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肺动脉高压患者骨形态发生蛋白受体2突变

中华高血压杂志 2016年第3期24卷 299-299页

作者： Van Der Bruggen CE happé cm Dorfmüller P Trip P Spruijt OA Rol N Hoevenaars F Houweling AC Girerd B Marcus JT Mercier O Humbert M Handoko ML Van Der Velden J Vonk Noordegraaf A Bogaard HJ Goumans MJ de Man FS 刘莉叶鹏

骨形态发生蛋白受体2（bone morphogenetic protein receptor 2,BMPR2）基因突变对肺动脉高压（pulmonary arterial hypertension,PAH）患者右心室压力负荷的影响尚未知。研究人员通过体内功能检查联合右、左心室分子与组织学分析,对伴... 详细信息

骨形态发生蛋白受体2（bone morphogenetic protein receptor 2,BMPR2）基因突变对肺动脉高压（pulmonary arterial hypertension,PAH）患者右心室压力负荷的影响尚未知。研究人员通过体内功能检查联合右、左心室分子与组织学分析,对伴或不伴BMPR2突变的PAH患者的右心室功能进行评估。方法与结果：纳入原发性或家族性PAH患者95例进行基因筛选,结果示28例患者存在BMPR2突变,67例无突变。应用右心导管术和心脏核磁共振检测。

关键词：骨形态发生蛋白受体基因突变肺动脉高压患者 hypertension 受体2 receptor arterial

Direct synthesis of per(poly)fluoroalkylmethyl-substituted electrophilic cyclopropane derivatives

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Chinese Journal of Chemistry 1995年第4期13卷 368-379页

作者： CHEN, J HU, cm CHINESE ACAD SCI SHANGHAI INST ORGAN CHEMSHANGHAI 200032PEOPLES R CHINA

A convenient and direct per(poly)fluoroalkylmethyl-introducing cyclopropanation reaction was described. In the presence of CrCl3/Fe, per(poly)fluoroalkyl iodides reacted with diethyl allylmalonate and its analogs to give per(poly)fluoroalkylmethyl-substituted electrophilic cyclopropane derivatives in high yields. This reaction was considered to proceed by two steps: radical addition followed by cyclopropanation.

关键词： FLUOROALKYL IODIDE DIETHYL ALLYLMALONATE CRCL3/FE REDOX SYSTEM ADDITION CYCLOPROPANATION

Addition of polyfluoropolyhaloethanes to alkenes

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Chinese Journal of Chemistry 1995年第3期13卷 273-279页

作者： CHEN, J HU, cm CHINESE ACAD SCI SHANGHAI INST ORGAN CHEMSHANGHAI 200032PEOPLES R CHINA

In the presence of CrCl3/Fe redox system, polyfluoropolyhaloethanes readily added to electron-deficient or electron-rich alkenes, giving the corresponding 1:1 hydropolyfluoroalkylation product or 1:1 adduct in high yields. This reaction provided a simple and convenient method to synthesize building blocks containing a CF3 or CF2 moiety.

关键词： CRCL3/FE REDOX SYSTEM POLYFLUOROPOLYHALOETHANE ALKENE ADDITION ADDUCT

Heme oxygenase-1 system and gastrointestinal tumors

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World Journal of Gastroenterology 2010年第21期16卷 2633-2637页

作者： Marie cm Lin Hsiangfu Kung The Brain Tumor Center and Neurosurgery Division Prince of Wales HospitalThe Chinese University of Hong Kong Li Ka Shing Institute of Medical Sciences the Chinese University of Hong Kong

Heme oxygenase-1(HO-1) system catabolizes heme into three products:carbon monoxide,biliverdin/bilirubin and free *** is involved in many physiological and pathophysiological processes.A great deal of data has demonstrated the roles of HO-1 in the formation,growth and metastasis of *** interest in this system by investigators involved in gastrointestinal tumors is fairly recent,and few papers on HO-1 have touched upon this *** review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal tumors studied to *** implications for possible therapeutic manipulation of HO-1 in gastrointestinal tumors are also discussed.

关键词： Heme oxygenase-1 Gastrointestinal tumors

DICE:An Effective Query Result Cache for Distributed Storage Systems

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Journal of Computer Science & Technology 2010年第5期25卷 933-944页

作者： Jun-Ki Min Member, A cm Mi-Young Lee School of Computer Science and Engineering Korea University of Technology and Education Byeongcheon-myeon Cheonan Chungnam 330-708 Korea Cloud Computing Research Department Electronics and Telecommunications Research Institute (ETRI) Daejeon 305-700 Korea

Due to the proliferation of Internet and Intranet,the distributed storage systems have received a lot of attention. These systems span a large number of machines and store huge amount of data for a lot of *** the distributed storage systems,a row can be directly accessed using a row *** concentrate on a problem of efficient processing of queries whose predicate is on a column but not a row *** this paper,we present a cache management technique,called DICE which maintains query results of range queries to support the next range *** accelerate the search time of the cached query results,we use modified Interval Ski *** addition,we devise a novel cache replacement policy since DICE maintains an interval rather than a data *** our cache replacement policy considers the properties of intervals,our proposed technique is more efficient than traditional buffer replacement *** experimental result demonstrates the efficiency of our proposed technique.

关键词： distributed system range query query caching Interval Skip List cache replacement

On bi-symmetric algebras

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Chinese Science Bulletin 1997年第21期42卷 1774-1778页

作者： Bai, cm Meng, DJ Nankai Univ Dept Math Tianjin 300071 Peoples R China

LEFT-symmetric algebra is a new kind of algebra system obtained from the studying of Lie al-gebra, Lie group and differential geometry. It is very useful for many topics in geometry andalgebra. In this note, we discus... 详细信息

关键词： bi-symmetric algebra anti-isomorphism transitive bi-symmetric algebra

SYNTHESIS OF 3-PER(POLY)FLUOROALKYLPYRAZOLES

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Chinese Chemical Letters 1995年第4期6卷 281-284页

作者： Tang, XQ Hu, cm Chinese Acad Sci Shanghai Inst Organ Chem Shanghai 200032 Peoples R China

The reaction of the adducts of per(poly)fluoroalkyl iodides and vinyl acetate with hydrazine monohydrate to give the corresponding 3-per(poly)fluoroalkylpyrazoles in excellent yields is described. The reaction might g... 详细信息

关键词： V

Synthesis of Pyridylazo-substituted Chromogenic Calix[4]arenes

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Chinese Chemical Letters 2001年第11期12卷 959-960页

作者： Jin, cm Lu, GY You, XZ Nanjing Univ State Key Lab Coordinat Chem Dept Chem Nanjing 210093 Peoples R China

This letter reports a novel method for preparing chromogenic calix[4]arenes, in which the 4-aminopyridine was diazotized with isoamyl nitrite in EtONa/EtOH, and mono(azo)-, bis(azo)- and tetra(azo)-substituted calix[4]arenes were obtained as main product respectively by diazo-coupling in different molar ratio to calix[4]arene in non-aqueous solution at 0-5 degrees.

关键词： chromogenic calixarene diazo-coupling isoamyl nitrite aminopyridine

The innate immune system in Parkinson's disease:a novel target promoting endogenous neuroregeneration

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Neural Regeneration Research 2015年第5期10卷 704-706页

作者： Johannes cm Schlachetzki Jürgen Winkler Department of Molecular Neurology Friedrich-AlexanderUniversity (FAU) Erlangen-Nürnberg University Hospital Erlangen

Parkinson＇s disease （PD） is a slowly progressing neuro- degenerative disorder clinically defined by key symptoms like bradykinesia, rigidity, resting tremor, and postural instability. Reduction of dopaminergic terminals in the caudate nucleus and putamen, i.e., the striatum, accom- panied by decreased striatal levels of dopamine, and most likely consecutive degeneration of dopaminergic neurons in the substantia nigra pars compacta （SNpc） are tightly linked to the onset of the motor symptoms. With the etiology of PD largely not yet well defined, there is accu- mulating evidence for increased immune activation in PD. The majority of studies favor a detrimental effect of microglia, the resident innate immune cells of the brain, on PD pathogenesis. In the presence of alpha-synuclein, inflammatory responses elicited by microglia may be initiated by pattern recognition receptors, e.g.,

关键词： SVZ GFAP PD