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Nano-Micro Letters 2015年第1期7卷 51-58页

作者： Jun Wang Jinting Jiu Teppei Araki Masaya Nogi Tohru Sugahara Shijo Nagao Hirotaka koga Peng He Katsuaki Suganuma State Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology The Institute of Scientific and Industrial Research Osaka University

Transparent electrode based on silver nanowires(Ag NWs) emerges as an outstanding alternative of indium tin oxide film especially for flexible electronics. However, the conductivity of Ag NWs transparent electrode is still dramatically limited by the contact resistance between nanowires at high transmittance. Polyvinylpyrrolidone(PVP) layer adsorbed on the nanowire surface acts as an electrically insulating barrier at wire–wire junctions, and some devastating post-treatment methods are proposed to reduce or eliminate PVP layer, which usually limit the application of the substrates susceptible to heat or pressure and burden the fabrication with high-cost, time-consuming, or inefficient processes. In this work, a simple and rapid pre-treatment washing method was proposed to reduce the thickness of PVP layer from 13.19 to0.96 nm and improve the contact between wires. Ag NW electrodes with sheet resistances of 15.6 and 204 X sq-1have been achieved at transmittances of 90 and 97.5 %, respectively. This method avoided any post-treatments and popularized the application of high-performance Ag NW transparent electrode on more substrates. The improved Ag NWs were successfully employed in a capacitive pressure sensor with high transparency, sensitivity, and reproducibility.

关键词： Silver nanowire Pre-treatment Transparent electrode Pressure sensor

Advances in polymer-stabilized Au nano-cluster catalysis : Interplay of theoretical calculations and experiments

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Chinese Journal of Catalysis 2016年第10期37卷 1588-1593页

作者： Hiroaki koga Yoshinori Ato Akihide Hayashi Kohei Tada Mitsutaka Okumura 京都大学催化剂与电池元素战略研究基地大阪大学科学研究院化学系

Polymer‐stabilized Au nano clusters （NCs） with mean diameters of 2–10 nm exhibit unique catalytic properties. Several studies have shown that the key factors affecting the catalytic activity of poly‐mer‐stabilized Au NCs are control of the Au NC size, appropriate selection of polymers and optimi‐zation of the reaction conditions. This is because polymer‐stabilized Au NCs exhibit a clear size effect in several catalytic reactions, and the catalytic activity differs with the type of polymer used and the reaction conditions. In order to elucidate the reason underlying the catalytic activity of the polymer‐stabilized Au NCs, much attention is being devoted to the interplay of theoretical calcula‐tions and experiments in catalysis by polymer stabilized Au NCs. The present article mainly summa‐rizes our progress in understanding this interplay in polymer‐stabilized Au NC catalysis.

关键词： Polymer-stabilized Au nano-clusterAerobic oxidation of alcoholsInterplay of theoretical calculations and experimentsSize effect ofAu nano-clusterRole of the polymers

Correlation between smoking habit and surgical outcomes on viral-associated hepatocellular carcinomas

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World Journal of Gastroenterology 2018年第1期24卷 58-68页

作者： Keita Kai Sho Komukai Hiroki koga Koutaro Yamaji Takao Ide Atsushi Kawaguchi Shinichi Aishima Hirokazu Noshiro Department of Pathology Saga University Hospital Clinical Research Center Saga University Hospital Department of Surgery Saga University Faculty of Medicine Department of Pathology and Microbiology Saga University Faculty of Medicine Center for Comprehensive Community Medicine Saga University Faculty of Medicine

AIM To investigate the association between smoking habits and surgical outcomes in hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC)(B-HCC) and hepatitis C virus(HCV)-related HCC(C-HCC) and clarify the clinicopathological features associated with smoking status in B-HCC and C-HCC *** We retrospectively examined the cases of the 341 consecutive patients with viral-associated HCC(C-HCC,n = 273; B-HCC, n = 68) who underwent curative surgery for their primary lesion. We categorized smoking status at the time of surgery into never, exand current smoker. We analyzed the B-HCC and C-HCC groups' clinicopathological features and surgical outcomes, i.e., disease-free survival(DFS), overall survival(OS), and disease-specific survival(DSS).Univariate and multivariate analyses were performed using a Cox proportional hazards regression model. We also performed subset analyses in both patient groups comparing the current smokers to the other *** The multivariate analysis in the C-HCC group revealed that current-smoker status was significantly correlated with both OS(P = 0.0039) and DSS(P = 0.0416).In the B-HCC patients, no significant correlation was observed between current-smoker status and DFS, OS,or DSS in the univariate or multivariate analyses. The subset analyses comparing the current smokers to the other patients in both the C-HCC and B-HCC groups revealed that the current smokers developed HCC at significantly younger ages than the other patients irrespective of viral infection *** A smoking habit is significantly correlated with the overall and disease-specific survivals of patients with C-HCC. In contrast, the B-HCC patients showed a weak association between smoking status and surgical outcomes.

关键词： Hepatocellular carcinoma Hepatitis B virus Hepatitis C virus Smoking Surgery Prognosis

Effective Palladium(Ⅱ)Catalyst for Oxypalladation of Alkene

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复旦学报(自然科学版) 2005年第5期44卷 711-712页

作者： T.Hosokawa Y.Kawamura K.Minami K.koga Department of Environmental Systems Engineering Kochi University of Technology185 MiyanokuchiTosayamadaKochi782-8502Japan

1 Introduction A variety of Pd(Ⅱ)-catalyzed oxidative transformations ot allcenes with oxygen nucleophiles are catalyzed by PdX_(2)(X=OAc,Cl,etc)with CuX_(n)(n=1 or 2)under O_(2).In the so-called Wacker catalyst of such,Pd(OAc)_(2) is less reactive compared to PdCl_(2).In an attempt to increase the reactivity of Pd(OAc)_(2),we have now found that tuning of Cu site with catechol gives an intriguing reactivity to Pd(OAc)_(2),which is unprecedented in the chemistry of palladium.

关键词： Palladium(Ⅱ)acetate copper(Ⅱ)acetate catechol wacker oxidation allylic alcohols vinyl ethers 2-alkoxy-4-benzylidenetetrahydrofurans

Effective Palladium(Ⅱ) Catalyst for Oxypalladation of Alkene

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复旦学报(自然科学版) 2005年第5期 101-102页

作者： T. Hosokawa,Y. Kawamura,K. Minami,K. koga Department of Environmental Systems Engineering Kochi University of Technology 185 Miyanokuchi Tosayamada Kochi 782-8502 Japan Department of Environmental Systems Engineering Kochi University of Technology 185 Miyanokuchi Tosayamada Kochi 782-8502 Japan Department of Environmental Systems Engineering Kochi University of Technology 185 Miyanokuchi Tosayamada Kochi 782-8502 Japan Department of Environmental Systems Engineering Kochi University of Technology 185 Miyanokuchi Tosayamada Kochi 782-8502 Japan

A Sightseeing Planning Support System with Gamification

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Journal of Geographic Information System 2021年第4期13卷 485-507页

作者： Yuro koga Kayoko Yamamoto Graduate School of Informatics and Engineering University of Electro-Communications Tokyo Japan

In recent years, as there has been a major change in the necessity and importance of sightseeing information, a platform to provide real-time sightseeing information according to the ever-changing circumstances is necessary. Additionally, it is effective to adopt gamification to increase users’ motivation to continuously utilize the system in order to provide them with more information. In the present study, in order to support users’ enjoyment in creating efficient and pleasant sightseeing plans, the system that incorporates gamification to increase motivation was developed combining with web-geographic information systems (Web-GIS) and sightseeing planning and sharing system. The system was operated over a period of 2 weeks in Chofu City, Tokyo Metropolis, Japan. Based on the results of a questionnaire survey for 51 users, though the operability of the 3 main functions incorporated with motivation by gamification was rated lower than those of the 2 basic functions, their usefulness was highly rated. Based on the results of the access log analysis, it was effective to design the system so that the same functions can be used regardless of the type of information terminal. Additionally, it was evident that the continuous utilization of the system could increase the number of sightseeing plans created by the users.

关键词： Sightseeing Planning Support System Gamification Mission Sightseeing Plan Creation and Sharing System Web Geographic Information Systems (Web-GISs)

Suppression of fibrosis in human pterygium fibroblasts by butyrate and phenylbutyrate

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International Journal of Ophthalmology(English edition) 2017年第9期10卷 1337-1343页

作者： Yuka koga Noriaki Maeshige Hiroto Tabuchi Mikiko Uemura Michiko Aoyama-Ishikawa Makoto Miyoshi Chikako Katakami Makoto Usami Division of Nutrition and Metabolism Department ofBiophysicsKobe University Graduate School of Health SciencesTomogaoka 7-10-2Suma-kuKobeJapan Department of Rehabilitation Science Kobe University Graduate School of Health SciencesTomogaoka 7-10-2Suma-kuKobeJapan Department of Ophthalmology Saneikai Tsukazaki HospitalWaku 68-1Aboshi-kuHimejiJapan Department of Nutrition Kobe University HospitalKobe University School of MedicineKusunoki-cho 7-5-2Chuo-kuKobeJapan

AIM：To evaluate the antifibrogenic effects of butyrate or phenylbutyrate,a chemical derivative of butyrate,in human pterygium ***：Human pterygium fibroblasts obtained from patient pterygium tissue were treated with butyrate or phenylbutyrate for *** ofα-smooth muscle actin,collagen I,collagen III and matrix metalloproteinase-1m RNA was measured by quantitative real-time reverse transcription polymerase chain reaction,and acetylated histone was evaluated by Western ***：Butyrate inhibitedα-smooth muscle actin,type III collagen and matrix metalloproteinase-1 expressions,and phenylbutyrate inhibited types I and III collagen and matrix metalloproteinase-1 expressions without changing cell viability as well as both of these increased histone *** results suggested that butyrate and phenylbutyrate suppress fibrosis through a mechanism involving histone deacetylase ***：This indicates that butyrate or phenylbutyrate have antifibrogenic effects in human pterygium fibroblasts and could be novel types of prophylactic and/or therapeutic drugs for pterygium,especially phenylbutyrate,which does not have the unpleasant smell associated with butyrate.

关键词： butyrate phenylbutymte pterygium fibroblasts antifibrogenic effect

Kidney GATA3^(+) regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury

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Cellular & Molecular Immunology 2021年第5期18卷 1249-1261页

作者： Ryota Sakai Minako Ito Kyoko Komai Mana Iizuka-koga Kazuhiko Matsuo Takashi Nakayama Osamu Yoshie Koichi Amano Hiroshi Nishimasu Osamu Nureki Masato Kubo Akihiko Yoshimura Department of Microbiology and Immunology Keio University School of Medicine35 ShinanomachiShinjuku-kuTokyo160-8582Japan Department of Rheumatology and Clinical Immunology Saitama Medical CenterSaitama Medical University1981 KamodaKawagoe350-8550Japan Medical Institute of Bioregulation Kyushu University 3-1-1 MaidashiHigashi-kuFukuoka812-8582Japan Division of Chemotherapy Kindai University Faculty of PharmacyHigashi-Osaka577-8502Japan The Health and Kampo Institute SendaiMiyagi981-3205Japan Department of Biological Science Graduate School of ScienceThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo113-0033Japan Center for Animal Disease Models Research Institute for Biomedical ScienceTokyo University of Science2669 YamazakiNoda-shiChiba278-0022Japan

FoxP3^(+)regulatory T cells(Tregs)play crucial roles in peripheral immune *** addition,Tregs that reside or accumulate in nonlymphoid tissues,called tissue Tregs,exhibit tissue-specific functions and contribute to the maintenance of tissue homeostasis and *** an experimental mouse model of crescentic glomerulonephritis induced by an anti-glomerular basement membrane antibody,Tregs started to accumulate in the kidney on day 10 of disease onset and remained at high levels(~30–35%of CD4^(+)T cells)during the late stage(days 21–90),which correlated with stable disease *** depletion on day 21 resulted in the relapse of renal dysfunction and an increase in Th1 cells,suggesting that Tregs are essential for disease control during the convalescence *** Tregs that accumulated in the kidney showed tissue Treg phenotypes,including high expression of GATA3,ST2(the IL33 receptor subunit),amphiregulin(Areg),and PPARγ.Although T-bet^(+) Tregs and RORγt^(+) Tregs were observed in the kidney,GATA3^(+) Tregs were predominant during the convalescence stage,and a PPARγagonist enhanced the accumulation of GATA3^(+) Tregs in the *** understand the function of specific genes in kidney Tregs,we developed a novel T cell transfer system to T cell-deficient *** experiment demonstrates that ST2,Areg,and CCR4 in Tregs play important roles in the accumulation of GATA3^(+) Tregs in the kidney and in the amelioration of renal *** data suggest that GATA3 is important for the recruitment of Tregs into the kidney,which is necessary for convalescence after renal tissue destruction.

关键词： Tissue Tregs autoantibody GATA3 kidney IL-33

Glycemic control indicators in patients with neonatal diabetes mellitus

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World Journal of Diabetes 2014年第2期5卷 198-208页

作者： Shigeru Suzuki Masafumi koga Department of Pediatrics Asahikawa Medical University Department of Internal Medicine Kawanishi City Hospital

Neonatal diabetes mellitus(NDM) is a type of diabetes mellitus caused by genetic abnormality which devel ops in insulin dependent state within 6 mo after birth HbA1c is widely used in clinical practice for diabetes mellitus as the gold standard glycemic control indica tor; however, fetal hemoglobin(HbF) is the main he moglobin in neonates and so HbA1c cannot be used as a glycemic control indicator in NDM. Glycated albumin(GA), another glycemic control indicator, is not affected by HbF. We reported that GA can be used as a glycemic control indicator in NDM. However, it was later found that because of increased metabolism of albumin, GA shows an apparently lower level in relation to plasma glucose in NDM; measures to solve this problem were needed. In this review, we outlined the most recen findings concerning glycemic control indicators in neo nates or NDM.

关键词： Glycemic control HbA1c Glycated albumin Fructosamine 1,5-anhydroglucitol Neonatal diabetes mellitus

Two Cases of Tuberculosis Manifesting as Cutaneous Solitary Mass in Patients with Adult T-Cell Leukemia/Lymphoma

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Journal of Tuberculosis Research 2016年第3期4卷 134-139页

作者： Monji koga Masaki Fujita Shinichi Imafuku Department of Dermatology Faculty of Medicine Fukuoka University Fukuoka Japan Department of Respiratory Medicine Fukuoka University School of Medicine Fukuoka Japan

Tuberculosis (TB) is a major public health problem worldwide and a large number of fatal cases are still reported. Immunocompetent individuals are naturally susceptible to TB, and immunocompromised patients have a greater risk of infection. Although patients with adult T-cell leukemia/lymphoma (ATL) are in an immunosuppressed condition, there is only one reported case of TB accompanied with ATL in the English- language literature in the field of dermatology. Here, we report two patients with chronic-type ATL infected with TB manifesting as cutaneous solitary masses. Case 1 was a 58-year-old woman diagnosed with lumbar abscess with pulmonary TB. Case 2 was an 84-year-old woman diagnosed with tuberculous lymphadenitis in the left cervical region. It is important to raise the differential diagnosis of TB and perform tissue culture for acid-fast bacilli as well as Interferon-Gamma release assay test when dermatologists encounter mass lesions in patients with ATL.

关键词： Tuberculosis Tuberculous Lymphadenitis Immunosuppression Adult T-Cell Leukemia/Lymphoma Regulatory T-Cell