New cytotoxic cerebroside from Gynura divaricata

作     者：Lei Chen Jin Jiang Wang Hong Tao Song Guo Gang Zhang Lu Ping Qin 

作者机构：Department of Pharmacy Fuzhou General Hospital of Nanjing Military Region Fuzhou 350025 China Department of Pharmacognosy School of Pharmacy Second Military Medical University Shanghai 200433 China School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2009年第20卷第9期

页      面：1091-1093页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 0902[农学-园艺学] 071002[理学-动物学] 090202[农学-蔬菜学] 

基　　金：supported by the Scientific Research Fund of Fujian Provincial Department of Science &Technology(No.2008Y0086) the Traditional Chinese Medicine Research Fund of Fujian Provincial Public Health Bureau(No.wzy0606),China 

主　　题：Gynura divaricata Cerebroside Cytotoxicity 

摘      要：A new cerebroside, gynuraoside （1）, was isolated from the aerial parts of Gynura divaricata DC. It was determined to be 1-0-13- o-glucopyranosyl-（2S,3 S,4R, 10E）-2- [（2＇R）-2^-hydroxyldocosanoyl-amino]- 10-octadecene- 1,3,4-triol on the basis of chemical and spectroscopic evidence. This compound showed strong cytotoxicity against L1210 leukemia cell line in vitro. 2009 Hong Tao Song. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.