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autoantibody profiles in autoimmune hepatitis and chronic hepatitis C identifies similarities in patients with severe disease

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World Journal of Gastroenterology 2017年第8期23卷 1345-1352页

作者： Kawa Amin Aram H Rasool Ali Hattem Taha AM Al-Karboly Taher E Taher Jonas Bystrom Department of Medical Science Respiratory Medicine and AllergologyClinical Chemistry and Asthma Research CentreUppsala University and University Hospital Department of Microbiology/Immunology School of MedicineUniversity of Sulaimani Laboratory Department General Hospital of Derbandixan Department of Community Health Sulaimani Polytechnic University Department of Medicine School of MedicineFaculty of Medical SciencesUniversity of Sulaimani Experimental Medicine and Rheumatology William Harvey Research InstituteBarts and the LondonQueen MaryUniversity of London

To determine how the auto-antibodies (Abs) profiles overlap in chronic hepatitis C infection (CHC) and autoimmune hepatitis (AIH) and correlate to liver *** of antinuclear Ab, smooth muscle antibody (SMA) and liver/kidney microsomal-1 (LKM-1) Ab and markers of liver damage were determined in the sera of 50 patients with CHC infection, 20 AIH patients and 20 healthy controls using enzyme linked immunosorbent assay and other immune *** found that AIH patients had more severe liver disease as determined by elevation of total IgG, alkaline phosphatase, total serum bilirubin and serum transaminases and significantly higher prevalence of the three non-organ-specific autoantibodies (auto-Abs) than CHC patients. Antinuclear Ab, SMA and LKM-1 Ab were also present in 36% of CHC patients and related to disease severity. CHC cases positive for auto-Abs were directly comparable to AIH in respect of most markers of liver damage and total IgG. These cases had longer disease duration compared with auto-Ab negative cases, but there was no difference in gender, age or viral load. KLM-1+ Ab CHC cases showed best overlap with ***-Ab levels in CHC may be important markers of disease severity and positive cases have a disease similar to AIH. Auto-Abs might have a pathogenic role as indicated by elevated markers of liver damage. Future studies will unravel any novel associations between these two diseases, whether genetic or other.

关键词： autoantibody Inflammatory diseases Immune system Hepatitis C virus Smooth muscle antibody Liver/kidney microsomal-1 autoantibody Anti-nuclear antibody

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Experimental Study of Serum Substantia Nigra Neuron autoantibody and Its Effect in Parkinson Disease Patients

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2001年第4期21卷 280-282页

作者：陈吉相曹学兵徐岩孙圣刚 Department of Neurology Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022

To investigate the serum substantia nigra neuron autoantibody and its effect in the patients with Parkinson disease (PD), substantia nigra slices and a rat model of injection of serum from PD patients in unilateral side substantia nigra were applied. The results showed that the positive rate of substantia nigra neuron autoantibody in PD patients was significantly higher than in the healthy control group (36.67 % vs 6.67 %, P 0.05). The sera from PD patients positive for substantia nigra neuron autoantibody could decrease the number of the dopaminergic neurons more seriously than those from MG and the healthy once respectively (both P <0.01). The results suggested that the immunological mechanism might partly play a role in the development of PD.

关键词： substantia nigra autoantibody serum Parkinson disease

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autoantibody against Cardiac β1-Adrenoceptor Induces Apoptosis in Cultured Neonatal Rat Cardiomyocytes

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Acta Biochimica et Biophysica Sinica 2006年第7期38卷 443-449页

作者： Yan GAO~1 Hui-Rong LIU~1 Rong-Rui ZHAO~1 Jian-Ming ZHI~(2*) 1 Department of Cardiovascular Physiology Shanxi Medical University,Taiyuan 030001,China 2 Department of Physiology,Shanghai Jiaotong University,College of Basic Medicine,Shanghai 200025,China DepartmentofCardiovascularPhysiology ShanxiMedicalUniversityTaiyuan030001China DepartmentofPhysiology ShanghaiJiaotongUniversityCollegeofBasicMedicineShanghai200025China

To clarify whether apoptosis is involved in the injury processes induced by autoantibodyagainst cardiac β1-adrenoceptor,we investigated the biological and apoptotic effects of antibodies on culturedneonatal rat *** rats were immunized with peptides corresponding to the second extra-cellular loop of the β1-adrenoceptor to induce the production of anti-β1-adrenoceptor antibodies in the ***（Ig）G in the sera was detected using synthetic antigen enzyme-linked immunosorbentassay and purified using the diethylaminoethyl cellulose ion exchange *** of cardiomyo-cytes was evaluated using agarose gel electrophoresis and flow *** results showed that thepositive serum IgG greatly increased the beating rates of cardiomyocytes and showed an"agonist-like"***,positive serum IgG induced cardiomyocyte apoptosis after treatment with β1-adrenoceptor overstimulation for *** effects of monoclonal antibody against β-adrenoceptor werealso found to be similar to those of positive serum *** was suggested that the autoantibody could inducecardiomyocyte apoptosis by excessive stimulation of β1-adrenoceptor.

关键词： β1-adrenoceptor rat cardiomyocyte autoantibody apoptosis

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An Evans Syndrome Case Expressing Anti-Jk<sup>a</sup>autoantibody under Condition of Primary IgA Immunodeficiency

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International Journal of Clinical Medicine 2015年第7期6卷 496-499页

作者： Takeshi Sugimoto Ayumi Tani Ikuyo Hayakawa Makoto Hashimoto Tomoko Yanai Ikuko Kubokawa Takeshi Mori Takeshi Kato Satoshi Hirase Nobuyuki Yamamoto Hironobu Minami Akira Hayakawa Department of Hematology and Oncology Kita-Harima Medical Center Ono Japan Department of Blood Transfusion Kobe University Hospital Kobe Japan Institute of Biomedical Research and Innovation Kobe Japan Department of Pediatric Medicine Kobe University Hospital Kobe Japan

Autoimmune haemolytic anaemia is a haemolytic disease resulting from an autoimmune reaction to the surface of red blood cells. A part of autoantibody is known to react with the blood type antigen. This is the case of a 14 years old female with Evans syndrome in which autoimmune haemolysis may cause from anti-Jka autoantibody reaction. As this case is complicated with primary IgA immunodeficiency syndrome, anti-Jka autoantibody may occur under the condition of primary immunodeficiency status, in which autoantibody production is accelerated. Considering the co-occurrence of autoimmune haemolytic anaemia and primary IgA immunodeficiency syndrome, analysis focusing on specificity for red blood cells antigens will be required in IgA immunodefi-ciency syndrome patients.

关键词： Anti-Jka autoantibody Evans Syndrome IgA Immunodeficiency

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A novel autoantibody in patients with primary hypertension： antibody against L-type Ca^2＋ channel

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Chinese Medical Journal 2008年第16期121卷 1513-1517页

作者： ZHOU Zi-hua WANG Jun XIAO Hua CHEN Zhi-jian WANG Min CHENG Xiang LIAO Yu-hua Institute of Cardiology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430022 China

Background Recently, it has been proposed that the autoantibodies against various cardiovascular receptors play a role in the pathogenesis of primary hypertension. In this study, we aimed to identify whether or not there are autoantibodies against cardiovascular L-type Ca^2＋ channels in patients with primary hypertension. Methods A peptide corresponding to the sequence 2-16 of the alc-subunit of L-type Ca^2＋ channel was used as an antigen to screen the autoantibodies from 90 patients with primary hypertension and 45 healthy controls by an enzyme-linked immunosorbent assay （ELISA）. The clinical data of 90 hypertensive patients were compared between patients with and without these autoantibodies. Results Serum from 3 （6.7%） of the 45 healthy controls, 33 （36.7%） of 90 hypertensives showed positive responses in ELISA （P 〈0.01）. The prevalence of such autoantibodies in two subgroups of hypertensives with coronary heart disease （9/21, 57.14%, P 〈0.05） and left ventricular diastolic dysfunction （28/63, 44.4%, P 〈0.05） was higher than in those without the corresponding complications. And the patients with such autoantibodies had lower E/A than patients without such autoantibodies （0.803±0.191 vs 1.004±0.322, P=0.002）. Conclusion There are autoantibodies against vascular L-tyPe Ca^2＋ channels in patients with primary hvnertension.

关键词： autoantibody primary hypertension L-trpe Ca^2+ channel

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autoantibody to MDM2:a potential serological marker of systemic lupus erythematosus associated with thrombocytopenia

Autoantibody to MDM2:a potential serological marker of syste...

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第十届全国免疫学学术大会

作者： Yuan Liu Guixiu Shi Department of Rheumatology and Clinical Immunology The First Hospital of Xiamen University

Introduction:Systemic lupus erythematosus(SLE)is one of the systemic autoimmune diseases characterized by the polyclonal autoantibody *** human homologue of the mouse double minute 2(MDM2),is well known as the negative regulator of ***2 has been reported to be overexpressed in SLE animal model and promote *** abnormally expressed proteins can induce autoimmune response,anti-MDM2 autoantibody was examined in SLE ***:Anti-MDM2 antibody in sera from 43 SLE patients and 69 healthy persons was investigated by *** samples were further confirmed by western *** immunological feathers of anti-MDM2 positive sera were analyzed by indirect immunofluorescence *** clinical significance of anti-MDM2 antibody was further analyzed in 45 SLE ***:The presence of anti-MDM2 in SLE patients was 23.30%,much higher than normal healthy persons(4.30%).These anti-MDM2 positive sera present a nuclear staining *** titer of anti-MDM2 autoantibody was significantly negatively associated with platelet ***:Anti-MDM2 autoantibody was detected at high prevalence in SLE patients,which may associate with *** study of anti-MDM2 in SLE patients should be clinically useful in understanding the pathogenesis of thrombocytopenia in SLE.

关键词： systemic lupus erythematosus human homologue of the mouse double minute 2 autoantibody thrombocytopenia

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Application of autoantibody detection in chronic liver disease

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iLABMED 2023年第2期1卷 103-108页

作者： Jinyu Han Jin Chen Yajie Wang Peking University Ditan Teaching Hospital BeijingChina Beijing Ditan Hospital Affiliated to Capital Medical University BeijingChina

autoantibody(AAb)detection has become one of the standards of diagnosis for autoimmune liver disease(AILD),and some AAbs have become specific biomarkers of *** addition,AAbs can be detected in patients with non-AILDs,such as viral hepatitis and alcoholic liver ***,the distribution characteristics and pathogenic mechanisms of AAbs in patients with non-AILD are *** article summarizes the characteristics of AAbs in several common clinical chronic liver diseases(CLDs)and discusses the value of AAb analysis in CLD.

关键词： alcoholic liver disease autoantibody autoimmune liver disease hepatitis B virus

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A Multiplex autoantibody Panel for Early Detection of Autoimmune Disease Activity

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Open Journal of Rheumatology and Autoimmune Diseases 2018年第2期8卷 43-52页

作者： Yuanyuan Yang Karthik Krishna Vinodh Ranganathan Vasanth Jayaraman Tianhao Wang Kang Bei Hari Krishnamurthy John J. Rajasekaran Vibrant America LLC San Carlos CA USA

Background: Detection of autoantibodies has played a consolidate role in diagnosis of systemic autoimmune disorders. A cascade autoantibody testing is usually performed by employing antinuclear antibodies (ANA) test as a first screening test and the other tests as second level determinations. Here, we present that supplementing extractable nuclear antigens (ENA) tests to the ANA test may capture more autoimmunity and provide critical medical information at an early stage. In this study, we?evaluated the clinical significance of a multiplex ANA + ENA panel. Methods: A cohort of 110 subjects, identified as ANA negative but ENA positive, were followed up for two years. The detection of their ANA and anti-ENA autoantibodies was assessed with a multiplex ANA + ENA panel at Vibrant America Clinical Laboratory. Results: During two years of multi-visit follow-up, 23 out of 110 subjects (20.9%) were found to become ANA positive within an average of 385 (±144) days. Histone (50/110, 45.5%) and Chromatin (25/110, 22.7%) antibodies were the most frequently found antibodies at their first visits. The subjects who were positive for RNP (5/8, 62.5%) and SSA (Ro) (10/22, 45.5%) have the highest ratio of conversion to positive ANA. No significant correlation was observed between the conversion frequency and the number of anti-ENA antibodies being carried. Conclusion: This study, which followed up on the subjects who had disparate ANA and ENA test results, showed that anti-ENA antibodies may exist years earlier than ANA. Combining ENA tests with ANA screening may reduce false negatives and improve sensitivity.

关键词： autoantibody ANA ENA Autoimmunity Connective Tissue Disorder

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Anti-ENA autoantibody profiles and humoral immune activation

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Journal of Medical Colleges of PLA(China) 1999年第1期14卷 41-44页

作者：邓安梅仲人前陈孙孝孔宪涛

Objective: To study the clinical significance of anti-ENA autoantibody profiles and its relationship withother immune markers. Methods: AntiuENA autoantibodies were tested with Western--blot while immunoglobulinsand complements were detected quantitatively by turbidimetry. Results: 1. High positive rate of anti--ENAautoantibody was detected but not specific in several autoimmune diseases; 2. lgG and IgA was increased in antiENA antibody positive sera while IgM, C3 and C4 was decreased; 3. Elevation of IgG and decrease of IgM, C3and CHS, were correlated with the number of bands of anti-- ENA autoantibodies by immunoblot; 4. Associationbetween clinical activity of diseases and C3, C4 and CH50 were tested. Conclusion: Humoral immune activation wasdemonstrated in patients with positive ENA autoantibody and positively correlated with the number of bands ofanti-- ENA autoantibodies.

关键词： profile of ENA autoantibody C3 C4 humoral immune activation

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Immunohistochemical Studies on Anti-keratin autoantibody

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Journal of Medical Colleges of PLA(China) 1990年第2期5卷 165-167,198页

作者：刘玉峰刘彦仿丁华野车乃增张泰山丁丽清樊平申 Department of Dermatology Xijing HospitalFourth Military Medical UniversityXi'an 710032

On the basis of the detection of IgG anti-keratin autoantibody (AK auto Ab)in human body fluids,it was shown that IgG AK auto Ab could hardly pass the blood-brain barrier,but it could easily penetrate the capillary walls into epithelial ***-der electron microscope,the interaction between AK auto Ab and keratinocyte is largelylocated in tonofilaments and desmosomes and is irrelevant to other *** of AK auto Ab suggest that the accumulation of AK auto Ab in keratinocy-te cytoplasm and transitory decrease of IgG AK auto Ab in serum of rabbits with sodiumsulfide dermatitis are related predominantly to keratinocytic injury.

关键词： keratin autoantibody

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