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C-terminal variants of the P2X7 receptor are associated with prostate cancer progression and bonemetastasis–evidence from clinical and pre-clinical data

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Cancer Communications 2023年第3期43卷 400-404页

作者： Haiping Song hector manuel Arredondo Carrera Alexandria Sprules Ying Ji Tongsong Zhang Jiepei He Eleanor Lawrence Alison Gartland Jian Luo Ning Wang Department of Internal Medicine-Oncology Qingdao Tumor HospitalThe Second Affiliated Hospital of Medical College of Qingdao UniversityQingdaoShandong 266042P.R.China The Mellanby Centre for Musculoskeletal Research Department of Oncology and MetabolismThe University of SheffieldSheffieldSouth Yorkshire S102RXUK Yangzhi Rehabilitation Hospital(Sunshine Rehabilitation Centre) Tongji University School of MedicineShanghai 201619P.R.China

Dear Editor Bone is the most common site for metastasis in prostate cancer(PCa),and identifying clinically useful biomarkers to predict the risk of currently incurable bone metastases is a major priority in PCa *** adenosine triphosphate(ATP)was shown to be a major biochemical constituent of the tumor microenvironment and regulates the tumor and host interactions by acting at P2 purinergic *** the P2 receptors,the ion channel P2X purinergic receptor 7(P2X7R)has an unusually long C-terminus containing 200 amino acids,which forms the molecular basis for the unique bi-function of P2X7R promoting cancer cell proliferation or inducing membrane permeabilization and apoptosis,upon activation by a low or high concentration of ATP,respectively.

关键词： metastasis cancer clinical

Intravascular Foreign Bodies： A Single-Institution Experience and Description of a Novel Modified Percutaneous Retrieval Technique

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Chinese Medical Journal 2018年第4期131卷 484-485页

作者： Mario Enrique Baltazares-Lipp Benito Sarabia-Ortega Juan Ignacio Soto-Gonzalez Carlos manuel Aboitiz-Rivera hector A Carmona-Ruiz Ruben Blachman-Braun Department of Hemodynamics and Echocardiography National Institute of Respiratory Diseases "Ismael Cosio Villegas" 14080 Mexico City Mexico Centro de Investigacion en Ciencias de la Salud F-acultad de Ciencias de la Saludl Universidad Anahuac Mexico Campus Norte Estado de Mexico 52786 Mexico

To the Editor： Catheters are frequently used as diagnostic and therapeutic devices that are frequently placed in critically ill patients. In addition, with the advantage of radiologic technology, the number of minimally invasive endovascular procedures has increased, and consequently the reports of intravascular foreign bodies （IFBs） and the numerous described IFBs retrieval technique.

关键词： REMOVAL

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Clinical and prognostic implications of delirium in elderly patients with non–ST-segment elevation acute coronary syndromes

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Journal of Geriatric Cardiology 2019年第2期16卷 121-128页

作者： Miquel Vives-Borras manuel Martinez-Selles Albert Ariza-Sole Maria T.Vidan Francesc Formiga hector Bueno Juan Sanchis Oriol Alegre Albert Duran-Cambra Ramon Lopez-Palop Emad Abu-Assi Alessandro Sionis LONGEVO-SCA Investigators Department of Cardiology Hospital de la Santa Creu i Sant PauInstitute of Biomedical Research I1B Sant PauCIBERCVUniversitat Autonoma de BarcelonaBarcelonaSpain department of Cardiology Hospital General Universitario Gregorio MarahonC1BERCVUniversidad ComplutenseUniversidad EuropeaMadridSpain Hospital Universitari de Bellvitge L'Hospitalet de LlobregatBarcelonaSpain Hospital General Universitario Gregorio Maranon IiSGMCIBERFESUniversidad ComplutenseMadrid.Spain Hospital Doce de Octubre Centro Nacional de Investigaciones CardiovascularesMadridSpain Hospital Clinico de Valencia INCLIVAUniversidad de ValenciaCIBERCVSpain Hospital Universitario San Juan AlicanteSpain Hospital Alvaro Cunqueiro VigoSpain 不详

Background Elderly patients with non-ST-segment elevation acute coronary syndromes(NSTE-ACS)may present delirium but its clinical relevance is *** study aimed at detennining the clinical associated factors,and prognostic implications of delirium in old-aged patients admitted for *** LONGEVO-SCA is a prospective multicenter registry including unselected patients with NSTE-ACS aged>80 *** variables and a complete geriatric evaluation were assessed during *** association between delirium and 6-month mortality was assessed by a Cox regression model weighted for a propensity score including the potential confounding *** also analysed its association with 6-month bleeding and cognitive or functional *** Among 527 patients included,thirty-seven(7%)patients presented delirium during the *** was more frequent in patients with dementia or depression and in those from nursing homes(27.0%vs.3.1%,24.3%vs.11.6%,and 11.1%V5.2.2%,respectively;all P<0.05).Delirium was significantly associated with in-hospital infections(27.0%vs.5.3%,P<0.001)and usage of diuretics(70.3%vs.49.8%,P=0.02).Patients with delirium had longer hospitalizations[median 8.5(5.5-14)vs.6.0(4.0-10)days,P=0.02]and higher incidence of 6-month bleeding and mortality(32.3%vs.10.0%and 24.3%vs.10.8%,respectively;both P<0.05)but similar cognitive or functional *** was independently associated with 6-month mortality(HR=1.47,95%CI:1.02-2.13,P=0.04)and 6-month bleeding events(OR=2.87;95%CI:1.98-4」6,P<0.01).Conclusions In-hospital delirium in elderly patients with NSTE-ACS is associated with some preventable risk factors and it is an independent predictor of 6-month mortality.

关键词： Acute coronary syndromes Delirium Prognosis The elderly

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Strategies to reduce hepatitis C virus recurrence after liver transplantation

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World Journal of Hepatology 2013年第5期5卷 237-250页

作者： Ruben Ciria María Pleguezuelo Shirin Elizabeth Khorsandi Diego Davila Abid Suddle hector Vilca-Melendez Sebastian Rufian manuel de la Mata Javier Briceo Pedro López Cillero Nigel Heaton Institute of Liver Studies King’s College HospitalLondon SE5 9RSUnited Kingdom Unit of Hepatology and Liver Transplantation University Hospital Reina Sofías/n 1400 CórdobaSpain Unit of Hepatobiliary Surgery and Liver Transplantation University Hospital Reina Sofías/n 1400 CórdobaSpain

Hepatitis C virus (HCV) is a major health problem that leads to chronic hepatitis, cirrhosis and hepatocellular carcinoma, being the most frequent indication for liver transplantation in several countries. Unfortunately, HCV re-infects the liver graft almost invariably following reperfusion, with an accelerated history of recurrence, leading to 10%-30% of patients progressing to cirrhosis within 5 years of transplantation. In this sense, some groups have even advocated for not retransplanting this patients, as lower patient and graftoutcomes have been reported. However, the management of HCV recurrence is being optimized and several strategies to reduce post-transplant recurrence could improve outcomes, decrease the rate of re-transplantation and optimize the use of available grafts. Three moments may be the focus of potential actions in order to decrease the impact of viral recurrence: the pretransplant moment, the transplant environment and the post-transplant management. In the pre-transplant setting, it is not well established if reducing the pre transplant viral load affects the risk for HCV progression after transplant. Obviously, antiviral treatment can render the patient HCV RNA negative post transplant but the long-term benefit has not yet been fully established to justify the cost and clinical risk. In the transplant moment, factors as donor age, cold ischemia time, graft steatosis and ischemia/reperfusion injury may lead to a higher and more aggressive viral recurrence. After the transplant, discussion about immunosuppression and the moment to start the treatment (prophylactic, pre-emptive or once-confirmed) together with new antiviral drugs are of interest. This review aims to help clinicians have a global overview of posttransplant HCV recurrence and strategies to reduce its impact on our patients.

关键词： Hepatitis C virus Recurrence Liver Trans- plantation Outcomes

Avocado Nutritional Diagnosis （Persea americana Mill.）＂Hass＂, Soil Fertility and Water Quality in Ocuituco, Morelos

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Journal of Chemistry and Chemical Engineering 2013年第11期7卷 1068-1073页

作者： hector Sotelo-Nava Oscar Gabriel Villegas-Torres Martha Lilia Dominguez-Patint Elias Hernfindez Castro Agustin Damian Nava Antonio Rodrlguez-Martmez Carlos manuel Acosta-Duran Maria Andrade-Rodriguez Iran Alia-Tej acal Faculty of Agricultural Sciences Universidad Aut6noma del Estado de Morelos Cuernavaca 62209 Mexico Faculty of Chemical Sciences and Engineering Universidad Aut6noma del Estado de Morelos Cuernavaca 62209 Mexico Unit of Agricultural and Environmental Sciences Universidad Autonoma de Guerrero Guerrero 39196 Mexico Engineering and Applied Science Research Center Universidad Autonoma del Estado de Morelos Cuernavaca 62209 Mexico

Morelos is the fourth in area cultivated and production volume of avocado. Of the 13 municipalities where it is farmed, Ocuituco represents 43.51% and Tetela del Volain 27.53%. Despite being one of the main fruit species in Morelos, no information related to the fertility of the soil where it is grown, the quality of water available for irrigation and nutritional status of this important fruit for the state. The study was conducted in the municipality of Ocuituco which identified three agro-habitats taking into account climate, landform, soil type and altitude. In each agro-habitat were carried out soil sampling to determine the physical and chemical characteristics based on the Mexican Official Standard NOM-021-SEMARNAT-2000, the chemical quality of water for irrigation as described by Richards （1954） and crop nutrient status of avocado ＂Hass＂ according to the methodology described by Maldonado （2002）. The soils had different physical and chemical characteristics, as well as the nutritional status of avocado trees in the three agro-habitats. The trees had excessive concentration of CI, Cu and Zn. Indices of optimal percentage deviation expressed different nutritional requirements. The water used for irrigation was of low salinity and sodium content, so it can be used without restrictions.

关键词： Soil fertility water quality nutrients Hass.

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舒曼集团总部

城市环境设计 2010年第1期 114-119页

作者： Juliette Bekkering Monica Adams Frank Venhorst Paul Michielsen Vincent hector Albert-Jan Vermeulen Sander van Schaik Michel Leunis manuel Aust Gerard Heerink Bekkering Adams建筑事务所

舒曼集团的新址选置优越,位于能俯瞰荷兰北部的A9高速公路边上,并与一个自然保护区相邻。作为一个独立建筑,它的每个侧面都有独特的特征和外观。建筑四角作了升高处理,为项目特殊的功能需要提供空间。

关键词：集团总部舒曼天井矿井

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细腻的“粗野主义”

现代装饰 2018年第3期 92-99页

作者： Atang Tshikare & OKHA Joost van Bleiswilk Jay Sae Jung Oh Gnstián Mohaded Christapher Gentner hector Estawe & manuel Bano & Age Salajoe Alessandro Zambelli Adate-C Stine Mikkelsen we+ 彭佳 Studio OS △ OOS Uhuru Design & Constance Guisset

＂粗野主义＂（Brutalism）的建筑流派盛行于20世纪50年代至70年代中期,可以被归入现代建筑流派的一种。其建筑特色以整体的粗犷为特点,在材料上尽可能保持自然本色,力图真实地展现材料粗粝的质感;于形式上则摆脱了传统风格的束缚,将结... 详细信息

＂粗野主义＂（Brutalism）的建筑流派盛行于20世纪50年代至70年代中期,可以被归入现代建筑流派的一种。其建筑特色以整体的粗犷为特点,在材料上尽可能保持自然本色,力图真实地展现材料粗粝的质感;于形式上则摆脱了传统风格的束缚,将结构的毛糙、沉重和粗野感作为审美的标准,呈现出一种野性、朴野的面貌。

关键词：粗野主义建筑流派设计师设计灵感家具产品色彩搭配边角料设计手法

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