Autoantibody profiles in autoimmune hepatitis and chronic hepatitis C identifies similarities in patients with severe disease

作     者：Kawa Amin Aram H Rasool Ali Hattem Taha AM Al-Karboly Taher E Taher Jonas Bystrom 

作者机构：Department of Medical ScienceRespiratory Medicine and AllergologyClinical Chemistry and Asthma Research CentreUppsala University and University Hospital Department of Microbiology/ImmunologySchool of MedicineUniversity of Sulaimani Laboratory DepartmentGeneral Hospital of Derbandixan Department of Community HealthSulaimani Polytechnic University Department of MedicineSchool of MedicineFaculty of Medical SciencesUniversity of Sulaimani Experimental Medicine and RheumatologyWilliam Harvey Research InstituteBarts and the LondonQueen MaryUniversity of London 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2017年第23卷第8期

页      面：1345-1352页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Supported by Bror Hjerpstedts Foundation Sweden 

主　　题：Autoantibody Inflammatory diseases Immune system Hepatitis C virus Smooth muscle antibody Liver/kidney microsomal-1 autoantibody Anti-nuclear antibody 

摘      要：To determine how the auto-antibodies (Abs) profiles overlap in chronic hepatitis C infection (CHC) and autoimmune hepatitis (AIH) and correlate to liver *** of antinuclear Ab, smooth muscle antibody (SMA) and liver/kidney microsomal-1 (LKM-1) Ab and markers of liver damage were determined in the sera of 50 patients with CHC infection, 20 AIH patients and 20 healthy controls using enzyme linked immunosorbent assay and other immune *** found that AIH patients had more severe liver disease as determined by elevation of total IgG, alkaline phosphatase, total serum bilirubin and serum transaminases and significantly higher prevalence of the three non-organ-specific autoantibodies (auto-Abs) than CHC patients. Antinuclear Ab, SMA and LKM-1 Ab were also present in 36% of CHC patients and related to disease severity. CHC cases positive for auto-Abs were directly comparable to AIH in respect of most markers of liver damage and total IgG. These cases had longer disease duration compared with auto-Ab negative cases, but there was no difference in gender, age or viral load. KLM-1+ Ab CHC cases showed best overlap with ***-Ab levels in CHC may be important markers of disease severity and positive cases have a disease similar to AIH. Auto-Abs might have a pathogenic role as indicated by elevated markers of liver damage. Future studies will unravel any novel associations between these two diseases, whether genetic or other.