Enriched photosensitizer for deep-seated-tumor photodynamic therapy

作     者：HONGRUI SHAN XUEQIAN WANG QIHENG WEI HAILANG DAI XIANFENG CHEN HONGRUI SHAN;XUEQIAN WANG;QIHENG WEI;HAILANG DAI;XIANFENG CHEN

作者机构：State Key Laboratory on Fiber Optic Local Area Communication Networks and Advanced Optical Communication SystemsDepartment of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Metal Matrix CompositesShanghai Key Laboratory for Molecular Engineering of Chiral DrugsSchool of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center of Light Manipulations and ApplicationsShandong Normal UniversityJinan 250358China 

出 版 物：《Photonics Research》 (光子学研究（英文版）)

年 卷 期：2024年第12卷第5期

页      面：1024-1035页

核心收录：

学科分类：081702[工学-化学工艺] 1002[医学-临床医学] 08[工学] 0817[工学-化学工程与技术] 100214[医学-肿瘤学] 10[医学] 

基　　金：Natural Science Foundation of Shanghai Municipality(23ZR1428400) Shanghai Municipal Science and Technology Major Project(2019SHZDZX01-06) National Natural Science Foundation of China(12104298,12192252) 

主　　题：treatment utilize utilizing 

摘      要：Photodynamic therapy(PDT)is an innovative approach that utilizes photochemical reactions for non-invasive disease *** PDT is limited by the low penetration depth of visible light required for ***,we employed upconversion nanoparticles(UCNPs)to extend the activation wavelength of photosensitizers into the infrared range,enabling a treatment depth of over 10 ***,we also used the abundant amino groups of branched polyethyleneimine(PEI)with spatial structure to enhance the loading capacity of protoporphyrin(PPIX),and we ultimately improved skin tumor clearance ***,we achieved tumor-specific treatment by utilizing folic acid(FA)targeting and active enrichment of *** to cellular experimental results,we demonstrated the remarkable reactive oxygen species generation capability of the material and ultra-low dark ***,we investigated the apoptosis mechanism and demonstrated that the synthesized nanoparticle stimulates the up-regulation of apoptosis-associated proteins Bax/Bcl-2 and Cyto *** in vivo experiments involving intravenous injection in mouse tails,we investigated the anticancer efficacy of the nanoparticle,confirming its excellent PDT *** research provides a promising avenue for future non-invasive treatment of deep-seated tumors,offering a method for the treatment and management of specific cancers.