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Occurrence and possible sources of antibiotic resistance genes in seawater of the South China Sea

Frontiers of Environmental Science & Engineering 2024年第9期18卷 27-38页

作者： Jian Lu Jun Wu Cui Zhang Jianhua Wang xia he CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone Research(YIC)Chinese Academy of Sciences(CAS)Shandong Key Laboratory of Coastal Environmental ProcessesYICCASYantai 264003China Yantai Research Institute Harbin Engineering UniversityYantai 264006China College of Environmental Science and Engineering Guilin University of TechnologyGuilin 541006China

Antibiotic resistance genes(ARGs)might have great effect on ecological security and human *** are important reservoirs that receive tremendous amounts of pollutants ***,information on the proliferation of ARGs in seawater is still *** study performed field sampling to investigate the occurrence and distribution of ARGs in seawater of the South China Sea,which is the deepest and largest sea in *** results showed that the total absolute abundances of ARGs in seawater samples ranged from 2.1×10^(3)to 2.3×10^(4)copies/mL,with an of 5.0×10^(3)copies/mL and a range of 2.2×10^(3)–1.8×10^(4)copies/mL for those with mobile genetic elements(MGEs).Genes resistant to multidrug,aminoglycoside,tetracycline,and fluoroquinolone antibiotics accounted for 77.3%–88.6%of total ARGs in *** and Cyanobacteria represented 32.1%–56.2%and 30.4%–49.5%of microbial community,***_MIT9313 and Clade_la were the prevalent genera in seawater of the South China *** co-occurrence relationship existed among ARGs,MGEs,and *** activities had critical influence on ARGs and *** wastewater,wastewater treatment plant effluent,sewage,aquaculture tailwater,and runoff were determined as the important sources of ARGs in seawater of the South China Sea based on positive matrix factorization analysis.

关键词： The South China Sea Antibiotic resistance genes Mobile genetic element Source apportionment

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Creep-Resistant Covalent Adaptable Networks with Excellent Selfhealing and Reprocessing Performance via Phase-Locked Dynamic Covalent Benzopyrazole-Urea Bonds

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Chinese Journal of Polymer Science 2024年第10期42卷 1545-1556,I0013页

作者： Miao Xie xiao-Rong Wang Zhan-Hua Wang he-Sheng xia State Key Laboratory of Polymer Materials Engineering Polymer Research InstituteSichuan UniversityChengdu610065China School of Petrochemical Engineering Liaoning Petrochemical UniversityFushun113001China

Covalent adaptive networks(CANs)are capable of undergoing segment rearrangement after being heated,which endows the materials with excellent self-healing and reprocessing performance,providing an efficient solution to the environment pollution caused by the plastic *** main challenge remains in developing CANs with both excellent reprocessing performance and creep-resistance *** this study,a series of CANs containing dynamic covalent benzopyrazole-urea bonds were developed based on the addition reaction between benzopyrazole and isocyanate *** calculation confirmed that relatively low dissociation energy is obtained through undergoing a five-member ring transition state,confirming excellent dynamic property of the benzopyrazole-urea *** verified by the FTIR results,this nice dynamic property can be well maintained after incorporating the benzopyrazole-urea bonds into polymer *** self-healing and reprocessing performance is observed by the 3-ABP/PDMS elastomers owing to the dynamic benzopyrazole-urea *** separation induced by the aggregation of the hard segments locked the benzopyrazole-urea bonds,which also makes the elastomers display excellent creep-resistance *** hard phase locking strategy provides an efficient approach to design CANs materials with both excellent reprocessing and creep-resistance performance.

关键词： Covalent adaptive networks Self-healing polymer Dynamic covalent bond

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Corrugated Graphene Paper Reinforced Silicone Resin Composite for Efficient Interface Thermal Management

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Chinese Journal of Polymer Science 2024年第7期42卷 1002-1014,I0010页

作者： Bo-Wen Wang heng Zhang Qing-xia he Hui-Tao Yu Meng-Meng Qin Wei Feng Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjin300350China International Engineering Institute Tianjin UniversityTianjin300350China

With the rapid development of high-power-density electronic devices,interface thermal resistance has become a critical barrier for effective heat management in high-performance electronic ***,there is an urgent demand for advanced thermal interface materials(TIMs)with high cross-plane thermal conductivity and excellent compressibility to withstand increasingly complex operating *** achieve this aim,a promising strategy involves vertically arranging highly thermoconductive graphene on ***,with the currently available methods,achieving a balance between low interfacial thermal resistance,bidirectional high thermal conductivity,and large-scale production is ***,we prepared a graphene framework with continuous filler structures in in-plane and cross-plane directions by bonding corrugated graphene to planar graphene *** interface interaction between the graphene paper framework and polymer matrix was enhanced via surface functionalization to reduce the interface thermal *** resulting three-dimensional thermal framework endows the polymer composite material with a cross-plane thermal conductivity of 14.4 W·m^(-1)·K^(-1)and in-plane thermal conductivity of 130W·m^(-1)·K^(-1)when the thermal filler loading is 10.1 wt%,with a thermal conductivity enhancement per 1 wt%filler loading of 831%,outperforming various graphene structures as *** its high thermal conductivity,low contact thermal resistance,and low compressive modulus,the developed highly thermoconductive composite material demonstrates superior performance in TIM testing compared with TFLEX-700,an advanced commercial TIM,effectively solving the interfacial heat transfer issues in electronic *** novel filler structure framework also provides a solution for achieving a balance between efficient thermal management and ease of processing.

关键词： Graphene paper Vertically aligned structure Cross-plane thermal conductivity Low compressive modulus Thermal interface material

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Marginal zone lymphoma with severe rashes: A case report

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World Journal of Clinical Cases 2024年第3期12卷 565-574页

作者： Si-Jun Bai Ye Geng Yi-Nan Gao Cai-xia Zhang Qian Mi Chen Zhang Jia-Ling Yang Si-Jie he Zhen-YingYan Jian-xia he Department of hematology Shanxi Provincial People’s HospitalTaiyuan 030012Shanxi ProvinceChina

BACKGROUND Marginal zone lymphoma(MZL)is an indolent subtype of non-Hodgkin lymphoma(NHL),which is rare clinically with severe rashes as the initial *** SUMMARY This study reports a case of MZL with generalized skin rashes accompanied by pruritus and purulent ***-line treatment with rituximab combined with zanubrutinib had poor ***,after switching to obinutuzumab combined with zanubrutinib,the case was alleviated,and the rashes *** For patients with advanced stage MZL not benefiting from type I anti-CD20 monoclonal antibody(mAb)combination therapy,switching to a type II anti-CD20 mAb combination regimen may be *** approach may provide a new perspective in the treatment of MZL.

关键词： Marginal zone lymphoma Mucosa-associated lymphoid tissue Extranodal marginal zone lymphoma Primary cutaneous marginal zone lymphoma Rituximab,Obinutuzumab Zanubrutinib Case report

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Timing theory integrated nursing combined behavior change integrated theory of nursing on primiparous influence

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World Journal of Clinical Cases 2024年第2期12卷 293-301页

作者： Yan-xia he Yang Lv Ting-Ting Lan Fang Deng Yuan-Yuan Zhang Department of Obstetrics and Gynecology Wuhan Children’s HospitalWuhan 430015Hubei ProvinceChina Center for Reproductive Medicine Department of Obstetrics and GynecologySichuan Provincial People's HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina

BACKGROUND The comprehension and utilization of timing theory and behavior change can offer a more extensive and individualized provision of support and treatment alternatives for *** has the potential to enhance the psychological well-being and overall quality of life for primipara,while also furnishing healthcare providers with efficacious interventions to tackle the psychological and physiological obstacles encountered during the stages of pregnancy and *** To explore the effect of timing theory combined with behavior change on selfefficacy,negative emotions and quality of life in patients with *** A total of 80 primipara cases were selected and admitted to our hospital between August 2020 and May *** cases were divided into two groups,namely the observation group and the control group,with 40 cases in each *** nursing interventions differed between the two groups,with the control group receiving routine nursing and the observation group receiving integrated nursing based on the timing theory and behavior *** study aimed to compare the pre-and post-nursing scores of Chinese Perceived Stress Scale(CPSS),Edinburgh Postpartum Depression Scale(EPDS),Self-rating Anxiety Scale(SAS),breast milk knowledge,self-efficacy,and SF-36 quality of life in both *** After nursing,the CPSS,EPDS,and SAS scores of the two groups was significantly lower than that before nursing,and the CPSS,EPDS,and SAS scores of the observation group was significantly lower than that of the control group(P=0.002,P=0.011,and P=0.001 respectively).After nursing,the breastfeeding knowledge mastery,selfefficacy,and SF-36 quality of life scores was significantly higher than that before nursing,and the breastfeeding knowledge mastery(P=0.013),self-efficacy(P=0.008),and SF-36 quality of life(P=0.011)scores of the observation group was significantly higher than that of the control *** The integration of timing theory and behavior

关键词： Timing theory Behavior change Primipara Bad mood Quality of life

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Multi-omics analyses provide insights into the evolutionary history and the synthesis of medicinal components of the Chinese wingnut

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Plant Diversity 2024年第3期46卷 309-320页

作者： Zi-Yan Zhang he-xiao xia Meng-Jie Yuan Feng Gao Wen-Hua Bao Lan Jin Min Li Yong Li College of Life Science and Technology Inner Mongolia Normal UniversityHohhot 010020China Key Laboratory of Biodiversity Conservation and Sustainable Utilization in Mongolian Plateau for College and University of Inner Mongolia Autonomous Region Hohhot 010022China College of Landscape and Art Henan Agricultural UniversityZhengzhou 450002China State Key Laboratory of Tree Genetics and Breeding Chinese Academy of ForestryBeijing 100091China

Chinese wingnut(Pterocarya stenoptera)is a medicinally and economically important tree species within the family ***,the lack of high-quality reference genome has hindered its in-depth *** this study,we successfully assembled its chromosome-level genome and performed multiomics analyses to address its evolutionary history and synthesis of medicinal components.A thorough examination of genomes has uncovered a significant expansion in the Lateral Organ Boundaries Domain gene family among the winged group in *** notable increase may be attributed to their frequent exposure to flood-prone *** further differentiation between Chinese wingnut and Cyclocarya paliurus,significant positive selection occurred on the genes of NADH dehydrogenase related to mitochondrial aerobic respiration in Chinese wingnut,enhancing its ability to cope with waterlogging *** genomic analysis revealed Chinese wingnut evolved more unique genes related to arginine synthesis,potentially endowing it with a higher capacity to purify nutrient-rich water *** of terpene synthase families enables the production of increased quantities of terpenoid volatiles,potentially serving as an evolved defense mechanism against herbivorous *** combined transcriptomic and metabolomic analysis,we identified the candidate genes involved in the synthesis of terpenoid *** study offers essential genetic resources for Chinese wingnut,unveiling its evolutionary history and identifying key genes linked to the production of terpenoid volatiles.

关键词： Genome Medicinal components Metabolome Pterocarya stenoptera Transcriptome

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骨免疫系统下类风湿关节炎继发骨质疏松的研究进展

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中国骨质疏松杂志 2024年第9期30卷 1400-1404页

作者：何霞定西市人民医院甘肃定西743000

类风湿关节炎(rheumatoid arthritis,RA)是一种自身免疫异常介导的慢性炎症性关节疾病,其特点是滑膜炎症和不可逆的骨侵蚀,与骨免疫系统功能异常有关。骨丢失是RA的典型后果,局部骨丢失能够导致发炎关节产生糜烂性改变,而全身性骨丢失... 详细信息

类风湿关节炎(rheumatoid arthritis,RA)是一种自身免疫异常介导的慢性炎症性关节疾病,其特点是滑膜炎症和不可逆的骨侵蚀,与骨免疫系统功能异常有关。骨丢失是RA的典型后果,局部骨丢失能够导致发炎关节产生糜烂性改变,而全身性骨丢失会继发骨质减少或明显的骨质疏松(osteoporosis,OP)。骨免疫学被定义为一个新的交叉学科领域,涉及了包括破骨细胞、成骨细胞、免疫细胞等在内的骨骼系统和免疫系统的相互作用。本文通过查阅相关国内外文献,综述了在骨免疫系统下目前RA继发OP的病理生理学方面取得的实质性进展,以期为预防RA及抗OP提供参考。

关键词：类风湿关节炎免疫细胞破骨细胞成骨细胞骨质疏松

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团体辅导对不同专业大学生职业生涯规划能力提升效果研究

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西部学刊 2024年第14期 120-124页

作者：贺霞武汉文理学院武汉430345

采用准实验法和问卷调查相结合的方法,在不同大学选取不同专业的部分学生为研究对象,将被试分为两组,开展为期六周的团体辅导。干预前后,分别使用职业生涯状况评价问卷对被试进行测量。结果显示:实验组学生后测的总分和各分量表的得分... 详细信息

采用准实验法和问卷调查相结合的方法,在不同大学选取不同专业的部分学生为研究对象,将被试分为两组,开展为期六周的团体辅导。干预前后,分别使用职业生涯状况评价问卷对被试进行测量。结果显示:实验组学生后测的总分和各分量表的得分均显著比对照组学生高,表明团体辅导对提高大学生职业生涯规划能力有显著的效果。此外,实验组的学生中,心理学专业学生的量表总分和各分量表得分均显著高于艺术类专业。实验表明,团体辅导在大学生职业生涯规划中具有正向影响,不同专业之间辅导效果存在差异。

关键词：团体辅导职业生涯规划大学生

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Epigenetic regulatory differentiation of hematopoietic stem cells to the red lineage

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Reproductive and Developmental Medicine 2024年第3期8卷 169-177页

作者： Hong-Xing Li Yi-Hong Chai xiao-Hong Sun xiao-xia he Ya-Ming Xi The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000China Key Laboratory for Reproductive Medicine and Embryo of Gansu Province Lanzhou 730000China Department of hematology The First Hospital of Lanzhou UniversityLanzhou 730000China

The differentiation process from hematopoietic stem cells(HSCs)to mature red blood cells(RBCs)is characterized by remarkable precision and is tightly controlled from the initial lineage commitment to eventual terminal *** is the dynamic journey of HSCs through various functional and phenotypic *** physiological course of erythrogenesis is intricately linked to significant changes in chromatin accessibility,necessitating precise coordination of transcription factors and epigenetic *** review presents a comprehensive overview of recent investigations into the molecular-level epigenetic regulatory factors that influence the differentiation of the erythroid *** encompasses the exploration of transcriptional,post-transcriptional,and post-translational regulatory *** intricate interplay of epigenetic and transcriptional regulatory networks in erythroid differentiation not only enhances our understanding of this fundamental biological process but also provides valuable insights into the underlying mechanisms contributing to the pathogenesis of disorders associated with abnormal erythroid *** findings hold significant promise for the development of novel therapeutic strategies to address these diseases and improve patient outcomes.

关键词： hematopoietic stem cells Differentiation Epigenetics Post-translational regulation

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点载荷作用下聚乙烯燃气管道的损伤分析

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中国塑料 2024年第3期38卷 67-72页

作者：蒲强何霞王国荣胡刚西南石油大学机电工程学院成都610500 西南石油大学能源装备研究院成都610500

通过单轴拉伸试验获得了聚乙烯(PE)材料弹性及屈服参数。建立了点载荷下的管-土有限元模型,研究了埋地燃气PE在点载荷下的力学响应,分析了点载荷尺寸、管道内压及管道直径的影响。基于DFDI(ductile failure damage indicator)模型,结合... 详细信息

通过单轴拉伸试验获得了聚乙烯(PE)材料弹性及屈服参数。建立了点载荷下的管-土有限元模型,研究了埋地燃气PE在点载荷下的力学响应,分析了点载荷尺寸、管道内压及管道直径的影响。基于DFDI(ductile failure damage indicator)模型,结合有限元仿真结果,对点载荷下的PE管进行了定量损伤计算。结果表明,与无点载荷管道的损伤结果对比可知,点载荷的存在增大了管道损伤;管道内压变化时管道损伤变化较大;管道直径变化时对PE管损伤影响较小,各管径下的损伤值都比较接近。

关键词：聚乙烯燃气管道点载荷 DFDI模型管道损伤

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