Suppression of Growth of Hela, EJ, SK-OV-3 and MDA-MB-231 Cells by Recombinant Human NK4

作     者：Hua Bai Hong Chen Chang-shan Ren 

作者机构：Tumor Institute China Medical University Shenyang 110001 China 

出 版 物：《Chinese Journal of Cancer Research》 (中国癌症研究（英文版）)

年 卷 期：2009年第21卷第1期

页      面：28-31页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：rhNK4 Tumor cells In vitro invasion 

摘      要：Objective： To study the effects of recombinant human Nk4 on the growth and invasion activities of tumor cells. Methods： The inhibition of recombinant human NK4 on human oophoroma, cervical tumor, breast tumor and gallbladder tumor cells was evaluated in vitro by basement membrane invasion assay. Results： rhNK4 could markedly inhibited the growth of human oophoroma, cervical tumor and breast tumor cells. The inhibition rates of human oophoroma, cervical tumor, breast tumor and gallbladder tumor cells were 48.2%, 29.2%, 58.4% and 30.1% respectively. Conclusion： rhNK4 factor can markedly inhibit the invasion of multiple tumor cells.