Design consideration of phthalocyanines as sensitizers for enhanced sono-photodynamic combinatorial therapy of cancer

作     者：Lindokuhle Cindy Nene Heidi Abrahamse Lindokuhle Cindy Nene;Heidi Abrahamse

作者机构：Laser Research CentreFaculty of Health SciencesUniversity of JohannesburgDoornfontein 2028South Africa 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2024年第14卷第3期

页      面：1077-1097页

核心收录：

学科分类：081702[工学-化学工艺] 1002[医学-临床医学] 08[工学] 0817[工学-化学工程与技术] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Research Foundation of South Africa based on the research supported by the South African Research Chairs Initiative of the Department of Science and Technology and National Research Foundation of South Africa(Grant No.98337) the University of Johannesburg the National Laser Centre the National Research Foundation-South African Research Chairs Initiative(NRF-SARChI)for their financial grant support 

主　　题：Sonodynamic therapy Photodynamic therapy Combinatorial therapy Phthalocyanines Sensitizer Cancer 

摘      要：Cancer remains one of the diseases with the highest incidence and mortality *** treatment modalities have demonstrated threatening drawbacks including invasiveness,noncontrollability,and development of resistance for some,including chemotherapy,radiation,and ***-photodynamic combinatorial therapy(SPDT)has been developed as an alternative treatment modality which offers a non-invasive and controllable therapeutic *** combines the mechanism of action of sonodynamic therapy(SDT),which uses ultrasound,and photodynamic therapy(PDT),which uses light,to activate a sensitizer and initiate cancer *** use of phthalocyanines(Pcs)as sensitizers for SPDT is gaining interest owing to their ability to induce intracellular oxidative stress and initiate toxicity under SDT and *** review discusses some of the structural prerequisites of Pcs which may influence their overall SPDT activities in cancer therapy.