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Acta Pharmaceutica Sinica B 2024年第3期14卷 1077-1097页

作者： Lindokuhle Cindy Nene heidi Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfontein 2028South Africa

Cancer remains one of the diseases with the highest incidence and mortality *** treatment modalities have demonstrated threatening drawbacks including invasiveness,noncontrollability,and development of resistance for some,including chemotherapy,radiation,and ***-photodynamic combinatorial therapy(SPDT)has been developed as an alternative treatment modality which offers a non-invasive and controllable therapeutic *** combines the mechanism of action of sonodynamic therapy(SDT),which uses ultrasound,and photodynamic therapy(PDT),which uses light,to activate a sensitizer and initiate cancer *** use of phthalocyanines(Pcs)as sensitizers for SPDT is gaining interest owing to their ability to induce intracellular oxidative stress and initiate toxicity under SDT and *** review discusses some of the structural prerequisites of Pcs which may influence their overall SPDT activities in cancer therapy.

关键词： Sonodynamic therapy Photodynamic therapy Combinatorial therapy Phthalocyanines Sensitizer Cancer

Occult hepatitis B virus infection among Egyptian blood donors

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World Journal of Hepatology 2013年第2期5卷 64-73页

作者： Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab heidi goubran Amal Bassili Gamal E Esmat Microbiology and Immunology Department Faculty of Medicine(for Girls)AlAzhar University11511 CairoEgypt Pediatric Department Hematology/Oncology DivisionFaculty of MedicineAin Shams University11511 CairoEgypt Community Medicine Department National Research Center12411 GizaEgypt Ain-Shams Maternity and Women's University Hospital 11511 CairoEgypt Community Enviromental and Occupational Medicine DepartmentFaculty of MedicineAin Shams University11511 CairoEgypt National Blood Transfusion Center 11511 CairoEgypt TB Surveillance officer STB/WHO/EMRO.Focal pointTropical Disease Research11511 CairoEgypt Tropical Medicine Department Faculty of Medicine-Cairo University11511 CairoEgypt

AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood ***:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus *** were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered *** HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/***,265 recipients were included,34 of whom were followed up for 3-6 *** were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and ***:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs *** by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed *** for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total *** DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of *** and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity a

关键词： Hepatitis B virus Total anti-HBc Occult hepatitis B virus infection Hepatitis B surface antigen Hepatitis B virus-DNA

Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

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Neural Regeneration Research 2025年第2期20卷 598-608页

作者： Daniella Da Silva Madeleen Jansen van Rensburg Anine Crous heidi Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.Brown Rafael J.Yáñez-Muñoz heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Experiences of Practical Nurses in Promoting the Rehabilitation of the Elderly and Their Education - A Secondary Publication

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Journal of Clinical and Nursing Research 2024年第4期8卷 340-352页

作者： Maria Korvola Sinikka Lotvonen heidi Siira Helvi Kyngäs Kaisa-Mari Saarela Gero Nursing Center Research Unit of Nursing Science and Health ManagementUniversity of OuluFinland Oulu University Hospital

The significance of rehabilitation-promoting nursing care is emphasized in aging Finland. According to studies, rehabilitation-promoting nursing care enhances the functional capacity of the elderly. The Elderly Services Act obliges municipalities to create a plan to support the elderly population, emphasizing home care and rehabilitation measures. A large portion of graduated practical nurses will be working with the elderly, so the education of practical nurses must meet the needs of the workforce. The study aimed to produce new information on the implementation of rehabilitation- promoting nursing care in the elderly service system and on the education of rehabilitation-promoting nursing care for the elderly in vocational institutions. The research data was collected in the autumn of 2020 through individual thematic interviews with practical nurse students (n = 8). The data was analyzed using inductive content analysis. Practical nurse students’ experiences of rehabilitation-promoting nursing care for the elderly were related to nurses’ time management, organizational practices, nursing competence, nurses’ attitudes, nurses’ practices, organizational development, implementation and development of practical education, factors affecting the use of aids, and technological aspects of aids in the future. In conclusion, it can be stated that the content of education and practical work life do not align. It is essential to increase competence in rehabilitation-promoting nursing care and to develop organizational practices.

关键词： Rehabilitation-promoting nursing care Elderly service system Practical nurse education Organizational practices Functional capacity

Neuroarchitecture Analysis in the Mis Abuelitos Nursing Home in Cochachinche, Huanuco, Peru - A Secondary Publication

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Journal of Architectural Research and Development 2024年第2期8卷 8-17页

作者： heidi Lins Maccha Montejo Renato Edu Barzola Gomez University of Huanuco HuanucoPeru.

Neuroarchitecture is a set of characteristics grouped into principles that seek to generate a certain behavior when *** principles will vary according to the type of user for whom the design is *** this research,these neuroarchitectural principles are identified in the nursing home Mis Abuelitos in Cochachinche,Huá*** home was designed and built with notions of nature and the Andean while emphasizing the occupants are the *** this purpose,qualitative research was carried out using two sequential criteria,the first was to identify what these principles are and the second was to recognize the principles within the *** principles that are assertively used for the elderly occupants were *** study observation was performed with observation and photographic sheets and was analyzed with *** processing *** was obtained that the three neuroarchitectural principles are present in the nursing home which are 67%of the recommended characteristics for the elderly.

关键词： Elderly Nursing home Neuroarchitecture Architectural principles

The malaria transmission in Anhui province China

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Infectious Disease Modelling 2023年第1期8卷 1-10页

作者： Eric Kamana Di Bai heidi E.Brown Jijun Zhao Complexity Science Institute Qingdao UniversityQingdaoChina Department of Epidemiology and Biostatistics Mel and Enid Zuckerman College of Public HealthThe University of ArizonaTucsonAZUSA

Plasmodium vivax and Plasmodium falciparum cases have opposite trends in Anhui China in the past *** term and seasonal trends in the transmission rate of *** in Africa has been well studied,however that of *** transmitted by Anopheles sinensis in China has not been *** is a lot of work on the relationship between *** cases and climatic factors in China,with sometimes contradicting ***,how climatic factors affect transmission rate of *** in China is *** used Anhui province as an example to analyze the recent transmission dynamics where two types of malaria have been reported with differing *** examined breakpoints of the *** and *** malaria long term dynamics in the recent *** locally transmitted *** malaria,we analyzed the transmission rate and its seasonality using the combined human and mosquitos SIR-SI model with time-varied mosquito biting *** identified the effects of meteorological factors on the seasonality in transmission rate using a GAM *** the imported *** ma-laria,we analyzed the potential reason for the observed increase in *** breakpoints of *** and *** dynamics happened in a same year,*** seasonality in the transmission rate of *** malaria was high(42.4%)and was linearly associated with temperature and nonlinearly with *** abrupt increase in im-ported *** cases after the breakpoint was significantly related to the increased annual Chinese investment in *** the conditions of the existing vectors of malaria,long-term trends in climatic fac-tors,and increasing trend in migration to/from endemic areas and imported malaria cases,we should be cautious of the possibility of the reestablishment of malaria in regions where it has been eliminated or the establishment of other vector-borne diseases.

关键词： Breakpoint Transmissionrate Biting rate Seasonality Climatic factors

“They Are Not Mixing With Others”:Finnish Lecturers’Perspectives on International Students’(Mis-)Encounters in Higher Education

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ECNU Review of Education 2022年第1期5卷 89-115页

作者： Carlos Mendoza Fred Dervin 袁梅 heidi Layne University of Helsinki Minzu University of China Faculty of Educational Sciences University of Helsinkisiltavuorenpenger 5AHelsinki 00014Finland

Purpose:Meeting“others,”especially so-called“local”students,is usually seen as a sign of success for intercultural learning and integration in research on study abroad and internationalization of higher *** studies have focused on how international students themselves describe their(mis-)*** this article,the authors consider lecturers’voices about this *** have an influence on the students’experiences since they spend a lot of time together in and outside ***/Approach/Methods:Using a thematic analysis and social network analysis of interview data with lecturers,and a critical perspective toward the dichotomy of“local”versus“international”students,a university in Finland,a popular destination thanks to its positive image in global education,serves as a case ***:The article identifies privileges,limits,and(missed)opportunities of encounters,as shared by the lecturers in focus group ***,the lecturers created hierarchies in the way they described the encounters between different kinds of *** signs of pluralizing both local and international students were also found in some lecturers’***/Value:The article ends with recommendations for institutions regarding the lecturers’problematic role of gatekeepers in student encounters and the limiting categories used in institutions of higher education to refer to students.

关键词： Encounters Finland international students internationalization system network analysis

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改写恐惧,拯救青春期焦虑

环球科学 2024年第13期 64-69页

作者： BJ·凯西海蒂·迈耶林颖(翻译) 盛文哲(翻译) 美国巴纳德学院美国波士顿大学系统神经科学中心不详

有关大脑发育和行为发展的研究,为帮助治疗患有常见焦虑及相关障碍的青少年,提供了新的方法。青春期是人类发育和学习的重要时期。在这个阶段,青少年会开始探索自己的社交世界,适应其中所发生的种种变化,逐渐形成对自己身份的认同感,拥... 详细信息

有关大脑发育和行为发展的研究,为帮助治疗患有常见焦虑及相关障碍的青少年,提供了新的方法。青春期是人类发育和学习的重要时期。在这个阶段,青少年会开始探索自己的社交世界,适应其中所发生的种种变化,逐渐形成对自己身份的认同感,拥有理想和抱负。也是在这个阶段,他们会从对父母(或其他照顾者)的依赖过渡到相对独立的状态,首次展示出特定的认知和情感需求,以及对生理变化、社交和性等方面的惊人适应力。不幸的是,该阶段也是绝大多数心理健康问题爆发的高峰期。

关键词：大脑发育青春期适应力社交世界生理变化照顾者青少年心理健康问题

How Does Topology Help Solve the Inscribed Rectangle Problem by Proving that Every Jordan Curve Has 4 Vertices that Form a Rectangle?

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Journal of Applied Mathematics and Physics 2023年第4期11卷 859-873页

作者： heidi Hassan Independent Researcher Cairo Egypt

When we stare into our complex surroundings, we see objects of different shapes and sizes. However, the shape that is always present, regardless of the complexity of the object, is the circle. The circle is arguably the most fascinating shape in the universe. A circle is defined as the set of all points equidistant from a given point, which, therefore, lies at the center of the circle. One of the various properties of circles is that it has infinite inscribed squares. This is because it is a continuous function, therefore if any point in the circle is transitioned by a specific factor, the other related points in the square would be shifted by the same factor. An ellipse is a similar shape with several inscribed squares. But does any closed curve have an inscribed square? This question was proposed by Otto Toeplitz in 1911 and to this day it is not answered. Another version of this problem is the inscribed rectangle problem which will be discussed in this paper.

关键词： Inscribed Rectangle Problem Topology Jordan Curve Mobius Strip