Kidney GATA3^(+) regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury
作者机构：Department of Microbiology and ImmunologyKeio University School of Medicine35 ShinanomachiShinjuku-kuTokyo160-8582Japan Department of Rheumatology and Clinical ImmunologySaitama Medical CenterSaitama Medical University1981 KamodaKawagoe350-8550Japan Medical Institute of Bioregulation Kyushu University3-1-1 MaidashiHigashi-kuFukuoka812-8582Japan Division of ChemotherapyKindai University Faculty of PharmacyHigashi-Osaka577-8502Japan The Health and Kampo InstituteSendaiMiyagi981-3205Japan Department of Biological ScienceGraduate School of ScienceThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo113-0033Japan Center for Animal Disease ModelsResearch Institute for Biomedical ScienceTokyo University of Science2669 YamazakiNoda-shiChiba278-0022Japan
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2021年第18卷第5期
页 面：1249-1261页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
基 金：supported by JSPS KAKENHI(S)JP17H06175,Challenging Research(P)JP18H05376 AMED-CREST JP 20gm1110009 grants to A.Y JSPS KAKENHI 17K15667,19H04817,and 19K16618,AMED-PRIME 20gm6210012,a research grant from the Kishimoto Foundation,the Tomizawa Jun-ichi&Keiko Fund of Molecular Biology Society of Japan for Young Scientist,a research grant for young investigators by The Mitsubishi Foundation to M.I by the Mochida Memorial Foundation for Medical and Pharmaceutical Research,the Takeda Science Foundation,the Uehara Memorial Foundation,the Naito Memorial Foundation,the Kanae Foundation,the SENSHIN Medical Research Foundation,the Astellas Foundation for Research on Metabolic Disorders,an Inoue Research Award,a Life Science Research Award,and Keio Gijuku Academic Developmental Funds
主 题：Tissue Tregs autoantibody GATA3 kidney IL-33
摘 要：FoxP3^(+)regulatory T cells(Tregs)play crucial roles in peripheral immune *** addition,Tregs that reside or accumulate in nonlymphoid tissues,called tissue Tregs,exhibit tissue-specific functions and contribute to the maintenance of tissue homeostasis and *** an experimental mouse model of crescentic glomerulonephritis induced by an anti-glomerular basement membrane antibody,Tregs started to accumulate in the kidney on day 10 of disease onset and remained at high levels(~30–35%of CD4^(+)T cells)during the late stage(days 21–90),which correlated with stable disease *** depletion on day 21 resulted in the relapse of renal dysfunction and an increase in Th1 cells,suggesting that Tregs are essential for disease control during the convalescence *** Tregs that accumulated in the kidney showed tissue Treg phenotypes,including high expression of GATA3,ST2(the IL33 receptor subunit),amphiregulin(Areg),and PPARγ.Although T-bet^(+) Tregs and RORγt^(+) Tregs were observed in the kidney,GATA3^(+) Tregs were predominant during the convalescence stage,and a PPARγagonist enhanced the accumulation of GATA3^(+) Tregs in the *** understand the function of specific genes in kidney Tregs,we developed a novel T cell transfer system to T cell-deficient *** experiment demonstrates that ST2,Areg,and CCR4 in Tregs play important roles in the accumulation of GATA3^(+) Tregs in the kidney and in the amelioration of renal *** data suggest that GATA3 is important for the recruitment of Tregs into the kidney,which is necessary for convalescence after renal tissue destruction.
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