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How the Aggregates Determine Bound Rubber Models in Silicone Rubber? A Contrast Matching Neutron Scattering Study

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Chinese Journal of Polymer Science 2021年第3期39卷 365-376,I0007页

作者： Li-Zhao Huang Yue Shui Wei Chen Zhong-Ming Li hong-tao song Guang-Ai Sun Jia-Zhuang Xu Gan-Ji Zhong Dong Liu Key Laboratory of Neutron Physics and Institute of Nucear Physics and Chemistry(NPC) China Academy of Engineeing Physict(CAEP)Mcnyang 621999China National Synchrotron Radiation Lab CAS Key Laboratory of soft Mtter Chemisty Anhui Provincial fngineing Laboratory of Advanced funcionad Poymer FilmUniversity of Science and Technology of ChinaHefei 230026China College of Polymer cience and Engineering state Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 61065China

The correlation between aggregates and bound rubber structures in silicone rubbers(S(phr)) with various silica fractions(ΦSi) has been investigated by contrast matching small-angle neutron scattering(SANS), swelling kinetics, and low-field nuclear magnetic resonance(NMR).Mixed solvents with deuterated cyclohexane fractions of 4.9% and 53.7% were chosen to match the scattering length densities of the matrix(SMP(phr)) and the filler(SMS(phr)), respectively. All the data consistently suggest that:(i) There is a critical threshold ΦSic between 10 and 30 phr;below ΦSic, the isolated aggregates are dominant, while beyond ΦSic, some rubber fraction is trapped among the agglomerate;(ii) ΦSiindependent thicknesses around 7.5 nm(NMR) and 8.6 nm(SANS) suggest that the bound rubber formation is determined by inherent properties of the components, and the power-law around 4.2 suggests an exponential changed gradient density of the bound rubber;(iii) SMS(80) presents a bicontinuous bound rubber with three characteristic lengths of 41, 100, and 234 nm. The expanded correlation length, a 20 nm smaller aggregate sizes suggest that such existent bicontinuous network in dry samples with less ΦSi is kind of impacted by swelling. With the obtained bound rubber models, the reinforcing mechanism of filled silicone rubber is elucidated.

关键词： Silicone rubber Bound rubber structures Small-angle neutron scattering(SANS) Nuclear magnetic resonance(NMR)

Progress of Animal Research on Electro-acupuncture Treatment for Depression

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Chinese Medical Sciences Journal 2014年第1期29卷 43-47页

作者： Yu-ping Mo Hai-jiang Yao hong-tao song An-ping Xu Yin-shan Tang Zhi-gang Li School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese Medicine

This paper summarized the Chinese literatures in the previous 5 years about the pre-clinical animal researches on the application of electro-acupuncture(EA) treatment for depression,searched in China National Knowledge Infrastructure(CNKI).The efficiency of EA treatment for depression and the mechanism of it were discussed,to shed light on new ideas and new fronts for the further research on depression in clinical or pre-clinical fields.

关键词： electro-acupuncture depression animal research review

男子400m个人混合泳分段成绩实证分析及体能分配特征研究

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中国体育科技 2015年第2期51卷 78-83页

作者：寻红星洪松涛湖南省体育科学研究所运动机能评定与恢复重点实验室湖南长沙410008

为了揭示近年来男子400m个人混合泳项目比赛呈现的特征,主要采用数理统计等方法对近年来国内、外重大游泳比赛成绩进行分析。与奥运会前3名水平相比较,全运会前3名混合泳运动员自由泳分段成绩胜出,但蝶泳、仰泳、蛙泳分段水平均要落后... 详细信息

为了揭示近年来男子400m个人混合泳项目比赛呈现的特征,主要采用数理统计等方法对近年来国内、外重大游泳比赛成绩进行分析。与奥运会前3名水平相比较,全运会前3名混合泳运动员自由泳分段成绩胜出,但蝶泳、仰泳、蛙泳分段水平均要落后。全运会上前8名运动员各个分段均落后于奥运会前8名运动员,差距最大的是仰泳,其次是蝶泳、蛙泳和自由泳。通过对2011—2013年国内、外重大游泳比赛参加个人混合泳决赛的运动员成绩统计来看,同组中,优秀运动员一般采用蝶泳、仰泳分段控制节奏,蛙泳和自由泳分段发力领先对手的体能分配方案;水平略差的运动员蝶泳和仰泳分段一般领先,后半程由于诸多原因呈落后趋势;还有一种表现形式,就是其他泳姿表现一般,但在自己优势泳姿上全力以赴,但从对应的名次来看,这种体能分配往往取得不了较好的成绩。研究表明,国内男子个人混合泳整体水平较国际水平尚有差距,后备人才梯队建设和项目制胜规律应该引起重视;从分段成绩上考虑,蝶泳和仰泳差距较大;从混合泳体能分配特征来看,各分段泳姿对总成绩的影响是不同的,游进过程中采用蝶泳、仰泳分段控制节奏,蛙泳和自由泳分段发力领先对手的分配方案,可能在同组中发挥更好成绩;单纯利用自己擅长泳姿,不注意整体体能分配,一般不会获得理想成绩。

关键词：男子 400m个人混合泳体能分配

Linezolid:A Review of Population Pharmacokinetic Studies

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Linezolid:A Review of Population Pharmacokinetic Studies

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

2018年中国药理学会定量药理学专业委员会学术年会

作者： Li-Li Zhang Chang-Cheng Sheng Ai-Wen Huang Xiao-Jiao Li hong-tao song Zheng Jiao Department of Pharmacy the 900th Hospital of PLA joint logistics support force Department of Pharmacy Huashan HospitalFudan University Department of Pharmacy Guizhou Provincial People's Hospital Phase I Clinical Trial Unit First HospitalJilin University

Background Linezolid is often used for the infections caused by drug-resistant Gram-positive *** studies suggested large interindividual pharmacokinetic variability for *** This review provides synthetic information on population pharmacokinetic(PK) studies of *** aims are to determine if there is a consensus on the structure model,which covariates have been identified and which covariates remains to be *** A literature search was conducted from PubMed,Web of Science,and Embase from their inception to 19 June *** studies were included in this review if they contained data analyzing PK parameters for linezolid in human beings using population PK *** lists of the selected articles were also *** Twenty studies in adults and one study in premature infants were ***-and onecompartment models were often used for the description of population pharmacokinetics of *** adults,first-order elimination was reported in 15 studies;other studies suggested Michaelis-Menten(MM) elimination,time-dependent autoinhibition elimination or parallel firstorder and MM *** clearance was well described by first-order elimination in premature *** covariates were tested and significant covariates in the final models included creatinine clearance(CL),total body weight(TBW),age,renal replacement therapy(dialysis,continuous veno-venous hemodiafiltration,or continuous veno-venous hemodialysis),liver function(ALT or the maximal liver function capacity(LiMAx)),ideal body weight(IBW),hemoglobin,lactate,fibrinogen,the SOFA(sepsis organ failure assessment) score,the presence of acute respiratory distress syndrome(ARDS),peritonitis,liver transplantation/resection and liver *** these,CL and TBW was the most *** inclusion of these covariates,the interindividual variability of CL was 23.2%-58% for adults and 38.3% for premature *** This re

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来源： cnki会议评论

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cnki会议

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin Dai Lei Ye tao song Shuai Huang Jia Wang tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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凹印刮墨刀工作性能模拟分析

包装工程 2018年第9期39卷 228-232页

作者：苗红涛宋卫生河南牧业经济学院郑州450046

目的预测凹版印刷刮墨刀最佳安装位置和使用要求。方法应用分析软件,分别建立油墨流体模型和刮墨刀固体模型,并进行液固耦合分析。结果刮墨刀在油墨冲击影响下,随着安装角度的增加,其刀锋处产生的位移变化率明显下降;随着刮墨刀厚度的增... 详细信息

目的预测凹版印刷刮墨刀最佳安装位置和使用要求。方法应用分析软件,分别建立油墨流体模型和刮墨刀固体模型,并进行液固耦合分析。结果刮墨刀在油墨冲击影响下,随着安装角度的增加,其刀锋处产生的位移变化率明显下降;随着刮墨刀厚度的增加,刀锋处位移逐渐减少。验证出在软包装印刷过程中,刮刀的最佳安装角度为55°~65°,易选用厚度为0.15 mm刮墨刀,在伸长量为5~6 mm时,才能使刮刀处于最佳刮墨状态。结论文中的研究为合理地选用和设计刮墨刀提供了参考,同时采用液固耦合分析凹版印刷过程的方法,对量化分析印刷过程具有一定的实际和理论意义。

关键词：刮墨刀液固耦合凹版印刷模拟分析

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动态三维超声心动图在二尖瓣修复术中的应用

复旦学报（医学版） 2004年第1期31卷 12-14,F002页

作者：洪涛宋凯王春生王敏生赵强复旦大学附属中山医院心外科上海200032

目的评价动态三维超声心动图在二尖瓣修复术中的作用。方法对15例二尖瓣脱垂行修复术的病人进行动态三维重建,并作术前和术后对照。结果术前三维重建能够清晰显示二尖瓣脱垂的部位、范围和瓣下结构的改变情况;术后三维重建能够显示... 详细信息

目的评价动态三维超声心动图在二尖瓣修复术中的作用。方法对15例二尖瓣脱垂行修复术的病人进行动态三维重建,并作术前和术后对照。结果术前三维重建能够清晰显示二尖瓣脱垂的部位、范围和瓣下结构的改变情况;术后三维重建能够显示瓣膜修复术后的形态改变,评价修复术的效果,同时可见软质瓣环不会改变二尖瓣环原有的生理特性,对左心基底部的活动影响较小。结论动态三维超声重建技术能够用于二尖瓣修复术术前挑选病人、术后及时观察效果,本研究为人工二尖瓣的合理设计提供依据。

关键词：动态超声心动图修复术手术治疗二尖瓣脱垂三维重建

电针对慢性应激抑郁大鼠犬尿氨酸代谢途径的影响

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中国现代医学杂志 2022年第7期32卷 37-41页

作者：宋洪涛武忠赛音朝克图罗彤赵俊内蒙古自治区人民医院内蒙古呼和浩特010010 内蒙古国际蒙医医院内蒙古呼和浩特010065 北京中医药大学针灸推拿学院北京100029

目的观察慢性应激抑郁模型大鼠海马区犬尿喹啉酸(KYNA)、喹啉酸(QUIN)、犬尿氨酸-3-单加氧酶(KMO)、3-羟基邻氨基苯甲酸3,4-双加氧酶(3-HAO)、犬尿氨酸转氧酶(KAT)的变化及电针的干预作用,探讨电针抗抑郁的作用机制。方法按照随机数字... 详细信息

目的观察慢性应激抑郁模型大鼠海马区犬尿喹啉酸(KYNA)、喹啉酸(QUIN)、犬尿氨酸-3-单加氧酶(KMO)、3-羟基邻氨基苯甲酸3,4-双加氧酶(3-HAO)、犬尿氨酸转氧酶(KAT)的变化及电针的干预作用,探讨电针抗抑郁的作用机制。方法按照随机数字表法将24只SD大鼠分成空白组、模型组、氟西汀组、电针组,每组6只。空白组不进行任何干预,其他3组通过慢性温和不可预知性应激刺激结合孤养的方法复制慢性应激抑郁模型;采用开野试验观察大鼠的行为学变化;采用酶联免疫吸附试验(ELISA)检测各组大鼠海马区KYNA、QUIN的变化;实时荧光定量聚合酶链反应(qRT-PCR)检测各组大鼠海马区KMO mRNA、3-HAO mRNA、KAT mRNA相对表达量。结果大鼠开野试验中,模型组大鼠应激前的水平运动次数、垂直运动次数与应激后比较,差异有统计学意义(P<0.05),应激21 d后模型组大鼠水平运动次数、垂直运动的次数较应激前减少,而氟西汀组和电针组可逆转此变化。模型组大鼠海马KYNA含量较空白组降低(P<0.05),电针组大鼠海马KYNA含量较模型组升高(P<0.05);模型组大鼠海马QUIN含量较空白组升高(P<0.05),氟西汀组和电针组大鼠海马QUIN含量较模型组降低(P<0.05)。模型组大鼠海马KMO mRNA、3-HAO mRNA、KAT mRNA相对表达量较空白组升高(P<0.05),氟西丁组和电针组较模型组降低(P<0.05)。结论电针可能通过调节犬尿氨酸代谢途径的异常来达到抗抑郁作用。

关键词：抑郁电针慢性应激犬尿氨酸代谢大鼠

Molecular mechanism of pancreatic ductal adenocarcinoma:The heterogeneity of cancer-associated fibroblasts and key signaling pathways

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World Journal of Clinical Oncology 2025年第2期16卷 18-28页

作者： Zhong-Yuan Hu Ding Ding Yu song Ya-Feng Deng Cheng-Ming Zhang tao Yu First School of Clinical Medicine Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina College of Acupuncture and Massage Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina Graduate School Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Digestive Department I Shaanxi Provincial Hospital of Traditional Chinese MedicineXi’an 710000Shaanxi ProvinceChina

Pancreatic ductal adenocarcinoma stands out as an exceptionally fatal cancer owing to the complexities associated with its treatment and diagnosis,leading to a notably low five-year survival *** study offers a detailed exploration of epidemiological trends in pancreatic cancer and key molecular drivers,such as mutations in CDKN2A,KRAS,SMAD4,and TP53,along with the influence of cancer-associated fibroblasts(CAFs)on disease *** particular,we focused on the pivotal roles of signaling pathways such as the transforming growth factor-βand Wnt/β-catenin pathways in the development of pancreatic cancer and investigated their application in emerging therapeutic *** study provides new scientific perspectives on pancreatic cancer treatment,especially in the development of precision medicine and targeted therapeutic strategies,and demonstrates the importance of signaling pathway research in the development of effective therapeutic *** studies should explore the subtypes of CAFs and their specific roles in the tumor microenvironment to devise more effective therapeutic methods.

关键词： Pancreatic cancer Fibroblasts Signaling pathways Tumor microenvironment