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Synthesis of Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors-1-(3-Phthalimido-2-oxobutyl)-4-Substituted-phenylpiperazines

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Chinese Chemical Letters 2000年第7期11卷 571-572页

作者： Xin chen Lin WANG Zhi Zhong ZHAO Xing Quan ZHANG Xiang hong chen hong shan chen(institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050 institute of medicinal biotechnology, Chinese Academy of M institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China institute of medicinal biotechnology Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100050 China

We have designed and synthesized a series of new phthalimidopiperazines, biological activity test show that the target compounds(Ic, Ie, ii) can inhibit HIV-I RT with IC50 20.0, 43.8, and 63.7 mu M, respectively.

关键词： piperazine phthalimide HIV1-RT inhibitor

Augmentation quotients for complex representation rings of dihedral groups

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Frontiers of Mathematics in China 2012年第1期7卷 1-18页

作者： shan CHANG hong chen Guoping TANG School of Mathematics Hefei University of Technology Hefei 230026 China School of Mathematical Sciences Soochow University Suzhou 215006 China School of Mathematical Sciences Graduate University of Chinese Academy of Sciences Beijing 100049 China

Denote by Dm the dihedral group of order 2m. Let R（Dm） be its complex representation ring, and let △（Dm） be its augmentation ideal. In this paper, we determine the isomorphism class of the n-th augmentation quoti... 详细信息

关键词： dihedral group representation augmentation quotient

Tailoring the texture and mechanical properties of 3%Y_(2)O_(3)p/ZGK200 composites fabricated by unidirectional and cross rolling followed by annealing

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Journal of Magnesium and Alloys 2024年第4期12卷 1479-1495页

作者： Xihai Li hong Yan Zhiwei shan Rongshi chen Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang 110016China School of Materials Science and Engineering University of Science and Technology of China72 Wenhua RoadShenyang 110016China School of Materials Science and Engineering Shandong University of Science and TechnologyQingdaoShandong 266590China Center for Advancing Materials Performance from the Nanoscale(CAMP-Nano)and Hysitron Applied Research Center in China(HARCC) State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an 710049China

3%Y_(2)O_(3)p/ZGK200 composites were subjected to unidirectional rolling(UR)and cross rolling(CR)at 400℃and 350℃followed by annealing at 300℃for 1 *** microstructure,texture and mechanical properties of rolled and annealed composites were systematically *** rolled composites exhibited a heterogeneous microstructure,consisting of deformed grains elongated along rolling direction(RD)and Y_(2)O_(3)particles bands distributed along *** annealing,static recrystallization(SRX)occurred and most deformed grains transformed into equiaxed grains.A non-basal texture with two strong T-texture components was obtained after UR while a non-basal elliptical/circle texture with circle multi-peaks was obtained after CR,indicating that rolling path had great influences on texture of the *** annealing process,R-texture component disappeared or weakened,as results,a non-basal texture with double peaks tilting from normal direction(ND)to transverse direction(TD)and a more random non-basal texture with circle multi-peaks were obtained for UR and CR composites,*** yield strength of rolled composites after UR showed obvious anisotropy along RD and TD while a low anisotropic yield strength was obtained after *** Y_(2)O_(3)particles broke during *** fracture of the composites was attributed to the existence of Y_(2)O_(3)clusters and interfacial debonding between particles and matrix during tension,as a result,the ductility was not as superior as matrix alloy.

关键词： Magnesium matrix composites Unidirectional rolling Cross rolling Texture Mechanical properties

Infrared spectral evolution of carbon stars

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Research in Astronomy and Astrophysics 2010年第4期10卷 363-382页

作者： Pei-Sheng chen Xiao-hong Yang hong-Guang shan National Astronomical Observatories /Yunnan Observatory and Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650011China Department of Physics Chongqing UniversityChongqing 400044China

We collected almost all Highly Processed Data Products （HPDP） of ISO SWS01 spectra for the Galactic visual carbon stars,infrared carbon stars,extreme carbon stars and carbon-rich proto-planetary nebulae （PPNs）.Those infrared spectra are primarily analyzed and *** is shown that either spectral shapes/peaks,or main molecular/dust features are evidenced to change in the sequence of visual carbon stars,infrared carbon stars,extreme carbon stars and carbon-rich ***,in this sequence,continua are gradually changed from blue to red and locations of spectral peaks of continua are also gradually changed from short wavelengths to long *** addition,in this sequence,intensities of main molecular/dust features are also gradually changed from prominent in the short wavelengths to prominent in the long ***,from 2MASS and IRAS photometric data,the sequence is also *** in this paper strongly support the previous suggestion for the evolution sequence of carbon-rich objects in our Galaxy,that is the sequence of visual carbon stars → infrared carbon stars → extreme carbon stars → carbon-rich PPNs.

关键词： infrared:stars - stars:carbon - stars:late type

Learning efficient text-to-image synthesis via interstage cross-sample similarity distillation

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Science China(Information Sciences) 2021年第2期64卷 19-30页

作者： Fengling MAO Bingpeng MA hong CHANG Shiguang shan Xilin chen School of Information Science and Technology ShanghaiTech University Key Laboratory of Intelligent Information Processing of Chinese Academy of Sciences (CAS) Institute of Computing TechnologyChinese Academy of Sciences University of Chinese Academy of Sciences CAS Center for Excellence in Brain Science and Intelligence Technology

For a given text, previous text-to-image synthesis methods commonly utilize a multistage generation model to produce images with high resolution in a coarse-to-fine manner. However, these methods ignore the interaction among stages, and they do not constrain the consistent cross-sample relations of images generated in different stages. These deficiencies result in inefficient generation and discrimination. In this study, we propose an interstage cross-sample similarity distillation model based on a generative adversarial network(GAN) for learning efficient text-to-image synthesis. To strengthen the interaction among stages,we achieve interstage knowledge distillation from the refined stage to the coarse stages with novel interstage cross-sample similarity distillation blocks. To enhance the constraint on the cross-sample relations of the images generated at different stages, we conduct cross-sample similarity distillation among the stages. Extensive experiments on the Oxford-102 and Caltech-UCSD Birds-200-2011(CUB) datasets show that our model generates visually pleasing images and achieves quantitatively comparable performance with state-of-the-art methods.

关键词： generative adversarialnetwork (GAN) text-to-image synthesis knowledge distillation

Suppression of Growth of Hela, EJ, SK-OV-3 and MDA-MB-231 Cells by Recombinant Human NK4

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Chinese Journal of Cancer Research 2009年第1期21卷 28-31页

作者： Hua Bai hong chen Chang-shan Ren Tumor institute China Medical University Shenyang 110001 China

Objective： To study the effects of recombinant human Nk4 on the growth and invasion activities of tumor cells. Methods： The inhibition of recombinant human NK4 on human oophoroma, cervical tumor, breast tumor and gallbladder tumor cells was evaluated in vitro by basement membrane invasion assay. Results： rhNK4 could markedly inhibited the growth of human oophoroma, cervical tumor and breast tumor cells. The inhibition rates of human oophoroma, cervical tumor, breast tumor and gallbladder tumor cells were 48.2%, 29.2%, 58.4% and 30.1% respectively. Conclusion： rhNK4 factor can markedly inhibit the invasion of multiple tumor cells.

关键词： rhNK4 Tumor cells In vitro invasion

Metagenomic analysis reveals hidden links between gut microbes and habitat adaptation among cave and surface dwelling Sinocyclocheilus species

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Zoological Research 2023年第4期44卷 793-807页

作者： hong-Yu chen Chun-Qing Li shan-Yuan chen Hen Xiao School of Ecology and Environmental Sciences Yunnan UniversityKunmingYunnan 650500China institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical SchoolKunmingYunnan 650031China

Intestinal microbes are closely related to vital host functions such as digestion and nutrient absorption,which play important roles in enhancing host *** a natural“laboratory”,caves provide an outstanding model for understanding the significance of gut microbes and feeding habits in the habitat adaptability of ***,research on the relationship between gut microbes,feeding habits,and the adaptability of troglobites remains *** this study,we compared the characteristics of the intestinal microbes of Sinocyclocheilus cavefish and surface fish and further established the relationship between intestinal and habitat ***,we conducted environmental DNA(eDNA)(metabarcoding)analysis of environmental samples to clarify the composition of potential food resources in the habitats of the Sinocyclocheilus cavefish and surface *** showed that the structure of the Sinocyclocheilus gut microbes was more related to ecological type(habitat type)than phylogenetic *** horizontal transfer of habitat microbes was a source of gut microbes,hosts also showed strong selection for inherent microbes as dominant *** in the composition and structure of gut microbes,especially dominant microbes,may enhance the adaptability of the two Sinocyclocheilus fish types from the perspectives of food intake,nutrient utilization,and harmful substance metabolism,suggesting that food resources,predation patterns,intestinal flora,digestive and absorptive capacity,and feeding habits and preferences are linked to habitat *** results should facilitate our understanding of the significance of fish gut microbes to habitat adaptation and provide a new perspective for studying the adaptive mechanisms of cavefish.

关键词： Cavefish Intestinal microbes Sinocyclocheilus Adaptive mechanism

Metabolomic characteristics of spontaneously hypertensive rats under chronic stress and the treatment effect of Danzhi Xiaoyao Powder, a traditional Chinese medicine formula

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Journal of Integrative Medicine 2022年第1期20卷 73-82页

作者： Shuai chen Jin Hu Deng-cheng Lu hong-yi Liu shan-shan Wei College of Basic Medical Sciences Yunnan University of Chinese MedicineKunming 650500Yunnan ProvinceChina Department of Endocrinology Yunnan Provincial Hospital of Traditional Chinese MedicineKunming 650021Yunnan ProvinceChina Key Laboratory of Syndrome Micro-Differentiation of Yunnan Province Kunming 650500Yunnan ProvinceChina

Objective: Numerous studies have demonstrated the close relationship between chronic stress and blood pressure(BP). Hypertensive subjects exhibit exaggerated reactions to stress, especially higher BP. The mechanisms by which stress affects pre-existing hypertension still need to be explored. Danzhi Xiaoyao Powder(DP), a historical traditional Chinese medicine formula, is a promising treatment for BP control in hypertensive patients under stress. The present study investigated the metabolomic disruption caused by chronic stress and the treatment effect and mechanism of ***: Spontaneously hypertensive rats(SHRs) were subjected to chronic restraint stress(CRS) for 4 weeks. BP was measured via the tail-cuff method, and anxiety-like behavior was quantified using the elevated-plus-maze test. Meanwhile, DP was administered intragastrically, and its effects were observed. Global metabolomic analysis was performed using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry, followed by multivariate statistical analysis to detect differential metabolites and ***: DP alleviated the CRS-induced increase in BP and anxiety-like behavior. Systematic metabolic differences were found among the three study groups. A total of 29 differential plasma metabolites were identified in both positive-and negative-ion modes. These metabolites were involved in triglyceride metabolism, amino acid(phenylalanine, tryptophan, and glycine) metabolism, and steroid hormone ***: These findings expose the metabolomic disturbances induced by chronic stress in SHRs and suggest an innovative treatment for this disorder.

关键词： Hypertension Stress Metabolomics Danzhi Xiaoyao Powder

Neuropsychiatric Symptoms,Parenting Stress and Social Support in Chinese Mothers of Children with Autism Spectrum Disorder

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Current Medical Science 2019年第2期39卷 291-297页

作者： Xiao-qian HUANG hong ZHANG shan chen Department of Neurology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Teaching and Research Section of Neuropsychiatry Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Pediatrics Union Hospital of Fujian Medical UniversityFuzhou 350001China

Although little is known about the current situation regarding autism spectrum disorder(ASD)in main land China,psychiatric disorders are common among Chinese mothers of preschool children with *** studies showed ASD child's behavioral symptoms,maternal anxiety,and maternal depressive symptoms were associated with overall parenting stress in northern *** the present study,we retrospectively analyzed medical records at the hospital related to neuropsychiatric symptoms,parenting stress and social support in mothers of children with ASD from southern China.A total of 80 mothers of children with ASD were *** them,34 mothers were in low-functioning ASD group(L-ASD group)and 46 mothers were in highfunctioning ASD group(H-ASD group).Identification of the ASD cases was confirmed with a Revised Autism Diagnostic *** symptoms,parenting stress and social support were measured by neuropsychiatric inventory(NPI),parenting stress index short form(PSISF),and multi-dimensional scale of perceived social support(MSPSS).Total mean score of the NPI in the L-ASD group was significantly higher than that in the H-ASD group(P<0.01).The subscale scores of NPI,including depression,anxiety,apathy,irritability,agitation,night time behavior disturbances and change in appetite were significantly higher in the L-ASD group than those in the H-ASD group(P<0.01 or P<0.05).Meanwhile,the total PSI-SF scores and the scores of parental distress(PD),parental-child dysfunctional interaction(PCDI)and difficult child(DC)in the L-ASD group were significantly higher than those in the H-ASD group(P<0.01 or P<0.05).The total score of MSPSS was also higher in the L-ASD group than in the H-ASD group(P<0.01).This study goes further to show the neuropsychiatric symptoms and parenting stress are significantly higher in mothers of children with ASD,and more social supports are needed for mothers of children with ASD from southern China,especially for mothers of children

关键词： autism spectrum disorder neuropsychiatric symptoms parenting stress social support mothers