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Direct detection and measurement of wall shear stress using a filamentous bio-nanoparticle

Nano Research 2015年第10期8卷 3307-3315页

作者： Daniela P. Lobo Alan M. Wemyss David J. Smith Anne Straube Kai b. betteridge Andrew H. J. Salmon Rebecca R. Foster Hesham E. Elhegni Simon C. Satchell haydn A. Little Raul Pacheco-Gomez Mark J. Simmons Matthew R. Hicks David O. bates Alison Rodger Timothy R. Dafforn Kenton P. Arkill DepartmentofChemistryandWarwickAnalyticalScienceCentre UniversityofWarwickCoventryCV47ALUK MOACDoctoralTrainingCentre UniversityofWarwickCoventryCV47ALUK Mathematics UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK CentreforMechanochemicalCellbiology WarwickMedicalSchoolUniversityofWarwickCoventryCV47ALUK PhysiologyandPharmacology UniversityofBristolUniversityWalkBristolBS81TDUK ClinicalSciences WhitsonStreetUniversityofBristolBristolBS13NYUK SchoolofChemistry UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK biosciences UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK ChemicalEngineering UniversityofBirminghamEdgbastonBirminghamWestMidlandsB152TTUK SchoolofMedicine UniversityofNottinghamQueen'sMedicalCentreNottinghamNG27UHUK biochemistry UniversityofBristolUniversityWalkBristolBS81TDUK

The wall shear stress （WSS） that a moving fluid exerts on a surface affects many processes including those relating to vascular function. WSS plays an important role in normal physiology （e.g. angiogenesis） and affects the microvasculature＇s primary function of molecular transport. Points of fluctuating WSS show abnormalities in a number of diseases; however, there is no established technique for measuring WSS directly in physiological systems. All current methods rely on estimates obtained from measured velocity gradients in bulk flow data. In this work, we report a nanosensor that can directly measure WSS in microfluidic chambers with sub-micron spatial resolution by using a specific type of virus, the bacteriophage M13, which has been fluorescently labeled and anchored to a surface. It is demonstrated that the nanosensor can be calibrated and adapted for biological tissue, revealing WSS in micro-domains of cells that cannot be calculated accurately from bulk flow measurements. This method lends itself to a platform applicable to many applications in biology and microfluidics.

关键词： microfluidics nanoparticle M13 bacteriophage wall shear stress fluorescent microscopy

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A solution scan of societal options to reduce transmission and spread of respiratory viruses:SARS-CoV-2 as a case study

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Journal of biosafety and biosecurity 2021年第2期3卷 84-90页

作者： William J.Sutherland Nigel G.Taylor David C.Aldridge Philip Martin Catherine Rhodes Gorm Shackelford Simon beard haydn b.lfield Andrew J.bladon Cameron brick Alec P.Christie Andrew P.Dobson Harriet Downey Amelia S.C.Hood Fangyuan Hua Alice C.Hughes Rebecca M.Jarvis Douglas MacFarlane William H.Morgan Anne-ChristineMupepele Stefan J.Marciniak Cassidy Nelson SeánÓhÉigeartaigh Clarissa Rios Rojas Katherine A.Sainsbury Rebecca K.Smith Lalitha S.Sundaram Ann Thornton John Watkins Thomas b.White Kate Willott Silviu O.Petrovan bioRISC(biosecurity Research Initiative at St Catharine’s) St Catharine’s CollegeCambridge CB21RLUK Department of Zoology University of CambridgeThe David Attenborough BuildingPembroke StreetCambridge CB23QZUK Tour du Valat Research Institute for the Conservation of Mediterranean Wetlands13200 ArlesFrance Centre for the Study of Existential Risk University of CambridgeCB21SBUK Department of Social Psychology University of AmsterdamNieuwe Achtergracht 129 B1018 WT AmsterdamNetherlands Department of Ecology and Evolutionary biology 117 Eno HallPrinceton UniversityNJ 08544USA Institute of Ecology College of Urban and Environmental SciencesPeking UniversityBeijing 100871PR China Centre for Integrative Conservation Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesXishuangbannaYunnan 666303PR China Te Kura Putaiao-School of Science Auckland University of TechnologyAucklandNew Zealand School of Psychological Sciences University of Western AustraliaPerth35 Stirling HwyCrawley WA 6009Australia Nature Conservation and Landscape Ecology Biometry and Environmental System AnalysisUniversity of FreiburgGermany Cambridge Institute for Medical Research University of CambridgeCambridge Biomedical CampusThe Keith Peters BuildingHills RoadCambridge CB20XYUK Future of Humanity Institute University of OxfordOxford OX11PTUK Faculty of Kinesiology Sportand RecreationUniversity of Alberta2-130V Van Vliet 21 Complex(University Hall)EdmontonAlberta T6G 2H9Canada Division of Population Medicine School of MedicineCardiff UniversityCardiff CF144YSUK

Societal biosecurity–measures built into everyday society to minimize risks from pests and diseases–is an important aspect of managing epidemics and *** aimed to identify societal options for reducing the transmission and spread of respiratory *** used SARS-CoV-2(severe acute respiratory syndrome coronavirus 2)as a case study to meet the immediate need to manage the COVID-19 pandemic and eventually transition to more normal societal conditions,and to catalog options for managing similar pandemics in the *** used a‘solution scanning’*** read the literature;consulted psychology,public health,medical,and solution scanning experts;crowd-sourced options using social media;and collated comments on a ***,we present a list of 519 possible measures to reduce SARS-CoV-2 transmission and *** provide a long list of options for policymakers and businesses to consider when designing biosecurity plans to combat SARS-CoV-2 and similar pathogens in the *** also developed an online application to help with this *** encourage testing of actions,documentation of outcomes,revisions to the current list,and the addition of further options.

关键词： biosecurity Coronavirus COVID-19 Disease control New normal Public health

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