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Intensive care unit readmission in adult Egyptian patients undergoing living donor liver transplant:A single-centre retrospective cohort study

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World Journal of Hepatology 2022年第6期14卷 1150-1161页

作者： Manar Salah Iman Fawzy Montasser Hanaa A el Gendy Alaa A Korraa Gamal M elewa Hany Dabbous Hossam R Mahfouz Mostafa Abdelrahman Mohammed Hisham Goda Mohamed Mohamed Bahaa el-Din Mahmoud el-Meteini heba A Labib Department of Tropical Medicine Ain Shams Center for Organ TransplantationAin Shams UniversityCairo 11566Egypt Department of Anaesthesia and Critical Care Ain Shams Centre for Organ TransplantationAin Shams UniversityCairo 11566Egypt Department of General Surgery and Liver Transplantation Ain Shams Centre for Organ TransplantationAin Shams UniversityCairo 11566Egypt

BACKGROUND Patients who undergo living donor liver transplantation(LDLT)may suffer complications that require intensive care unit(ICU)*** To identify the incidence,causes,and outcomes of ICU readmission after *** A retrospective cohort study was conducted on patients who underwent *** collected data included patient demographics,preoperative characteristics,intraoperative details;postoperative stay,complications,causes of ICU readmission,and *** were divided into two groups according to ICU readmission after hospital *** factors for ICU readmission were identified in univariate and multivariate *** The present study included 299 ***-one(10.4%)patients were readmitted to the ICU after *** who were readmitted to the ICU were older in age(53.0±5.1 vs 49.4±8.8,P=0.001)and had a significantly higher percentage of women(29%vs 13.4%,P=0.032),diabetics(41.9%vs 24.6%,P=0.039),hypertensives(22.6%vs 6.3%,P=0.006),and renal(6.5%vs 0%,P=0.010)patients as well as a significantly longer initial ICU stay(6 vs 4 d,respectively,Pelp provide optimal care and tailor follow-up to reduce the rate of ICU readmission.

关键词： Intensive care units Liver transplantation Patient readmission Risk factors

Origanum vulgare *** extract alleviates finasteride-induced oxidative stress in mouse liver and kidney

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Asian Pacific Journal of Tropical Biomedicine 2021年第5期11卷 194-204页

作者： Qi-Feng Sun Shi-Xiang Chen Zhang-Feng Tang Xiao-Yi Song Fa Jing Hao-Tian Wu Zhong-Yang Ding Attalla el-kott Diaa Massoud heba Khalifa Department of Hepatobiliary and Vascular Surgery Jinan City People's HospitalJinanShandong Province271100China Department of Hepatology Zhejiang University Ming Zhou HospitalNingboZhejiang Province315199China Department of General Surgery Wuxi Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Traditional Chinese MedicineWuxiJiangsu Province214023China Biology Department College of ScienceKing Khalid UniversityAbhaSaudi Arabia Zoology Department College of ScienceDamanhour UniversityDamanhourEgypt Biology Department College of ScienceJouf UniversityP.O.Box 2014SakakaAl-JoufSaudi Arabia Zoology Department Faculty of ScienceFayoum UniversityFayoumEgypt

Objective:To investigate the hepatorenoprotective effects of Origanum vulgare *** finasteride-induced oxidative injury in the liver and kidney of ***:Liquid chromatography-electrospray ionization-tandem mass spectrometry(LC-ESI/MS)analysis was utilized to yield a fingerprint of Origanum vulgare polyphenolic *** BALB/c mice received 0.5 mL/day distilled water,finasteride(25 mg/kg/day for 10 d),and 100,200,or 400 mg/kg/day finasteride+Origanum vulgare extract with 6 mice per group for five *** day 36,liver and kidney function as well as pro-and antiinflammatory(IFN-γ,IL-12,IL-6,TNF-α,IL-1β,and IL-10)cytokines were *** total antioxidant status,nitric oxide(NO),and malondialdehyde levels as well as the activities of NO synthase and catalase were also *** study was conducted to assess the effect of Origanum vulgare extract on finasteride-induced renal and hepatic ***:Twenty-five major polyphenolic compounds were identified in the Origanum vulgare extract by LC-ESI/*** vulgare extract,especially at 200 and 400 mg/kg/day doses,significantly improved liver and kidney biochemical indices,decreased inflammatory cytokines,increased total antioxidant status and NO synthase and catalase activities,as well as decreased plasma NO and malondialdehyde levels in a dose-dependent manner as compared to the finasteride *** results further confirmed the protective effect of Origanum vulgare ***:Origanum vulgare extract ameliorates finasterideinduced hepatic and renal biochemical and histopathological alterations,and restores antioxidant/oxidant balance.

关键词： Kidney Liver Origanum vulgare L. Inflammation Antioxidant

Metabolites Composition of Bacillus subtilis HussainT-AMU Determined by LC-MS and Their Effect on Fusarium Dry Rot of Potato Seed Tuber

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Phyton-International Journal of Experimental Botany 2023年第3期92卷 783-799页

作者： Touseef Hussain Abrar A.Khan heba I.Mohamed Plant Pathology and Nematology Section Department of BotanyAligarh Muslim UniversityAligarhIndia Biological and Geological Sciences Department Faculty of EducationAin Shams UniversityCairoEgypt

Fusarium dry rot is considered to be the most critical soilborne and postharvest disease that damages potato tubers worldwide when they are stored for a long *** study was performed to demonstrate the effect of crude extract,culture filtrate,and cell suspension obtained from the bacterium Bacillus subtilis Hussain T-AMU,on the net house and *** oil-contaminated soil,through the serial dilution method,biosurfactant bacteria were isolated on nutrient agar *** isolate and screen the prospective biosurfactant strain,various biosurfactant screening methods were *** protocols were carried out for morphological,molecular,and chemical *** disease incidences were significantly decreased under net house and field conditions after treatment with biosurfactant extract(20%,70%),culture filtrate(23%,49%),and bacterial cell suspension(46%,27%),*** results indicate a significant effect of *** HussainT-AMU against Fusarium *** characterization of the partially purified extract by gas-chromatography indicated the existence of a high amount of methyl ester fatty *** quantitative analysis determined the presence of lipopeptide-surfactin,fengycin,and iturin in the biosurfactant *** electron microscopy revealed that morphological variation was revealed in the structure of stomata size in leaves and in the mycelia of the pathogen that was *** promising biocontrol agent can be a plausible option for further research and can also be used for the production of green biomolecules at an additional industrial level.

关键词： Biosurfactant biocontrol agents disease severity lipopeptide stomata

The Role of Serum Trace elements and Oxidative Stress in Egyptian Breast Cancer Patients

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Advances in Breast Cancer Research 2016年第1期5卷 37-47页

作者： Mona Mohamed K. el-Deeb heba G. el-Sheredy Ayman Farouk Mohammed Department of Chemical Pathology Medical Research Institute Alexandria University Alexandria Egypt Department of Cancer Management and Research Medical Research Institute Alexandria University Alexandria Egypt Department of Surgery Medical Research Institute Alexandria University Alexandria Egypt

Background: Oxidative stress is considered to be involved in the pathophysiology of all cancers. Studies indicated that the levels of oxidative stress markers increased in breast cancer. Trace metals are essential to normal human homeostasis. When present in an abnormal expression, they contribute in many pathological processes. Some trace metals are claimed to be carcinogenic and capable of inducing a toxic effect through the formation of free radicles and acting as cofactors in the oxidative damage of biological macromolecules and DNA. Objective: Our aim was to investigate the serum levels of some trace elements (Copper, Zinc and Cadmium), the total oxidative and anti-oxidative capacity (TOC and TAC) in patients with breast cancer in comparison to patients with benign breast tumours. Patients and Methods: The present study included 65 females. The participates were divided into 2 main groups: control group which consisted of 20 apparently healthy female;the patient groups which divided into 3 groups: group B included 15 patients with benign breast tumours, group N consisted of 15 newly diagnosed breast cancer patients and group M included 15 patients with metastatic breast cancer. Results: The mean serum levels of Copper, Zinc, and Cadmium were significantly higher in the three patients groups (B, N and M) than the control group. Similarly, serum uric acid (UA) and (TAC) levels showed significant higher level in both breast cancer groups as compared to the benign group. However TOC levels showed only significantly higher level in metastatic group. Conclusions: The present study suggested elevated TAC, UA and TOC in breast cancer patients. The increased levels of trace elements could lead to formation of free radicals or other reactive oxygen species. The serum profile of these trace metals may be helpful in predicting prognosis of breast cancer.

关键词： Trace elements Oxidative Capacity Breast Cancer Antioxidants

The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury

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Neural Regeneration Research 2021年第1期16卷 49-57页

作者： Saifudeen Ismael heba A.Ahmed Tusita Adris Kehkashan Parveen Parth Thakor Tauheed Ishrat Department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA Department of Biochemistry Hamdard UniversityNew DelhiIndia Neuroscience Institute University of Tennessee Health Science CenterMemphisTNUSA

Although the precise mechanisms contributing to secondary brain injury following traumatic brain injury are complex and obscure,a number of studies have demonstrated that inflammatory responses are an obvious and early feature in the pathogenesis of traumatic brain *** are multiprotein complexes that prompt the stimulation of caspase-1 and subsequently induce the maturation and secretion of proinflammatory cytokines,such as interleukin-1β and *** cytokines play a pivotal role in facilitating innate immune responses and *** various inflammasome complexes,the NOD-like receptor family pyrin domain-containing 3(NLRP3)inflammasome is the best characterized,a crucial role for NLRP3 has been demonstrated in various brain diseases,including traumatic brain *** recent studies have revealed the contribution of NLRP3 inflammasome in identifying cellular damage and stimulating inflammatory responses to aseptic tissue injury after traumatic brain *** more important,blocking or inhibiting the activation of the NLRP3 inflammasome may have substantial potential to salvage tissue damage during traumatic brain *** this review,we summarize recently described mechanisms that are involved in the activation and regulation of the NLRP3 ***,we review the recent investigations on the contribution of the NLRP3 inflammasome in the pathophysiology of TBI,and current advances and challenges in potential NLRP3-targeted therapies.A significant contribution of NLRP3 inflammasome activation to traumatic brain injury implies that therapeutic approaches focused on targeting specific inflammasome components could significantly improve the traumatic brain injury outcomes.

关键词： inflammation interleukin-1β NLRP3-inflammasome caspase-1 MCC950 traumatic brain injury

Binary Oriented Feature Selection for Valid Product Derivation in Software Product Line

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Computers, Materials & Continua 2023年第9期76卷 3653-3670页

作者： Muhammad Fezan Afzal Imran Khan Javed Rashid Mubbashar Saddique heba G.Mohamed Department of CS&SE International Islamic UniversityIslamabad44000Pakistan Information Technology Services University of OkaraOkara56300Pakistan Departmet of Computer Science MLC LabOkara56300Pakistan Department of Computer Science&Engineering University of Engineering&Technology LahoreNarowal CampusNarowal51601Pakistan Department of electrical Engineering College of EngineeringPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia

Software Product Line(SPL)is a group of software-intensive systems that share common and variable resources for developing a particular *** feature model is a tree-type structure used to manage SPL’s common and variable features with their different relations and problem of Crosstree Constraints(CTC).CTC problems exist in groups of common and variable features among the sub-tree of feature models more diverse in Internet of Things(IoT)devices because different Internet devices and protocols are ***,managing the CTC problem to achieve valid product configuration in IoT-based SPL is more complex,time-consuming,and ***,the CTC problem needs to be considered in previously proposed approaches such as Commonality VariabilityModeling of Features(COVAMOF)andGenarch+tool;therefore,invalid products are *** research has proposed a novel approach Binary Oriented Feature Selection Crosstree Constraints(BOFS-CTC),to find all possible valid products by selecting the features according to cardinality constraints and cross-tree constraint problems in the featuremodel of ***-CTC removes the invalid products at the early stage of feature selection for the product ***,this research developed the BOFS-CTC algorithm and applied it to,IoT-based feature *** findings of this research are that no relationship constraints and CTC violations occur and drive the valid feature product configurations for the application development by removing the invalid product *** accuracy of BOFS-CTC is measured by the integration sampling technique,where different valid product configurations are compared with the product configurations derived by BOFS-CTC and found 100%*** BOFS-CTC eliminates the testing cost and development effort of invalid SPL products.

关键词： Software product line feature model internet of things crosstree constraints variability management

Helicobacter pylori may be an initiating factor in newly diagnosed ulcerative colitis patients: A pilot study

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World Journal of Clinical Cases 2018年第13期6卷 641-649页

作者： Loai Mansour Ferial el-Kalla Abdelrahman Kobtan Sherief Abd-elsalam Mohamed Yousef Samah Soliman Lobna Abo Ali Walaa elkhalawany Ibrahim Amer heba Harras Maha M Hagras Mohamed elhendawy Tropical Medicine and Infectious Diseases Department Faculty of Medicine Tanta University Hepatology and Gastroenterology Department Faculty of Medicine Kafr El-Sheikh University Pathology Department Faculty of Medicine Tanta University Clinical Pathology Department Faculty of Medicine Tanta University

AIM To directly visualize Helicobacter pylori(H. pylori) by the highly sensitive and specific technique of immunohistochemical staining in colonic tissue from patients newly diagnosed with ulcerative colitis(UC).METHODS Colonoscopic biopsies from thirty patients with newly diagnosed UC and thirty controls were stained with Giemsa stain and immunohistochemical stain for detection of H. pylori in the colonic tissue. Results were confirmed by testing H. pylori Ag in the stool then infected patients were randomized to receive either anti H. pylori treatment or *** Twelve/30(40%) of the UC patients were positive for H. pylori by Giemsa, and 17/30(56.6%) by immunohistochemistry stain. Among the control group 4/30(13.3%) and 6/30(20 %) were positive for H. pylori by Giemsa and immunohistochemistry staining respectively. H. pylori was significantly higher in UC than in controls(P = 0.04 and 0.007). All Giemsa positive patients and controls were positive by immunohistochemical stain. Four cases of the control group positive for H. pylori also showed microscopic features consistent with early *** H. pylori can be detected in colonic mucosa of patients with UC and patients with histological superficial ulcerations and mild infiltration consistent with early UC. There seems to be an association between UC and presence of H. pylori in the colonic tissue. Whether this is a causal relationship or not remains to be discovered.

关键词： Ulcerative colitis Immunohistochemical staining Inflammatory bowel disease Helicobacter pylori Giemsa stain

Structure and Properties of Sn-9Zn Lead-Free Solder Alloy with Heat Treatment

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Engineering（科研） 2010年第3期2卷 172-178页

作者： Mahmoud Hammam Fardos Saad Allah el Said Gouda Yaser el Gendy heba Abdel Aziz 不详

The Sn-9Zn lead-free solder alloy was prepared by conventional casting technique then cold-rolled into long sheets of 1 mm thickness and 3 mm width. It was annealed at 80, 120 and 160°C for 60 min to investigate the effect of isochronal heat treatment on structure and mechanical properties of the cold rolled Sn-9Zn alloy. The results showed that, the crystallite size and lattice strain have opposite behavior with increasing annealing temperature due to recovery and recrystalization processes associated with the heat treatment process. Vickers micro-hardness number increases continuously from 155 to 180 MPa with increasing annealing temperature. Ultimate tensile strength (UTS) was also calculated. It was found that, it is equal to 61.4 MPa for the non annealed sample and slightly decreases to 60.5 and 58.2 MPa for samples annealed at 80 and 120°C, respectively. While, increases to 65.4 MPa for the sample annealed at 160°C. Also, ductility increases with increasing annealing temperature in opposite manor with the UTS. The new method for Micro-creep behavior as well as the creep rate calculated by this method has been characterized at room temperature.

关键词： Cold Rolling Annealing Lead-Free Solder Alloy Micro-Creep Micro-Hardness

Biological Control of Root-Knot Nematode Meloidogyne incognita in Psoralea corylifolia Plant by Enhancing the Biocontrol Efficacy of Trichoderma harzianum Using Press Mud

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Phyton-International Journal of Experimental Botany 2022年第8期91卷 1757-1777页

作者： Yasar Nishat Mohammad Danish heba I.Mohamed Hisamuddin Shaikh Abeer elhakem Section of Plant Pathology and Nematology Department of BotanyAligarh Muslim UniversityAligarh202002India Department of Biological and Geological Sciences Faculty of EducationAin Shams UniversityCairo11341Egypt Department of Biology College of Science and Humanities in Al-KharjPrince Sattam Bin Abdulaziz UniversityAl-Kharj11942Saudi Arabia

Meloidogyne incognita is a plant pathogen causing root-knot disease and loss of crop *** present study aimed to use Trichoderma harzianum as a biocontrol agent against plant-parasitic nematodes and used press mud,which is a solid waste by-product of sugarcane,as a biocontrol agent and ***,the combined application of *** and press mud may enhance nematode control and plant *** analysis of press mud using scanning electron microscopy(SEM)integrated with an Energy Dispersive X-ray(EDX)analyzer revealed the presence of different elements such as C,O,Mg,Si,P,K,Ca,Cu and *** addition,a greenhouse study was conducted to investigate the combined effects of press mud and *** on *** reproduction and growth and the biochemical features of Psoralea *** results showed that plant length,dry biomass,leaf area,the number of seeds per plant,chlorophyll a,chl b,carotenoid content,nitrate reductase,carbonic anhydrase,and nitrogen content were significantly increased(P≤0.05)in the T2 plants(plants were treated with 100 g of press mud+50 mL *** before one week of *** inoculation),over inoculated plants(IC).Antioxidant enzyme activity of ascorbate peroxidase(APX),catalase(CAT),peroxidase(POD),and superoxide dismutase(SOD)in the foliage of *** was significantly increased when plants were treated with press mud+***.A significant reduction in the number of egg masses,nematode population,and root-knot index(RKI)was found in plants with T2 *** results suggest that the combined application of *** and press mud has the potential to control the *** infection and can be used as an environmentally safe alternative to chemical nematicides and also help in the removal of sugarcane waste that causes environmental pollution.

关键词： Growth improvement antioxidant enzymes nitrate reductase carbonic anhydrase root-knot index