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Arterioportal shunt incidental to treatment with oxaliplatin that mimics recurrent gastric cancer

World Journal of Gastroenterology 2017年第33期23卷 6187-6193页

作者： hong-beum kim Sang-Gon Park Department of Premedical Course Chosun University School of Medicine Department of Internal Medicine HematooncologyChosun University Hospital

Arterioportal shunt(APS) is an organic communication between the hepatic arterial system and the portal venous system. The APS is one of the major causes of transient hepatic attenuation differences on dynamic computed tomography(CT) or magnetic resonance imaging(MRI). This condition is usually associated with trauma,liver cirrhosis,and malignancies of the liver. However,there has been no report about oxaliplatininduced APS. A 41-year-old male was diagnosed with Stage ⅢB gastric cancer. The patient initially underwent neoadjuvant chemotherapy with capecitabine and oxaliplatin After 3 cycles of therapy,the mass had markedly decreased,and a total gastrectomy with splenectomy was performed. Since the malignancy was locally invasive,the patient was continued on the same regimen of the adjuvant chemotherapy. After 3 more cycles,a computed tomography revealed a 1 cm sized arterial-enhancing nodule in the right lobe of the liver. An MRI revealed an arterial enhancing lesion,and a positron emission tomography CT scan showed a hypermetabolic lesion in the same portion of the liver. We tried to perform a liver biopsy; however,an ultrasonography could not detect any mass. A presumptive diagnosis of an APS due to a recurred cancer was made. We found a similar but slightly different case report of an oxaliplatin-induced liver injury,mimicking a metastatic tumor on an MRI. Based on a prior report,the patient was continuedon treatment with adjuvant chemotherapy following discontinuation of oxaliplatin. After 2 cycles,the arterial enhancing liver mass resolved,supporting the final diagnosis of an APS,related to oxaliplatin-induced sinusoidal injury. The patient has not experienced any a relapse after two years of additional follow up recurrent gastric cancer upon interpretation of multiple imaging modalities.

关键词： Liver Arterioportal shunt Recurred cancer Oxaliplatin Transient hepatic attenuation differences

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Extremely rare case of successful treatment of metastatic ovarian undifferentiated carcinoma with high-dose combination cytotoxic chemotherapy: A case report

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World Journal of Clinical Cases 2020年第19期8卷 4488-4493页

作者： hong beum kim Hee Jeong Lee Ran hong Sang-Gon Park Department of Premedical Course Chosun University School of MedicineGwngju 505717South Korea Department of Internal Medicine Hemato-oncologyChosun University HospitalGwangju 505717South Korea Department of Pathology Chosun University HospitalGwangju 505717South Korea

BACKGROUND Ovarian undifferentiated carcinomas are significantly rare and have an aggressive clinical *** resection is the only curative treatment in early-stage ovarian undifferentiated carcinomas that has a favorable *** case of recurrent and metastatic disease,palliative chemotherapy is the only available ***,the effectiveness of standard chemotherapy regimen is not well-known,specifically in the case of extra-ovarian *** report an ovarian undifferentiated carcinoma of recurrent and inoperable advanced stage that was successfully treated with high-dose combination *** SUMMARY A 52-year-old woman presented with a 1-mo history of right lower quadrant and epigastric pain.A computed tomography(CT)scan of the abdomen revealed a multicystic mass with extensive internal necrosis of the right ovary without evidence of metastatic disease.A total hysterectomy with bilateral salpingooophorectomy and omentectomy was performed,but the surgery had a positive resection ***,it was diagnosed as ovarian undifferentiated carcinoma with sarcomatoid *** adjuvant chemotherapy was planned,it was delayed for 6 wk because of postoperative recovery,and the patient complained of abdominal pain.A CT scan and positron emission tomography-CT revealed a huge mass with multiple nodules in the pelvic cavity and para-aortic lymph node *** of standard therapy such as paclitaxel and platinum,combined chemotherapy with etoposide,ifosfamide,and cisplatin was *** patient experienced no recurrence for 5 *** This is a case of metastatic ovarian undifferentiated carcinoma with sarcomatoid change that was successfully treated with high-dose combination cytotoxic chemotherapy.

关键词： Ovarian undifferentiated carcinoma Sarcomatoid change Chemotherapy Etoposide,ifosfamide,cisplatin Case report

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Acute myelomonocytic leukemia during pembrolizumab treatment for non-small cell lung cancer: A case report

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World Journal of Clinical Cases 2020年第13期8卷 2833-2840页

作者： hong-beum kim Sang-Gon Park Ran hong Seong-Ho Kang Yong Sub Na Department of Premedical Course Chosun University School of MedicineGwangju 61452South Korea Department of Hemato-oncology Chosun University HospitalGwangju 61453South Korea Department of Pathology Chosun University HospitalGwangju 61453South Korea Department of Laboratory Medicine Chosun University HospitalGwangju 61453South Korea Department of Pulmonology and Critical Care Medicine Chosun University HospitalGwangju 61453South Korea

BACKGROUND Pembrolizumab is a highly selective IgG4 kappa isotype monoclonal antibody against the programmed cell death-1(PD-1)*** the treatment of nonsmall cell lung cancer(NSCLC),pembrolizumab has demonstrated significant efficacy,significant survival outcomes,long-lasting responses,and a good safety profile compared with cytotoxic *** SUMMARY A 79-year-old Korean male presented with a left side palpable neck *** ultrasound-guided core-needle biopsy of the largest neck mass was performed,and squamous cell carcinoma was confirmed based on the histological and immunohistochemical *** was diagnosed with squamous cell carcinoma of the lung with multiple lymph nodes and rib metastases(T1N3M1b,Stage IVA)using enhanced chest computed tomography and 18F-fluorodeoxyglucose positron emission/computed *** 4 cycles of gemcitabine and carboplatin,we clinically judged the disease as *** to the high PD-1 expression demonstrated by the patient,pembrolizumab was initiated(200 mg every 3 wk).After 3 cycles of pembrolizumab,a complete response was *** the 4th cycle of pembrolizumab,the white blood cell count was markedly *** blood smear analysis and bone marrow biopsy were *** patient was diagnosed with acute myelomonocytic *** We present the first report of acute myelomonocytic leukemia during pembrolizumab treatment in an NSCLC patient;the mechanism remains unknown.

关键词： Acute myeloid leukemia Immunotherapy Non-small cell lung cancer Adverse events Case report

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Bronchobiliary fistula after ramucirumab treatment for advanced gastric cancer: A case report

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World Journal of Clinical Cases 2019年第19期7卷 3039-3046页

作者： hong-beum kim Yong Sub Na Hee-Jeong Lee Sang-Gon Park Department of Premedical Course Chosun University School of MedicineDong-guGwangju 501-717South Korea Department of Internal Medicine PulomonologyChosun University HospitalDong-guGwangju 501-717South Korea Department of Internal Medicine Hemato-oncologyChosun University HospitalDong-guGwangju 501-717South Korea

BACKGROUND Bronchobiliary fistula(BBF)is a rare disease characterized by an abnormal connection between the biliary system and *** causes of BBF include trauma and infections,and more recent causes include malignancies and certain cancer *** is an antivascular endothelial growth factor receptor 2 monoclonal antibody,currently used as a second-line treatment for gastric *** SUMMARY A 43-year-old man visited our hospital with the complaint of *** was diagnosed with inoperable advanced gastric cancer owing to invasion of the hepatic hilum by the *** percutaneous transhepatic biliary drainage(PTBD)and stent placement,capecitabine and oxaliplatin were administered as first-line palliative *** tumor progressed,and paclitaxel and ramucirumab were administered as second-line ***,on the first day of the second cycle,the patient suddenly developed dyspnea and *** was diagnosed on the basis of the presence of bilious sputum and the results of computed tomography,and PTBD was *** This is the first report of BBF after administration of the new antiangiogenic agent ramucirumab.

关键词： Ramucirumab Liver Bronchobiliary fistula Advanced gastric cancer Case report

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Isolated peritoneal lymphomatosis defined as post-transplant lymphoproliferative disorder after a liver transplant: A case report

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World Journal of Clinical Cases 2019年第24期7卷 4299-4306页

作者： hong beum kim Ran hong Yung Sub Na Woo Young Choi Sang Gon Park Hee Jeong Lee Department of Premedical Course Chosun University School of MedicineGwangju 501-717South Korea Department of Pathology Chosun University Hospital365 Pilmun-daeroDong-guGwangju 501-717South Korea Department of Internal Medicine PulomonologyChosun University HospitalGwangju 501-717South Korea Department of Plastic and Reconstructive Surgery Chosun University HospitalGwangju 501-717South Korea Department of Internal Medicine Hemato-oncologyChosun University HospitalGwangju 501-717South Korea MD PhDDepartment of HematoOncologyChosun University Hospital365 Pilmun-daeroDong-guGwangju 501-717South Korea

BACKGROUND Post-transplant lymphoproliferative disorder(PTLD) is a fatal complication of solid organ transplantation or allogenic hematopoietic stem cell transplantation that is associated with immunosuppressive therapy. Potential manifestations are diverse, ranging from reactive lymphoid hyperplasia to high-grade *** is usually of B-cell origin and associated with Epstein-Barr virus(EBV)infection. Herein, we describe a case of PTLD involving the peritoneal *** has been only case of PTLD as a diffuse large B-cell lymphoma(DLBCL) in the *** SUMMARY The patient was a 62-year-old man who had been receiving immunosuppressive therapy with tacrolimus since undergoing a liver transplant 15 years prior. He reported that he had experienced abdominal discomfort and anorexia 1 month prior to the current admission. Abdominal pelvic computed tomography(CT)revealed peritoneal and omental mass-like lesions without bowel ***-guided biopsy was performed, and he was histologically diagnosed with EBV-negative DLBCL. Positron emission tomography(PET)-CT depicted peritoneum and omentum involvement only, without any lymphadenopathy or organ masses, including in the gastrointestinal tract. Six cycles of chemotherapy with a "R-CHOP" regimen(rituximab-cyclophosphamide, doxorubicin, vincristine, prednisolone) were administered,and PET-CT performed thereafter indicated complete *** This is the first report of isolated peritoneal lymphomatosis defined as PTLD in a liver transplant recipient.

关键词： Case report Diffuse large B-cell lymphoma Epstein-Barr virus infection Posttransplant lymphoproliferative disorder R-CHOP Isolated peritoneal lymphomatosis

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Evaluation of internal void related defects in reinforced concrete slab using electromagnetic wave properties

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 525-535页

作者： Minju Kang Jinyoung hong Taemin Lee Doyun kim Hajin Choi School of Architecture Soongsil UniversitySeoul 06978Republic of Korea

This study aims to develop a damage-detection algorithm based on the electromagnetic wave properties inside a reinforced concrete *** proposed method involves employing two algorithms based on data measured using ground-penetrating radar—a common electromagnetic wave method in civil *** possible defect area was identified based on the energy dissipated by the damage in the frequency-wavenumber domain,with the damage localized using the calculated relative permittivity of the *** proposed method was verified through a finite difference time-domain-based numerical analysis and a testing slab with artificial *** a result of verification,the proposed method quickly identified the presence of damage inside the concrete,especially for honeycomb-like defects located at the top of the *** study has practical significance in scanning structures over a large area more quickly than other non-destructive testing methods,such as ultrasonic methods.

关键词： GPR concrete defect electromagnetic wave relative permittivity non-destructive testing(NDT)

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Trifunctional robust electrocatalysts based on 3D Fe/N-doped carbon nanocubes encapsulating Co4N nanoparticles for efficient battery-powered water electrolyzers

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Carbon Energy 2024年第6期6卷 124-139页

作者： Hyung Wook Choi hongdae Lee Jun Lu Seok Bin Kwon Dong In Jeong beum Jin Park Jiwon kim Bong Kyun Kang Gun Jang Dae Ho Yoon Ho Seok Park SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea School of Chemical Engineering Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Department of Electronic Materials Devicesand Equipment EngineeringSoonchunhyang UniversityAsan CityChungnamRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea

Herein,we have designed a highly active and robust trifunctional electrocatalyst derived from Prussian blue analogs,where Co_(4)N nanoparticles are encapsulated by Fe embedded in N-doped carbon nanocubes to synthesize hierarchically structured Co_(4)N@Fe/N-C for rechargeable zinc-air batteries and overall water-splitting *** confirmed by theoretical and experimental results,the high intrinsic oxygen reduction reaction,oxygen evolution reaction,and hydrogen evolution reaction activities of Co_(4)N@Fe/N-C were attributed to the formation of the heterointerface and the modulated local electronic ***,Co_(4)N@Fe/N-C induced improvement in these trifunctional electrocatalytic activities owing to the hierarchical hollow nanocube structure,uniform distribution of Co_(4)N,and conductive encapsulation by Fe/***,the rechargeable zinc-air battery with Co_(4)N@Fe/N-C delivers a high specific capacity of 789.9 mAh g-1 and stable voltage profiles over 500 ***,the overall water electrolyzer with Co_(4)N@Fe/N-C achieved better durability and rate performance than that with the Pt/C and IrO2 catalysts,delivering a high Faradaic efficiency of 96.4%.Along with the great potential of the integrated water electrolyzer powered by a zinc-air battery for practical applications,therefore,the mechanistic understanding and active site identification provide valuable insights into the rational design of advanced multifunctional electrocatalysts for energy storage and conversion.

关键词： battery-powered electrolyzers hierarchical structure Prussian blue analog trifunctional electrocatalyst zinc-air battery

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Insights into the changes in the surface properties of goethite with Ni in the lattice in the presence of salicylhydroxamic acid:Experimental and density functional theory studies

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International Journal of Minerals,Metallurgy and Materials 2024年第4期31卷 665-677页

作者： Levie Mweene Gilsang hong Hee-Eun Jeong Hee-won Kang Hyunjung kim Department of Earth Resources and Environmental Engineering Hanyang University222 Wangsimni-roSeongdong-guSeoul 04763Republic of Korea

Comparative experiments and theoretical analysis of the surface chemistry changes of goethite(GT)and goethite containing Ni(GTN)in the lattice in the presence of salicylhydroxamic acid(SA)were *** was revealed that in the presence of 100 g·t^(-1)of SA,the flotation recovery of GTN and GT increased with increasing pH,achieving a maximum recovery of 98.9%for both minerals at p H 8.3 and decreasing beyond that pH,with GTN having a slightly higher recovery than GT,except at pH *** was further confirmed by the higher complexation energies of GTN···SA(-883.87 kJ·mol^(-1))compared with GT···SA(-604.23 kJ·mol^(-1))resulting from covalent,closed-shell,and conventional hydrogen *** higher adsorption of SA onto GTN relative to GT was due to the formation of aπ-hole in GTN,thereby promoting a higher interaction of the collector with the ***,the presence of Ni in the GT lattice improves and decreases the adsorption and desorption of SA onto and from the mineral,respectively,compared with those onto and from GT.

关键词： nickel goethite adsorption salicylhydroxamic acid recovery

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Advances in Wireless,Batteryless,Implantable Electronics for Real‑Time,Continuous Physiological Monitoring

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Nano-Micro Letters 2024年第3期16卷 254-302页

作者： Hyeonseok kim Bruno Rigo Gabriella Wong Yoon Jae Lee Woon‑hong Yeo IEN Center for Wearable Intelligent Systems and Healthcare Georgia Institute of TechnologyAtlantaGA 30332USA George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA School of Electrical and Computer Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Wallace H.Coulter Department of Biomedical Engineering Georgia Tech and Emory University School of MedicineAtlantaGA 30332USA Parker H.Petit Institute for Bioengineering and Biosciences Institute for MaterialsInstitute for Robotics and Intelligent MachinesGeorgia Institute of TechnologyAtlantaGA 30332USA

This review summarizes recent progress in developing wireless,batteryless,fully implantable biomedical devices for real-time continuous physiological signal monitoring,focusing on advancing human health *** considerations,such as biological constraints,energy sourcing,and wireless communication,are discussed in achieving the desired performance of the devices and enhanced interface with human *** addition,we review the recent achievements in materials used for developing implantable systems,emphasizing their importance in achieving multi-functionalities,biocompatibility,and *** wireless,batteryless devices offer minimally invasive device insertion to the body,enabling portable health monitoring and advanced disease ***,we summarize the most recent practical applications of advanced implantable devices for human health care,highlighting their potential for immediate commercialization and clinical uses.

关键词： Implantable electronics Biomedical systems Batteryless devices Wireless electronics Physiological signal monitoring

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Recent developments in selective laser processes for wearable devices

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Bio-Design and Manufacturing 2024年第4期7卷 517-547页

作者： Youngchan kim Eunseung Hwang Chang Kai Kaichen Xu Heng Pan Sukjoon hong Optical Nanoprocessing Lab Department of Mechanical EngineeringBK21 FOUR ERICA-ACE CenterHanyang University55 Hanyangdaehak-RoSangnok-GuAnsan 15588Republic of Korea Multiscale Manufacturing Lab J.Mike Walker’66 Department of Mechanical EngineeringTexas A&M UniversityCollege StationTX 77843USA State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310058China

Recently,the increasing interest in wearable technology for personal healthcare and smart virtual/augmented reality applications has led to the development of facile fabrication *** have long been used to develop original solutions to such challenging technological problems due to their remote,sterile,rapid,and site-selective processing of *** this review,recent developments in relevant laser processes are summarized under two separate ***,transformative approaches,such as for laser-induced graphene,are *** addition to design optimization and the alteration of a native substrate,the latest advances under a transformative approach now enable more complex material compositions and multilayer device configurations through the simultaneous transformation of heterogeneous precursors,or the sequential addition of functional layers coupled with other electronic *** addition,the more conventional laser techniques,such as ablation,sintering,and synthesis,can still be used to enhance the functionality of an entire system through the expansion of applicable materials and the adoption of new ***,various wearable device components developed through the corresponding laser processes are discussed,with an emphasis on chemical/physical sensors and energy *** addition,special attention is given to applications that use multiple laser sources or processes,which lay the foundation for the all-laser fabrication of wearable devices.

关键词： Selective laser process Wearable device Transformative approach Laser-induced graphene Ablation Sintering Synthesis

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