The innate immune system in Parkinson's disease:a novel target promoting endogenous neuroregeneration

作     者：Johannes CM Schlachetzki Jürgen Winkler 

作者机构：Department of Molecular NeurologyFriedrich-AlexanderUniversity (FAU) Erlangen-NürnbergUniversity Hospital Erlangen 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2015年第10卷第5期

页      面：704-706页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the ELAN-Fonds(program No.10.08.18.1) the Interdisciplinary Center for Clinical Research(IZKF E9 and N3)of the Medical Faculty,FAU Erlangen-Nürnberg 

主　　题：SVZ GFAP PD 

摘      要：Parkinson＇s disease （PD） is a slowly progressing neuro- degenerative disorder clinically defined by key symptoms like bradykinesia, rigidity, resting tremor, and postural instability. Reduction of dopaminergic terminals in the caudate nucleus and putamen, i.e., the striatum, accom- panied by decreased striatal levels of dopamine, and most likely consecutive degeneration of dopaminergic neurons in the substantia nigra pars compacta （SNpc） are tightly linked to the onset of the motor symptoms. With the etiology of PD largely not yet well defined, there is accu- mulating evidence for increased immune activation in PD. The majority of studies favor a detrimental effect of microglia, the resident innate immune cells of the brain, on PD pathogenesis. In the presence of alpha-synuclein, inflammatory responses elicited by microglia may be initiated by pattern recognition receptors, e.g.,