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World Journal of Traditional Chinese Medicine 2019年第3期5卷 173-179页

作者： Guang-ping Zhang Hai-Jing Zhang Teng-Fei Chen hong-ping hou ping Su Yun-Hang Gao Yi-Fei Yang Zu-Guang Ye Atomized Inhalation Preparation Research Center Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences

Objective: In this study, the hepatotoxic components of Polygoni multiflori Radix and Polygoni multiflori Radix Praeparata(known as Heshouwu [HSW] and Zhiheshouwu [ZHSW] in China, respectively) were screened, isolated, and identified. Materials and Methods: The ethanol extracts of HSW and ZHSW were separated into 80 fractions according to their polarity in the preparation liquid phase. Chang liver cell line was used to screen the toxic components of HSW and ZHSW in vitro. The obtained toxic mixture was further collected, isolated, and identified to confirm the hepatotoxic compounds of HSW and ZHSW. Results: The identifid hepatotoxic compounds include 2,3,5,4’-tetrah ydroxystilbene-2-O-β-D-glucoside, emodin, physcion-8-O-β-d-glucoside, physcion, and citreorosein, the fist two among them were the main components of HSW and ZHSW. After processing of HSW, the contents of 2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucoside and emodin in ZHSW were signifiantly decreased. Conclusions: The traditional processing with herb has signifiant effects on the components, especially the toxic components, in the extract of HSW and is an effective method to reduce its toxicity.

关键词： 2,3,5,4’-tetra-hydroxystilbene-2-O-β-D-glucoside emodin hepatotoxicity Polygoni multiflori Radix Polygoni multiflori Radix Praeparata

Mitochondria are Main Targets of Time/Dose-Dependent Oxidative Damage-Based Hepatotoxicity Caused by Rhizoma Dioscoreae Bulbiferae in Mice

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World Journal of Traditional Chinese Medicine 2020年第4期6卷 461-468页

作者： hong-ping hou Guang-ping Zhang Han Li Teng-Fei Chen Yun-Hang Gao Ling Song Zhong-Xiu Zhang Zu-Guang Ye Atomization Inhalation Research Center Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijingChina

Background:Rhizoma Dioscoreae bulbiferae could cause liver damage,which limited its application in the *** and Objectives:To explore the mechanism of hepatotoxicity of Rhizoma Dioscoreae bulbiferae in *** and Methods:In the present study,the water extraction of Rhizoma Dioscoreae bulbiferae(W.E.R)was administrated via intragastrical with Low(19.6 g/kg),Middle(28.0 g/kg),and High(40.0 g/kg)dose in *** each time point 14 days,21 days,and 28 days,the body weight,liver coefficient,indexes of liver function alkaline phosphatase(ALP),alanine aminotransferase(ALT)and aspartate transaminase(AST),various biochemical biomarkers of liver tissue and mitochondria were detected and ***:We found that W.E.R could decrease the body weight,increase the liver coefficient and the expression levels of indexes of liver function in ***,we investigated that W.E.R could increase the expression levels of reactive oxygen species(ROS)and malondialdehyde(MDA),decrease the expression levels of adenosine triphosphate(ATP)and improve the enzyme activities of total superoxide dismutase(SOD).Third,we found that W.E.R could increase the enzyme activities of manganese-superoxide dismutase,decrease the enzyme activities of sodium-potassium adenosine triphosphatase(Na+-K+-ATPase)and calcium-magnesium adenosine triphosphatase(Ca 2+-Mg 2+-ATPase).Finally,we analyzed that there were significant negative correlations between body weight,expression level of ATP,activity of Na+-K+-ATPase,activity of Ca 2+-Mg 2+-ATPase and time,*** were significant positive correlations between liver coefficient,ALP,ALT,AST,expression levels of ROS,MDA and time,***:All the results above indicated that W.E.R could cause the hepatotoxicity based on the oxidative damage in mice,which and mitochondria might be the main targets.

关键词： Correlation hepatotoxicity mitochondria oxidative damage Rhizoma Dioscoreae bulbiferae

Multi-functional Hollow Structures for Intelligent Drug Delivery

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Chemical Research in Chinese Universities 2024年第3期40卷 394-412页

作者： hou ping YANG Nailiang WANG Dan State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190P.R.China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049P.R.China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing 100049P.R.China

Multi-fountional hollow structures have emerged as promising platforms for intelligent drug delivery due to their unique properties,such as high loading capacities and programmed drug *** particular,hollow multishell structures(HoMSs)with multilevel shell and space can regulate the molecular-level interaction between drugs and materials,so as to achieve the temporal-spatial order and sequential release of *** anisotropic hollow structures can control the drug diffusion process by inducing the macroscopic interface flow through autonomous movement,realizing the targeted drug transport and *** this paper,a key focus will be HoMSs with their temporal-ordered architectures and anisotropic hollow carriers with directional *** synthesis mechanisms,structure-property relationships,smartly programmed drug delivery and biomedical applications will be discussed,providing insights into designing next-generation intelligent drug carriers.

关键词： Hollow multishell structure Anisotropic hollow structure Intelligent drug carrier Temporal-spatial order Directional movement

Ordered Bicontinuous Network Structures Regulated by Orientational Interactions in a Rod-Coil Block Copolymer

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Chinese Journal of Polymer Science 2024年第5期42卷 636-642,I0008页

作者： Xiao-Lin Lyu Shi-Chu Yang An-Qi Xiao ping-ping hou Wei Zhang hong-Bing Pan Zhi-Hao Shen Xing-He Fan Qi-Feng Zhou Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China Key Laboratory of Advanced Materials Technologies International(HongKong Macao and Taiwan)Joint Laboratory on Advanced Materials TechnologiesCollege of Materials Science and EngineeringFuzhou UniversityFuzhou350108China

The rich phase behavior of block copolymers(BCPs)has drawn great attention in recent ***,the double diamond(DD)phase is rarely obtained because of the competition between the minimization of interfacial energy and packing ***,a rod-coil BCP containing mesogen-jacketed liquid crystalline polymer is designed to acquire ordered bicontinuous network *** reduction of internal energy originating from the orientational interaction among the rod blocks can compensate for the free energy penalty of packing frustration to stabilize the DD *** resulting BCP can also experience lamellae-to-DD and double gyroid-to-lamellae transitions by changing the annealing *** results make the rod-coil BCP an excellent candidate for the self-assembly of ordered network structures,demonstrating great potential in nanopatterning and metamaterials.

关键词： Block copolymer Rod-coil Ordered bicontinuous phase Double diamond Double gyroid

Toxicity Classification and Detoxification Strategies of Chinese Materia Medica

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World Journal of Traditional Chinese Medicine 2015年第4期1卷 33-37页

作者： Guang-ping Zhang hong-ping hou Zu-Guang Ye Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences

In recent years, more and more poison incidents of Chinese Materia Medica(CMM) were reported by China and other countries, which made people to doubt about the safety of CMM, especially for the toxic CMM. In this review, the toxicity of CMM and the toxicity classification of CMM were introduced. And traditional TCM theory and methods particularly used for control and attenuation of CMM's toxicity were described in detail. The traditional processing technology and CMM drug combination were most important detoxifying measures used in CMM formulation and clinical practice. Finally, some factors that have influence on occurrence of CMM's toxicity were discussed such as different species, producing technology and so on.

关键词： Toxicity of Chinese Materia Medica Drug Combination Drug interaction Detoxification Toxicity-influencing factor Toxicology

Vascular endothelial growth factor/connective tissue growth factor and proteomic analysis of aqueous humor after intravitreal conbercept for proliferative diabetes retinopathy

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1816-1827页

作者： hou-Shuo Li Xiao Lyu Ao Rong Yan-Long Bi Wei Xu hong-ping Cui Department of Ophthalmology Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China Department of Ophthalmology Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

AIM:To investigate the role of connective tissue growth factor(CTGF)and vascular endothelial growth factor(VEGF)in the protein profile of the aqueous humor in patients with proliferative diabetic retinopathy(PDR)following intravitreal injection of ***:This study included 72 PDR patients and 8 cataract patients as *** patients were divided into 3 groups according to the intervals of 3,5,and 7d between intravitreal conbercept(IVC,0.5 mg/0.05 mL)injection and pars plana vitrectomy(PPV)*** humor samples were collected before and after IVC and PPV for VEGF and CTGF levels detected with enzyme-linked immunosorbent assay(ELISA).The differential proteomics of 10 patients who underwent PPV surgery 5d after IVC and 8 normal controls was studied,Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis were performed on the data,and the protein interaction network of 23 differential proteins was ***:Post-IVC,VEGF levels decreased and CTGF levels increased significantly in aqueous humor,with the CTGF/VEGF ratio rising significantly at all *** chromatography tandem mass spectrometry(LC-MS/MS)identified differentially expressed proteins between preand post-IVC *** and KEGG analyses revealed involvement in immune response,stress response,complement and coagulation cascades,ferroptosis,and PPAR signaling *** analysis highlighted key proteins like APOA1,C3,and transferrin(TF).ELISA assay confirmed the differential expression of proteins such as HBA1,SERPINA1,COL1A1,and ACTB,with significant changes in the IVC ***:The study demonstrates that IVC effectively reduces VEGF levels while increasing CTGF levels,thereby modifying the CTGF/VEGF ratio,and IVC significantly alters the protein profile in the aqueous humor of patients with *** analysis reveals that these changes are associated with critical biological pathways and protein interactions involved in immune respons

关键词： proliferative diabetic retinopathy conbercept vascular endothelial growth factor connective tissue growth factor proteomics

Revealing effect of Al content on oxidation of novel Co-Cr-Nb-W carbide-strengthened superalloy

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Rare Metals 2024年第9期43卷 4521-4534页

作者： Chen Ling Shang-ping Li Jie hou He-Li Luo Central Iron&Steel Research Institute Beijing 100081China Beijing GAONA Materials&Technology Co. Ltd.Beijing 100081China

The high-temperature oxidation behavior of novel Co-Cr-Nb-W carbide-strengthened wear-resistance alloys with different Al contents(1wt%,2wt%and 3wt%)at 950,1000 and 1050℃was thoroughly investigated by scanning electron microscopy,X-ray diffraction,X-ray photoelectron spectroscopy and field emission electron probe *** porous property of NbC in-situ oxidation products(Nb_(2)O_(5),Co Nb_(2)O_(6)and Co_(4)Nb_(2)O_(9))induces a multi-layered oxide scale with micropores and ***-Cr-Nb-W alloy with 1 wt%Al undergoes catastrophic oxidation and spalling above 1000℃.The outward transportation of Cr and Co is effectively restrained by a continuous Al_(2)O_(3)scale formed around NbC in-situ oxidation region when Al content reaches 3 wt%.The β-Co Al in Co-Cr-Nb-W alloy with 3 wt%Al has an oxidation priority over eutectic carbides and the alloy matrix which are both enriched with Cr,thereby preventing the formation of Cr-depletion area and improving the self-healing ability of the oxide film.A slight change in Al content has a remarkable influence on the cooperative effect of Al and Cr and multiplies the antioxidant capacity of Co-Cr-Nb-W alloy above 1000℃.

关键词： High-temperature oxidation behavior Oxidation kinetics Superalloy Wear-resistant alloy Microstructure

Study on moisture absorption characteristics of glass fibrereinforced epoxy resin material for composite insulators based on the 3D-Fick model

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High Voltage 2024年第4期9卷 888-901页

作者： Yuming Zhang Yunpeng Liu Sizu hou Jianghai Geng ping Wang Hebei Provincial Key Laboratory of Power Transmission Equipment Security Defense North China Electric Power UniversityBaodingChina Hebei Key Laboratory of Power Internet of Things Technology BaodingChina

Long-term exposure to moisture leads to a gradual deterioration of performance and reduced service life of glass fibre-reinforced epoxy resin(GFRP)material in composite ***,it is necessary to analyse the moisture absorption characteristics of GFRP material and the evolution of damage to their internal interface *** absorption tests on GFRP rod material used in composite insulators to obtain their three-dimensional diffusion coefficients are *** force microscopy was then employed to obtain the composite material system's fibre/matrix interfacial phase ***,a finite element model incorporating representative volume elements with interfacial phases and a mesoscale transient moisture absorption finite element model for the composite material was ***,the moisture absorption characteristics of GFRP material and the evolution of damage to the interfacial phase under thermal-humidity cycling conditions were *** results showed that the diffusion coefficient along the fibre direction in GFRP material was higher than that in the perpendicular *** moisture diffusion finite element model,incorporating an anisotropic interfacial phase,fitted the anisotropic diffusion coefficients of GFRP material more *** moisture invaded the GFRP material,the mismatch stresses continuously increased during the moisture ***,the non-uniform arrangement of fibres resulted in uneven distribution of moistureinduced stresses inside the material,leading to higher mismatch stresses in areas with dense fibre arrangements in the *** high and low humidity cycles led to the development of micro-cracks,micro-porosity,and interface debonding along the fibre direction at the GFRP material interfaces,thereby affecting the anisotropic moisture absorption characteristics of the *** findings of this study provide valuable insights into the mechanisms underlying the

关键词： composite fibre moisture

Constrained clustering with weak label prior

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Frontiers of Computer Science 2024年第3期18卷 117-132页

作者： Jing ZHANG Ruidong FAN hong TAO Jiacheng JIANG Chenping hou College of Sciences National University of Defense TechnologyChangsha 410073China

Clustering is widely exploited in data *** has been proved that embedding weak label prior into clustering is effective to promote its *** researches mainly focus on only one type of ***,in many real scenarios,two kinds of weak label prior information,e.g.,pairwise constraints and cluster ratio,are easily obtained or already *** to incorporate them to improve clustering performance is important but rarely *** propose a novel constrained Clustering with Weak Label Prior method(CWLP),which is an integrated *** the unified spectral clustering model,the pairwise constraints are employed as a regularizer in spectral embedding and label proportion is added as a constraint in spectral *** approximate a variant of the embedding matrix more precisely,we replace a cluster indicator matrix with its scaled *** of fixing an initial similarity matrix,we propose a new similarity matrix that is more suitable for deriving clustering *** for the theoretical convergence and computational complexity analyses,we validate the effectiveness of CWLP through several benchmark datasets,together with its ability to discriminate suspected breast cancer patients from healthy *** experimental evaluation illustrates the superiority of our proposed approach.

关键词： clustering weak label prior cluster ratio pairwise constraints

An Analytical Method for Delineating Feasible Region for PV Integration Capacities in Net-zero Distribution Systems Considering Battery Energy Storage System Flexibility

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 475-487页

作者： Shida Zhang Shaoyun Ge hong Liu Guocheng hou Chengshan Wang School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China

To provide guidance for photovoltaic(PV)system integration in net-zero distribution systems(DSs),this paper proposes an analytical method for delineating the feasible region for PV integration capacities(PVICs),where the impact of battery energy storage system(BESS)flexibility is ***,we introduce distributionally robust chance constraints on network security and energy/carbon net-zero requirements,which form the upper and lower bounds of the feasible ***,the formulation and solution of the feasible region is *** resulting analytical expression is a set of linear inequalities,illustrating that the feasible region is a polyhedron in a high-dimensional space.A procedure is designed to verify and adjust the feasible region,ensuring that it satisfies network loss constraints under alternating current(AC)power *** studies on the 4-bus system,the IEEE 33-bus system,and the IEEE 123-bus system verify the effectiveness of the proposed *** is demonstrated that the proposed method fully captures the spatio-temporal coupling relationship among PVs,loads,and BESSs,while also quantifying the impact of this relationship on the boundaries of the feasible region.

关键词： Net-zero distribution system photovoltaic(PV)integration capacity feasible region battery energy storage system(BESS).