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hepatitis B virus infection:A favorable prognostic factor for intrahepatic cholangiocarcinoma after resection

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World Journal of Gastroenterology 2011年第10期17卷 1292-1303页

作者： hua-Bang Zhou hui Wang Yu-Qiong Li Shuang-Xi Li Hao Wang Dong-Xun Zhou Qian-Qian Tu Qing Wang Shan-Shan Zou Meng-Chao Wu he-ping hu Departmentof Comprehensive Treatment II Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200433 China

AIM： To study the prognostic factors for intrahepatic cholangiocarcinoma （ICC） and evaluate the impact of chronic hepatitis B virus （HBV） infection on survival rate of ICC patients. METHODS： A total of 155 ICC patients who underwent macroscopic curative resections （R0 and R1） were enrolled in this retrospective study and divided into group A with HBV infection and group B without HBV infection according to their chronic HBV infection, represented by positive hepatitis B surface antigen （HBsAg） in serum or in liver tissue. Clinicopathological characteristics and survival rate of the patients were evaluated. RESULTS： All patients underwent anatomical resection. Their 1- and 3-year survival rates were 60.6% and 32.1%, respectively. Multivariate analyses revealed that HBV infection, hepatolithiasis, microscopic satellite lesion, and lymphatic metastasis were the independent prognostic factors for the survival rate of ICC patients. The median disease-free survival time of the patients was 5.0 too. The number of tumors, microscopic satellite lesion, and vascular invasion were the independent prognostic factors for the disease-free survival rate of the patients. The prognostic factors affecting the survival rate of ICC patients with HBV infection and those without HBV infection were not completely consistent. Alkaline phosphatase 〉 119 U/L, microscopic satellite lesion, vascular invasion, and lymphatic metastasis were the independent factors for the patients with HBV infection, while r-glutamyltransferase 〉 64 U/L, microscopic satellite lesion, and poor tumor differentiation were the independent factors for the patients without HBV infection. CONCLUSION： HBV infection is a valuable clinical factor for predicting tumor invasiveness and clinical outcome of ICC patients. ICC patients with HBV infection should be distinguished from those without HBV infection because they have different dinicopathological characteristics, prognostic factors and outcomes after surgical resectio

关键词： Intrahepatic cholangiocarcinoma hepatitis B virus Survival Prognosis

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地理信息系统在重金属污染研究中的应用

环境与职业医学 2017年第6期34卷 549-554页

作者：胡维贺莉萍胡琳湘南学院公共卫生学院湖南郴州423000

地理信息系统(geographic information systems,GIS)已成为公共卫生领域中的一个创新和重要的研究方法,是一个集采集、存取、传输、检索、分析和展示空间数据(或信息)于一体的计算机系统。由于GIS的实用性和灵活性,由GIS生成的动态数据... 详细信息

地理信息系统(geographic information systems,GIS)已成为公共卫生领域中的一个创新和重要的研究方法,是一个集采集、存取、传输、检索、分析和展示空间数据(或信息)于一体的计算机系统。由于GIS的实用性和灵活性,由GIS生成的动态数据库可以管理来自不同数据源的信息,分析环境相关疾病的时间、空间相关性。GIS也被越来越多地用于监视、分析和模拟重金属在环境中的迁移和对人群健康的影响。本文综述GIS在重金属污染及其健康影响的监测和分析中的一些成功案例,对GIS在重金属污染源的探索、重金属污染风险的评估、重金属致癌效应和非致癌效应的研究等方面的应用进行简述,以期为GIS在重金属污染研究中被更广泛地应用提供依据。

关键词：地理信息系统重金属污染人体健康

Laboratory research of the first confirmed pregnant woman case of avian influenza A (H5N1) by etiology in China

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Laboratory research of the first confirmed pregnant woman ca...

华东六省一市生物化学与分子生物学学会2006年学术交流会

作者： LIU yan,LI qun,hu wan-fu,MA ming-ying,LIU li-ping,he jun,hu shou-kui,REN jun (Ankui Provincial Center for Disease Control and Prevention,hefei 230061,China)

Objective To ascertain causation of a pregnant woman with undefined pneumonia reported from the People’s Hospital of Tongling city in Anhui province on November 2005. Methods The patient’s tracheal aspirates and serum being collected were tested by both RT-PCR and real-time PCR to detect viral nucleic acids of A/H5Nl,A/H7N7,A/H9N1,and were inoculated into special pathogen free(SPF) and were sequenced and analyzed. Results HA gene of A/H5N1 virus were positive in tracheal aspirates. The results of hemagglutinin(HA) gene of A/Anhui/1/2005 sequencing showed that the receptor specificity and the connecting peptide between HA1 and HA2 were still avian influenza origin. Conclusion The undefined pneumonia case was confirmed as the first human case of avian influenza (H5N1) virus infection by etiology in the mainland of china.

关键词： Avian influenza H5N1 subtype Laboratory study

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超声波辅助提取橡胶籽粕中粗蛋白的研究

粮食与油脂 2017年第8期30卷 55-60页

作者：郭雄彭吟雪何东平胡传荣武汉轻工大学食品科学与工程学院湖北武汉430023 国家粮食局粮油资源综合开发工程技术研究中心湖北武汉430023

以低温浸出橡胶籽粕为原料,通过超声波辅助提取橡胶籽粕中蛋白。在单因素试验结果的基础上,选取提取温度、液料比、超声功率和碱溶pH 4个因素进行Box-Behnken响应面法试验设计,以粗蛋白的提取率为响应值,对提取工艺参数进行优化。在提... 详细信息

以低温浸出橡胶籽粕为原料,通过超声波辅助提取橡胶籽粕中蛋白。在单因素试验结果的基础上,选取提取温度、液料比、超声功率和碱溶pH 4个因素进行Box-Behnken响应面法试验设计,以粗蛋白的提取率为响应值,对提取工艺参数进行优化。在提取时间为60 min时,橡胶籽粕蛋白最佳提取工艺为超声功率315W、提取温度52℃、液料比46∶1(m L/g)、碱溶pH 10、酸沉pH 4.5的条件下,橡胶籽粕蛋白的提取率为82.51%。

关键词：橡胶籽粕超声波辅助 Box-Behnken响应面法粗蛋白优化

无溶剂体系酶法制备富含甘油二酯稻米油的研究

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粮食与油脂 2017年第6期30卷 58-62页

作者：郭雄万聪何东平胡传荣武汉轻工大学食品科学与工程学院湖北武汉430023 国家粮食局粮油资源综合开发工程技术研究中心湖北武汉430023

以高酸值稻米油和单甘酯为原料,在单因素试验的基础上,利用P1ackett-Burman试验对各因素进行筛选,得出反应时间、反应温度、酶添加量是影响酶法制备富含甘油二酯稻米油工艺的主要因素;再利用Box-Behnken响应面法优化,得到最佳工艺条件... 详细信息

以高酸值稻米油和单甘酯为原料,在单因素试验的基础上,利用P1ackett-Burman试验对各因素进行筛选,得出反应时间、反应温度、酶添加量是影响酶法制备富含甘油二酯稻米油工艺的主要因素;再利用Box-Behnken响应面法优化,得到最佳工艺条件为反应时间9.7h、反应温度67℃、酶添加量3%,在此工艺条件下,稻米油中甘油二酯的含量达到46.68%。

关键词：甘油二酯高酸值稻米油 Plackett-Burman设计 Box-Behnken响应面法优化酶法

Gradual upregulation of OCI-5 expression during occurrence and progression of rat hepatocellular carcinoma

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hepatobiliary & Pancreatic Diseases International 2006年第2期5卷 257-261页

作者： Wei-Jun Jiang, Xiao-Bo Man, Liang Tang, Hong-Yin Song, Shen-Jing Li, Guo-Jun Cai, Xiu-hua Qiu and he-ping hu Department of Gastroenterology, Shanghai Tongren Hospital, Shanghai 200050, China Department of Gastroenterology, Eastern hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China Department of Phannacology, Second Military Medical University, Shanghai 200433, China Department of Gastroenterology Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China.

BACKGROUND: OCI-5, the rat homologene of human glypican 3 ( GPC3), is confirmed upregulated in hepatocellular carcinoma (HCC). The present study was undertaken to detect gene expression change of OCI-5 during occurrence and progression of rat HCC. METHODS: Male Sprague-Dawley rats were given diethyl-nitrosamine ( DENA) to induce HCC. Three DENA-induced rats and one control rat were sacrificed every week for 18 weeks during the development of HCC. Tissues specimens were snap-frozen in liquid nitrogen and total RNA was isolated. Sk-hepl cells were treated with DENA at different concentrations. The gene expression levels of OCI-5 and GPC3 were detected with the RT-PCR method. RESULTS: OCI-5 was not expressed in normal rat liver tissues. When HCC occurred and aggravated, OCI-5 expression was gradually elevated to a very high level. GPC3 was not expressed in the DENA-treated Sk-hepl cells. CONCLUSIONS: OCI-5 was not expressed in normal rat liver tissues but in rat HCC tissues. High-expression of OCI-5 in DENA-induced rat HCC model was the gene expression change of HCC not the DENA-induced gene expression. The expression level of OCI-5 was not only elevated in rat HCC but also gradually along the occurrence and progression of HCC, indicating that GPC3 might serve as a sensitive marker of early stage HCC.

关键词： OCI-5 gene expression carcinoma, hepatocellular rat

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宪政程序的概念、特征和价值

四川师范大学学报（社会科学版） 2003年第5期30卷 21-25页

作者：何正平胡燕四川省高校师资培训中心四川师范大学法学院四川成都610068

宪政程序是宪政主体在创制宪法、实施宪法和维护宪法的政治实践过程中,按照法律规定的程式、步骤、方法实施法律行为而形成的权利义务关系的总和。宪政程序具有实践性、稳定性和自治性特征,同时,宪政程序具有工具性价值、目的性价值。

关键词：宪政程序实践性自治性宪法工具性价值目的性价值

3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

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Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying Hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong Li Yuewei Chen Nian Liu Jing he Jue Shi Zihe hu Yanyan Zhou Zhijian Xie Yong he State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

Effect of Nb-V microalloying on the hot deformation behavior of medium Mn steels

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 360-368页

作者： Yumeng Wang Qinyi Guo Bin hu Haiwen Luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

The influence of Nb-V microalloying on the hot deformation behavior and microstructures of medium Mn steel(MMS)was investigated by uniaxial hot compression *** establishing the constitutive equations for simulating the measured flow curves,we successfully constructed deformation activation energy(Q)maps and processing maps for identifying the region of flow *** concluded the following consequences of Nb-V alloying for MMS.(i)The critical strain increases and the increment diminishes with the increasing deformation temperature,suggesting that NbC precipitates more efficiently retard dynamic recrystallization(DRX)in MMS compared with solute Nb.(ii)The deformation activation energy of MMS is significantly increased and even higher than that of some reported high Mn steels,suggesting that its ability to retard DRX is greater than that of the high Mn content.(iii)The hot workability of MMS is improved by narrowing the hot processing window for the unstable flow stress,in which fine recrystallized and coarse unrecrystallized grains are present.

关键词： medium manganese steel niobium-vanadium microalloying flow behavior dynamic recrystallization hot workability