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Screening Preeclamptic Cord Plasma for Proteins Associated with Decreased Breast Cancer Susceptibility

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Genomics, Proteomics & Bioinformatics 2013年第6期11卷 335-344页

作者： hoi Pang Low Ashutosh Tiwari Jagadeesh Janjanam li Qiu Chien-I Chang William C.Strohsnitter Errol R.Norwitz Sun W.Tam James E.Evans Karin M.Green Joao A.Paulo Mats Lambe Chung-Cheng Hsieh Department of Cancer Biology University of Massachusetts Medical School Department of Chemistry Michigan Technological University Department of Obstetrics and Gynecology Tufts Medical Center Proteomics and Mass Spectrometry Facility Department of Biochemistry and Molecular PharmacologyUniversity of Massachusetts Medical School Department of Chemistry and Biochemistry Clark University Roskamp Institute Inc. Department of Cell Biology Harvard Medical School Department of Medical Epidemiology and Biostatistics Karolinska Institute

Preeclampsia, a complication of pregnancy characterized by hypertension and proteinuria, has been found to reduce the subsequent risk for breast cancer in female offspring. As this pro- tective effect could be due to exposure to preeclampsia-specific proteins during intrauterine life, the proteomic profiles of umbilical cord blood plasma between preeclamptic and normotensive pregnancies were compared. Umbilical cord plasma samples, depleted of 14 abundant proteins, were subjected to proteomic analysis using the quantitative method of nanoACQUITy ultra performance liquid chromatography-mass spectrometry with elevated energy mode of acquisitionE （NanoUPLC-MSE）. Sixty-nine differentially expressed proteins were identified, of which 15 and 6 proteins were only detected in preeclamptic and normotensive pregnancies, ***, expression of 8 proteins （gelsolin, complement C5, keratin type I cytoskeletal 10, pigment epithelium-derived factor, complement factor B, complement component C7, hemoglobin subunit gamma-2 and alpha-fetoprotein） were up-regulated in preeclampsia with a fold change of 1〉 2.0 when compared to normotensive pregnancies. The identification of alpha-fetoprotein in pre- eclamptic umbilical cord blood plasma supported the validity of this screen as alpha-fetoprotein has anti-estrogenic properties and has previously been linked to preeclampsia as well as a reduced breast cancer risk. The findings of this pilot study may provide new insights into the mechanistic link between preeclampsia and potentially reduced breast cancer susceptibility in adult life.

关键词： Biomarkers Intrauterine environment Mass spectrometry Pregnancy Prenatal Preeclampsia

高阶电离层延迟对PPP-AR对流层参数估计的影响

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测绘科学 2024年第4期49卷 57-64页

作者：张兵良方卓王立诗云李珊珊南京农业大学公共管理学院南京210095 南京数维测绘有限公司南京211808 中铁四院集团南宁勘察设计院有限公司南宁430007

针对高阶电离层(hoi)延迟对精密单点定位模糊度固定(PPP-AR)对流层参数估计的影响。该文使用了香港卫星定位参考网(SatRef)的16个连续运行参考站(CORS)测站的观测数据估计了对流层参数,并分析不同电离层环境hoi延迟的影响。实验结果表明... 详细信息

针对高阶电离层(hoi)延迟对精密单点定位模糊度固定(PPP-AR)对流层参数估计的影响。该文使用了香港卫星定位参考网(SatRef)的16个连续运行参考站(CORS)测站的观测数据估计了对流层参数,并分析不同电离层环境hoi延迟的影响。实验结果表明,太阳风暴和地磁风暴活动期间,hoi延迟对PPP-AR对流层天顶湿延迟(ZWD)最大影响达到4.03 mm,南北梯度相比东西梯度更易受到hoi延迟的影响。实验结果进一步表明,通过GPS/Galileo PPP-AR可以显著降低hoi延迟对ZWD,南北梯度和东西梯度的影响,均方根(RMS)值分别降低了17%,15%,21%。

关键词：高阶电离层延迟精密单点定位模糊度固定天顶湿延迟梯度

A Universal Strategy to Utilize Polymeric Semiconductor for Perovskite Solar Cells with Enhanced Efficiency and Longevity

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A Universal Strategy to Utilize Polymeric Semiconductor for ...

第五届新型太阳能电池学术研讨会

作者： Fangchao li Jianyu yuan Xufeng ling yannan Zhuang yingguo yang Sin Hang Cheung Carr hoi yi Ho Xingyu Gao Wanli Ma Soochow University

In this contribution, we successfully report a facile and universal method to fabricate perovskite solar cells(PSCs) with enhanced efficiency and stability. Through dissolving functional conjugated polymers in antisolvent chlorobenzene to treat the spinning CHNHPbI perovskite film, the resultant devices exhibit significantly enhanced efficiency and longevity simultaneously. In-depth characterizations demonstrate that thin polymer layer well covers the top surface of perovskite film, resulting in certain surface passivation and morphology modification. More importantly, we have shown that through rational chemical modification, namely molecular fluorination, the air-stability and photo-stability of the perovskite solar cells are remarkably enhanced. Considering the vast selection of conjugated polymer materials and easy functional design, we expect promising new results in further enhancement of device performance. We believe our findings provide exciting insights into the role of conjugated polymer in improving the current perovskite-based solar cells.

关键词： conjugated polymer perovskite solar cells fluorination and stability

In vivo Angiogenesis Screening and Mechanism of Action of Novel Tanshinone Derivatives Produced by One-pot Combinatorial Modification of Natural Tanshinone Mixture from Salvia Miltiorrhiza

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In vivo Angiogenesis Screening and Mechanism of Action of No...

第十四届全国中药和天然药物学术研讨会

作者： Zhe-Rui Zhang Jin-Hang li Shang li Ai-lin liu Pui-Man hoi Hai-yan Tian Wen-Cai ye Simon Ming yuen Lee Ren-Wang Jiang University of Macau Jinan University Chinese Academy of Medical Sciences and Peking Union Medical College

＜正＞Background Natural products present in low quantity in herb medicines constitute an important source of chemical ***,the isolation of sufficient amounts of these low abundant constituents for structural modification has been a challenge for several decades and subsequently halts research on the utilization of this important source of chemical entities for

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Impact of small-for-size liver grafts on medium-term and long-term graft survival in living donor liver transplantation: A meta-analysis

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World Journal of Gastroenterology 2019年第36期25卷 5559-5568页

作者： Ka Wing Ma Kelly Hiu Ching Wong Albert Chi yan Chan Tan To Cheung Wing Chiu Dai James yan yue Fung Wong hoi She Chung Mau Lo Kenneth Siu Ho Chok Department of Surgery Queen Mary Hospital Hong Kong China li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong China Department of Surgery The University of Hong Kong Hong Kong China Department of Medicine Queen Mary Hospital Hong Kong China

BACKGROUND Small-for-size grafts (SFSGs) in living donor liver transplantation (LDLT) could optimize donor postoperative outcomes and also expand the potential donor pool. Evidence on whether SFSGs would affect medium-term and long-term recipient graft survival is lacking. AIM To evaluate the impact of small-for-size liver grafts on medium-term and longterm graft survival in adult to adult LDLT. METHODS A systematic review and meta-analysis were performed by searching eligible studies published before January 24, 2019 on PubMed, EMBASE, and Web of Science databases. The primary outcomes were 3-year and 5-year graft survival. Incidence of small-for-size syndrome and short term mortality were also extracted. RESULTS This meta-analysis is reported according to the guidelines of the PRISMA 2009 Statement. Seven retrospective observational studies with a total of 1821 LDLT recipients were included in the meta-analysis. SFSG is associated with significantly poorer medium-term graft survival. The pooled odds ratio for 3-year graft survival was 1.58 [95% confidence interval 1.10-2.29, P = 0.014]. On the other hand, pooled results of the studies showed that SFSG had no significant discriminatory effect on 5-year graft survival with an odds ratio of 1.31 (95% confidence interval 0.87-1.97, P = 0.199). Furthermore, incidence of small-for-size syndrome detected in recipients of SFSG ranged from 0-11.4% in the included studies. CONCLUSION SFSG is associated with inferior medium-term but not long-term graft survival. Comparable long-term graft survival based on liver graft size shows that smaller grafts could be accepted for LDLT with appropriate flow modulatory measures. Close follow-up for graft function is warranted within 3 years after liver transplantation.

关键词： living donor liver transplantation Small-for-size grafts Small-for-size syndrome Graft survival

维普期刊数据库评论

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从读者问卷调查看澳门图书馆事业现况

图书馆论坛 2005年第6期25卷 308-313页

作者：杨开荆赵新力胡珂澳门大学中国科学技术信息研究所北京100038

通过对700多位澳门图书馆读者进行问卷调查,从读者阅读兴趣、利用图书馆情况、对目前图书馆及文献的满意度、对未来发展的期望等多方面进行分析研究。务求客观如实地掌握目前澳门图书馆的现状,为探讨未来发展对策提供参考依据。

关键词：澳门图书馆读者问卷调查

Neuroglobin promotes neurite outgrowth via differential binding to PTEN and Akt

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Neuroglobin promotes neurite outgrowth via differential bind...

中国神经科学学会第十届全国学术会议

作者： li li Qian-Rong liu Xiri-Xin Xiong Ju-Mei liu Xiao-Jing Lai yong Chen Feng Pan Shang-Bin yu Albert Cheung hoi yu Xiao-Qian Chen School of Basic Medicine Tongji Medical College Key Laboratory of Neurological Diseases Ministry of EducationHubei Provincial Key Laboratory of Neurological Diseases Huazhong University of Science and Technology School of Basic Medical Sciences Health Science Center Neuroscience Research Institute Key Laboratory for Neuroscience Ministry of Education KeyLaboratory for Neuroscience Ministry of Public Health Peking University

Neuroglobin,the third mammalian globin with a hexa-coordinated heme,exists predominantly in neurons of *** plays an important role in neuronal death upon ischemia and oxidative *** physiological function of neuroglobin remains ***,we report a novel function of neuroglobin in neurite ***-down neuroglobin exhibited a prominent neurite-deficient phenotype in mouse neuroblastoma N2a *** neuroglobin prevented neurite outgrowth while ectopic expression of neuroglobin but not homologous cytoglobin promoted neurite outgrowth of N2a cells upon serum *** primary cultured rat cerebral cortical neurons,neuroglobin was up-regulated and preferentially distributed in neurites during neuronal *** of neuroglobin but not cytoglobin in cultured cortical neurons promoted axonal outgrowth while knocking-down of neuroglobin retarded axonal *** overexpression suppressed phosphatase and tensin homolog（PTEN） but increased Akt phosphorylation during neurite *** fluorescence complementation and glutathione S-transferase pull-down assays revealed mat neuroglobin and various mutants（E53Q,E118Q,K119N,H64A,H64L,y44D） bound with Akt and PTEN *** E53Q mutant showed a prominent reduced PTEN-binding but increased Akt-binding,resulting in decreased p-PTEN,increased p-Akt and increased neurite *** together,we demonstrate a critical role of neuroglobin in neuritogenesis or development via interacting with PTEN and Akt differentially to activate PI3K/Akt pathway,providing potential therapeutic applications of neuroglobin for axonopathy in neurological diseases.

关键词： Ngb neuron axon regeneration PI3K/Akt

简化流程的多晶硅像素电极透反LCD基板的研究

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光电子．激光 2008年第7期19卷 872-876页

作者：李阳孟志国吴春亚王文郭海成南开大学光电子所天津市光电子薄膜器件与技术重点实验室天津300071 香港科技大学电机与电子工程系中国香港不详

鉴于MIC P+-Poly-Si薄膜具有比较好的电学特性和近似半透半反的光学特性,本文提出一种以此用作透反双重功能LCD下电极的LCD基板的设计考虑。并针对MIC多晶硅薄膜在红、绿和蓝三色区的透射率与反射率的差异,采用不同面积的铝反射片巧妙... 详细信息

鉴于MIC P+-Poly-Si薄膜具有比较好的电学特性和近似半透半反的光学特性,本文提出一种以此用作透反双重功能LCD下电极的LCD基板的设计考虑。并针对MIC多晶硅薄膜在红、绿和蓝三色区的透射率与反射率的差异,采用不同面积的铝反射片巧妙地予以平衡和补偿。校正结果表明在可见光范围内,其红光、绿光和蓝光处的透射率和反射率基本符合白光平衡的要求。用该薄膜多晶硅作LCD像素电极技术制备的AMLCD中,其像素电极既是驱动TFT的漏极的延伸,而铝反射镜又是与TFT的电极连线同层制备。这样,不仅可以制备出性能良好透、反双功能的LCD基板,而且明显简化了AMLCD制备工艺流程。工艺流程的简化将有利降低制造成本。

关键词： LCD 多晶硅薄膜电极光谱校正透反LCD 简化流程

金属诱导单一方向横向晶化薄膜晶体管以及栅控型轻掺杂漏极结构的研究

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物理学报 2005年第7期54卷 3363-3369页

作者：孟志国吴春亚李娟熊绍珍郭海成王文南开大学信息学院光电子器件与技术研究所光电子薄膜器件与技术天津市重点实验室光电信息技术科学教育部重点实验室(南开大学天津大学)天津300071 香港科技大学电机电子工程系

提出了一种低温金属单向诱导横向晶化的多晶硅薄膜晶体管(LT_MIUCpoly_SiTFT)的技术.使用该技术可在大面积廉价玻璃衬底上制备出高迁移率、低漏电电流、具有较好均匀性的多晶硅器件.在进一步的研究中,设计了一种新型的栅控轻掺杂漏区(GM... 详细信息

提出了一种低温金属单向诱导横向晶化的多晶硅薄膜晶体管(LT_MIUCpoly_SiTFT)的技术.使用该技术可在大面积廉价玻璃衬底上制备出高迁移率、低漏电电流、具有较好均匀性的多晶硅器件.在进一步的研究中,设计了一种新型的栅控轻掺杂漏区(GM_LDD)结构,有效地解决了在较高源漏电压下的栅诱导漏电问题.使得LT_MIUC poly_SiTFT更适用于高质量的有源矩阵显示器.

关键词：轻掺杂漏金属诱导结构栅控晶化多晶硅薄膜晶体管有源矩阵显示器玻璃衬底漏电电流 poly 迁移率硅器件均匀性 TFT 技术 Si