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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 287-290页

作者： Kensuke Yamamura Toru Beppu Tatsunori Miyata hirohisa okabe Katsunori Imai Takatoshi Ishiko Department of Surgery Yamaga City Medical CenterYamagaJapan Department of Gastroenterological Surgery Graduate School of Life SciencesKumamoto UniversityKumamotoJapan

Curability and safety are essential for patients with advanced liver malignancy undergoing extended liver *** the future liver remnant(FLR)volume is insufficient,portal embolization with or without hepatic arterial or venous embolization or a conventional two-stage hepatectomy(TSH)can be performed(1,2).Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)was introduced in 2007.

关键词： Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS) comprehensive ALPPS preoperative risk assessment(CAPRA)score mortality

The Number of Positive Tumor Marker Status Is Beneficial for the Selection of Therapeutic Modalities in Patients with Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2017年第2期5卷 165-168页

作者： Toru Beppu Shigeki Nakagawa Hidetoshi Nitta hirohisa okabe Takayoshi Kaida Katsunori Imai Hiromitsu Hayashi Yuki Koga Kunitaka Kuramoto Daisuke Hashimoto Yo-ichi Yamashita Akira Chikamoto Takatoshi Ishiko Hideo Baba Department of Surgery Yamaga City Medical Center Kumamoto Japan Department of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto Japan Department of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto Japan

Hepatic resection (HR) and radiofrequency ablation (RFA) are popular local therapies for early-stage hepatocellular carcinoma (HCC).Alpha-fetoprotein,Lens culinaris agglutininreactive fraction of alpha-fetoprotein,and des-c-carboxy prothrombin are well-known and useful tumor markers for *** positive number status of these tumor markers has recently been demonstrated as beneficial for predicting outcome for HCC patients treated with local *** the normal ranges reported have differed by institution,the positivity of tumor markers is consistent and can easily be *** and Wakayama's group clearly demonstrated the following:1) Regardless of the degree of tumor stage,a triple-positive tumor marker profile can predict poor outcome in HCC patients undergoing HR;2) For RFA alone,HCC patients with double-and triple-positive status,having less than three lesions and lesions ≤3 cm in diameter show comparably insufficient outcomes;3) For HCC patients with lesions ≤5 cm in Child-Pugh grade A,HR is preferred over RFA;4) Microvascular invasion rates increased even in the double-positive patients,while poorly differentiated HCC was frequently observed only in the triple-positive patients;and 5) RFA with chemoembolization,anatomical liver resection,and postoperative adjuvant chemoembolization or hepatic arterial chemotherapy might improve the outcome for patients with highly malignant HCC with multiple positive tumor ***,the impacts of these therapies still need to be evaluated in prospective comparative studies.

关键词： Triple-positive tumor markers Double-positive tumor markers Hepatocellular carcinoma Hepatic resection Radiofrequency ablation Alpha-fetoprotein Des-γ-carboxy prothrombin Lens culinaris agglutinin reactive fraction of alpha-fetoprotein

A novel cylindrical sandwich plate inspired by beetle elytra and its compressive properties

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Science China Technological Sciences 2024年第11期67卷 3465-3476页

作者： SONG YiHeng RUAN SiHan HAO Ning okabe YoJi School of Engineering The University of Tokyo School of Civil Engineering Southeast University School of Engineering RMIT University Institute of Industrial Science The University of Tokyo

The design and experimental analysis of a semi-cylindrical structure known as the cylindrical beetle elytron plate(CBEP) were presented. Radial compression tests and finite element simulation were performed on CBEPs under 30° and 45° inclined sliding support constraints, with a comparison made to cylindrical honeycomb plate(CHP). The study aims to investigate the superior compression performance and enhancement mechanisms of CBEPs. The results demonstrate that CBEPs exhibit a 14%–26% increase in specific load-bearing capacity and a 20% increase in specific energy absorption compared with CHPs with equal core wall thickness. Distinct “Z-shaped” tearing failures were observed, with honeycomb plates showing tearing at the center of the honeycomb walls, while beetle elytron plates exhibited tearing along the midline of the trabeculae. Three different stress patterns,including elastic-plastic development stage of arch, plastic hinge node stage, and rigid node stage, were identified and analyzed to explain the mechanical performance improvements and failure characteristics. Considering that structural damage to trabeculae mostly occurs at its junction with the skin, it is recommended to add chamfers to the junctions of CBEP. Therefore, this paper lays the groundwork for the engineering application of CBEP.

关键词： beetle elytron cylindrical beetle elytron plate compression performance failure characteristics enhancement mechanism

Epithelial-mesenchymal transition in gastroenterological cancer

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Journal of Cancer Metastasis and Treatment 2015年第1期1卷 183-189页

作者： hirohisa okabe Kosuke Mima Seiya Saito Hiromitsu Hayashi Katsunori Imai Hidetoshi Nitta Daisuke Hashimoto Akira Chikamoto Takatoshi Ishiko Toru Beppu Hideo Baba Department of Gastroenterological Surgery Graduate School of Life SciencesKumamoto UniversityKumamoto 860-8556Japan Department of Multidisciplinary Treatment for Gastroenterological Cancer Kumamoto University HospitalKumamoto 860-8556Japan.

Epithelial-mesenchymal transition(EMT)was first reported as an essential process in embryonic cells and later showed that cancer cells,regardless of the context,exhibited a similar phenomenon that was crucial for tumor *** cells lose their adhesive characteristic capacity which is necessary for their functions but gain a mesenchymal *** change from epithelial to the mesenchymal phenotype of cancer cells makes it difficult to understand the mechanism underlying cancer biology and tumor progression.A number of transcription factors involved in tumor cell EMT and microRNA-regulated EMT have been *** review discussed recent findings and new players in EMT in gastrointestinal *** the molecular mechanisms of tumor progression are sometimes context-dependent,the recent findings of EMT have been reviewed in a context-dependent manner.

关键词： Epithelial-mesenchymal transition gastrointestinal cancer microRNA transcription factor

Exploring the effect of cooling rate on non-isothermal crystallization of copolymer polypropylene by fast scanning calorimetry

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China Foundry 2024年第4期21卷 379-386页

作者： Yang Liao Ye-yuan Hu Kosuke Ikeda Ryoji okabe Rui-fen Wu Ryota Ozaki Qing-yan Xu Key Laboratory for Advanced Materials Processing Technology School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Composite Laboratory Research&Innovation Center Mitsubishi Heavy Industries Ltd.Nagasaki 8510392Japan

Polypropylene is commonly used as a binder for ceramic injection molding,and rapid cooling is often encountered during ***,the crystallization behavior of polypropylene shows a strong dependence on cooling rate due to its semi-crystalline ***,the influence of cooling rate on the quality of final product cannot be *** this study,the fast differential scanning calorimetry(FSC)test was performed to study the influence of cooling rate on the non-isothermal crystallization behavior and non-isothermal crystallization kinetics of a copolymer polypropylene(PP BC03B).The results show that the crystallization temperatures and crystallinity decrease as the cooling rate *** addition,two exothermic peaks occur when cooling rate ranges from 30 to 300 K·s^(-1),indicating the formation of another crystal ***,Ozawa and Mo equations were used to explore the non-isothermal crystallization kinetics,and it can be concluded that the Mo method is suitable for this study.

关键词： cooling rate crystallization temperature crystallinity non-isothermal crystallization kinetics FSC copolymer polypropylene

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Risk factors for lymph node metastasis in patients with pancreatic neuroendocrine neoplasms

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World Journal of Clinical Oncology 2022年第6期13卷 520-528页

作者： Yosuke Nakao Hiromitsu Hayashi Yo-ichi Yamashita Ofuchi Takashi Kazuki Matsumura Norio Uemura Fumimasa Kitamura Rumi Itoyama Toshihiko Yusa Katsunobu Taki Tatsunori Miyata Takaaki Higashi Shigeki Nakagawa hirohisa okabe Katsunori Imai Hideo Baba Department of Gastroenterological Surgery Kumamoto UniversityKumamoto 860-8556Japan

BACKGROUND Although PNENs generally have a better prognosis than pancreatic cancers,some PNENs display malignant behavior including lymph node(LN)*** tumor resection can be the only potentially curative treatment for patients with resectable ***,the indications for LN dissection are still *** the last decade,minimally invasive surgery such as laparoscopic pancreatic surgery(LPS)has been increasingly performed for pancreatic tumors including *** To investigate the risk factors for LN metastasis in PNENs and to select appropriate patients for limited surgery by *** From April 2001 to December 2019,92 patients underwent pancreatic resection for PNENs at Kumamoto University ***,82 patients were enrolled in this *** perioperative factors,we examined the predictive factors for LN metastasis in *** Among the 82 patients,the percentage of LN metastasis according to the pathological findings was 12%(10/82 cases).The median tumor size was 12 mm(range:5-90 mm).The median tumor size in the LN-positive group(37 mm)was significantly larger than that in the LN-negative group(12 mm)(P=0.0001).Multivariate analyses revealed that larger tumor size(≥20 mm)was an independent risk factor for LN metastasis(odds ratio 16.8,P=0.0062).In patients with small tumors(≤10 mm),LN metastasis was not *** Larger tumor size(≥20 mm)is an independent risk factor for LN metastasis in *** smaller PNENs(≤10 mm),we may be able to choose limited surgery without LN dissection.

关键词： Lymph node metastasis Pancreatic neuroendocrine neoplasms Risk factor Tumor size

EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors

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Signal Transduction and Targeted Therapy 2024年第2期9卷 679-692页

作者： Keith Al-Hasani Safiya Naina Marikar Harikrishnan Kaipananickal Scott Maxwell Jun okabe Ishant Khurana Thomas Karagiannis Julia J.Liang Lina Mariana Thomas Loudovaris Thomas Kay Assam El-Osta Epigenetics in Human Health and Disease Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia Department of Diabetes Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia Epigenetics in Human Health and Disease Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia School of Science STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and Diabetes Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia Department of Medicine and Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Institute of Diabetes and Obesity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongSha TinHong Kong SAR Biomedical Laboratory Science Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-cells are a type of endocrine cell found in pancreatic islets that synthesize,store and release *** type 1 diabetes(T1D),T-cells of the immune system selectively destroy the insulin-producingβ-*** of these cells leads to a lifelong dependence on exogenous insulin administration for ***,there is an urgent need to identify novel therapies that stimulateβ-cell growth and induceβ-cell *** and others have shown that pancreatic ductal progenitor cells are a promising source for regeneratingβ-cells for T1D owing to their inherent differentiation *** transcriptional suppression is refractory to exocrine reaction and tightly controls the regenerative potential by the EZH2 *** the present study,we show that transient stimulation of exocrine cells,derived from juvenile and adult T1D donors to the FDAapproved EZH2 inhibitors GSK126 and Tazemetostat(Taz)influence a phenotypic shift towards aβ-like cell *** transition from repressed to permissive chromatin states are dependent on bivalent H3K27me3 and H3K4me3 chromatin *** EZH2 is fundamental toβ-cell regenerative *** pancreatic ductal cells exhibit insulin production and secretion in response to a physiological glucose challenge ex *** pre-clinical studies underscore the potential of small molecule inhibitors as novel modulators of ductal progenitor differentiation and a promising new approach for the restoration ofβ-like cell function.

关键词： EZH2 struction inhibitors

Mechanisms of fertilization elucidated by gene-manipulated animals

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Asian Journal of Andrology 2015年第4期17卷 646-652页

作者： Masaru okabe Center for Genetic Analysis for Biological ResponsesResearch Institute for Microbial Diseases OsakaUniversity Yamadaoka 3-1 Suita Osaka 565-0871Japan.

Capacitation and the acrosome reaction are key phenomena in mammalian fertilization. These phenomena were found more than 60 years ago. However, fundamental questions regarding the nature of capacitation and the timing of the acrosome reaction remain unsolved. Factors were postulated overtime, but as their roles were not verified by gene-disruption experiments, widely accepted notions concemingthe mechanism of fertilization are facing modifications. Today, although in vitro fertilization systems remain our central research tool, the importance of in vivo observations must be revisited. Here, primarily focusing on our own research, I summarize how in vivo observations using gene-manipulated animals have elucidated new concepts in the mechanisms of fertilization.

关键词： Mechanisms fertilization gene-manipulated

Role and limitations of rehabilitation-induced neural network remodeling after stroke

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Neural Regeneration Research 2018年第12期13卷 2087-2088页

作者： Naohiko okabe Osamu Miyamoto Second Department of Physiology Kawasaki Medical School

There is plenty of evidence that proves the beneficial and reliable effects of rehabilitation therapy,making it the most common treatment for patients with chronic *** is believed that rehabilitation improves functional recovery through neural network remodeling,which is observed as a motor map reorganization or functional connectivity change assessed by intracortical microstimulation or functional magnetic resonance imaging（MRI）.

关键词： Role and limitations of rehabilitation-induced neural network remodeling after stroke

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Axonal remodeling in the corticospinal tract after stroke： how does rehabilitative training modulate it？

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Neural Regeneration Research 2017年第2期12卷 185-192页

作者： Naohiko okabe Kazuhiko Narita Osamu Miyamoto Second Department of Physiology Kawasaki Medical School 577 Matsushima Kurashiki City Okayama Japan

Stroke causes long-term disability, and rehabilitative training is commonly used to improve the consecutive functional recovery. Following brain damage, surviving neurons undergo morphological alterations to reconstruct the remaining neural network. In the motor system, such neural network remodeling is observed as a motor map reorganization. Because of its significant correlation with functional recovery, motor map reorganization has been regarded as a key phenomenon for functional recovery after stroke. Although the mechanism underlying motor map reorganization remains unclear, increasing evidence has shown a critical role for axonal remodeling in the corticospinal tract. In this study, we review previous studies investigating axonal remodeling in the corticospinal tract after stroke and discuss which mechanisms may underlie the stimulatory effect of rehabilitative training. Axonal remodeling in the corticospinal tract can be classified into three types based on the location and the original targets of corticospinal neurons, and it seems that all the surviving corticospinal neurons in both ipsilesional and contralesional hemisphere can participate in axonal remodeling and motor map reorganization. Through axonal remodeling, corticospinal neurons alter their output selectivity from a single to multiple areas to compensate for the lost function. The remodeling of the corticospinal axon is influenced by the extent of tissue destruction and promoted by various therapeutic interventions, including rehabilitative training. Although the precise molecular mechanism underlying rehabilitation-promoted axonal remodeling remains elusive, previous data suggest that rehabilitative training promotes axonal remodeling by upregulating growth-promoting and downregulating growth-inhibiting signals.

关键词： stroke rehabilitative training axonal remodeling corticospinal tract motor map reorganization motor system neurotrophic factor functional compensation neural activity growth promoting signal growth inhibitory signal task-specific training

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