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Design consideration of phthalocyanines as sensitizers for enhanced sono-photodynamic combinatorial therapy of cancer

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1077-1097页

作者： Lindokuhle Cindy Nene heidi Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfontein 2028South Africa

Cancer remains one of the diseases with the highest incidence and mortality *** treatment modalities have demonstrated threatening drawbacks including invasiveness,noncontrollability,and development of resistance for some,including chemotherapy,radiation,and ***-photodynamic combinatorial therapy(SPDT)has been developed as an alternative treatment modality which offers a non-invasive and controllable therapeutic *** combines the mechanism of action of sonodynamic therapy(SDT),which uses ultrasound,and photodynamic therapy(PDT),which uses light,to activate a sensitizer and initiate cancer *** use of phthalocyanines(Pcs)as sensitizers for SPDT is gaining interest owing to their ability to induce intracellular oxidative stress and initiate toxicity under SDT and *** review discusses some of the structural prerequisites of Pcs which may influence their overall SPDT activities in cancer therapy.

关键词： Sonodynamic therapy Photodynamic therapy Combinatorial therapy Phthalocyanines Sensitizer Cancer

Blockchain privacy and regulatory compliance:Towards a practical equilibrium

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Blockchain(Research and Applications) 2024年第1期5卷 1-9页

作者： Vitalik Buterin Jacob Illum Matthias Nadler Fabian schär Ameen Soleimani Ethereum Foundation Switzerland Chainalysis United States of America University of Basel Switzerland Privacy Pools United States of America

We study Privacy Pools,a novel smart contract-based privacy-enhancing *** protocol introduces a mechanism for users to reveal certain properties of their transaction without having to reveal the transaction *** core concept involves allowing users to publish a zero-knowledge proof,demonstrating that their funds(do not)originate from known(un-)lawful sources,without publicly revealing their entire transaction *** is achieved by proving membership in custom association sets,which are designed to demonstrate compliance with regulatory frameworks or social *** illustrate how this mechanism can create a separating equilibrium between compliant and non-compliant *** work describes the technical underpinnings,incentives,and broader implications of this mechanism,highlighting how Privacy Pools-like protocols can create more private yet compliant blockchain transactions.

关键词： Blockchain Privacy Regulation Smart contracts Zero-knowledge proofs

Diagenetic history and porosity evolution of the Middle Permian clastic-carbonate mixed system,Indus Basin,Pakistan:Implications for reservoir development

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Energy Geoscience 2024年第4期5卷 156-173页

作者： Bilal Wadood Suleman Khan Michael Wagreich Torsten Vennemann Hong Li Matee Ullah Katerina schöpfer Department of Geology University of SwabiAnbar-Swabi23561Pakistan State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi'an710069China Department of Geology University of ViennaViennaA-1090Austria Department of Geology University of PeshawarPeshawar25120Pakistan Institute of Earth Surface Dynamics University of LausanneLausanneCH-1015Switzerland Department of Lithospheric Research University of ViennaViennaA-1090Austria

This study deals with unraveling the diagenesis-induced porosity evolution in a mixed clastic-carbonate sequence of the Middle Permian Indus Basin,*** data sets including outcrop,petrography,cathodoluminescence,scanning electron microscopy(SEM),mineralogy,and geochemical isotopic compositions were integrated to establish a link between porosity evolution and *** spatial thickness and facies variations of the strata at outcrop scale are inherently controlled by the underlying bathymetry of the basin with deepening westward *** low values ofδ^(18)O of the target strata,relative to average values of the Permian carbonate,hints to diagenetic alteration in the *** data sets used in this study reveal modification of the strata in four environments,that is,i)early marine diagenesis indicated by micritization,pervasive dolomitization and isopachous fibrous cements,followed by ii)meteoric dissolution,and iii)shallow burial diagenetic processes including the precipitation of blocky cement,compaction of skeletal and non-skeletal allochems,and stylolites,and iv)a deep burial environment,characterized by pressure solution,and *** clastic intervals host subangular to subrounded quartz grains,floating textures,and almost complete absence of deleterious clay minerals,consequently resulting in the preservation of primary *** primary porosity of carbonate intervals is preserved in the form of intercrystalline and intracrystalline *** secondary porosity evolved through various diagenetic phases in the form of fractures and *** diagenetic solution mediated by organic matter in carbonates may have experienced both bacterial decomposition and thermochemical sulfate reduction,precipitating sulfides within the *** plug porosity/permeability analyses generally suggest high porosity in the siliciclastic unit,and carbonates with wackestone fabric while lower values were observed for the inner shelf pure

关键词： Reservoir Diagenesis Porosity Permian Indus Basin

DPY19L3 promotes vasculogenicmimicry by its C-mannosyltransferase activity

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Oncology Research 2024年第4期32卷 607-614页

作者： HASSAN BAYDOUN YUJI KATO HIROKI KAMO ANNA HÜsch HAYATO MIZUTA RYOTA KAWAHARA SIRO SIMIZU Department of Applied Chemistry Faculty of Science and TechnologyKeio UniversityYokohama223-8522Japan Department of Pharmacy and Biochemistry Faculty of ScienceUniversity of TübingenTübingen72074Germany

C-mannosylation is a post-translational modification that occurs intracellularly in the endoplasmic *** humans,biosynthesis of C-mannosylation in proteins containing thrombospondin type 1 repeat is catalyzed by the DPY19 family;nonetheless,biological functions of protein C-mannosylation are not yet fully understood,especially in tumor *** mimicry(VM)is the formation of fluid-conducting channels by highly invasive and genetically deregulated tumor cells,enabling the tumors to form matrix-embedded vasculogenic structures,containing plasma and blood cells to meet the metabolic demands of rapidly growing *** this study,we focused on DPY19L3,a C-mannosyltransferase,and aimed to unravel its role in *** of DPY19L3 inhibited the formation of VM in HT1080 human fibrosarcoma ***-expression of wild-type DPY19L3 recovered VM formation;however,DPY19L3 isoform2,an enzymatic activity-defect mutant,did not restore it,suggesting that the C-mannosyltransferase activity of DPY19L3 is crucial to its ***,the knockdown of DPY19L3 in MDA-MB-231 breast cancer cells hindered its network formation ***,our findings suggest that DPY19L3 is required for VM formation and stipulate the relevance of C-mannosylation in oncogenesis.

关键词： C-mannosylation Vasculogenic mimicry DPY19L3

Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration Research 2025年第2期20卷 598-608页

作者： Daniella Da Silva Madeleen Jansen van Rensburg Anine Crous heidi Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

Endoscopic submucosal dissection and endoscopic mucosal resection for esophageal and gastric lesions:A comparison of procedures

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第2期7卷 66-71页

作者： Gustav Holm schæbel Andreas Weise Mucha Charlotte Egeland Michael Patrick Achiam Department of Surgery and Transplantation Copenhagen University Hospital RigshospitaletBlegdamsvej 92100 CopenhagenDenmark

Objective Esophageal and gastric lesions are effectively managed with minimally invasive upper endoscopic procedures such as endoscopic mucosa resection(EMR)and endoscopic submucosal dissection(ESD),offering patients alternatives to invasive *** ESD is well established in Eastern Asia,its adoption in Denmark for superficial esophageal cancer is *** study presents real-world data on the feasibility,safety,and hospitalization duration associated with ESD and EMR for esophageal and gastric *** A retrospective analysis was conducted on patients who underwent ESD or EMR at a specialized center in Denmark from October 2016 to June *** on treatment,indication,lesion location,hospitalization duration,procedure duration,specimen size,complications,recurrence,and one-year overall survival were *** comparisons utilized the Mann-Whitney U test,independent sample median test,and chi-squared *** The study included 130 patients(144 procedures):72 underwent ESD and 58 underwent *** with EMR,ESD resulted in greater percentages of en bloc and R0 resections(98.8%vs.64.1%,p<0.001;and 83.9%vs.23.8%,p<0.001),greater complication rates(28.7%vs.3.1%,p<0.001)and longer procedure times(119.5 min vs.37.0 min,p<0.001).The ESD procedure time significantly decreased over time(p=0.01).The local recurrence rates were 14.5%for ESD and 23.8%for EMR(p=0.767).The one-year overall survival rates were similar between the groups(95.8%vs.94.8%,p=0.553).Conclusion Both ESD and EMR are safe and viable for treating esophageal and gastric *** offers advantages but requires more time and *** findings support the literature,emphasizing the importance of considering patient-specific factors and surgeon proficiency in selecting the appropriate procedure.

关键词： Endoscopic submucosal dissection Endoscopic mucosa resection Gastroesophageal cancer Real-world data

Degeneration of foundation cushion species induced by ecological constraints can cause massive changes in alpine plant communities

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Science China(Life Sciences) 2024年第4期67卷 789-802页

作者： Jianguo Chen Xufang Chen Lishen Qian Yazhou Zhang Bo Li Honghua Shi Lu Sun Christian schöb Hang Sun Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China College of Resources and Environment Yunnan Agricultural UniversityKunming 650500China Área de Biodiversidad y Conservación Universidad Rey Juan CarlosMóstoles 28933Spain

Foundational cushion plants can re-organize community structures and sustain a prominent proportion of alpine biodiversity,but they are sensitive to climate *** loss of cushion species can have broad consequences for associated *** potential plant community changes with the population dynamics of cushion plants remain,however,*** eight plant communities along a climatic and community successional gradient,we assessed cushion population dynamics,the underlying ecological constraints and hence associated plant community changes in alpine communities dominated by the foundational cushion plant Arenaria *** population dynamics of Arenaria are attributed to ecological constraints at a series of life history *** functions are constrained by increasing associated beneficiary plants;subsequent seedling establishment is constrained by temperature,water and light availability,extreme climate events,and interspecific competition;strong competitive exclusion may accelerate mortality and degeneration of cushion *** with cushion dynamics,species composition,abundance and community structure gradually *** cushion plants completely degenerate,previously cushion-dominated communities shift to relatively stable communities that are overwhelmingly dominated by *** warming may accelerate the degeneration process of *** of this foundational cushion plant will possibly induce massive changes in alpine plant communities and hence ecosystem functions in alpine *** assessment of the population dynamics of foundation species is critical for an effective conservation of alpine biodiversity.

关键词： alpine ecosystem biodiversity change climate change plant community dynamics foundation species global warming population dynamics

Removal of endocrine disrupting chemicals from water through urethane functionalization of microfiltration membranes via electron beam irradiation

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 61-74页

作者： Zahra Niavarani Daniel Breite Muhammad Yasir Vladimir Sedlarik Andrea Prager Nadja schönherr Bernd Abel Roger Gläser Agnes schulze Leibniz Institute of Surface Engineering eV.(IOM) Permoserstrasse 1504318 LeipzigGermany Centre of Polymer Systems University InstituteTomas Bata University in ZlinTrida Tomase Bati 567876001 ZlinCzech Republic Institute of Chemical Technology Leipzig UniversityLinnestrasse 304103 LeipzigGermany

Polyethersulphone(PES)membranes modified with urethane functional groups were prepared through an interfacial reaction using electron beam *** removal of eight endocrine disrupting chemicals(EDCs)was studied using both pristine and functionalized PES *** prepared membranes underwent characterization using several techniques,including attenuated total reflectance-Fourier transform infrared(ATR-FTIR)spectroscopy,scanning electron microscopy,contact angle analysis,and measurements of pure water ***,dynamic adsorption experiments were conducted to evaluate the adsorption mechanism of the prepared membrane toward the eight *** urethane functionalized membranes were hydrophilic(52°contact angle)and maintained a high permeate flux(26000 L/h m^(2) bar)throughout the filtration *** adsorption results demonstrated that the introduction of urethane functional groups on the membranes significantly enhanced the removal efficiency of 17β-estradiol,estriol,bisphenol A,estrone,ethinylestradiol,and *** adsorption loading of 17β-estradiol on the functionalized PES membrane was 6.7±0.7 mg/m^(2),exhibiting a 5-fold increase compared to the unmodified PES *** membranes were successfully regenerated and reused for three adsorption cycles without experiencing any loss of adsorption capacity.

关键词： Surface functionalization Electron beam irradiation Microfiltration Endocrine disrupting chemicals

Spatiotemporal drivers of Nature's contributions to people:A countylevel study

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Environmental Science and Ecotechnology 2024年第4期20卷 323-332页

作者： Wei Jiang Bojie Fu Zhongguo Shu Yihe Lv Guangyao Gao Xiaoming Feng Stefan schüler Xing Wu Cong Wang State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesNo.18 Shuangqing Road100085BeijingChina Functional Agrobiodiversity Georg-August-Universit€at G€ottingenGrisebachstraße 637077G€ottingenGermany

Nature's contributions to people(NCP)encompass both the beneficial and detrimental effects of living nature on human quality of life,including regulatory,material,and non-material ***,vital NCPs have been deteriorating,accelerated by changes in both natural and anthropogenic drivers over recent *** the often inevitable trade-offs between NCPs due to their spatially and temporally uneven distributions,few studies have quantitatively assessed the impacts of different drivers on the spatial and temporal changes in multiple NCPs and their *** we evaluate the effects of precipitation,temperature,population,gross domestic product,vegetation restoration,and urban expansion on four key regulatory NCPs-habitat maintenance,climate regulation,water quantity regulation,and soil protection-in Nei Mongol at the county *** observe increasing trends in climate regulation and soil protection from 2000 to 2019,contrasted with declining trends in habitat maintenance and water quantity *** have identified the dominant positive and negative drivers influencing each NCP across individual counties,finding that natural drivers predominantly overpowered anthropogenic ***,we discover significant spatial disparities in the tradeoff or synergy relationships between NCPs across the *** findings illustrate how the impacts of various drivers on NCPs and their interrelationships can be quantitatively evaluated,offering significant potential for application in various spatial *** an understanding of trade-offs and scale effects,these insights are expected to support and inform policymaking at both county and provincial levels.

关键词： Potential regulating contributions Natural and anthropogenic drivers Path analysis Trade-off or synergy relationship China