Clinical and prognostic implications of delirium in elderly patients with non–ST-segment elevation acute coronary syndromes

作     者：Miquel Vives-Borras Manuel Martinez-Selles Albert Ariza-Sole Maria T.Vidan Francesc Formiga Hector Bueno Juan Sanchis Oriol Alegre Albert Duran-Cambra Ramon Lopez-Palop Emad Abu-Assi Alessandro Sionis LONGEVO-SCA Investigators 

作者机构：Department of CardiologyHospital de la Santa Creu i Sant PauInstitute of Biomedical Research I1B Sant PauCIBERCVUniversitat Autonoma de BarcelonaBarcelonaSpain department of CardiologyHospital General Universitario Gregorio MarahonC1BERCVUniversidad ComplutenseUniversidad EuropeaMadridSpain Hospital Universitari de BellvitgeL'Hospitalet de LlobregatBarcelonaSpain Hospital General Universitario Gregorio MaranonIiSGMCIBERFESUniversidad ComplutenseMadrid.Spain Hospital Doce de OctubreCentro Nacional de Investigaciones CardiovascularesMadridSpain Hospital Clinico de ValenciaINCLIVAUniversidad de ValenciaCIBERCVSpain Hospital Universitario San JuanAlicanteSpain Hospital Alvaro CunqueiroVigoSpain 不详 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2019年第16卷第2期

页      面：121-128页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：supported by the funding from the Spanish Society of Cardiology 

主　　题：Acute coronary syndromes Delirium Prognosis The elderly 

摘      要：Background Elderly patients with non-ST-segment elevation acute coronary syndromes(NSTE-ACS)may present delirium but its clinical relevance is *** study aimed at detennining the clinical associated factors,and prognostic implications of delirium in old-aged patients admitted for *** LONGEVO-SCA is a prospective multicenter registry including unselected patients with NSTE-ACS aged80 *** variables and a complete geriatric evaluation were assessed during *** association between delirium and 6-month mortality was assessed by a Cox regression model weighted for a propensity score including the potential confounding *** also analysed its association with 6-month bleeding and cognitive or functional *** Among 527 patients included,thirty-seven(7%)patients presented delirium during the *** was more frequent in patients with dementia or depression and in those from nursing homes(27.0%vs.3.1%,24.3%vs.11.6%,and 11.1%V5.2.2%,respectively;all P0.05).Delirium was significantly associated with in-hospital infections(27.0%vs.5.3%,P0.001)and usage of diuretics(70.3%vs.49.8%,P=0.02).Patients with delirium had longer hospitalizations[median 8.5(5.5-14)vs.6.0(4.0-10)days,P=0.02]and higher incidence of 6-month bleeding and mortality(32.3%vs.10.0%and 24.3%vs.10.8%,respectively;both P0.05)but similar cognitive or functional *** was independently associated with 6-month mortality(HR=1.47,95%CI:1.02-2.13,P=0.04)and 6-month bleeding events(OR=2.87;95%CI:1.98-4」6,P0.01).Conclusions In-hospital delirium in elderly patients with NSTE-ACS is associated with some preventable risk factors and it is an independent predictor of 6-month mortality.