalFuzhouFujian ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第6期

页      面：1293-1299页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China,No.81772452(to NL) the Fujian Province Joint Funds for the Innovation of Science and Technology,No.2020Y9065(to NL) Fujian Province Special Foundation for Natural Science Innovation Project,No.2016B014(to NL) the Natural Science Foundation of Fujian Province,No.2019J01160(to XHJ) 

主　　题：apoptosis axonal regeneration c-Jun exosomes functional remodeling ischemic stroke JNK1 mesenchymal stem cells synaptic formation treadmill exercise 

摘      要：Treadmill exercise and mesenchymal stem cell transplantation are both practical and effective methods for the treatment of cerebral ***,whether there is a synergistic effect between the two remains *** this study,we established rat models of ischemia/reperfusion injury by occlusion of the middle cerebral artery for 2 hours and reperfusion for 24 *** models were perfused with bone marrow mesenchymal stem cell-derived exosomes(MSC-exos)via the tail vein and underwent 14 successive days of treadmill *** assessment,histopathology,and immunohistochemistry results revealed decreased neuronal apoptosis and cerebral infarct volume,evident synaptic formation and axonal regeneration,and remarkably recovered neurological function in rats subjected to treadmill exercise and MSC-exos *** effects were superior to those in rats subjected to treadmill exercise or MSC-exos treatment ***,further investigation revealed that the activation of JNK1/c-Jun signaling pathways regulated neuronal apoptosis and synaptic-axonal *** findings suggest that treadmill exercise may exhibit a synergistic effect with MSC-exos treatment,which may be related to activation of the JNK1/c-Jun signaling *** study provides novel theoretical evidence for the clinical application of treadmill exercise combined with MSC-exos treatment for ischemic cerebrovascular disease.