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Hepatic steatosis prevents heme oxygenase-1 induction by isoflurane in the rat liver

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World Journal of Gastroenterology 2011年第37期17卷 4184-4190页

作者： Patrick Stoll Christian I Schwer Ulrich Goebel hartmut Buerkle Alexander Hoetzel Rene Schmidt Department of Anesthesiology and Critical Care Medicine Freiburg University Medical Center

AIM:To characterize the inductive effects of isoflurane(ISO) on hepatic heme oxygenase-1(HO-1) in an animal model of hepatic ***:Lean(LEAN) and obese(FAT) Zucker rats were randomized into 4 groups:1:LEAN + pentobarbital sodium(PEN);2:LEAN + ISO;3:FAT + PEN;4:FAT + *** animals were mechanically ventilated for 6 *** vitro analyses of liver tissue included determination of HO-1 mRNA and protein expression as well as measurement of HO enzyme activity and immunohistochemical ***:Compared to PEN treatment,ISO administration profoundly induced hepatic HO-1 mRNA and protein expression and significantly increased HO enzyme activity in lean Zucker *** contrast,no difference in HO-1 gene expression was observed after ISO or PEN anesthesia in obese Zucker ***:The present study demonstrates that ISO is an inducer of hepatic HO-1 gene expression in non-steatotic organs but failed to upregulate HO-1 in steatotic livers.

关键词： Isoflurane Heme oxygenase Hepatic steatosis Heme oxygenase-1 Volatile anesthetics

Single-operator cholangioscopy for biliary complications in liver transplant recipients

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World Journal of Gastroenterology 2017年第22期23卷 4064-4071页

作者： Anna Hüsing-Kabar Hauke Sebastian Heinzow hartmut Hans-Jürgen Schmidt Carina Stenger Hans Ulrich Gerth Michele Pohlen Gerold Tholking Christian Wilms Iyad Kabar Department of Transplant Medicine University Hospital Muenster Department of Medicine D Division of General Internal MedicineNephrology and RheumatologyUniversity Hospital Muenster Department of Medicine A Hematology and OncologyUniversity Hospital Muenster

To evaluate cholangioscopy in addition to endoscopic retrograde cholangiopancreatography (ERCP) for management of biliary complications after liver transplantation (LT).METHODSTwenty-six LT recipients with duct-to-duct biliary reconstruction who underwent ERCP for suspected biliary complications between April and December 2016 at the university hospital of Muenster were consecutively enrolled in this observational study. After evaluating bile ducts using fluoroscopy, cholangioscopy using a modern digital single-operator cholangioscopy system (SpyGlass DS™) was performed during the same procedure with patients under conscious sedation. All patients received peri-interventional antibiotic prophylaxis and bile was collected during the intervention for microbial analysis and for antibiotic susceptibility ***-three biliary complications were found in a total of 22 patients, whereas four patients showed normal bile ducts. Anastomotic strictures were evident in 14 (53.8%) patients, non-anastomotic strictures in seven (26.9%), biliary cast in three (11.5%), and stones in six (23.1%). A benefit of cholangioscopy was seen in 12 (46.2%) patients. In four of them, cholangioscopy was crucial for selective guidewire placement prior to planned intervention. In six patients, biliary cast and/or stones failed to be diagnosed by ERCP and were only detectable through cholangioscopy. In one case, a bile duct ulcer due to fungal infection was diagnosed by cholangioscopy. In another case, signs of bile duct inflammation caused by acute cholangitis were evident. One patient developed post-interventional cholangitis. No further procedure-related complications occurred. Thirty-seven isolates were found in bile. Sixteen of these were gram-positive (43.2%), 12 (32.4%) were gram-negative bacteria, and Candida species accounted for 24.3% of all isolated microorganisms. Interestingly, only 48.6% of specimens were sensitive to prophylactic ***-operator c

关键词： Cholangioscopy Endoscopic retrograde cholangiopancreatography Liver transplantation Biliary complications Biliary strictures

Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice

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Liver Research 2021年第2期5卷 79-87页

作者： Hua Sun Hong-Min Ni Jennifer M.McCracken Jephte Y Akakpo Sam Fulte Tara McKeen hartmut Jaeschke Hua Wang Wen-Xing Ding Department of Pharmacology Toxicology and TherapeuticsThe University of Kansas Medical CenterKansas CityKSUSA Department of Oncology The First Affiliated Hospital of Anhui Medical UniversityHefeiChina

Background:Acetaminophen(APAP)overdose can cause liver injury and liver failure,which is one of the most common causes of drug-induced liver injury in the United *** activation of autophagy by inhibiting mechanistic target of rapamycin(mTOR)protects against APAP-induced liver injury likely via autophagic removal of APAP-adducts and damaged *** the present study,we aimed to investigate the role of genetic ablation of mTOR pathways in mouse liver in APAP-induced liver injury and liver repair/***:Albumin-Cre(Alb-Cre)mice,mTOR^(f/f) and Raptor^(f/f) mice(C57BL/6J background)were crossbred to produce liver-specific mTOR knockout(L-mTOR KO,Alb Cret/-,mTOR^(f/f))and liver-specific Raptor KO(L-Raptor,Alb Cret/-,Raptor^(f/f))***-Cre littermates were used as wild-type(WT)*** mice were treated with APAP for various time points for up to 48 *** injury,cell proliferation,autophagy and mTOR activation were ***:We found that genetic deletion of neither Raptor,an important adaptor protein in mTOR complex 1,nor mTOR,in the mouse liver significantly protected against APAP-induced liver injury despite increased hepatic autophagic *** deletion of Raptor or mTOR in mouse livers did not affect APAP metabolism and APAP-induced c-Jun N-terminal kinase(JNK)activation,but slightly improved mouse survival likely due to increased hepatocyte ***:Our results indicate that genetic ablation of mTOR in mouse livers does not protect against APAP-induced liver injury but may slightly improve liver regeneration and mouse survival after APAP overdose.

关键词： Acetaminophen(APAP) Autophagy Hepatotoxicity Liver injury Liver regeneration Mechanistic target of rapamycin(mTOR) Regulatory associated protein of mTOR complex(Raptor)

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防水鞋面革和防水变色革的水性涂饰

中国皮革 2009年第15期38卷 4-6,10页

作者： hartmut Huber 刘鹏杰(译) 科莱恩产品有限责任公司德国不详

详细介绍了防水鞋面革和防水变色革的涂饰方法,包括坯革的准备、粘合层、底涂、顶涂过程中产品的选择和过程参数的确定,以及涂饰过程中的注意事项。

关键词：防水革鞋面革变色革涂饰

Automaton Model with Variable Cell Size for the Simulation of Pedestrian Flow

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Automaton Model with Variable Cell Size for the Simulation o...

The Seventh International Conference on Information and Management Sciences

作者： Günter Brwolff hartmut Schwandt Technische Universitt Berlin Fakultt ⅡInstitut für Mathematik Sekr.MA 6-4Strabe des 17.Juni 13510623 BerlinGermany

＜正＞The simulation of pedestrian flow is an important issue in many modem traffic systems and *** planning and control of pedestrian flow is crucial for large buildings,shopping malls,airports,railway stations,cruise ships and ferries,manifestation places,sport stadiums etc., in order that optimal traffic throughput for daily usage can already be guaranteed at the time of *** evacuation scenarios can be considered in this context. Common simulation approaches are either discrete or contin- *** continuous models,which rely on mathematical models originally developed for fluids and gases,are better suited for the modelling of somehow global phenomena, individual aspects are given more consideration in the discrete *** discrete models for pedestrian flow are based on cellular automata,however,traditional cellular automaton models work with a fixed cell *** at any given time,the states of the cells are always well-defined by the automaton’s transition rules,the current simulation object positioned in a grid cell can be considered as the cell state *** view of the original definition of the cellular automaton,we can understand the cell size as the minimal two-dimensional space the simulation objects（***- ans）reserve for themselves *** the current paper, we present a two-dimensional automaton model to simulate pedestrian flow in which the cell size can be dynamically modified in a virtual *** can be easily observed in real world scenarios that the aforesaid minimal but exclusive space a pedestrian takes may be"elastic"（variable）,espe- cially when pedestrian density and the discrepancy of the flow-in and flow-out rates of the system are given sufficient ***,this virtual flexibility of the cell size is favourable and necessary in the simulation of pedestrian flow where the minimal space required by a pedestrian is not confined to be *** virtual cell size in our model

关键词： cellular automaton pedestrian flow simulation variable cell size

The Tree Structure for Time-of-flight Dataset Representation

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The Tree Structure for Time-of-flight Dataset Representation

The Ninth International Conference on Information and Management Sciences

作者： Matthias Plaue Gnter Brwolff hartmut Schwandt Institut fr Mathematik Technische Universitt BerlinGermanya

＜正＞In the current paper,we present a tree-like structure for the object representation in time-of-flight（TOF） datasets which enables an efficient computation of the object contour *** generated contour lines can be further processed in object detection and recognition for the TOF *** illustrate this idea in the application of a monitoring system using the TOF ranging *** addition,we also present a fast algorithm of visualizing the object contour lines as unstructured（that ***）pixels.

关键词： tree time-of-flight contour line object detection/recognition

Cubic Lipid Phase Crystallization of Membrane Proteins

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Cubic Lipid Phase Crystallization of Membrane Proteins

10～(th) International Conference on the Crystallization of Biological Macromlecules

作者： hartmut Luecke Lutz Vogeley John Spudich University of California IrvineCA92697-3900USA University of California IrvineCA92697-3900USA University of California IrvineCA92697-3900USA

＜正＞ Cubic Lipid Phase （CLP）: The CLP method for membrane protein crystallization has been refined to allow large-scale screening of various membrane proteins. The various parameters （CLP lipid, water content, bilayer lipid additive, pH, ionic strength, precipitating agent etc.） can be varied. Three distinct seven-transmembrane proteins where crystallized and their structures *** （BR）: High-resolution maps from X-ray diffraction of bacteriorhodopsin crystal obtained in CLP and some of its photointermediates have yielded insights to how the isomerization of the bound retinal drives ion transport.

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Nanoscopic Tip Sensors Fabricated by Gas Phase Etching of Optical Glass Fibers

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Photonic Sensors 2012年第4期2卷 331-339页

作者： Jorg BIERLICH Jens KOBELKE David BRAND Konstantin KIRSCH Jan DELLITH hartmut BARTELT IPHT Institute of Photonic Technology Albert-Einstein-Sir. 9 07745 Jena Germany EAH University of Applied Sciences Carl-Zeiss-Promenade 2 07745 Jena Germany

Silica-based fiber tips are used in a variety of spectroscopic, micro- or nano-scopic optical sensor applications and photonic micro-devices. The miniaturization of optical sensor systems and the technical implementation using optical fibers can provide new sensor designs with improved properties and functionality for new applications. The selective-etching of specifically doped silica fibers is a promising method in order to form complex photonic micro structures at the end or within fibers such as tips and cavities in various shapes useful for the all-fiber sensor and imaging applications. In the present study, we investigated the preparation of geometrically predefined, nanoscaled fiber tips by taking advantage of the dopant concentration profiles of highly doped step-index fibers. For this purpose, a gas phase etching process using hydrofluoric acid （HF） vapor was applied. The shaping of the fiber tips was based on very different etching rates as a result of the doping characteristics of specific optical fibers. Technological studies on the influence of the etching gas atmosphere on the temporal tip shaping and the final geometry were performed using undoped and doped silica fibers. The influence of the doping characteristics was investigated in phosphorus-, germanium-, fluorine- and boron-doped glass fibers. Narrow exposed as well as protected internal fiber tips in various shapes and tip radiuses down to less than 15 nm were achieved and characterized geometrically and topologically. For investigations into surface plasmon resonance effects, the fiber tips were coated with nanometer-sized silver layers by means of vapour deposition and finally subjected to an annealing treatment.

关键词： Optical fiber tips nanoprobes gas phase etching doping tip shaping metal coating

Generation and use of human 3D-C AD models

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Generation and use of human 3D-C AD models

实验力学国际会议

作者： Juergen Grotepass hartmut Speyer Ralf Kaiser Engineering Solutions Tecmath AG Sauerwiesen 2 67661 Kaiserslautern Germany Engineering Solutions Tecmath AG Sauerwiesen 2 67661 Kaiserslautern Germany Engineering Solutions Tecmath AG Sauerwiesen 2 67661 Kaiserslautern Germany

＜正＞ Individualized Products are one of the ten mega trends of the 21 st Century with human modeling as the key issue for tomorrow’s design and product development. The use of human modeling software for computer based ergonomic simulations within the production process increases quality while reducing costs by 30-50% and shortening production time. This presentation focuses on the use of human 3D-CAD models for both, the ergonomic design of working environments （i.e. cockpits, vehicles） and made to measure garment ***, the entire production chain can be designed, individualized models generated and analyzed in 3D computer environments. Anthropometric design for ergonomics is matched to human needs, thus preserving health. Ergonomic simulation includes topics as human vision, reachability, kinematics, force and comfort analysis and international design *** Germany more than 17 Billions of Mark are moved to other industries, because clothes do not fit. Individual clothing tailored to the customer’s preference means surplus value, pleasure and perfect *** body scanning technology is the key to generation and use of human 3D-CAD models for both, the ergonomic design of working environments （i.e. cockpits, vehicles） and made to measure garment production.

关键词： 3D-Bodyscanning population specific human anthropometric models individual production made to measure garments RAMSIS