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Gynecology and Obstetrics Clinical Medicine 2021年第1期1卷 2-4页

作者： R.Marshall Austin Chengquan Zhao Department of Pathology Magee-Womens HospitalUniversity of Pittsburgh Medical Center300 Halket StreetPittsburghPA15213USA

Risk-Based Management Consensus Guidelines have been published in 2020 in the United States(US)by the American Society for Colposcopy and Clinical Pathology(ASCCP)^(1-3).These US guidelines evolved from earlier 2012 guidelines^(4)which were the first to be based on the principle of“equal management for equal risk.”This referred specifically to the risk of a patient developing invasive cervical cancer,“estimated by the surrogate end-point of the 5-year-risk of cervical intraepithelial neoplasia(CIN)grade 3(CIN3)or more severe diagnoses(CIN3+)”^(1).Still more recently released American Cancer Society(ACS)Guidelines for Cervical Cancer Screening-2020 similarly use CIN3 and CIN3+as the“best surrogate measure of incident cervical cancer risk,”given the absence of US clinical trial data sufficiently powered to evaluate cervical cancer risk^(5).We have argued that neither CIN3 nor CIN3+are equivalent and reliable surrogate end-points for invasive cervical cancer *** means that cervical screening guidelines based on these surrogate risk end-points could prove to be significantly misleading^(6).

关键词： cervical invasive utilize

How to utilize the Art of Making Teaching Contain Interest

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河南教育学院学报（哲学社会科学版） 1994年第1期13卷 100-105页

ＨｏｗｔｏＵｔｉｌｉｚｅｔｈｅＡｒｔｏｆＭａｋｉｎｇＴｅａｃｈｉｎｇＣｏｎｔａｉｎ　ＩｎｔｅｒｅｓｔＷｕＪｉｎｙｅＴｈｅｒｅｉｓｓｕｃｈａｖｅｒａｉｏｎｓｐｒｅａｄｉｎｓｉｎｆｏｒｅｉｇｎｌａｎｇｕａｓｅｔｅａｃｈｉ... 详细信息

ＨｏｗｔｏＵｔｉｌｉｚｅｔｈｅＡｒｔｏｆＭａｋｉｎｇＴｅａｃｈｉｎｇＣｏｎｔａｉｎ　ＩｎｔｅｒｅｓｔＷｕＪｉｎｙｅＴｈｅｒｅｉｓｓｕｃｈａｖｅｒａｉｏｎｓｐｒｅａｄｉｎｓｉｎｆｏｒｅｉｇｎｌａｎｇｕａｓｅｔｅａｃｈｉｎｇｔｈａｔＣｈｉｎｅｓｅｓｔｕｄ...

关键词： utilize

Nanofabricated high turn-density spiral coils for on-chip electromagneto-optical conversion

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Microsystems & Nanoengineering 2024年第2期10卷 181-192页

作者： Ilhan Bok Alireza Ashtiani Yash Gokhale Jack Phillips Tianxiang Zhu Aviad Hai Department of Biomedical Engineering University of Wisconsin–MadisonMadisonWIUSA Department of Electrical and Computer Engineering University of Wisconsin–MadisonMadisonWIUSA Wisconsin Institute for Translational Neuroengineering(WITNe) University of Wisconsin–MadisonMadisonWIUSA

Circuit-integrated electromagnets are fundamental building blocks for on-chip signal transduction,modulation,and tunability,with specific applications in environmental and biomedical micromagnetometry.A primary challenge for improving performance is pushing quality limitations while minimizing size and fabrication complexity and retaining spatial *** efforts have exploited highly involved three-dimensional synthesis,advanced insulation,and exotic material ***,we present a rapid nanofabrication process that employs electron beam dose control for high-turn-density diamond-embedded flat spiral coils;these coils achieve efficient on-chip electromagnetic-to-optical signal *** fabrication process relies on fast 12.3 s direct writing on standard poly(methyl methacrylate)as a basis for the metal lift-off *** with 70 micrometer overall diameters and 49–470 nm interturn spacings with corresponding inductances of 12.3–12.8 nH are *** utilize optical micromagnetometry to demonstrate that magnetic field generation at the center of the structure effectively correlates with finite element modeling *** designs based on our process can be integrated with photolithography to broadly enable optical magnetic sensing and spin-based computation.

关键词： utilize retaining high

New Second-Level-Discrete Zeroing Neural Network for Solving Dynamic Linear System

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1521-1523页

作者： Min Yang School of Robotics Hunan UniversityChangsha 410082China

Dear Editor,This letter deals with a new second-level-discretization method with higher precision than the traditional first-level-discretization ***,the traditional discretization method utilizes the first-order time derivative information,and it is termed first-level-discretization *** contrast,the new discretization method not only utilizes the first-order time derivative information,but also makes use of the second-order derivative *** combining the new second-level-discretization method with zeroing neural network(ZNN),the second-level-discrete ZNN(SLDZNN)model is proposed to solve dynamic(i.e.,time-variant or time-dependent)linear *** experiments and application to angle-of-arrival(AoA)localization show the effectiveness and superiority of the SLDZNN model.

关键词： method derivative utilize

Modularization of adhesion G protein-coupled receptor(aGPCR)structure:how alternative splicing regulates synaptogenesis

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1793-1795页

作者： Tobias Langenhan Rudolf Schönheimer Institute of Biochemistry Division of General BiochemistryMedical FacultyLeipzig UniversityLeipzigGermany Comprehensive Cancer Center Central Germany(CCCG) Leipzig UniversityLeipzigGermany Institute of Biology Faculty of Life SciencesLeipzig UniversityLeipzigGermany

A recent report has uncovered a fascinating aspect of how neurons utilize alternative splicing of transcripts of an adhesion G protein-coupled receptor(aGPCR)gene to serve specific functions in the life of a synapse.1 The work provides significant insight into the ability of cells to support distinct biochemical and physiological operations through post-transcriptional processing of genetic information that is encoded in a single aGPCR locus.

关键词： GPCR utilize operations

Enriched photosensitizer for deep-seated-tumor photodynamic therapy

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Photonics Research 2024年第5期12卷 1024-1035页

作者： HONGRUI SHAN XUEQIAN WANG QIHENG WEI HAILANG DAI XIANFENG CHEN State Key Laboratory on Fiber Optic Local Area Communication Networks and Advanced Optical Communication Systems Department of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Metal Matrix Composites Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsSchool of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center of Light Manipulations and Applications Shandong Normal UniversityJinan 250358China

Photodynamic therapy(PDT)is an innovative approach that utilizes photochemical reactions for non-invasive disease *** PDT is limited by the low penetration depth of visible light required for ***,we employed upconversion nanoparticles(UCNPs)to extend the activation wavelength of photosensitizers into the infrared range,enabling a treatment depth of over 10 ***,we also used the abundant amino groups of branched polyethyleneimine(PEI)with spatial structure to enhance the loading capacity of protoporphyrin(PPIX),and we ultimately improved skin tumor clearance ***,we achieved tumor-specific treatment by utilizing folic acid(FA)targeting and active enrichment of *** to cellular experimental results,we demonstrated the remarkable reactive oxygen species generation capability of the material and ultra-low dark ***,we investigated the apoptosis mechanism and demonstrated that the synthesized nanoparticle stimulates the up-regulation of apoptosis-associated proteins Bax/Bcl-2 and Cyto *** in vivo experiments involving intravenous injection in mouse tails,we investigated the anticancer efficacy of the nanoparticle,confirming its excellent PDT *** research provides a promising avenue for future non-invasive treatment of deep-seated tumors,offering a method for the treatment and management of specific cancers.

关键词： treatment utilize utilizing

A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells(TCR-T cells)against hepatocellular carcinoma

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2215-2230页

作者： Wei Zhu Zhiming Zhang Jinzhang Chen Xiaolan Chen Lei Huang Xiaoyong Zhang Xuan Huang Na Ma Weikang Xu Xuan Yi Xinyu Lu Xin Fu Siwei Li Guoheng Mo Yiyue Wang Guosheng Yuan Mengya Zang Qi Li Xiaotao Jiang Yajing He Sha Wu Yukai He Yongyin Li Jinlin Hou State Key Laboratory of Organ Failure Research Guangdong Provincial Key Laboratory of Viral Hepatitis ResearchDepartment of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhouChina Institute of Cellular Medicine Newcastle University Medical SchoolNewcastleUK Department of Pathology The First People’s Hospital of FoshanFoshanChina Dermatology Hospital Southern Medical UniversityGuangzhouChina Department of Immunology School of Basic Medical SciencesSouthern Medical UniversityGuangzhouChina Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhouChina Key Laboratory of Proteomics of Guangdong Province Demonstration Center for Experimental Education of Basic Medical Sciences of ChinaGuangzhouChina Medical College of Georgia Augusta University112015th StreetAugustaGAUSA

Strategies to improve T cell therapy efficacy in solid tumors such as hepatocellular carcinoma(HCC)are urgently *** common cytokine receptorγchain(γc)family cytokines such as IL-2,IL-7,IL-15 and IL-21 play fundamental roles in T cell development,differentiation and effector *** study aims to determine the combination effects of IL-21 in T cell therapy against HCC and investigate optimized strategies to utilize the effect of IL-21 signal in T cell *** antitumor function of AFP-specific T cell receptor-engineered T cells(TCR-T)was augmented by exogenous IL-21 in vitro and in ***-21 enhanced proliferation capacity,promoted memory differentiation,downregulated PD-1 expression and alleviated apoptosis in TCR-T after activation.A novel engineered IL-21 receptor was established,and TCR-T armed with the novel engineered IL-21 receptors(IL-21R-TCR-T)showed upregulated phosphorylated STAT3 expression without exogenous IL-21 ***-21R-TCR-T showed better proliferation upon activation and superior antitumor function in vitro and in ***-21R-TCR-T exhibited a less differentiated,exhausted and apoptotic phenotype than conventional TCR-T upon repetitive tumor antigen *** novel IL-21 receptor in our study programs powerful TCR-T and can avoid side effects induced by IL-21 systemic *** novel IL-21 receptor creates new opportunities for next-generation TCR-T against HCC.

关键词： hepatocellular TCR utilize

Universal Machine Learning Kohn–Sham Hamiltonian for Materials

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Chinese Physics Letters 2024年第7期41卷 95-110页

作者：钟阳于宏宇杨吉辉郭星宇向红军龚新高 Key Laboratory of Computational Physical Sciences(Ministry of Education) Institute of Computational Physical SciencesState Key Laboratory of Surface Physicsand Department of PhysicsFudan UniversityShanghai 200433China Shanghai Qi Zhi Institute Shanghai 200030China

While density functional theory(DFT)serves as a prevalent computational approach in electronic structure calculations,its computational demands and scalability limitations ***,leveraging neural networks to parameterize the Kohn-Sham DFT Hamiltonian has emerged as a promising avenue for accelerating electronic structure *** advancements,challenges such as the necessity for computing extensive DFT training data to explore each new system and the complexity of establishing accurate machine learning models for multi-elemental materials still *** these hurdles,this study introduces a universal electronic Hamiltonian model trained on Hamiltonian matrices obtained from first-principles DFT calculations of nearly all crystal structures on the Materials *** demonstrate its generality in predicting electronic structures across the whole periodic table,including complex multi-elemental systems,solid-state electrolytes,Moir´e twisted bilayer heterostructure,and metal-organic ***,we utilize the universal model to conduct high-throughput calculations of electronic structures for crystals in GNoME datasets,identifying 3940 crystals with direct band gaps and 5109 crystals with flat *** offering a reliable efficient framework for computing electronic properties,this universal Hamiltonian model lays the groundwork for advancements in diverse fields,such as easily providing a huge data set of electronic structures and also making the materials design across the whole periodic table possible.

关键词： Hamiltonian utilize twisted

Editorial for Special Issue on Multi-modal Representation Learning

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Machine Intelligence Research 2024年第4期21卷 615-616页

作者： Deng-Ping Fan Nick Barnes Ming-Ming Cheng Luc Van Gool Nankai University China&ETH ZürichSwitzerland Australian National University Australia Nankai University China ETH Zürich Switzerland

The past decade has witnessed the impressive and steady development of single-modal AI technologies in several fields,thanks to the emergence of deep *** studied,however,is multi-modal AI-commonly considered the next generation of AI-which utilizes complementary context concealed in different-modality inputs to improve *** naturally learn to form a global concept from multiple modalities(i.e.,sight,hearing,touch,smell,and taste),even when some are incomplete or ***,in addition to the two popular modalities(vision and language),other types of data such as depth,infrared information,and events are also important for multi-modal learning in real-world scenes.

关键词： modal utilize incomplete

Toward quantum unmanned systems

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Science China(Technological Sciences) 2024年第7期67卷 2277-2280页

作者： CHENG ShuMing QI HongSheng SUN Yue LIU LiJun XIE ShaoRong REN XiaoQiang Department of Control Science and Engineering Tongji UniversityShanghai 200092China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China Cipher Cloud Core Ltd. Beijing 100085China College of Mathematics and Computer Science Shanxi Normal UniversityLinfen 041081China School of Computer Engineering and Science Shanghai UniversityShanghai 200444China School of Mechatronic Engineering and Automation Shanghai UniversityShanghai 200444China

1 Quantum information technology Quantum information technology utilizes physical systems at the microscopic level, such as photon, atom, ion, and superconducting, to accomplish information-processing tasks that are impossible for the classical macroscopic world. During the past decade, significant process has been achieved in the pursuit of quantum technology into practical applications,generating great research interest from various domains, with the potential to radically change our information infrastructure [1–3].

关键词： quantum utilize generating

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