Linezolid:A Review of Population Pharmacokinetic Studies
作者单位：Department of Pharmacythe 900th Hospital of PLA joint logistics support force Department of PharmacyHuashan HospitalFudan University Department of PharmacyGuizhou Provincial People's Hospital Phase I Clinical Trial UnitFirst HospitalJilin University
会议名称：《2018年中国药理学会定量药理学专业委员会学术年会》
会议日期：2018年
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
摘 要：Background Linezolid is often used for the infections caused by drug-resistant Gram-positive *** studies suggested large interindividual pharmacokinetic variability for *** This review provides synthetic information on population pharmacokinetic(PK) studies of *** aims are to determine if there is a consensus on the structure model,which covariates have been identified and which covariates remains to be *** A literature search was conducted from PubMed,Web of Science,and Embase from their inception to 19 June *** studies were included in this review if they contained data analyzing PK parameters for linezolid in human beings using population PK *** lists of the selected articles were also *** Twenty studies in adults and one study in premature infants were ***-and onecompartment models were often used for the description of population pharmacokinetics of *** adults,first-order elimination was reported in 15 studies;other studies suggested Michaelis-Menten(MM) elimination,time-dependent autoinhibition elimination or parallel firstorder and MM *** clearance was well described by first-order elimination in premature *** covariates were tested and significant covariates in the final models included creatinine clearance(CL),total body weight(TBW),age,renal replacement therapy(dialysis,continuous veno-venous hemodiafiltration,or continuous veno-venous hemodialysis),liver function(ALT or the maximal liver function capacity(LiMAx)),ideal body weight(IBW),hemoglobin,lactate,fibrinogen,the SOFA(sepsis organ failure assessment) score,the presence of acute respiratory distress syndrome(ARDS),peritonitis,liver transplantation/resection and liver *** these,CL and TBW was the most *** inclusion of these covariates,the interindividual variability of CL was 23.2%-58% for adults and 38.3% for premature *** This re