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Rapunzel syndrome is not just a mere surgical problem: A case report and review of current management

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World Journal of Clinical Cases 2017年第2期5卷 50-55页

作者： Obinna Obinwa David Cooper Faraz Khan James m O'Riordan Department of Surgery the Adelaide and Meath Hospital Dublin Incorporating the National Children’s Hospital

Recurrent Rapunzel syndrome(RRS) is a rare clinical presentation with fewer than six cases reported in the Pub med literature. A report of RRS and literature review is presented. A 25-year-old female was admitted to hospital with a 4-wk history of epigastric pain and swelling. She had a known history of trichophagia with a previous admission for Rapunzel syndrome requiring a laparotomy nine years earlier, aged 16. Psychological treatment had been successfully achieved for nine years with outpatient hypnotherapy sessions only, but she defaulted on her last session due to stressors at home. The abdominal examination demonstrated an epigastric mass. Computer tomography scan revealed a large gastric bezoar and features of aspiration pneumonia. The patient underwent emergency open surgical laparotomy for removal as the bezoar could not be removed endoscopically. The bezoar was cast in a shape that mimicked the contours of the stomach and proximal small bowel, hence the diagnosis of RRS. The patient was seen by a psychiatrist and was commenced on Quetiapine before discharge. She continues to attend follow-up.

关键词： Trichobezoars Rapunzel syndrome Recurrence Obsessive compulsive disorders Case report

克林霉素磷酸酯软膏剂的高效液相色谱法测定与制剂稳定性

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上海医科大学学报 1997年第4期24卷 289-291页

作者：段更利戴小平郭仲秋程务本上海医科大学药物分析教研室 200032 上海新亚药业公司药物研究所 200041 上海职工医学院 200237

建立1％克林霉素磷酸酯软膏剂高效液相色谱测定法，研究该制剂的稳定性，为进一步开发此药奠定基础。HPLC仪，ShimadzuLC－9A；色谱柱为150mm×6mmID（ODS，5μm）；流动相为乙睛-磷酸盐缓冲液（27：73）；检测波长210nm。结果：工作曲... 详细信息

建立1％克林霉素磷酸酯软膏剂高效液相色谱测定法，研究该制剂的稳定性，为进一步开发此药奠定基础。HPLC仪，ShimadzuLC－9A；色谱柱为150mm×6mmID（ODS，5μm）；流动相为乙睛-磷酸盐缓冲液（27：73）；检测波长210nm。结果：工作曲线方程Y=-57.18＋1364．48X，r=0.9997（n＝6）；回收率100.4％；天内天间的相对标准差分别为1.24％、1.80％。在40℃加速试验3个月，3个批号标示量含量分别为101.7％、105.2％及106.0％。强光照射10d，3个批号的标示量含量分别为101.7％、104．1％及105.3％。结论：建立的HPLC法具有简便、快速、准确度高及重现性好等优点；该软膏剂对强光照射不敏感，室温保存稳定，值得开发。

关键词：克林霉素磷酸酯软膏剂高效液相色谱稳定性

molecularly imprinted polymer for pre-concentration of esculetin from tobacco followed by the UPLC analysis

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Science China Chemistry 2014年第12期57卷 1751-1759,1-2页

作者： RAZWAN SARDAR m. JIN Yan KONG Guang Hui LI Hai Fang LIN Jin-ming Department of Chemistry Beijing Key Laboratory of Microanalytical Methods and Instrumentation Tsinghua University Nova med Pharmaceuticals Pvt. Ltd. Yunnan Academy of Tobacco Agricultural Science

molecularly imprinted polymers(mIPs)for solid-phase extraction and pre-concentration of esculetin have been successfully prepared by the bulk polymerization method using esculetin as a template *** of varying composition were prepared using different monomers(4-vinylpyridine,methacrylic acid,and acrylamide),ethylene glycol dimethacrylate as the cross-linker,2,2-azobis(2-methylpropinitrile)as the initiator,and different porogen solvents(ethanol,acetone/methanol,and acetonitrile).The best polymer was obtained when 4-vinylpyridine was used as the monomer and acetone/methanol(3:2)as the porogen solvent,whereas the template:-monomer:-cross-linker ratio was 1:4:*** imprinting factor of the selected mIPs for esculetin was *** polymers were evaluated according to their selective recognition properties for esculetin and structurally-related compounds(esculin,scopoletin,coumarin,and 7-methoxycoumarin).Chemical and morphological characterizations of the polymers were investigated by FTIR and scanning electron microscope,which confirmed a high degree of *** area,pore volume,and pore size of the polymer were investigated by Brunauer-Emmett-Teller *** were also successfully used as solid-phase adsorbent materials for the extraction of esculetin from tobacco *** contents in dried tobacco leaves were found to be(9.27±0.17)μg g-1.

关键词： molecularly imprinted polymer esculetin tobacco UPLC

Are we ready for telemonitoring inflammatory bowel disease?A review of advances,enablers,and barriers

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World Journal of Gastroenterology 2023年第7期29卷 1139-1156页

作者： Javier Del Hoyo mónica millán Alejandro Garrido-marín mariam Aguas Department of Gastroenterology La Fe University and Polytechnic HospitalValencia 46026Spain Department of Surgery La Fe University and Polytechnic HospitalValencia 46026Spain Health Research Institute La Fe La Fe University and Polytechnic HospitalValencia 46026Spain

This review summarizes the evidence about telemonitoring in patients with inflammatory bowel disease(IBD). To give an overview of the advances performed, as well as the enablers and barriers which favoured/hindered telemonitoring implementation. We performed a literature search in Pub med, EmBASE, medLINE, Cochrane Database, Web of Science and Conference Proceedings. Titles and abstracts published up to September 2022 were screened for a set of inclusion criteria: telemonitoring intervention, IBD as the main disease, and a primary study performed. Ninety-seven reports were selected for full review. Finally, 20 were included for data extraction and critical appraisal. most studies used telemonitoring combined with tele-education, and programs evolved from home telemanagement systems towards web portals through m Health applications. Web systems demonstrated patients’ acceptance, improvement in quality of life, disease activity and knowledge, with a good cost-effectiveness profile in the short-term. Initially, telemonitoring was almost restricted to ulcerative colitis, but new patient reported outcome measures, home-based tests and mobile devices favoured its expansion to different patients’ categories. However, technological and knowledge advances led to legal, ethical, economical and logistic issues. Standardization of remote healthcare is necessary, to improve the interoperability of systems as well as to address liability concerns and users’ preferences. Telemonitoring IBD is well accepted and improves clinical outcomes at a lower cost in the short-term. Funders, policymakers, providers, and patients need to align their interests to overcome the emerging barriers for its full implementation.

关键词： Inflammatory bowel disease Telemedicine Telemonitoring Information and communication technology Crohn´s disease Ulcerative colitis

RAmAN SPECTROSCOPIC STUDY ON PREDICTION OF TREATmENT RESPONSE IN CERVICAL CANCERS

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Journal of Innovative Optical Health Sciences 2013年第2期6卷 63-70页

作者： S.RUBINA m.S.VIDYASAGAR C.mURALI KRISHNA Chilakapati Laboratory Advanced Centre for TreatmentResearch and Education in CancerTata Memorial Centre Kharghar 410210India Department of Radiotherapy and Oncology Shirdi Sai Baba Cancer Hospital Kasturba Medical College Manipal UniversityManipal 576104India

Concurrent chemoradiotherapy(CCRT)is the choice of treatment for locally adv anced cervical cancers;however,tumors exhibit diverse response to *** prediction of tumor response leads to individualizing treatment *** evaluation criteria in solid tumors(RECIST),the current modality of tumor response assessment,is often subject ive and carried out at the first visit after treatment,which is about four ***,there is a need for better predictive tool for *** spectroscopic techniques,sensitive to molecular alteration,are being pursued as potential diagnostic *** pilot study ains to explore the fiber-optic-based Raman spectroscopy approach in prediction of tumor response to CCRT,before taking up extensive in vivo *** vivo Raman spectra were acquired from biopsies collected from 11 normal(148 spectra),16 tumor(201 spectra)and 13 complete response(151 CR spectra),one partial response(8 PR spectra)and one nonresponder(8 NR spectra)*** was analyzed using principal component linear discriminant analysis(PC-LDA)followed by leave-one-out cross-validation(LOO-CV).Findings suggest that normal tissues can be efficiently classified from both pre-and post-treated tumor biopsies,while there is an overlap between pre-and post-CCRT tumor *** of CR,PR and NR tissues were subjected to principal component analysis(PCA)and a tendency of classification was observed,corroborating previous ***,this study further supports the feasibility of Raman spectroscopy in prediction of tumor radioresponse and prospective noninvasive in vivo applications.

关键词： Concurrent chemoradiotherapy tumor response principal component linear discriminant analysis principal component analysis response evaluation criteria in solid tumors

基于PIC16C57单片机的智能低电阻测量仪

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现代电子技术 2002年第4期25卷 27-29页

作者：尹波邓奕湖南江南机器厂科技部湘潭411207 湖南工程学院机械工程系湘潭411101

介绍一种以 PIC16 C5 7单片机为核心的低电阻测量仪 ,与普通的低电阻测量仪不同的是 :该测量仪的测试电流仅为 0 .5 m A并加有多种保护电路 ,具有很高的安全性能。主要应用于军工、国防。

关键词：智能低电阻测量仪 PIC单片机火工品保护电路

Intrahepatic pancreatic pseudocyst:A review of the world literature

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World Journal of Hepatology 2016年第35期8卷 1576-1583页

作者： Andrew Demeusy motahar Hosseini Anne m Sill Steven C Cunningham Department of Surgery Saint Agnes Hospital

AImTo investigate and summarize the literature regarding the diagnosis and management of intrahepatic pancreatic pseudocysts (IHPP). mETHODSA literature search was performed using Pubmed (medLINE) and Google Scholar databases, followed by a manual review of reference lists to ensure that no articles were missed. All articles, case reports, systematic reviews, letters to editors, and abstracts were analyzed and tabulated. Bivariate analyses were performed, with significance accepted at P RESULTSWe found 41 published articles describing 54 cases since the 1970s, with a fairly steady rate of publication. Patients were predominantly male, with a mean age of 49 years. In 42% of published cases, the IHPP was the only reported pseudocyst, but 58% also had concurrent pseudocysts in other extrapancreatic locations. Average IHPP size was 9.5 cm and they occurred most commonly (48%) in the left hemiliver. Nearly every reported case was managed with an intervention, most with a single intervention, but some required up to three interventions. Percutaneous treatment with either simple aspiration or with an indwelling drain were the most common interventions, frequently performed along with stenting of the pancreatic duct. The size of the IHPP correlated significantly with both the duration of treatment (P = 0.006) and with the number of interventions required (P = 0.031). The duration of therapy also correlated with the initial white blood cell (WBC) count (P = 0.048). CONCLUSIONDiagnosis of IHPP is difficult and often missed. Initial size and WBC are predictive of the treatment required. With appropriate intervention, most patients achieve resolution.

关键词： Pseudocyst Intrahepatic Percutaneous Pancreatic Drainage

Survival after pulmonary metastasectomy in colorectal cancer patients:does a history of resected liver metastases worsen the prognosis?A literature review

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Cancer Biology & medicine 2017年第3期14卷 281-286页

作者： Jon Zabaleta Borja Aguinagalde Iker Lopez Arantza Fernandez-monge Jose m.Izquierdo Jose I.Emparanza Thoracic surgery service Hospital UniversitarioDonostiaGipuzkoa 20014Spain

Objective: To assess the impact of past liver metastases on the survival duration of patients who are undergoing surgery for lung ***: We conducted a review of literature published from 2007 to 2014. The studies were identified by searching Pub med,medLINE, and Embase and were supplemented by a manual search of the references listed by the retrieved studies. The following search terms were used: lung metastasectomy, pulmonary metastasectomy, lung metastases, and lung metastasis. We selected retrospective and prospective studies published from 2007 to 2014 on patients with lung metastases from colorectal cancer and were undergoing surgery with curative intent. We excluded reviews, studies that focused on surgical techniques, patients who were treated non-surgically, analyses of specific subgroups of patients, and those that did not report follow-up of the patients undergoing ***: We identified 28 papers that assessed survival after lung metastases, 21 of which were mostly retrospective studies that identified previous liver metastases to explore their impact on patient survival. In more than half of the papers analyzed(63.2%),patients with a history of resected liver metastases had a lower survival rate than those who did not have such a history, and the difference was statistically significant in eight of these studies. However, data were presented differently, and authors reported mean survival time, survival rates, or hazard ***: A history of liver metastases seems to be a negative prognostic factor, but the individual data need to undergo a meta-analysis.

关键词： Lung metastasis liver colorectal cancer review

依那普利与氯沙坦对1型糖尿病患者肾脏及视网膜病变的影响

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中国中西医结合肾病杂志 2009年第8期10卷 673-673页

作者： mauer m N Engl J med 张益民（摘）李幼姬（校）不详中山大学附属第二医院肾内科 510120 中山大学附属第一医院肾脏病研究所 510080

肾脏及视网膜病变是1型糖尿病最重要的并发症,糖尿病患者一旦被检测到白蛋白尿即意味着肾脏结构发生了病理改变.已往的研究表明肾素-血管紧张素系统(RAS)阻滞剂较其他类型降压药可更有效地延缓已发生蛋白尿、糖尿病、肾小球滤过率(GFR)... 详细信息

肾脏及视网膜病变是1型糖尿病最重要的并发症,糖尿病患者一旦被检测到白蛋白尿即意味着肾脏结构发生了病理改变.已往的研究表明肾素-血管紧张素系统(RAS)阻滞剂较其他类型降压药可更有效地延缓已发生蛋白尿、糖尿病、肾小球滤过率(GFR)下降的肾脏病进展,并可降低糖尿病肾病患者的蛋白尿.最近的DI-RECT研究报告了RAS阻滞剂可降低血压正常且无糖尿病肾病、蛋白尿正常的1型糖尿病患者视网膜病变的发生率,但是对已经出现轻-中度视网膜病变的患者无效.我们的研究旨在评价RAS阻滞剂(包括ACEI和ARB)对血压、蛋白尿均正常的1型糖尿病患者肾脏与视网膜结构的影响.

关键词：视网膜病变糖尿病患肾脏结构依那普利肾素-血管紧张素系统糖尿病肾病患者氯沙坦 RAS阻滞剂