Mechanisms for progression of cervical squamous premalignant lesions:Implications in cervical cancer screening

作     者：Jian Yu Rao, M. D., Associate Professor Dept. of Pathology and Lab Med Jonsson Comprehensive Cancer Center University of California at Los Angeles 

会议名称：《第八次全国妇产科学学术会议》

会议日期：2004年

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

摘      要：Morphological changes of cervical squamous premalignant lesions have been well defined in the past. These changes include the gradual progression from HPV - associated koilocytie atypia,, to low grade dysplasia, to high grade dysplasia, to carcinoma in situ, and eventually invasive carcinoma. Cytological and histological monitoring by Papsmear and cervical biopsy, coupled with colposcopic examination as well as cone/leep biopsy,have been a successful strategy in reducing the incidence of cervical squamous cell carcinoma. While the latency from HPV infection to cancer is long (around 15 to 20 years), and only a small group of women with HPV infection eventually develop