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Development of the Investigation Tool of a Study State and Practical Use of MyPage

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Computer Technology and Application 2012年第9期3卷 594-600页

作者： Yoshito Yamamoto Yasuko Hayashibara hiroshi ichikawa Hiroo Hirose Faculty of Science Tokyo University of Science Tokyo 162-8601 Japan Faculty of Home Economics Otsuma Women's University Tokyo 102-8357 Japan Faculty of Management of Administration and Information Tokyo University of Science Suwa 391-0213 Japan

Internetwork environment at university has been improved to supply often the lecture materials to students through websites. Along with such a tendency, the number of students who use PC (Personal computer) has also increased during the lesson at university. Hereupon, the authors investigate whether the students will get high scores in tests when some limitations are imposed on the students" use of the PC during lecture and when they are not. The authors create the tool to check the students" learning situation and to grasp which student is performing the PC operations, which are not related to the ongoing lesson, during the lecture. Teaching assistant carrying the iPad is made to walk around the class during the lecture and collect data of the students. In addition, the authors develop "MyPage" that the students can be given access to their personal information including individual class absence/tardiness, lesson comprehension and question understanding level of them and after using MyPage, the authors examine its effectiveness as a tool and its relationship with their attendance rate.

关键词：工具页面开发网络环境个人电脑 iPad 个人信息学生

Design of Blended Learning with WBT in Higher Education

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通讯和计算机（中英文版） 2013年第1期10卷 97-103页

作者： hiroshi ichikawa Yasuko Hayashibara Hiroo Hirose Yoshito Yamamoto Faculty of Home Economics Otsuma Women's University Tokyo 1028357 Japan Faculty of Management of A dministration and Information To kyo University of Science Nagano 3910292 Japan Faculty of Science Tokyo University of Science Tokyo 1628601 Japan

The effectiveness of e-learning is being examined in higher education with the support of the advanced ICT (information and communication technology) and the educational policy research. However, e-learning is not steadily becoming popular due to a large number of processes for creating the e-learning contents, the e-learning cost problems and the public"s lack of understanding of the importance and necessity of e-learning. On the assumption that especially the students in regular day school programs will attend classes on campus, the authors can not explain completely the importance and necessity of e-learning only under the time and space advantages that the students can learn whenever and wherever they want. Hereafter, the authors will report the practical use of "Blended Learning" combining the WBT (web based training) and the face-to-face class that could be a solution to the above problem.

关键词：电子学习高等教育 WBT 混合式设计教育政策通信技术学习内容

Rosuvastatin reduces rat intestinal ischemia-reperfusion injury associated with the preservation of endothelial nitric oxide synthase protein

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World Journal of Gastroenterology 2006年第13期12卷 2024-2030页

作者： Yuji Naito Kazuhiro Katada Tomohisa Takagi Hisato Tsuboi Masaaki Kuroda Osamu Handa Satoshi Kokura Norimasa Yoshida hiroshi ichikawa Toshikazu Yoshikawa Department of Medical Proteomics Kyoto Prefectural University of Medicine Kyoto 602-8566Japan Inflammation and Immunology Graduate School of Medical Science Kyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Biomedical Safety Science Kyoto Prefectural University of Medicine Kyoto 602-8566Japan Molecular Gastroenterology and Hepatology Graduate School of Medical Science Kyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Food Sciences and Nutritional Health The Faculty of Human Environment Kyoto Prefectural UniversityKyoto 606-8522Japan

瞄准：为了在 ischemia-reperfusion (红外) 上调查 rosuvastatin 的保护的效果，并且在内皮的氮的氧化物 synthase (eNOS ) 的表示上决定这个代理人的效果，在老鼠导致了小肠的损害和发炎蛋白质。方法：肠的损坏被为 30 min 夹钳优异 m... 详细信息

瞄准：为了在 ischemia-reperfusion (红外) 上调查 rosuvastatin 的保护的效果，并且在内皮的氮的氧化物 synthase (eNOS ) 的表示上决定这个代理人的效果，在老鼠导致了小肠的损害和发炎蛋白质。方法：肠的损坏被为 30 min 夹钳优异 mes 伤寒动脉和腹的箱子在男 Sprague-Dawley 老鼠导致，为 60 min 由灌注列在后面。在生理盐水溶解的 Rosuvastatin intraperitoneally 被管理在局部缺血前的 60 min。肠的粘膜损害和发炎的严厉被几个生物化学的标记，以及由组织检查所见评估。eNOS 的蛋白质层次被西方的污点决定。结果：当粘膜的索引损坏，管腔内血红素和蛋白质的层次显著地在假冒操作组与那些相比在红外组被增加。然而，这些增加被处理显著地以一种剂量依赖者方式与 rosuvastatin 禁止。rosuvastatin 的保护的效果被组织检查所见也证实。到红外的小肠的暴露导致了 thiobarbituric 的重要增加描绘的粘膜发炎酸反应的物质，联系织物的 myeloperoxidase 活动，和老鼠的粘膜内容导致 cytokine 的嗜中性的 chemoattractant-1 (CINC-1 ) 和肿瘤坏死 factor-alpha (TNF-alpha ) 。在红外以后的煽动性的参数的这些增加被预告的处理显著地在 10 mg/kg 的剂量与 rosuvastatin 禁止。而且， CINC-1 和 TNF-alpha 的 mRNA 表示在红外以后被增加，并且这增加被 rosuvastatin 也禁止。eNOS 的粘膜蛋白质层次在红外期间减少了，但是在与 rosuvastatin 对待的老鼠被保存。结论：Rosuvastatin 禁止老鼠红外导致的肠的损害和发炎，和它的保护与 eNOS 的保藏被联系蛋白质。

关键词：肠疾病缺血再灌注损伤内皮氧化酶蛋白基因

Lansoprazole ameliorates intestinal mucosal damage induced by ischemia-reperfusion in rats

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World Journal of Gastroenterology 2004年第19期10卷 2814-2817页

作者： hiroshi ichikawa Norimasa Yoshida Tomohisa Takagi Naoya Tomatsuri Kazuhiro Katada Yutaka Isozaki Kazuhiko Uchiyama Yuji Naito Takeshi Okanoue Toshikazu Yoshikawa Department of Food Sciences and Nutritional Health Faculty of Human EnvironmentKyoto Prefectural University606-8522Japan Department of Molecular Gastroenterology and Hepatology Graduate School of Medical SciencesKyoto Prefectural University of Medicine606-8522Japan Department of Inflammation and Immunology Graduate School of Medical SciencesKyoto Prefectural University of Medicine606-8522Japan

AIM: To investigate the protective effect of lansoprazoleon ischemia and reperfusion (I/R)-induced rat intestinalmucosal injury in vivo.METHODS: Intestinal damage was induced by clampingboth the superior mesenteric artery and the celiac trunkfor 30 rain followed by reperfusion in male Sprague-Dawleyrats. lansoprazole was given to rats intraperitoneally 1 hbefore vascular clamping.RESULTS: Both the intraluminal hemoglobin and proteinlevels, as indices of mucosal damage, significantlyincreased in I/R-groups comparion with those of sham-operation groups. These increases in intraluminal hemoglobinand protein levels were significantly inhibited by the treatmentwith lansoprazole at a dose of 1 mg/kg. Small intestineexposed to I/R resulted in mucosal inflammation that wascharacterized by significant increases in thiobarbituric acid-reactive substances (TBARS), tissue-associatedmyeloperoxidase activity (MPO), and mucosal content of ratcytokine-induced neutrophil chemoattractant-1 (CINC-1).These increases in TBARS, MPO activities and CINC-1 contentin the intestinal mucosa after I/R were all inhibited bypretreatment with lansoprazole at a dose of 1 mg/kg.Furthermore, the CINC-1 mRNA expression was increasedduring intestinal I/R, and this increase in mRNA expressionwas inhibited by treatment with lansoprazole.CONCLUSION: Lansoprazole inhibits lipid peroxidation andreduces development of intestinal mucosal inflammationinduced by I/R in rats, suggesting that lansoprazole mayhave a therapeutic potential for I/R injury.

关键词：羊毛二烯肠道黏膜病多次灌注液老鼠血色素

Intrathoracic esophagojejunostomy using OrVil^(TM) for gastric adenocarcinoma involving the esophagus

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World Journal of Gastrointestinal Surgery 2014年第12期6卷 235-240页

作者： Kazuhito Yajima Tatsuo Ka Shin-ichi Kosugi Yosuke Kano Takashi Ishikawa hiroshi ichikawa Takaaki Hanyu Toshifumi Wakai Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences

AIM: To demonstrate a new surgical technique of lower mediastinal lymphadenectomy and intrathoracic anastomosis of esophagojejunostomy using OrV il^(TM). METHODS: After a total median phrenotomy, the supradiaphragmatic and lower thoracic paraesophageal lymph nodes were transhiatally dissected. The esophagus was cut off using a liner stapler and OrV il^(TM)was inserted. Finally, end-to-side esophagojejunostomy was created by using a circular stapler. From July 2009,we adopted this surgical technique for five patients with gastric cancer involving the lower esophagus. RESULTS: The median operation time was 314 min(range; 210-367 min), and median blood loss was 210 mL(range; 100-838 mL). The median numbers of dissected lower mediastinal nodes were 3(range; 1-10). None of the patients had postoperative complications including anastomotic leakage and stenosis. Themedian hospital stay was 16 d(range: 15-20 d). The median length of esophageal involvement was 14 mm(range: 6-48 mm) and that of the resected esophagus was 40 mm(range: 35-55 mm); all resected specimens had tumor-free margins.CONCLUSION: This surgical technique is easy and safe intrathoracic anastomosis for the patients with gastric adenocarcinoma involving the lower esophagus.

关键词： esophagus adenocarcinoma anastomosis median esophageal resected gastrectomy thoracic inserted margins

The Association between Sentinel Lymph Node Metastasis and Ki-67 Labeling Index

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Advances in Breast Cancer Research 2013年第3期2卷 60-65页

作者： Yu Koyama hiroshi ichikawa Jun Sakata Eiko Sakata Kumiko Tatsuda Miki Hasegawa Chie Toshikawa Naoko Manba Mayuko Ikarashi Toshifumi Wakai Division of Digestive & General Surgery Niigata University Graduate School of Medical & Dental Sciences Niigata Japan

Background: The purpose of this study was to elucidate the association between sentinel lymph node (SLN) metastasis and Ki67 labeling index and to elucidate whether Ki-67 was useful or not for prediction of SLN metastasis in breast cancer. Methods: We identified 343 invasive breast cancer patients with sentinel lymph node biopsy (SLNB) from 2003 to 2012. The association between SLN status and clinicopathological features, molecular subtypes and Ki-67 labeling index were evaluated. Results: SLN metastasis was detected in 79 patients (23.0%). SLN metastasis was significantly associated with clinical T-stage (p = 0.0003), lymphovascular involvement (LVI) (p 0.0001). Ki-67 labeling index of primary tumor was significantly lower in SLN positive patients (p = 0.0331), and Ki-67 cut-off point of 7.5% was useful for dividing SLN positive from negative (p = 0.0197). Conclusion: Low value of Ki-67 labeling index, in addition to progression of clinical T-stage and presence of LVI, is significantly associated with SLN metastasis, and it seems to be useful to consider Ki-67 labeling index for SLN metastasis prediction.

关键词： Breast Cancer Sentinel Lymph Node Molecular Subtypes Ki-67 Labeling Index

Microarray Profiling of Gene Expression Patterns in Giomerular Celis of Astaxanthin-Treated Diabetic Mice: An Approach on Nutrigenomics

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Microarray Profiling of Gene Expression Patterns in Giomerul...

The International Meeting of the Society for Free Radical Research(SFRR)-Asia & the Third International Symposium on Natural Antioxidants-Molecular Mechanisms and Health Effects(ISNA)

作者： Yuji Naito Satomi Akagiri Masaaki Kuroda Tomohisa Takagi Osamu Handa Satoshi Kokura hiroshi ichikawa Norimasa Yoshida Toshikazu Yoshikawa Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto

Diabetic nephropathy is characterized by the proliferation of glomerular mesangium cells and the accumulation of extra-cellular matrix. In the previous study, we demonstrated that astaxanmin reduced glomerular oxidative stress as well as inhibited the increase of urinary albumin in diabetic db/db mice. High-density DNA microarrays that examine expression of many genes simultaneously not only can provide new information about gene function, but also generate insights into transcriptional processes, and identify new mechanism of pathogenesis. The aim of the present study is to determine the gene expression patterns in glomerular cells of astaxanthin-treated mice by using a microarray technique.

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日本的技术史研究概况

自然科学史研究 2020年第3期39卷 387-393页

作者：市川浩王坤国立广岛大学综合科学部日本广岛县东广岛市镜山739-8511 山东青年政治学院外国语学院日语教研室

本文回顾了近现代日本的技术史研究概况,也涉及技术社会经济学、技术哲学等领域。相关发展分为三个阶段:(1)20世纪30年代开始严肃探讨技术哲学及相关社会问题,研究方法源自马克思主义学派,由此开创了一个新的领域——技术论(Gijutsu-ron... 详细信息

本文回顾了近现代日本的技术史研究概况,也涉及技术社会经济学、技术哲学等领域。相关发展分为三个阶段:(1)20世纪30年代开始严肃探讨技术哲学及相关社会问题,研究方法源自马克思主义学派,由此开创了一个新的领域——技术论(Gijutsu-ron)。他们关注技术社会-哲学、技术社会学之类的问题,也尝试开展技术史的研究。与此不同,另一个学派秉持技术乐观主义,强调几乎所有的社会和经济问题都可以通过加强工业中的科学研究来解决。(2)二战后马克思主义学派的学术地位显著上升并分化为两个方向。一方认为技术的本质是对"客观规律的主观运用",另一方则认为技术的本质是"劳动手段体系"。此外,"技术文化史"学派也很活跃,他们非常重视技术演进的文化特征,开展实证研究,成效显著。(3)20世纪80年代出现新的学术潮流,认为日本经济增长的历程是世界上最成功和最普遍的经验之一。他们否定马克思主义学派和"技术文化史"学派曾赋予日本的"落后"、"畸形"和"文化特殊性"等观点,也产生了很大的影响力。同时,"科学-技术-社会论"(STS)和"技术体系的社会建构论"也传播到了日本。

关键词：日本技术史技术论编史学学术潮流

The design and engineering strategies of metal tellurides for advanced metal-ion batteries

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Journal of Energy Chemistry 2024年第2期89卷 579-598,I0013页

作者： Wenmiao Zhao Xiaoyuan Shi Bo Liu hiroshi Ueno Ting Deng Weitao Zheng Key Laboratory of Automobile Materials of MOE School of Materials Science and EngineeringJilin Provincial International Cooperation Key Laboratory of High-Efficiency Clean Energy MaterialsJilin UniversityChangchun 130012JilinChina Key Laboratory of Polyoxometalate Science of Ministry of Education Northeast Normal UniversityChangchun 130024JilinChina Key Laboratory of Preparation and Application of Environmental Friendly Materials(Jilin Normal University) Ministry of EducationChangchun 130103JilinChina Creative Interdisciplinary Research Division The Frontier Research Institute for Interdisciplinary Sciences(FRIS)Department of ChemistryGraduate School of ScienceTohoku UniversitySendai 980-8578Japan

Owning various crystal structures and high theoretical capacity,metal tellurides are emerging as promising electrode materials for high-performance metal-ion batteries(MBs).Since metal telluride-based MBs are quite new,fundamental issues raise regarding the energy storage mechanism and other aspects affecting electrochemical performance.Severe volume expansion,low intrinsic conductivity and slow ion diffusion kinetics jeopardize the performance of metal tellurides,so that rational design and engineering are crucial to circumvent these disadvantages.Herein,this review provides an in-depth discussion of recent investigations and progresses of metal tellurides,beginning with a critical discussion on the energy storage mechanisms of metal tellurides in various MBs.In the following,recent design and engineering strategies of metal tellurides,including morphology engineering,compositing,defect engineering and heterostructure construction,for high-performance MBs are summarized.The primary focus is to present a comprehensive understanding of the structural evolution based on the mechanism and corresponding effects of dimension control,composition,electron configuration and structural complexity on the electrochemical performance.In closing,outlooks and prospects for future development of metal tellurides are proposed.This work also highlights the promising directions of design and engineering strategies of metal tellurides with high performance and low cost.

关键词： Metal tellurides Metal-ion battery Energy storage mechanism Material design and engineering