检索结果-南通市图书馆

Rehabilitative Ultrasound Imaging within Clinical Practice

在线全文

学校读者我要写书评

暂无评论

中国运动医学杂志 2009年第5期28卷 572-574页

作者： Noelle m. Selkow med ATC 3rd Year Doctoral Student University of Virginia

Introduction Rehabilitative Ultrasound Imaging(RUSI)is on the rise among clinical rehabilitation of patients with varying *** use of real-time ultrasound has increased the effectiveness of clinical techniques,improved... 详细信息

关键词：复原超声成像临床实践 RUSI 运动医学

Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer:A systematic review

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative medicine 2024年第2期22卷 137-162页

作者： Bizhar Ahmed Tayeb Ikhwan Yuda Kusuma Alaa A.m.Osman Renáta minorics Institute of Pharmacodynamics and Biopharmacy Faculty of PharmacyUniversity of Szeged6720 SzegedHungary Institution of Clinical Pharmacy Faculty of PharmacyUniversity of Szeged6725 SzegedHungary Department of Clinical Pharmacy and Pharmacy Practice Faculty of PharmacyUniversity of Gezira20 Wad MadaniSudan Pharmacy Study Program Facuity of HealthUniversitas Harapan BangsaPurwokerto 53182Indonesia

Background:The field of personalized medicine has gained increasing attention in cancer care,with the aim of tailoring treatment strategies to individual patients for improved *** medicine,with its long-standing historical use and extensive bioactive compounds,offers a rich source of potential treatments for various diseases,including ***:To provide an overview of the current knowledge and evidence associated with incorporating herbal compounds into precision medicine strategies for cancer ***,to explore the general characteristics of the studies included in the analysis,focusing on their key features and *** strategy:A comprehensive literature search was conducted from multiple online databases,including Pub med,Scopus,Web of Science,and *** search strategy was designed to identify studies related to personalized cancer medicine and herbal *** criteria:Publications pertaining to cancer research conducted through in vitro,in vivo,and clinical studies,employing natural products were included in this *** extraction and analysis:Two review authors independently applied inclusion and inclusion criteria,data extraction,and assessments of methodological *** quality assessment and biases of the studies were evaluated based on modified Jadad scales.A detailed quantitative summary of the included studies is presented,providing a comprehensive description of their key features and ***:A total of 121 studies were included in this review for *** of them were considered as comprehensive experimental investigations both in vitro and in *** majority(n=85)of the studies included in this review were conducted in vitro,with 44 of them specifically investigating the effects of herbal medicine on animal ***,7 articles with a combined sample size of 31,271 patients,examined the impact of herbal medicine in clinical ***:Personal

关键词： Cancer Herbal medicine Personalized medication Active phytochemicals Natural compound

Autoantibodies against beta cells to predict early insulin requirements in pediatric patients with clinically diagnosed type 2 diabetes

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第8期15卷 1717-1725页

作者： Jorge m molina Patricia G medina Rita A Gomez Julia R Herrera Nancy L martínez Brenda Hernández Yesenia García Department of Endocrinology Children’s Hospital Federico GomezMexico 06720Mexico National medical Center"Siglo XXI" UMAE Hosp EspecialidadesUnidad Invest Med Epidemiol ClinMexican Social Security InstituteMexico 06720Mexico Research Division UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIMexican Institute of Social SecurityMexico 06720Mexico Epidemiology Research Unit in Endocrinology and Nutrition Federico Gómez Children’s HospitalMexico 06720Mexico Department of Endocrinology Comprehensive Health Unit for Trans PersonsMexico 11340Mexico

BACKGROUND Autoimmunity has emerged as a probable disease modifier in patients with clinically diagnosed type 2 diabetes mellitus(T2Dm),that is,patients who have insulin resistance,obesity,and other cardiovascular risk factors,suggesting that the presence of glutamic acid decarboxylase(anti-GAD65),islet antigen 2(anti-IA2),and zinc transporter 8(anti-Zn8T)antibodies could have deleterious effects on beta cell function,causing failure and earlier requirement for insulin *** To evaluate anti-GAD65,anti-IA2 and anti-Zn8T as predictors of early insulin requirement in adolescents with a clinical diagnosis of *** This was a case–control study in patients with clinically diagnosed with T2Dm(68 cases and 64 controls with and without early insulin dependence respectively),male and female,aged 12–18 ***,blood pressure,glucose,insulin,C-peptide,glycated hemoglobin A1c,and lipid profiles were *** was used to measure anti-GAD65,anti-IA2,and anti-Zn8T *** statistics,Pearson'sχ2 test,Student's t test,and logistic regression was performed.Pmale),with a mean age was 15.9±1.3 years,and there was a disease evolution time of 4.49±0.88 *** presence of anti-GAD65,anti-IA2,and anti-Zn8T positivity was found in 29.5%,18.2%,and 15.9%,*** the groups by early or no insulin dependence showed that the group with insulin had a higher frequency of antibody positivity:anti-GAD65 odds ratio(OR):2.42(1.112–5.303,P=0.026);anti-IA2:OR:1.55(0.859–2.818,P=0.105);and anti-Zn8T:OR:7.32(2.039–26.279,P=0.002).CONCLUSION Anti-GAD65 positivity was high in our ***-GAD65 and anti-Zn8T positivity showed a significantly depleted beta cell reserve phenotype,leading to an increased risk of early insulin dependence.

关键词： Diabetes Obesity Adolescents Autoimmunity Beta cell Insulin requirements

CLINICAL STUDY OF LASERNEEDLE ACUPUNCTURE

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Acupuncture-moxibustion 2001年第4期11卷 43-49页

作者： med. m. Weber Facharzt für Allgemeinmedizin, Lnsstr. 10, 37697 Lauenfrde, Germany Facharzt fǖr Allgemeinmedizin L(o)nsstr. 10 37697 Lauenf(o)rde Germany

We are reporting over 500 acupuncture cases, a wide range of illnesses ranging from orthopedic, internal, neurological and psychological diseases, all of which were treated with a newly developed and therefore available Laserneedle system. This system was highly successful in treatment of a variety of illnesses including HWS, BWS and LWS Syndromes, gonarthritis, coxarthritis, rhizarthrosis, periarthritis of the shoulder, epicondylitis humeri radialis, tendinitis, fibromyalgia and PCP, morbus Bechterew, paralysis after stroke, migraine and other headache syndrome, tinnitus, trigeminal neuralgia, gastropathy, bronchial asthma, AVK, mental depression and other psychovegatative burnout syndrome by using both body acupoints and otopoints. Treatment was made by simultaneously using 8 Laserneedles which were not pricked into, but stuck onto the skin. The Laserneedles emit red and infrared Laserrays with a high energy output, so that perceptible, vegetative stimulation can be detected at the acupunctrured sites. We found out, that especially in the therapy resistant, long standing cases and cases with chronic back and spine problems, considerable improvements in easing pain and increasing mobility could be made. Recognizable success was made by using Laserneedles in cases suffering from psychological illnesses, especially psychosomatic related Burnout syndrome and cases of exhaustion. Usually after 2～3 treatments, efficient success was made, without any side effects what so ever.

关键词： Laserneedle system Body acupoints and otopoints Various diseases

Geophysics Contribution for the Determination of Aquifers with a Case Study

在线全文

学校读者我要写书评

暂无评论

International Journal of Geosciences 2012年第1期3卷 117-125页

作者： Latifa Ouadif Lahcen Bahi Ahmed Akhssas Khadija Baba med menzhi 3GE Laboratory Mohammadia Engineering School Mohammed V Agdal University Rabat Morocco

The determination and monitoring of aquifer formations on the eastern border of moroccan Gharb basin are very difficult because of their spatial and temporal variation. To delimit these formations, a geophysical survey of 52 geoelectric soundings was performed with a mesh of 500 m and electrodes distance between 1000 m and 3000 m. Geoelectric sections and resistivity maps show a horst and graben structure. The correlation of existing oil drillings shows that the Jurassic and Neogene formations are both affected by normal faults causing Jurassic deposits collapse with local thickening of the miocene deposits, and reverse faults delimiting tectonic slices due to tension caused by prerifaine nappe advance. This fact confirms the generated structure by the resistivity method. The isobath map of resistant formations's roof show average depths extending from 400 to 800 m for calcareous sandstone that are potential aquifers while oil drillings indicate over 1000 m depths.

关键词： Aquifer Prerifaine Nappe Resistivity method Geophysical Survey Gharb Basin

mechanisms for progression of cervical squamous premalignant lesions:Implications in cervical cancer screening

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mechanisms for progression of cervical squamous premalignant...

Tissue inhibitor of metalloproteinase-1 protects mCF-7 breast cancer cells from paclitaxel-induced apoptosis by decreasing the stability of cyclin B1

第八次全国妇产科学学术会议

作者： Jian Yu Rao, m. D., Associate Professor Dept. of Pathology and Lab med Jonsson Comprehensive Cancer Center University of California at Los Angeles

morphological changes of cervical squamous premalignant lesions have been well defined in the past. These changes include the gradual progression from HPV - associated koilocytie atypia,, to low grade dysplasia, to high grade dysplasia, to carcinoma in situ, and eventually invasive carcinoma. Cytological and histological monitoring by Papsmear and cervical biopsy, coupled with colposcopic examination as well as cone/leep biopsy,have been a successful strategy in reducing the incidence of cervical squamous cell carcinoma. While the latency from HPV infection to cancer is long (around 15 to 20 years), and only a small group of women with HPV infection eventually develop

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

南京医科大学学报（自然科学版） 2010年第5期30卷 720-720页

作者： Wang,T Lv,JH Zhang,XF Li,CJ Han,X Sun,YJ Nanjing med Univ,Key Lab Human Funct Genom Jiangsu Prov,Nanjing 210029,Peoples R China Nanjing med Univ,Dept Cell Biol & med Genet,Nanjing 210029,Peoples R China Nanjing Univ,Sch med,Nanjing 210008,Peoples R China Nanjing med Univ,Ctr Canc,Nanjing 210029,Peoples R China

Paclitaxel(PTX) is a very effective drug in treating *** disturbs microtubule dynamics and impairs the transition of cells from metaphase to anaphase in mitosis,leading to cell death by ***,the effectiveness of PTX in cancer chemotherapy is hampered by drug resistance in some *** inhibitor of metalloproteinase-1(TImP-1) is well known to be capable of inhibiting *** tumor tissue TImP-1 levels have been significantly associated with a poor response to *** hypothesized that TImP-1 could reduce the sensitivity of breast cancer cells to PTX by inhibiting *** test this hypothesis,we first examined the effects of TImP-1 on the apoptosis induced by PTX and investigated the effects of TImP-1 on the expression and stability of cyclin B1 that critically regulates the metaphase to anaphase transition during mitosis in mCF-7 breast cancer *** data demonstrate that TImP-1 could significantly decrease the sensitivity of mCF-7 cells to PTX-induced apoptosis,attenuate mitotic blockage in G(2) /m,and enhance the degradation of cyclin *** further investigate whether the inhibitory effect of TImP-1 on PTX-induced apoptosis is mediated by lowering levels of cyclin B1,a cyclin B1-expression plasmid was transfected into clone overexpressing *** levels of PTX-induced apoptosis were then *** data showed that the TImP-1-based decrease in PTX-induced apoptosis was reversed by cyclin *** data indicate that TImP-1 can protect breast cancer cells from PTX-induced apoptosis by decreasing the stability of cyclin B1.

关键词：肺癌癌细胞临床化疗

酪氨酸激酶抑制剂BIBFll20治疗特发性肺纤维化的有效性

在线全文

学校读者我要写书评

暂无评论

中华结核和呼吸杂志 2012年第3期35卷 197-197页

作者： Richeldi L Costabel U Selman m et a1．NEngl J med 北京大学第一医院呼吸内科 100034

背景和目的：特发性肺纤维化（IPF）是一种进行性发展的、病死率很高的肺部疾病。研究结果显示，被数种酪氨酸激酶受体激活的信号通路参与了肺纤维化的过程，因此有人提出抑制这些受体有可能减慢IPF的进展。方法：在一项为期12个月的Ⅱ... 详细信息

背景和目的：特发性肺纤维化（IPF）是一种进行性发展的、病死率很高的肺部疾病。研究结果显示，被数种酪氨酸激酶受体激活的信号通路参与了肺纤维化的过程，因此有人提出抑制这些受体有可能减慢IPF的进展。方法：在一项为期12个月的Ⅱ期临床试验中，我们在IPF患者中评价了4种不同口服剂量的酪氨酸激酶抑制剂BIBFll20与安慰剂相比的有效性和安全性。主要研究终点为用力肺活量（FVC）的年下降率，次要终点包括急性加重的次数、生活质量[用圣乔治呼吸问卷（SGRQ）测定]和肺总量等。结果：共432例IPF患者随机分组后，分别接受BIBFll20的4种剂量之一（50mg1次／d，50mg2次／d，100mg2次／d，或150mg2次／d）或安慰剂。在接受150mg2次／d组中，FVC每年下降0．06L，而安慰剂组每年下降0．19L（多重校正的封闭检验P=0．06，分层检验P=0．01）。与安慰剂相比，该剂量还使急性加重的发生率降低（每100人中分别为15．7次／年、2．4次／年，P=0．02），使SGRQ评分（根据0-100评分量表进行评价，分数越低表明生活质量越好）小幅下降，而安慰剂组SGRQ评分增加（分别为-0．66、5．46，P=0．007）。150mg2次／d组与安慰剂组比较，胃肠道症状（导致150mg20：／d组停药比安慰剂组多）和肝脏转氨酶升高更为常见。结论：与安慰剂相比，酪氨酸酶抑制剂B1BFll20（150mg，2次／d）可降低IPF患者肺功能的年下降率，减少急性加重的次数以及改善生活质量。

关键词：酪氨酸激酶抑制剂特发性肺纤维化有效性圣乔治呼吸问卷酪氨酸酶抑制剂治疗 Ⅱ期临床试验口服剂量

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

麻醉与镇痛 2011年第4期7卷 46-55页

作者： matthias Haenggi, mD Heidi Ypparila-Wolters, PhD Sarah Buerki, cand. med Rebekka Schlauri, cand. med Ilkka Korhonen, PhD Jukka Takala, mD, PhD Stephan m. Jakob, mD, PhD 马競(译) 王焱林(校) Department of Intensive Care medicine Bern University Hospital and University of Bern Bern Switzerland VTF Technical Research Centre of Finland Tampere Finland 不详

背景包括镇静评分和常规镇静暂停在内的镇静方案，有助干减少机械通气时间和重症监护病房（ICU）入住时间。因临床上对于镇静深度的评估工作量大、仅能间断进行且干扰镇静和睡眠，所以通过脑电生理信号评估镇静深度的替代方法已经开始... 详细信息

背景包括镇静评分和常规镇静暂停在内的镇静方案，有助干减少机械通气时间和重症监护病房（ICU）入住时间。因临床上对于镇静深度的评估工作量大、仅能间断进行且干扰镇静和睡眠，所以通过脑电生理信号评估镇静深度的替代方法已经开始倍受青睐：我们想明确听觉诱发相关电位（ERPs）、脑电双频指数（BIS）和墒（Entropy）是否也能够评估临床镇静深度。方法选择10例择期全麻下行胸部或腹部手术的患者。手术后进入ICU，逐渐减少丙泊酚和瑞芬太尼靶控镇静程度[采用Rickmond Agitation镇静评分（RASS），-5分极深镇静，-4分深度镇静，-3～-1分中度镇静，0分清醒]期间，记录脑电图、BIS、状态熵（SE）、反应墒（RE）和ERPs。手术前或手术后数天测量指标的相关基础水平。结果基线、PASS-5分、RASS-4分、RASS-3至-1分和PASS-0分，对应的BIS值分别是94[4]（中位数，四分位数间距）、47[15]、68[9]、75[10]和88[6]；对应的SE值分别是87[3]、46[10]、60[22]、74[21]和87[5]；对应的RE值分别是97[4]、48[9]、71[25]、81[8]和96[3]（P〈0．05，Friedman检验）。BIS和墒都有高变异度。当单独考虑ERP振幅100时，各个镇静水平的ERPs值差异无显著性：但是、复括双参数主要变量分析的ERP辨别分析显示区别深度镇静、中度镇静和清醒状态的推算概率PK大约是0．89。与PK对应的RE，SE和BIS值分别是0．88、0．89和0．85。结论ERPs、BIS和熵均不能替代基于标准评分系统的临床镇静评估。全麻后对于极深镇静、深度到中度镇静和清醒的辨别，ERPs和脑电图仅能提供相似的PK值。BIS和熵存在较高的个体间和个体自身变异度，使其难以确定预测镇静水平的目标值范围，因而在危重患者中的使用受到限制。ERPs的变异度还不清楚。

关键词：脑电双频指数重症监护病房镇静评分危重患者相关电位听觉诱发状态熵 Friedman