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Long-term effects of lamivudine treatment in Japanese chronic hepatitis B patients

World Journal of Gastroenterology 2011年第24期17卷 2945-2952页

作者： Masayuki Murata Norihiro Furusyo Mami Unno Eiichi Ogawa Kazuhiro Toyoda hiroaki taniai Hachiro Ohnishi Jun Hayashi Department of General Internal Medicine Kyushu University Hospital Department of Environmental Medicine and Infectious Disease Faculty of Medical SciencesKyushu University

AIM： To analyze the association between the emergence of tyrosine-methionine-asparatate-asparatate （YMDD） mutants （reverse transcription; rtM204I/V） and deterioration of liver function during long-term lamivudine treatment of Japanese patients with chronic hepatitis B virus （HBV） infection. METHODS： The data of 61 consecutive Japanese pa- tients with chronic hepatitis B who underwent continu- ous lamivudine treatment for more than 24 mo and had a virological response were analyzed. Analysis of YMDD mutants was done by real-time polymerase chain reaction with LightCycler probe hybridization assay for up to 90 mo （mean, 50.8 too; range, 24-90 too）.RESULTS： A mixed mutant-type （YMDD ＋ tyrosine-iso- leucine-asparatate-asparatate： YIDD or tyrosine-valineasparatate-asparatate： YVDD） or a mutant-type （YIDD or YVDD） were found in 57.4% of 61 patients at i year, 78.7% of 61 patients at 2 years, 79.6% of 49 patients at 3 years, 70.5% of 34 patients at 4 years, 68.4% of 19 patients at 5 years, 57.1% of 14 patients at 6 years, and 33.3% of 6 patients at 7 years. Of the 61 patients, 56 （92%） had mixed mutant- or a mutant-type. Only 5 （8%） had no mutants at each observation point. Vi- rological breakthrough was found in 26 （46.4%） of 56 patients with YMDD mutants, 20 of whom had a hepa- titis flare-up： the remaining 30 （53.6%） had neither a virological breakthrough nor a flare-up. All 20 patients who developed a hepatitis flare-up had a biochemical and virological response after adefovir was added to the lamivudine treatment. CONCLUSION： Our results suggest that it is possible to continue lamivudine treatment, even after the emergence of YMDD mutants, up to the time that the patients develop a hepatitis flare-up.

关键词： Tyrosine-methionine-asparatate-asparatatemutant Hepatitis B virus Lamivudine Drug resistance

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Effects of plating factors on morphology and appearance of electrogalvanized steel sheets

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中国有色金属学会会刊：英文版 2009年第4期19卷 835-841页

作者： hiroaki N AKANO Department of Materials Science and Engineering Faculty of EngineeringKyushu University

Because the lightness,the gloss and the press-formability of electrogalvanized steel sheets change depending on the morphology of deposited Zn,control of this factor is essential to improving these *** effects of plating factors on the morphology of deposited Zn were systematically discussed both from the crystallographic viewpoint of epitaxy between Zn and steel and from the electrochemical viewpoint of the overpotential for Zn *** factors include crystal orientation of steel substrate,current density,flow rate,temperature,addition of inorganic compounds to the solution and pre-adsorption of organic *** plating factors affect the overpotential for Zn deposition and epitaxy between Zn and *** crystal orientation index of the Zn basal plane and the platelet crystal size of Zn are decreased with increasing the overpotential for Zn *** are also decreased with decreasing the epitaxy between Zn and steel,even when the overpotential is kept *** the overpotential for Zn deposition is increased,the surface roughness of deposited Zn increases because of an increase in the inclination of the Zn basal plane to the steel *** the epitaxy between Zn and steel is decreased without changing the overpotential,the surface roughness is reduced due to the decrease in platelet crystal size of Zn,although the inclination of the Zn basal plane is somewhat *** lightness of deposited Zn is enhanced with decreasing the surface roughness of Zn.

关键词：电镀锌钢板外观形态

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On the generalized derivations of bimodules

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Frontiers of Mathematics in China 2017年第1期12卷 135-142页

作者： hiroaki KOMATSU Faculty of Computer Science and Systems Engineering Okayama Prefectural University Soja 719-1197 Japan

Recently, we introduced the notion of a generalized derivation from a bimodule to a bimodule. In this paper, we give a more general notion based on commutators which covers generalized derivations as a special case. U... 详细信息

关键词： Generalized derivation separable algebra extension

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Robust SOF Stackelberg game for stochastic LPV systems

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Science China(Information Sciences) 2021年第10期64卷 21-38页

作者： hiroaki MUKAIDANI Hua XU Graduate School of Advanced Science and Engineering Hiroshima University Faculty of Business Sciences The University of Tsukuba

A robust static output feedback（SOF） Stackelberg game with multiple followers in stochastic linear parameter varying（LPV） systems is investigated. The conditions for the existence of a robust SOF Stackelberg strategy set under H;constraints are established by the cross-coupled matrix inequality（CCMI）.To determine this strategy set, the optimization problems corresponding to the relevant cost bounds are defined, and their solution sets are derived using the Karush-Kuhn-Tucker conditions. The results show that the robust SOF Stackelberg strategy set can be obtained by solving higher-order cross-coupled matrix equations（CCMEs）. Because CCMEs are complex and difficult to solve numerically, a heuristic algorithm is developed by combining the CCMEs with the CCMIs. The convergence property is proven using the Krasnoselskii-Mann（KM） iteration algorithm. Finally, two numerical examples are solved to demonstrate the reliability and usefulness of the proposed heuristic algorithm.

关键词： Stackelberg games linear parameter varying (LPV) stochastic systems cross-coupled matrix equations (CCMEs)

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Temperature Dependence and P/Zn Ratio in Phosphoric Acid Treatment of Zinc Oxide

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Journal of Materials Science & Technology 2016年第5期32卷 432-436页

作者： hiroaki Onoda Yurie Sato Department of Informatics and Environmental Sciences Kyoto Prefectural University1-5Shimogamo Nakaragi-cyoSakyo-kuKyoto 606-8522Japan

Zinc oxide, which has photocatalytic activity, is used as white pigment for cosmetics. A certain degree of sebum on the skin is decomposed by ultraviolet radiation in sunlight. In this work, zinc oxide was shaken with phosphoric acid to synthesize a white pigment for cosmetics. Zinc oxide was set with 0.1 mol/L of phosphoric acid at P/Zn = 1/1 and 1/2, and then shaking in hot water for 1 h. The chemical composition, powder properties, photocatalytic activity, color phase, and smoothness of the obtained powder were studied. The P/Zn ratio in preparation had an effect on the reaction between phosphoric acid and zinc oxide. The photocatalytic activity of zinc oxide was inhibited by phosphoric acid treatment. The obtained samples had enough high reflectance at the visible light region.

关键词： Zinc oxide Photocatalytic activity Powder processing

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pH-controlled hydrothermal synthesis of titanium phosphates and their powder properties

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Journal of Advanced Ceramics 2014年第4期3卷 326-331页

作者： hiroaki ONODA Taisuke YAMAGUCHI Department of Informatics and Environmental Sciences Kyoto Prefectural University1-5Shimogamo Nakaragi-cyoSakyo-kuKyoto 606-8522Japan

Titanium phosphates were prepared from titanium chloride and sodium pyrophosphate at various pH in hydrothermal process as a novel white pigment for *** chemical composition,powder properties,photo catalytic activity,colour phase and smoothness were *** obtained materials had a higher Ti/P ratio than that used in preparation conditions because of the formation of titanium oxide and *** samples prepared at pH=4 had particles smaller than 100μ*** phosphates had less photo catalytic activity to protect the sebum on the *** obtained materials in hydrothermal process and their thermal products at 100℃showed high reflectance in the range of visible light.

关键词： titanium phosphates pyrophosphate pH photo catalytic activity smoothness

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Synthesis of bulk lanthanum polyphosphate and other rare earth phosphates through hydrothermal hot-pressing

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Journal of Advanced Ceramics 2013年第4期2卷 301-307页

作者： hiroaki ONODA Taro YAMASAKI Department of Informatics and Environmental Sciences Faculty of Life and Environmental SciencesKyoto Prefectural University1-5Shimogamo Nakaragi-choSakyo-kuKyoto 606-8522Japan

Bulk samples of lanthanum polyphosphate were synthesized through a hydrothermal hot-pressing(HHP)*** this process,pressing temperature,pressure and volume of water were varied in order to improve the density and strength of the resulting *** strength of the bulk samples was estimated through drilling and ultrasonic *** order to improve the strength of the materials,the use of microwave irradiation was *** polyphosphate formed porous bulk samples with a filling factor of approximately 70%,which was calculated from real and theoretical *** respect to machinable strength,a drilled hole greater than 7.0 mm in diameter was obtained on some bulk samples,and the diameter of the samples was 14 *** HHP process is a useful method for obtaining bulk samples of lanthanum *** lanthanum polyphosphate containing water crumbled easily to a powder form upon ***,these bulk samples retained their shape upon ultrasonication,despite containing water,after exposure to microwave irradiation,and also experienced minimal weight ***,to study the effect of microwave heating,bulk lanthanum orthophosphate,yttrium orthophosphate and polyphosphate were also examined.

关键词： lanthanum polyphosphate hydrothermal hot-pressing(HHP)process machinable strength vibration strength microwave heating

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Effect of mechanical treatment on the powder properties of zinc phosphate white pigments

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Journal of Advanced Ceramics 2015年第4期4卷 312-317页

作者： hiroaki ONODA Miho HARUKI Department of Informatics and Environmental Sciences Kyoto Prefectural University1-5Shimogamo Nakaragi-cyoSakyo-kuKyoto 606-8522Japan

Zinc oxide,which has photocatalytic activity,is used as a white pigment for cosmetics,resulting in a certain amount of sebum on the skin to be decomposed by the ultraviolet radiation in the *** this work,zinc phosphates as novel white pigments for use in cosmetics were prepared from zinc nitrate and sodium dihydrogen phosphate,and then ball-milled under various *** chemical composition,powder properties,photocatalytic activity,color phase,moisture retention,and smoothness of the zinc phosphates were *** zinc phosphate particle size was decreased by mechanical *** particular,the sample treated with sodium lactate solution had much smaller *** milled zinc phosphates exhibited less photocatalytic activity than zinc oxide,and thus should not decompose sebum on the *** milled zinc phosphates showed sufficiently high reflectance within the range of visible light to act as novel white *** sample treated with sodium lactate solution had higher water retention than the sample treated with ***,the slip resistance and roughness of the powder particles decreased as a result of treatment with sodium lactate solution.

关键词： white pigment zinc phosphate mechanical treatment photocatalytic activity water retention

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Synthesis and catalytic properties of iron-cerium phosphate prepared in ethylene glycol using additives

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Journal of Advanced Ceramics 2013年第1期2卷 49-54页

作者： hiroaki ONODA Takeshi SAKUMURA Department of Informatics and Environmental Sciences Kyoto Prefectural University1-5Shimogamo Nakaragi-choSakyo-kuKyoto 606-8522Japan

The effects of cerium substitution,use of additives,and heating temperature on the chemical composition and catalytic activity of iron phosphate were ***-cerium phosphate was prepared from iron nitrate,ammonium cerium nitrate,and sodium phosphate in ethylene glycol using sodium dodecyl-sulfate or acetylacetone as *** chemical composition,particle shape and size distribution of the obtained samples were respectively evaluated based on ICP and XRD,SEM,and laser diffraction/scattering *** catalytic activity was evaluated based on the decomposition of the complex formed from formaldehyde,ammonium acetate,and *** peaks corresponding to FePO_(4) were observed for the samples heated at 600℃whereas samples treated at lower temperatures were ***-cerium phosphates heated at 200℃and 400℃exhibited high catalytic activity for the decomposition of the aforementioned complex.

关键词： iron phosphate cerium substitution ethylene glycol ICP analysis catalytic property

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Influences of additives on phosphoric acid treatment of titanium dioxide as a novel white pigment

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Journal of Advanced Ceramics 2015年第3期4卷 211-216页

作者： Aki MATSUKURA hiroaki ONODA Department of Informatics and Environmental Sciences Kyoto Prefectual University1-5Shimogamo Nakaragi-cyoSakyo-kuKyoto 606-8522Japan

Titanium dioxide is a photocatalytically active substance used as a white pigment for *** sunlight,titanium dioxide catalyzes decomposition of a certain amount of sebum on the skin by ultraviolet ***,a novel white pigment for use in cosmetics was developed from titanium dioxide and phosphoric acid at pH=4 with and without glycerin,sodium lactate,lactic acid,and *** chemical composition,powder properties,photocatalytic activity,color phase,and smoothness of the samples were *** of glycerin led to a decline in the intensity of the X-ray diffraction(XRD)peak of TiO_(2) relative to that of the other *** particle size of the materials prepared with and without additives was 0.3μm;however,extensive aggregation was observed in the obtained *** photocatalytic activity of TiO_(2) was inhibited by phosphoric acid *** materials prepared with sodium lactate,lactic acid,and glycerin exhibited higher photocatalytic activity than that prepared without *** obtained materials showed a high reflectance in the range of visible light,and the L^(*)values in L^(*)a^(*)b^(*) color space were high(where L^(*)defines lightness,a^(*) denotes the red/green value,and b^(*) the yellow/blue value).These results indicate that the samples prepared in this work are suitable for use as white pigments.

关键词： phosphoric acid titanium dioxide photocatalytic activity particle size

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