Long-term functional outcomes improved with deep brain stimulation in patients with disorders of consciousness

作     者：Yi Yang Qiheng He Yuanyuan Dang Xiaoyu Xia Xin Xu Xueling Chen Jizong Zhao Jianghong He 

作者机构：Department of NeurosurgeryBeijing Tiantan HospitalCapital Medical UniversityBeijingChina Translational Medicine CenterChinese Institute for Brain ResearchBeijingChina Beijing Institute of Brain DisordersCapital Medical UniversityBeijingChina Department of NeurosurgeryPLA General HospitalBeijingChina Academician OfficeChina National Clinical Research Center for Neurological DiseasesBeijingChina 

出 版 物：《Stroke & Vascular Neurology》 (卒中与血管神经病学（英文）)

年 卷 期：2023年第8卷第5期

页      面：368-378页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：the following funding sources:the National Natural Science Foundation of China(81600919) Beijing Municipal Science and Technology Commission(Z161100000516165 and Z171100001017162) Beijing Nova Program(Z181100006218050) 

主　　题：stimulation patients admitted 

摘      要：Background Deep brain stimulation(DBS)has been preliminarily applied to treat patients with disorders of consciousness(DoCs).The study aimed to determine whether DBS was effective for treating patients with DoC and identify factors related to patients’*** Data from 365 patients with DoCs who were consecutively admitted from 15 July 2011 to 31 December 2021 were retrospectively *** regression and subgroup analysis were performed to adjust for potential *** primary outcome was improvement in consciousness at 1 *** An overall improvement in consciousness at 1 year was achieved in 32.4%(12/37)of the DBS group compared with 4.3%(14/328)of the conservative *** full adjustment,DBS significantly improved consciousness at 1 year(adjusted OR 11.90,95%CI 3.65-38.46,p0.001).There was a significant treatment×follow up interaction(H=14.99,p0.001).DBS had significantly better effects in patients with minimally conscious state(MCS)compared with patients with vegetative state/unresponsive wakefulness syndrome(p for interaction0.001).A nomogram based on age,state of consciousness,pathogeny and duration of DoCs indicated excellent predictive performance(c-index=0.882).Conclusions DBS was associated with better outcomes in patients with DoC,and the effect was likely to be significantly greater in patients with *** should be cautiously evaluated by nomogram preoperatively,and randomised controlled trials are still needed.