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Weekend and nighttime effect on the prognosis of peptic ulcer bleeding

World Journal of Gastroenterology 2012年第27期18卷 3578-3584页

作者： Young Hoon Youn Yong Jin Park Jae Hak Kim Tae Joo jeon Jae hee Cho Hyojin Park Department of Internal Medicine Gangnam Severance HospitalYonsei University College of MedicineSeoul 135-720South Korea Department of Internal Medicine Dongguk University Ilsan HospitalDongguk University College of MedicineGyeonggi-do 410-773South Korea Department of Internal Medicine Inje University Sanggye Paik HospitalInje University College of MedicineSeoul 139-707South Korea Department of Internal Medicine Kwandong University Myungji HospitalKwandong University College of MedicineGyeonggi-do 412-270South Korea

AIM:To evaluate whether weekend or nighttime admission affects prognosis of peptic ulcer bleeding despite early ***:Retrospective data collection from four referral centers,all of which had a formal out-of-hours emergency endoscopy service,even at weekends.A total of 388 patients with bleeding peptic ulcers who were admitted via the emergency room between January 2007 and December 2009 were *** parameters included time from patients' arrival until endoscopy,mortality,rebleeding,need for surgery and length of hospital ***:The weekday and weekend admission groups comprised 326 and 62 patients,*** were no significant differences in baseline characteristics between the two groups,except for younger age in the weekend *** patients (97%) had undergone early endoscopy,which resulted in a low mortality rate regardless of point of presentation (1.8% overall vs 1.6% on the weekend).The only outcome that was worse in the weekend group was a higher rate of rebleeding (12% vs 21%,P = 0.030).However,multivariate analysis revealed nighttime admission and a high Rockall score (≥ 6) as significant independent risk factors for rebleeding,rather than weekend ***:Early endoscopy for peptic ulcer bleeding can prevent the weekend effect,and nighttime admission was identified as a novel risk factor for rebleeding,namely the nighttime effect.

关键词： Early endoscopy Nighttime effect Pepticulcer bleeding Rebleeding Weekend effect

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Design of an 8 bit differential paired eFuse OTP memory IP reducing sensing resistance

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Journal of Central South University 2012年第1期19卷 168-173页

作者： JANG Ji-Hye 金丽妍 jeon Hwang-Gon KIM Kwang-Il HA Pan-Bong KIM Young-hee Department of Electronic Engineering Changwon National University9 Sarim-DongChangwon 641-773Korea

For the conventional single-ended eFuse cell, sensing failures can occur due to a variation of a post-program eFuse resistance during the data retention time and a relatively high program resistance of several kilo ohms. A differential paired eFuse cell is designed which is about half the size smaller in sensing resistance of a programmed eFuse link than the conventional single-ended eFuse cell. Also, a sensing circuit of sense amplifier is proposed, based on D flip-flop structure to implement a simple sensing circuit. Furthermore, a sensing margin test circuit is proposed with variable pull-up loads out of consideration for resistance variation of a programmed eFuse. When an 8 bit eFuse OTP IP is designed with 0.18 ~tm standard CMOS logic of TSMC, the layout dimensions are 229.04 μm ×100.15μm. All the chips function successfully when 20 test chips are tested with a program voltage of 4.2 V.

关键词： eFuse differential paired efuse cell one time programmable memory sensing resistance D flip-flop based sense amplifier

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Electrochemical determination of the degree of atomic surface roughness in Pt-Ni alloy nanocatalysts for oxygen reduction reaction

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Carbon Energy 2021年第2期3卷 375-383页

作者： Tae-Yeol jeon Seung-Ho Yu Sung J.Yoo hee-Young Park Sang-Kyung Kim Beamline Department Pohang Accelerator Laboratory(PAL)PohangRepublic of Korea Department of Chemical and Biological Engineering Korea UniversitySeoulRepublic of Korea Fuel Cell Center Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea Fuel Cell Research Center Korea Institute of Energy Research(KIER)DaejeonRepublic of Korea

Pt-Ni alloy nanocrystals with Pt-enriched shells were prepared by selective etching of surface Ni using sulfuric acid and *** changes in the electronic and geometric structure of the alloy nanoparticles at the surface were elucidated from the electrochemical surface area,the potential of zero total charge(PZTC),and relative surface roughness,which were determined from CO-and CO_(2)-displacement experiments before and after 3000 potential cycles under oxygen reduction reaction *** the highest activity and durability were achieved in hydroquinone-treated Pt–Ni,sulfuric acidtreated one showed the lower activity and durability despite its higher surface Pt concentration and alloying *** PZTC and QCO_(2)/QCO ratio(desorption charge of reductively adsorbed CO_(2) normalized by COad-stripping charge)depend on surface *** particular,QCO_(2)/QCO ratio change better reflects the roughness on an atomic scale,and PZTC is also affected by the electronic modification of Pt atoms in surface *** this study,a comparative study is presented to find a relationship between surface structure and electrochemical properties,which reveals that surface roughness plays a critical role to improve the electrochemical performance of Pt-Ni alloy catalysts with Pt-rich surfaces.

关键词： electrocatalyst fuel cell oxygen reduction reaction Pt-Ni surface roughness

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中老年群体的BMI、久坐行为、身体活动水平、年龄歧视和老龄化焦虑的关系研究

中老年群体的BMI、久坐行为、身体活动水平、年龄歧视和老龄化焦...

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第二届陕西省体育科学大会

作者：李静 Seung-Yong KIM Chae-hee PARK

随着人口老龄化现象以惊人的速度席卷全球,各国都在积极推动健康老龄化和积极老龄化,身体活动不足和久坐行为已严重影响到人们的健康,甚至与全因死亡率和跌倒风险有关。年龄歧视和老龄化焦虑是实现健康老龄化的主要阻碍因素之一,老年人... 详细信息

随着人口老龄化现象以惊人的速度席卷全球,各国都在积极推动健康老龄化和积极老龄化,身体活动不足和久坐行为已严重影响到人们的健康,甚至与全因死亡率和跌倒风险有关。年龄歧视和老龄化焦虑是实现健康老龄化的主要阻碍因素之一,老年人的身心健康问题直接影响到整个社会的健康,是我们面临的重大课题。研究目的:调查中老年群体的BMI、久坐行为、身体活动水平,年龄歧视和老龄化焦虑的现状及其相互间的关联性,为即将步入老年阶段的中老年群体提高晚年幸福感,构建积极健康的老年生活提供基础资料。研究方法:采取随机抽样的方法于2023年在中国S地区选取264名中老年人(男性87名,女性177名)为调查对象。根据性别、BMI(kg/m2)、婚姻状况、吸烟状况、受教育程度、主观健康状况等因素分层对中老年群体的身体活动水平、年龄歧视和老龄化焦虑程度进行问卷测量。身体活动水平分为高强度(VPA)、中强度(MPA)、低强度(LP A),每次至少持续10分钟才记录为有效。数据分析使用SPSS 22.0和AMOS 25.0统计软件进行因子分析、t检验、Pearson's r、方差分析(ANOVA)和路径分析。研究结果:结果表明,61.8%的中老年群体的BMI值高于正常数值范围;中老年群体的久坐行为、身体活动水平的调查结果显示,男性的久坐行为、VPA、MPA均高于女性的水平;中老年群体的BMI与VPA呈负相关关系(r=-.148, p=.016),BMI与MPA呈负相关关系(r=-.164, p=.008),久坐行为与LPA成负相关关系(r=-.135, p=.028);中老年群体的年龄歧视与老龄化焦虑呈正相关关系(r=.539,p=.000)。结论:VPA和MPA不同程度会影响中老年群体的BMI指数,适当增加身体活动量,减少久坐行为,能有效降低老年人的BMI指数。为改善老龄化社会结构中的老龄化焦虑,实现健康老龄化,不仅需要社会结构层面的努力,还需要减少社会群体中的年龄歧视,提高个体对健康老龄化的再认识,促使中老年人为今后步入健康老年生活做好充分准备。

关键词： BMI 久坐行为身体活动年龄歧视老化焦虑

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Immunoglobulin G4-related spinal pachymeningitis:A case report

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World Journal of Clinical Cases 2024年第32期12卷 6551-6558页

作者： Tae-Seok Chae Da-Sol Kim Gi-Wook Kim Yu Hui Won Myoung-Hwan Ko Sung-hee Park jeong-Hwan Seo Department of Physical Medicine&Rehabilitation Jeonbuk National University Medical SchoolJeonju 54907South Korea Department of Physical Medicine&Rehabilitation Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University HospitalJeonju 54907South Korea

BACKGROUND Immunoglobulin G4-related disease(IgG4-RD)is a complex immune-mediated condition that causes fibrotic inflammation in several organs.A significant clinical feature of IgG4-RD is hypertrophic pachymeningitis,which manifests as inflammation of the dura mater in intracranial or spinal *** IgG4-RD can affect multiple areas,the spine is a relatively rare site compared to the more frequent involvement of intracranial *** SUMMARY A 70-year-old male presented to our hospital with a two-day history of fever,altered mental status,and generalized *** initial brain magnetic resonance imaging(MRI)revealed multiple small infarcts across various cerebral *** the second day after admission,a physical examination revealed motor weakness in both lower extremities and diminished sensation in the right lower *** evaluation revealed findings consistent with acute motor sensory *** initial management with intravenous immunoglobulin for presumed Guillain-Barrésyndrome,the patient exhibited progressive worsening of motor *** the 45th day of hospitalization,an enhanced MRI of the entire spine,focusing specifically on the thoracic 9 to lumbar 1 vertebral level,raised the suspicion of IgG4-related spinal ***,the patient was administered oral prednisolone and participated in a comprehensive rehabilitation program that included gait training and lower extremity strengthening *** IgG4-related spinal pachymeningitis,diagnosed on MRI,was treated with corticosteroids and a structured rehabilitation regimen,leading to significant improvement.

关键词： Immunoglobulin G4 related disease Immunoglobulin G4 related spinal pachymeningitis Manual motor test Electromyography Magnetic resonance imaging Case report

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Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-Young Park Chulhwan Kwak Yoonji Lee Dae-Geun Song Jae Woo Jung Haesong Lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun Hae Lee Wonsik Kim Soyeon Kim Chang-Duck Jun Jeanho Yun Sun Choi Hyun-Woo Rhee Kwang-Hyeon Liu Jung Weon Lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

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Three-Tesla magnetic resonance elastography for hepatic fibrosis:Comparison with diffusion-weighted imaging and gadoxetic acid-enhanced magnetic resonance imaging

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World Journal of Gastroenterology 2014年第46期20卷 17558-17567页

作者： hee Sun Park Young Jun Kim Mi Hye Yu Won Hyeok Choe Sung Il Jung Hae jeong jeon Department of Radiology Konkuk University School of MedicineSeoul 143-729South Korea Digestive Disease Center Konkuk University School of MedicineSeoul 143-729South Korea

AIM: To evaluate the feasibility of 3-Tesla magnetic resonance elastography (MRE) for hepatic fibrosis and to compare that with diffusion-weighted imaging (DWI) and gadoxetic acid-enhanced magnetic resonance (MR) imag... 详细信息

关键词： Magnetic resonance elastography Hepatic fibrosis Diffusion weighted imaging Gadoxetic acid enhanced magnetic resonance imaging Serum markers

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Schizonepeta tenuifolia inhibits collagen stimulated platelet function via suppressing MAPK and Akt signaling

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The Journal of Biomedical Research 2019年第4期33卷 250-257页

作者： Bo-Ra jeon Muhammad Irfan Minki Kim Seung Eun Lee jeong Hoon Lee Man hee Rhee Laboratory of Physiology and Cell Signaling College of Veterinary MedicineKyungpook National UniversityDaegu 41566Republic of Korea Department of Herbal Crop Research National Institute of Horticultural and Herbal ScienceEumseong 27709Republic of Korea.

The prevalence of cardiovascular diseases(CVDs)is increasing at a rapid pace in developed countries,and CVDs are the leading cause of morbidity and *** products and ethnomedicine have been shown to reduce the risk of ***(S.)tenuifolia is a medicinal plant widely used in China,Korea,and Japan and is known to exhibit anti-inflammatory,antioxidant,and immunomodulatory *** hypothesized that given herbal plant exhibit pharmacological activities against CVDs,we specifically explored its effects on platelet *** aggregation was evaluated using standard light transmission *** calcium mobilization was assessed using Fura-2/AM,and granule secretion(ATP release)was measured in a *** binding to integrin a_(Ⅱb)β_3,was assessed using flow *** of mitogen-activated protein kinase(MAPK)signaling molecules and activation of the protein kinase B(Akt)was assessed using Western blot ***,extract potently and significantly inhibited platelet aggregation,calcium mobilization,granule secretion,and fibrinogen binding to integrin a_(Ⅱb)β_***,all extracts significantly inhibited MAPK and Akt *** extract inhibited platelet aggregation and granule secretion,and attenuated collagen mediated GPVI downstream signaling,indicating the potential therapeutic effects of these plant extracts on the cardiovascular system and platelet *** suggest that *** extract may be a potent candidate to treat platelet-related CVDs and to be used as an antiplatelet and antithrombotic agent.

关键词： S.tenuifolia platelet MAPK Akt natural antithrombotic agent

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Friction Behavior of Magnetorheological Fluids with Different Material Types and Magnetic Field Strength

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Chinese Journal of Mechanical Engineering 2016年第1期29卷 84-90页

作者： ZHANG Peng LEE Kwang-hee LEE Chul-hee Department of Mechanical Engineering Inha University

Magnetorheological （MR） fluid is a type of a smart material that can control its mechanical properties under a magnetic field. Iron particles in MR fluid form chain structures in the direction of an applied magnetic field, which is known as MR effect, resulting in variation of stiffness, shear modulus, damping and tribological characteristics of MR fluid. As MR effect depends on the density of particles in the fluid or the strength of a magnetic field, the experiments are conducted to evaluate the friction property under reciprocating motion by changing the types of MR fluid and the strength of a magnetic field. The material of aluminum, brass, and steel are chosen for specimen as they are the most common material in mechanical applications. The surfaces of specimen are also observed by optical microscope before and after experiments to compare the surfaces with test conditions. The comparing results show that the friction coefficient increases as the strength of a magnetic field increases in regardless of types of MR fluid or the material. Also the density of particle in MR fluid affects the friction characteristic. The results from this research can be used to improve the performance of mechanical applications using MR fluid.

关键词： Magnetorheological (MR) fluid friction characteristics smart material magnetic field

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2D material inorganic liquid crystals for tunable deep UV light modulation

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National Science Review 2022年第12期9卷 62-63页

作者： Young hee Lee Department of Energy Science and Department of Physics Sungkyunkwan University IBS Center for Integrated Nanostructure Physics Institute for Basic Science Sungkyunkwan University

Modulation of light refers to the modulation of electromagnetic radiation in the optical region including visible light as well as ultraviolet and infrared radiation,in which the amplitude (and therefore the intensity),phase,frequency or polarization of the radiated oscillations can be changed [1].Optical modulator devices are widely used in industry,as represented by liquid crystal optical modulators having an annual global market worth of over US$100 ***,

关键词： EXFOLIATION

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