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Long-term functional outcomes improved with deep brain stimulation in patients with disorders of consciousness

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Stroke & Vascular Neurology 2023年第5期8卷 368-378页

作者： Yi Yang qiheng he Yuanyuan Dang Xiaoyu Xia Xin Xu Xueling Chen Jizong Zhao Jianghong he Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Translational Medicine Center Chinese Institute for Brain ResearchBeijingChina Beijing Institute of Brain Disorders Capital Medical UniversityBeijingChina Department of Neurosurgery PLA General HospitalBeijingChina Academician Office China National Clinical Research Center for Neurological DiseasesBeijingChina

Background Deep brain stimulation(DBS)has been preliminarily applied to treat patients with disorders of consciousness(DoCs).The study aimed to determine whether DBS was effective for treating patients with DoC and identify factors related to patients’*** Data from 365 patients with DoCs who were consecutively admitted from 15 July 2011 to 31 December 2021 were retrospectively *** regression and subgroup analysis were performed to adjust for potential *** primary outcome was improvement in consciousness at 1 *** An overall improvement in consciousness at 1 year was achieved in 32.4%(12/37)of the DBS group compared with 4.3%(14/328)of the conservative *** full adjustment,DBS significantly improved consciousness at 1 year(adjusted OR 11.90,95%CI 3.65-38.46,phere was a significant treatment×follow up interaction(H=14.99,phe effect was likely to be significantly greater in patients with *** should be cautiously evaluated by nomogram preoperatively,and randomised controlled trials are still needed.

关键词： stimulation patients admitted

Pb induced dislocation defects of PtCo systems: Strain-triggered oxygen reduction reaction for PEMFC

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Nano Research 2024年第4期17卷 2462-2472页

作者： Chun Jin qiheng Wang Jingjun Liu Beijing Key Laboratory of Electrochemical Process and Technology for Materials Beijing 100029China Beijing University of Chemical Technology Beijing 100029China

Design and development of advanced electrocatalysts with high performance and low Pt consumption are crucial for reducing the kinetic energy barrier of the cathode oxygen reduction reaction(ORR)and improving the efficiency of proton exchange membrane fuel cells(PEMFC).In this study,we demonstrate a Pb-modulated PtCo system for efficient ORR,in which the inclusion of Pb in ternary alloys induces dislocation defects due to the significant difference in atomic ***-PtCoPb was confirmed to exhibit significantly higher ORR activity and stability in acidic *** practical PEMFC applications,it outperforms the corresponding commercial Pt/C with a mass activity of 0.58 A·mgPt^(-1),making it a promising alternative to state-of-the-art Pt-based *** combination of experimental results and density functional theory(DFT)calculations offers valuable atomic-level insights into the dislocation *** with a larger atomic radius is located in the lattice stretching region below the dislocation slip plane,forming a structure similar to a Cottrell atmosphere,which reduces the dislocation energy and puts the system in a lower energy *** Cottrell atmosphere pins the dislocation structure and stabilizes the ternary *** adjusting the amount of added Pb,a moderate level of dislocation density induces a tuned strain effect,thereby enhancing the electrocatalytic mechanism by optimizing the electronic structure of the alloy surface and the adsorption and desorption of oxygen *** work provides valuable insights into the design and development of lattice dislocation defect structures to trigger strain effects for improving ORR performance.

关键词： dislocation defect strain effect Pb-modulated oxygen reduction reaction

KRAS mutation-induced EndMT of brain arteriovenous malformation is mediated through the TGF-β/BMP-SMAD4 pathway

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Stroke & Vascular Neurology 2023年第3期8卷 197-206,I0006-I0027页

作者： Hongyuan Xu Ran Huo Hao Li Yuming Jiao Jiancong Weng Jie Wang Zihan Yan Junze Zhang Shaozhi Zhao qiheng he Yingfan Sun Shuo Wang Yong Cao Department of Neurosurgery Beijing Tiantan HospitalCapital medical universityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Beijing Neurosurgical Institute Capital Medical UniversityBeijingChina

Objective Somatic KRAS mutations have been identified in the majority of brain arteriovenous malformations(bAVMs),and subsequent in vivo experiments have confirmed that KRAS mutation in endothelial cells(ECs)causes AVMs in mouse and zebrafish *** previous study demonstrated that the KRASG12D mutant independently induced the endothelial-mesenchymal transition(EndMT),which was reversed by treatment with the lipid-lowering drug ***,the underlying mechanisms of action were *** We used human umbilical vein ECs(HUVECs)overexpressing the KRASG12D mutant for Western blotting,quantitative real-time PCR,and immunofluorescence and wound healing assays to evaluate the EndMT and determine the activation of downstream *** of SMAD4 by RNA interference was performed to explore the role of SMAD4 in regulating the *** ECs expressing the KRASG12D mutant were obtained to verify the SMAD4 ***,we performed a coimmunoprecipitation assay to probe the mechanism by which lovastatin affects *** HUVECs infected with KRASG12D adenovirus underwent the *** growth factor beta(TGF-β)and bone morphogenetic protein(BMP)signalling pathways were activated in the KRASG12D-mutant HUVECs and ECs in bAVM *** down SMAD4 expression in both KRASG12D-mutant HUVECs and ECs in bAVM tissues inhibited the *** attenuated the EndMT by downregulating p-SMAD2/3,p-SMAD1/5 and acetylated SMAD4 expression in KRASG12D-mutant *** Our findings suggest that the KRASG12D mutant induces the EndMT by activating the ERK-TGF-β/BMP-SMAD4 signalling pathway and that lovastatin inhibits the EndMT by suppressing TGF-β/BMP pathway activation and SMAD4 acetylation.

关键词： KRAS SMAD4 inhibited

Enriched photosensitizer for deep-seated-tumor photodynamic therapy

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Photonics Research 2024年第5期12卷 1024-1035页

作者： HONGRUI SHAN XUEQIAN WANG qiheng WEI HAILANG DAI XIANFENG CheN State Key Laboratory on Fiber Optic Local Area Communication Networks and Advanced Optical Communication Systems Department of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Metal Matrix Composites Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsSchool of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center of Light Manipulations and Applications Shandong Normal UniversityJinan 250358China

Photodynamic therapy(PDT)is an innovative approach that utilizes photochemical reactions for non-invasive disease *** PDT is limited by the low penetration depth of visible light required for ***,we employed upconversion nanoparticles(UCNPs)to extend the activation wavelength of photosensitizers into the infrared range,enabling a treatment depth of over 10 ***,we also used the abundant amino groups of branched polyethyleneimine(PEI)with spatial structure to enhance the loading capacity of protoporphyrin(PPIX),and we ultimately improved skin tumor clearance ***,we achieved tumor-specific treatment by utilizing folic acid(FA)targeting and active enrichment of *** to cellular experimental results,we demonstrated the remarkable reactive oxygen species generation capability of the material and ultra-low dark ***,we investigated the apoptosis mechanism and demonstrated that the synthesized nanoparticle stimulates the up-regulation of apoptosis-associated proteins Bax/Bcl-2 and Cyto *** in vivo experiments involving intravenous injection in mouse tails,we investigated the anticancer efficacy of the nanoparticle,confirming its excellent PDT *** research provides a promising avenue for future non-invasive treatment of deep-seated tumors,offering a method for the treatment and management of specific cancers.

关键词： treatment utilize utilizing

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Small amount but big impact:Trace oxygen interstitially inserted PtCu alloys by microalloying for efficient oxygen reduction catalysis

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Nano Research 2024年第8期17卷 7001-7012页

作者： qiheng Wang Zhiguo Chen Jingyan Zhang Jingjun Liu Beijing Key Laboratory of Electrochemical Process and Technology for Materials Beijing 100029China Beijing University of Chemical Technology Beijing 100029China

The introduction of small size non-metal elements(e.g.,oxygen)into solid solution alloys may be a promising strategy for fabricating efficient Pt-based catalysts with high activity and stability toward oxygen reduction reaction(ORR).herein,oxygen interstitially inserted PtCu(O-PtCu)alloys are firstly designed by an oxygen-microalloying strategy,through ultraviolet(UV)irradiation-assisted galvanic replacement in an aqueous solution containing H_(2)PtCl_(6) and Cu_(2)O nanowires as sacrificial *** obtained O-PtCu alloys feature a typical face-centered cubic(FCC)structure with majority Pt,Cu atoms as building bricks and trace interstitial oxygen(1.65 wt.%)existed in the octahedral sites surrounding Cu atoms,leading to a short-range disordered *** alloy reaches a recorded half-wave potential of 0.96 V(*** hydrogen electrode(Rhe))and mass activity of 0.48 A·mgPt^(−1),much higher than those of commercial Pt/*** the accelerated degradation test(ADT),the mass activity lost only 4.2%after 10k cycles,while the commercial Pt/C lost 66.7%under the same *** with pure Pt and undoped PtCu alloy,the remarkably improved performance can be attributed to the lattice distortion and energy band reconstruction caused by the interstitial oxygen atoms in form of Cu–O ***,the stable Cu–O bonds delay the possible place exchange between surface Pt atoms and surface-adsorbed oxygen species,thereby hindering Pt dissolution,providing a new paradigm to address Pt degradation ***,the introduction of interstitial oxygen into Pt-based alloys may be a facile and smart strategy for the development of advanced Pt-based alloys electrocatalysts.

关键词： oxygen-microalloying platinum alloys octahedral interstices oxygen reduction reaction

Somatic GJA4 mutation in intracranial extra-axial cavernous hemangiomas

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Stroke & Vascular Neurology 2023年第6期8卷 453-462,I0003-I0037页

作者： Ran Huo Yingxi Yang Hongyuan Xu Shaozhi Zhao Dong Song Jiancong Weng Ruochen Ma Yingfan Sun Jie Wang Yuming Jiao Junze Zhang qiheng he Ruolei Wu Shuo Wang Ji-Zong Zhao Junting Zhang Jiguang Wang Yong Cao Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyHong KongChina Division of Life Science Center for Systems Biology and Human Health and State Key Laboratory of Molecular NeuroscienceThe Hong Kong University of Science and TechnologyHong KongChina Department of Neurosurgery China-Japan Friendship HospitalBeijingChina School of Medical Technology Beijing Institute of TechnologyBeijingChina Hong Kong Center for Neurodegenerative Diseases InnoHKHong Kong SARChina Beijing Neurosurgical Institute Capital Medical UniversityBeijingChina

Objective Extra-axial cavernous hemangiomas(ECHs)are sporadic and rare intracranial occupational lesions that usually occur within the cavernous *** aetiology of ECHs remains *** Whole-exome sequencing was performed on ECH lesions from 12 patients(discovery cohort)and droplet digital polymerase-chain reaction(ddPCR)was used to confirm the identified mutation in 46 additional cases(validation cohort).Laser capture microdissection(LCM)was carried out to capture and characterise subgroups of tissue *** and functional investigations were carried out in human umbilical vein endothelial cells and a newly established mouse *** We detected somatic GJA4 mutation(c.121G>T,p.G41C)in 5/12 patients with ECH in the discovery cohort and confirmed the finding in the validation cohort(16/46).LCM followed by ddPCR revealed that the mutation was enriched in lesional *** vitro experiments in endothelial cells demonstrated that the GJA4 mutation activated SGK-1 signalling that in turn upregulated key genes involved in cell hyperproliferation and the loss of arterial *** with wild-type littermates,mice overexpressing the GJA4 mutation developed ECH-like pathological morphological characteristics(dilated venous lumen and elevated vascular density)in the retinal superficial vascular plexus at the postnatal 3 weeks,which were reversed by an SGK1 inhibitor,*** We identified a somatic GJA4 mutation that presents in over one-third of ECH lesions and proposed that ECHs are vascular malformations due to GJA4-induced activation of the SGK1 signalling pathway in brain endothelial cells.

关键词： intracranial superficial hemangioma

Multiomics and blood-based biomarkers of moyamoya disease: protocol of Moyamoya Omics Atlas (MOYAOMICS)

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中华神经外科杂志(英文) 2024年第03期

作者： Ge Peicong Yin Zihan Tao Chuming Zeng Chaofan Yu Xiaofan Lei Shixiong Li Junsheng Zhai Yuanren Ma Long he qiheng Liu Chenglong Liu Wei Zhang Bojian Zheng Zhiyao Mou Siqi Zhao Zhikang Wang Shuang Sun Wei Guo Min Zheng Shuai Zhang Jia Deng Xiaofeng Liu Xingju Ye Xun Zhang Qian Wang Rong Zhang Yan Zhang Shaosen Wang Chengjun Yang Ziwen Zhang Nijia Wu Mingxing Sun Jian Zhou Yujia Shi Zhiyong Ma Yonggang Zhou Jianpo Yu Shaochen Li Jiaxi Lu Junli Gao Faliang Wang Wenjing Chen Yanming Zhu Xingen Zhang Dong Zhao Jizong Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China China National Clinical Research Center for Neurological Diseases Beijing China Department of Neurosurgery Beijing Hospital National Center of Gerontology Beijing China Department of Radiology Beijing Tiantan Hospital Beijing China Department of Ultrasound Beijing Tiantan Hospital Capital Medical University Beijing China Department of Neurology Beijing Tiantan Hospital Beijing China Department of Neurosurgery Beijing Friendship Hospital Capital Medical University Beijing China Department of Neurosurgery Beijing Chaoyang Hospital Capital Medical University Beijing China Department of Neurosurgery Beijing Childrens Hospital Capital Medical University Beijing China Department of Neurosurgery The Affiliated Children’s Hospital Capital Institute of Pediatrics Beijing China Department of Neurosurgery Beijing Changping District Hospital Beijing China Department of Neurosurgery Dongfang Hospital Beijing University of Chinese Medicine Beijing China Department of Neurosurgery Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing China Department of NeuroInterventional Surgery Binzhou Medical University Hospital Binzhou Shandong China Department of Neurosurgery Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Neurosurgery The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China Department of Neurosurgery The First Affiliated Hospital of Xi’an Jiaotong University Shaanxi Xi’an China Department of Neurosurgery West China Hospital Sichuan University Chengdu China Department of Neurosurgery Center for Rehabilitation Medicine Zhejiang Provincial Peoples Hospital Affiliated Peoples Hospital Hangzhou Medical College Hangzhou Zhejiang China Beijing Institute of hepatology Beijing YouAn Hospital Capital Medical University Beijing China Department of Neu

Background Moyamoya disease (MMD) is a rare and complex cerebrovascular disorder characterized by the progressive narrowing of the internal carotid arteries and the formation of compensatory collateral vessels. The etiology of MMD remains enigmatic, making diagnosis and management challenging. The MOYAOMICS project was initiated to investigate the molecular underpinnings of MMD and explore potential diagnostic and therapeutic *** The MOYAOMICS project employs a multidisciplinary approach, integrating various omics technologies, including genomics, transcriptomics, proteomics, and metabolomics, to comprehensively examine the molecular signatures associated with MMD pathogenesis. Additionally, we will investigate the potential influence of gut microbiota and brain-gut peptides on MMD development, assessing their suitability as targets for therapeutic strategies and dietary interventions. Radiomics, a specialized field in medical imaging, is utilized to analyze neuroimaging data for early detection and characterization of MMD-related brain changes. Deep learning algorithms are employed to differentiate MMD from other conditions, automating the diagnostic process. We also employ single-cellomics and mass cytometry to precisely study cellular heterogeneity in peripheral blood samples from MMD *** The MOYAOMICS project represents a significant step toward comprehending MMD’s molecular underpinnings. This multidisciplinary approach has the potential to revolutionize early diagnosis, patient stratification, and the development of targeted therapies for MMD. The identification of blood-based biomarkers and the integration of multiple omics data are critical for improving the clinical management of MMD and enhancing patient outcomes for this complex disease.

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智能交通感知新范式:面向元宇宙的交通标志检测架构

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电子与信息学报 2024年第3期46卷 777-789页

作者：王俊帆陈毅高明煜何志伟董哲康缪其恒杭州电子科技大学电子信息学院杭州310018 浙江省装备电子重点实验室杭州310018 浙江大学电气工程学院杭州310027 浙江华锐捷技术有限公司杭州310051

交通标志检测对智能交通系统和智能驾驶的安全稳定运行具有重要作用。数据分布不平衡、场景单一会对模型性能造成较大影响,而建立一个完备的真实交通场景数据集需要昂贵的时间成本和人工成本。基于此,该文提出一个面向元宇宙的交通标志... 详细信息

交通标志检测对智能交通系统和智能驾驶的安全稳定运行具有重要作用。数据分布不平衡、场景单一会对模型性能造成较大影响,而建立一个完备的真实交通场景数据集需要昂贵的时间成本和人工成本。基于此,该文提出一个面向元宇宙的交通标志检测新范式以缓解现有方法对真实数据的依赖。首先,通过建立元宇宙和物理世界之间的场景映射和模型映射,实现检测算法在虚实世界之间的高效运行。元宇宙作为一个虚拟化的数字世界,能够基于物理世界完成自定义场景构建,为模型提供海量多样的虚拟场景数据。同时,该文结合知识蒸馏和均值教师模型建立模型映射,应对元宇宙和物理世界之间存在的数据差异问题。其次,为进一步提高元宇宙下的训练模型对真实驾驶环境的适应性,该文提出启发式注意力机制,通过对特征的定位和学习来提高检测模型的泛化能力。所提架构在CURE-TSD,KITTI,VKITTI数据集上进行实验验证。实验结果表明,所提面向元宇宙的交通标志检测器在物理世界具有优异的检测效果而不依赖大量真实场景,检测准确率达到89.7%,高于近年来其他检测方法。

关键词：元宇宙智能交通系统交通标志检测场景映射模型映射

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公共数据资源与企业全要素生产率——基于地方政府数据开放的准自然实验

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系统工程理论与实践 2024年第6期44卷 1815-1833页

作者：吴武清李祁恒章柳漪赵越中国人民大学商学院北京100872 新加坡管理大学会计学院新加坡178900

政府开放公共数据资源是其推动数据要素价值释放的重大战略举措.然而,开放的公共数据资源是否被社会公众所利用从而释放数据要素价值仍是一个有待检验的实证问题.为此,本文基于企业高质量发展视角,研究开放的公共数据资源与企业全要素... 详细信息

政府开放公共数据资源是其推动数据要素价值释放的重大战略举措.然而,开放的公共数据资源是否被社会公众所利用从而释放数据要素价值仍是一个有待检验的实证问题.为此,本文基于企业高质量发展视角,研究开放的公共数据资源与企业全要素生产率的关系,以反映公共数据资源作为促进企业高质量发展动力方面的价值.以2010年至2019年A股上市公司为样本,以地方政府数据开放平台上线为准自然实验,使用多期双重差分模型,本文发现,与没有位于数据开放省份的企业相比,位于数据开放省份的企业在数据开放后其全要素生产率更高,表明开放的公共数据资源具有提高企业全要素生产率的价值.该回归结果在经过平行趋势检验、安慰剂检验、替换变量衡量方法、加入滞后项等稳健性测试后仍然成立.机制检验发现,管理层对公共数据资源需求更大、数据资源处理能力更强的企业,或者外部利益相关者监督企业所需公共数据资源更多的企业,主回归效应更显著,表明企业全要素生产率的提升是由于信息处理成本的下降进而促进企业内外部利益相关者对公共数据资源的使用.进一步研究发现,开放公共数据资源降低了企业的经营费用、盈余管理和融资约束.本文丰富了公共数据资源经济后果及其作用机制的相关研究,为政府数据开放实践提供了理论支撑,同时为数据资源价值提供了可靠的因果证据.

关键词：公共数据资源全要素生产率政府数据开放数据要素高质量发展

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