Risk factors for lymph node metastasis in patients with pancreatic neuroendocrine neoplasms
作者机构：Department of Gastroenterological SurgeryKumamoto UniversityKumamoto 860-8556Japan
出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)
年 卷 期：2022年第13卷第6期
页 面：520-528页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Lymph node metastasis Pancreatic neuroendocrine neoplasms Risk factor Tumor size
摘 要：BACKGROUND Although PNENs generally have a better prognosis than pancreatic cancers,some PNENs display malignant behavior including lymph node(LN)*** tumor resection can be the only potentially curative treatment for patients with resectable ***,the indications for LN dissection are still *** the last decade,minimally invasive surgery such as laparoscopic pancreatic surgery(LPS)has been increasingly performed for pancreatic tumors including *** To investigate the risk factors for LN metastasis in PNENs and to select appropriate patients for limited surgery by *** From April 2001 to December 2019,92 patients underwent pancreatic resection for PNENs at Kumamoto University ***,82 patients were enrolled in this *** perioperative factors,we examined the predictive factors for LN metastasis in *** Among the 82 patients,the percentage of LN metastasis according to the pathological findings was 12%(10/82 cases).The median tumor size was 12 mm(range:5-90 mm).The median tumor size in the LN-positive group(37 mm)was significantly larger than that in the LN-negative group(12 mm)(P=0.0001).Multivariate analyses revealed that larger tumor size(≥20 mm)was an independent risk factor for LN metastasis(odds ratio 16.8,P=0.0062).In patients with small tumors(≤10 mm),LN metastasis was not *** Larger tumor size(≥20 mm)is an independent risk factor for LN metastasis in *** smaller PNENs(≤10 mm),we may be able to choose limited surgery without LN dissection.
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