检索结果-南通市图书馆

Microfluidic chips for the endothelial biomechanics and mechanobiology of the vascular system

BIOCELL 2021年第4期45卷 797-811页

作者： haoran su KEXIN LI XIAO LIU JING DU LI WANG XIAOYAN DENG YUBO FAN Beijing Advanced Innovation Centre for Biomedical Engineering Key Laboratory for Biomechanics and Mechanobiology of Chinese Education MinistrySchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina100083 School of Engineering Medicine Beihang UniversityBeijingChina100083 Artificial Intelligence Key Laboratory of Sichuan Province School of Automation and Information EngineeringSichuan University of Science and EngineeringZigongChina643000 Beijing Research Center of Urban System Engineering BeijingChina

Endothelial cells arranged on the vessel lumen are constantly stimulated by blood flow,blood pressure and pressureinduced cyclic *** stimuli are sensed through mechanical sensory structures and converted into a series of functional responses through mechanotransduction *** process will eventually affect vascular ***,there has been an urgent need to establish in vitro endothelial biomechanics and mechanobiology of models,which reproduce three-dimensional structure vascular *** recent years,the rapid development in microfluidic technology makes it possible to replicate the key structural and functionally biomechanical characteristics of ***,we summarized the progress of microfluidic chips used for the investigation of endothelial biomechanics and mechanobiology of the vascular ***,we elucidated the contribution of shear stress and circumferential stress,to vascular ***,we reviewed some applications using microfluidic technology in angiogenesis and vasculogenesis,endothelial permeability and mechanotransduction,as well as the blood-brain barrier under these physical ***,we discussed the future obstacles in terms of the development and application of microfluidic vascular chips.

关键词： Endothelial cells Vascular system Mechanotransduction Microfluidic chip

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The role of hemoglobin in nitric oxide transport in vascular system

引用

Medicine in Novel Technology and Devices 2020年第1期5卷 1-6页

作者： haoran su Xiao Liu Jing Du Xiaoyan Deng Yubo Fan Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education Institute of Nanotechnology for Single Cell AnalysisBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China

Nitric oxide(NO)plays a pivotal role in vascular homeostasis and its functions practice in a dose-dependent manner in which too high and too low NO concentration may both induce the development of cardiovascular diseases,which indicates the balance between NO formation and scavenging is *** presented over the last two decades has indicated hemoglobin(Hb)can affect NO dynamic *** role of Hb was once thought to play in NO signaling as inhibiting NO transport,but now several mechanisms have found that Hb may preserve and even regulate NO *** the tremendous amount of work devoted to this field,major questions concerning precise mechanisms of NO activity preservation as well as if and how Hb creates NO activity remain *** this review,we discuss the role of hemoglobin in NO formation,transport and *** also discuss how these mechanisms of the imbalance between NO and hemoglobin induce related diseases,which may serve as the basis for novel therapeutics.

关键词： Hemoglobin Nitric oxide Transport Balance Diseases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

我国居民财产性收入比重的合理性测度研究

引用

当代经济科学 2019年第2期41卷 66-76页

作者：苏浩然中央财经大学统计与数学学院北京100081

本文选取中国1992—2015年小口径的财产性收入数据和社会经济指标,建立财产性收入分配体系,界定财产性收入比重合理性的内涵和外延,依据外延对财产性收入比重合理性进行测度。结果显示:从财产性收入分配起点和分配过程视角,现阶段中国... 详细信息

本文选取中国1992—2015年小口径的财产性收入数据和社会经济指标,建立财产性收入分配体系,界定财产性收入比重合理性的内涵和外延,依据外延对财产性收入比重合理性进行测度。结果显示:从财产性收入分配起点和分配过程视角,现阶段中国居民财产性收入比重是基本合理和合理的。但从财产性收入分配结果视角分析,中国居民财产性收入比重合理性变动幅度较大,财产性收入比重大幅波动是造成合理性变动的主要原因。基于测度模型和数值模拟对居民财产性收入比重的合理性区间进行测算,结果显示中国居民财产性收入比重在合理性区间内并未呈现大幅度增加或减少。为此,应稳步提高居民财产性收入,并采取监督和预警措施来保障居民财产性收入合理发展。

关键词：财产性收入收入分配合理性区间分配系统协调

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Utilizing biodegradable alloys as guided bone regeneration(GBR)membrane:Feasibility and challenges

引用

Science China Materials 2022年第10期65卷 2627-2646页

作者： Kai Chen Li Zhao Jie sun Xuenan Gu Chenyang Huang haoran su Yubo Fan Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China Department of Stomatology The Fifth Medical CenterChinese PLA General HospitalBeijing 100036China

Guided bone regeneration(GBR)is a therapeutic procedure used to enhance alveolar bone volume before dental *** non-absorbable membranes(i.e.,titanium membranes)typically require a second surgery to remove,whereas absorbable membranes(i.e.,collagen membranes)will fail when put over extensive bone lesions due to their low mechanical *** GBR membrane that has been sought is still being *** metals(BMs),particularly Mg and Zn,have recently been postulated as promising barrier membrane ***,the goal of this research is to evaluate the mechanical and biological feasibility of using BMs as GBR *** shows that BMs have a wide range of potential applications as GBR membranes,owing to their benign biocompatibility,sufficient mechanical support,tunable degradation rate,good osteogenic capabilities,broad-spectrum antibacterial behavior,and improved wound healing *** rapid degradation rate,hydrogen evolution impact,and stress corrosion cracking behavior all pose obstacles to the use of Mg-based membranes,which can be improved by surface modifications,heat treatment,alloying,*** to its acceptable degradation rate and lack of gas production,Zn appears to be a better candidate for usage as a GBR *** general,advances in the development of BMs have paved the door for BMs to be used as GBR membranes in oral clinical trials.

关键词： biodegradable alloy guided bone regeneration biocompatibility mechanical property osteogenic performance

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research on the Monitoring Method of Rice Blast Disease at Canopy Scale Based on UAV Multispectral Imaging

Research on the Monitoring Method of Rice Blast Disease at C...

引用

第43届中国控制会议

作者： haoran su Yi Pan Linlin Qin Gang Wu Chun Shi YiKun Wang Sheng Hua ShouWei Luo Department of automation University of Science and Technology of China Anhui Xiyangyang Agricultural Technology Co. Ltd

Rice ranks first in both sown area and total production among domestic grain crops, making it the most important food crop in China. Rice blast, also known as rice smut, is one of the most severe diseases in rice production, posing a significant challenge to rice farmers. To address this issue, a method has been developed for detecting the severity of rice blast using unmanned aerial vehicle(UAV) based on low altitude remote sensing technology and multi-spectral imaging technology. It involved collecting multi-spectral images of rice fields using UAV and extracting 18 spectral features(4 spectral bands + 14vegetation indices) and 32 texture features from these images. Pearson correlation analysis and recursive feature elimination algorithm were used to eliminate redundant features and identify sensitive feature combinations. These feature combinations were used as inputs for the RF and SVM algorithms to construct a model for the severity of rice blast disease. Simultaneously,the ResNet-18 convolutional neural network was trained using the R, G, B, and NIR bands as inputs. The results showed that the fusion of spectral and texture features can effectively improve the recognition rate of machine learning models. The convolutional neural network model based on ResNet-18 achieved the highest classification accuracy(OA=89.31%) for rice blast disease, outperforming the support vector machine classifier(OA=82.46%) and random forest classifier(OA=75.81%). It has been demonstrated that UAV multispectral imaging technology can accurately detect rice blast disease, while also offering the advantages of speed and non-destructiveness.

关键词： UAV multispectral images rice blast machine learning deep learning ResNet-18

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people

引用

Journal of Genetics and Genomics 2024年第5期51卷 517-530页

作者： Yuntao sun Mengge Wang Qiuxia sun Yan Liu Shuhan Duan Zhiyong Wang Yunyu Zhou Jun Zhong Yuguo Huang Xinyu Huang Qingxin Yang Xiangping Li haoran su Yan Cai Xiucheng Jiang Jing Chen Jiangwei Yan Shengjie Nie Liping Hu Junbao Yang Renkuan Tang Chuan-Chao Wang Chao Liu Xiaohui Deng Libing Yun Guanglin He West China School of Basic Science&Forensic Medicine Sichuan UniversityChengduSichuan 610041China Institute of Rare Diseases West China Hospital of Sichuan UniversitySichuan UniversityChengduSichuan 610000China Center for Archaeological Science Sichuan UniversityChengduSichuan 610000China Faculty of Forensic Medicine Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510275China Guangzhou Forensic Science Institute GuangzhouGuangdong 510055China Department of Forensic Medicine College of Basic MedicineChongqing Medical UniversityChongqing 400331China School of Clinical Medical Sciences North Sichuan Medical CollegeNanchongSichuan 637100China School of Basic Medical Sciences North Sichuan Medical CollegeNanchongSichuan 637100China School of Forensic Medicine Kunming Medical UniversityKunmingYunnan 650500China School of Stomatology North Sichuan Medical CollegeNanchongSichuan 637100China Department of Medical Laboratory North Sichuan Medical CollegeNanchongSichuan 637007China School of Life Sciences Xiamen UniversityXiamenFujian 361005China Anti-Drug Technology Center of Guangdong Province GuangzhouGuangdong 510230China School of Forensic Medicine Shanxi Medical UniversityJinzhongShanxi030600China

Tibeto-Burman(TB)people have endeavored to adapt to the hypoxic,cold,and high-UV high-altitude environments in the Tibetan Plateau and complex disease exposures in lowland rainforests since the late Paleolithic ***,the full landscape of genetic history and biological adaptation of geographically diverse TB-speaking people,as well as their interaction mechanism,remain ***,we generate a whole-genome meta-database of 500 individuals from 39 TB-speaking populations and present a comprehensive landscape of genetic diversity,admixture history,and differentiated adaptative features of geographically different TB-speaking *** identify genetic differentiation related to geography and language among TB-speaking people,consistent with their differentiated admixture process with incoming or indigenous ancestral source populations.A robust genetic connection between the Tibetan-Yi corridor and the ancient Yellow River people supports their Northern China origin *** finally report substructure-related differentiated biological adaptative signatures between highland Tibetans and Loloish *** signatures associated with the physical pigmentation(EDAR and SLC24A5)and metabolism(ALDH9A1)are identified in Loloish people,which differed from the high-altitude adaptative genetic architecture in ***-related genomic resources provide new insights into the genetic basis of biological adaptation and better reference for the anthropologically informed sampling design in biomedical and genomic cohort research.

关键词： Tibeto-Burman people Genetic profile Natural selection Genetic diversity Biological adaptation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

水肥施用对斑竹发笋及竹笋品质的影响

引用

世界竹藤通讯 2019年第6期17卷 9-15页

作者：苏浩然国际竹藤中心竹藤科学与技术重点实验室

应用正交试验设计,研究了灌溉次数、施肥量和立竹密度对博爱县斑竹笋产量、竹笋品质和经济效益的影响。结果表明:影响斑竹发笋指标的各因素主次关系以施肥量为主导因子,其次是灌溉次数,立竹密度影响最小;不同因素对发笋指标影响程度不一... 详细信息

应用正交试验设计,研究了灌溉次数、施肥量和立竹密度对博爱县斑竹笋产量、竹笋品质和经济效益的影响。结果表明:影响斑竹发笋指标的各因素主次关系以施肥量为主导因子,其次是灌溉次数,立竹密度影响最小;不同因素对发笋指标影响程度不一样,施肥量对各指标影响均达到显著水平,灌溉次数对发笋数量影响显著,对鲜笋产量影响不显著,立竹密度影响均不显著;影响发笋数量和鲜笋产量的因素排列顺序为施肥量>灌溉次数>立竹密度;3个因素对提高斑竹笋蛋白质含量和降低灰分含量有促进作用,可提高斑竹笋品质。获得最多发笋数量、鲜笋产量的处理为立竹密度9 000~11 000株/hm^2、施肥量3 000 kg/hm^2、灌溉次数为6次/年;提高斑竹竹笋品质的最优水平组合为立竹密度9 000~11 000株/hm^2、施肥量2 250 kg/hm^2、灌溉次数为5次/年;获得最大经济效益的最优水平组合为立竹密度5 000~7 000株/hm^2、施肥量2 250 kg/hm^2、灌溉次数为6次/年。

关键词：水肥施用斑竹发笋竹笋品质经济效益河南博爱县

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

DCS联合FTS理念在严重肺挫伤并发肋骨骨折患者救治中的应用效果

引用

反射疗法与康复医学 2022年第15期3卷 137-140页

作者：苏浩然济宁市第三人民医院(济宁市兖州区人民医院)重症医学科山东济宁272100

目的探讨损伤控制(DCS)联合快速康复外科(FTS)理念在严重肺挫伤并发肋骨骨折患者救治中的运用效果.方法回顾性分析2020年2月-2022年2月本院收治的84例严重肺挫伤并发肋骨骨折患者的临床资料,将采用常规救治的42例纳入对照组,将在救治过... 详细信息

目的探讨损伤控制(DCS)联合快速康复外科(FTS)理念在严重肺挫伤并发肋骨骨折患者救治中的运用效果.方法回顾性分析2020年2月-2022年2月本院收治的84例严重肺挫伤并发肋骨骨折患者的临床资料,将采用常规救治的42例纳入对照组,将在救治过程中应用DCS联合FTS理念的42例纳入观察组.对比两组的机体恢复情况、并发症发生率、急性生理和慢性健康状况(APACHEⅡ)评分.结果观察组术后72 h的疼痛视觉模拟评分为(2.01±0.35)分,低于对照组,机械通气时间、胸管留置时间、ICU住院时间、总住院时间分别为(0.58±0.16)d、(2.13±0.38)d、(3.24±0.78)d、(13.29±2.11)d,均短于对照组,组间差异有统计学意义(P<0.05).观察组的并发症发生率为2.50%,低于对照组的19.05%,差异有统计学意义(P<0.05).观察组治疗后的APACHEⅡ评分为(6.12±1.07)分,低于对照组,差异有统计学意义(P<0.05).结论DCS联合FTS理念的应用能提升严重肺挫伤并发肋骨骨折患者的救治效果,减少并发症的发生,改善机体健康水平,促进术后恢复.

关键词：肋骨骨折严重肺挫伤损伤控制快速康复外科理念并发症

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

维持肝切除手术病人体温恒定专项护理干预的临床观察

引用

护理研究 2019年第21期33卷 3821-3822页

作者：常宝张莹胥静宿浩然华中科技大学同济医学院附属同济医院

[目的]探讨维持肝切除手术病人体温恒定对病人手术及麻醉恢复安全性的影响。[方法]选择144例肝切除手术病人,随机分为专项组(72例)和常规组(72例),两组麻醉方式相同,常规组入手术室后采取常规护理措施,专项组在常规组的基础上采取预防... 详细信息

[目的]探讨维持肝切除手术病人体温恒定对病人手术及麻醉恢复安全性的影响。[方法]选择144例肝切除手术病人,随机分为专项组(72例)和常规组(72例),两组麻醉方式相同,常规组入手术室后采取常规护理措施,专项组在常规组的基础上采取预防低体温专项护理干预,比较两组病人拔管时间、苏醒时间、体温变化及恢复过程中不良事件发生情况。[结果]专项组病人较常规组病人术中体温恒定,专项组术后拔管时间及苏醒时间较对照组缩短,且专项组不良事件发生率明显减少,差异均有统计学意义(P<0.05)。[结论]对肝切除手术病人积极采取预防低体温专项护理干预,能有效地缩短术后苏醒时间,维持体温恒定,预防低体温等不良事件发生。

关键词：肝切除术手术中体温低体温不良事件

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evolutionary history and biological adaptation of Han Chinese people on the Mongolian Plateau

引用

hLife 2024年第6期2卷 296-313页

作者： Xiangping Li Mengge Wang haoran su Shuhan Duan Yuntao sun Hongyu Chen Zhiyong Wang Qiuxia sun Qingxin Yang Jing Chen Ting Yang Yuguo Huang Jie Zhong Xiucheng Jiang Jinyue Ma Shijia Chen Yunhui Liu Lintao Luo Xinyu Lin Shengjie Nie Chao Liu Liping Hu Guanglin He School of Forensic Medicine Kunming Medical UniversityYunnanChina Center for Archaeological Science Sichuan UniversitySichuanChina Institute of Rare Diseases West China Hospital of Sichuan UniversitySichuan UniversitySichuanChina Anti-Drug Technology Center of Guangdong Province GuangdongChina West China School of Basic Science&Forensic Medicine Sichuan UniversitySichuanChina School of Laboratory Medicine North Sichuan Medical CollegeSichuanChina Institute of Basic Medicine and Forensic Medicine North Sichuan Medical CollegeSichuanChina Center for Genetics and Prenatal Diagnosis Affiliated Hospital of North Sichuan Medical CollegeSichuanChina Research Center for Genomic Medicine North Sichuan Medical CollegeSichuanChina Department of Forensic Medicine College of Basic MedicineChongqing Medical UniversityChongqingChina School of Forensic Medicine Shanxi Medical UniversityShanxiChina Department of Medical Genetics West China HospitalSichuan UniversitySichuanChina

Complex demographic processes and natural selection pressures are critical to resolving patterns of the molecular genetic basis of adaptive traits or complex *** ancient genome data allow us to trace how key traits evolved in different human populations over time,connecting ancient population history with disease susceptibility in western *** fill this gap in eastern Eurasians and provide deep insights into the evolutionary history of the populationspecific genetic basis of complex biological traits,we explored the evolutionary basis of adaptive traits in one integrative modern and ancient genomic database,including 225 out of 5583 genomes first reported *** comprehensively characterized the demographic history and biological adaptation of Han Chinese individuals on the Mongolian Plateau based on the allele frequency spectrum and haplotype-resolved *** found strong genetic homogeneity among geographically different Han populations from Inner Mongolia(IMH).We reconstructed their admixture models and demographic events,revealing that IMH had a close genetic relationship with ancient millet farmers and obtained additional gene flow from Altaic-speaking *** enrichment of selected candidate genes suggested that essential metabolism-related genes promoted the rapid adaptation of eastern Eurasians to ancient environmental shifts and dietary changes during agricultural *** trajectory reconstruction of metabolism-related genes of methylenetetrahydrofolate reductase(MTHFR)and fatty acid desaturase 1(FADS1)suggested that ancient dietary shifts during the Neolithic transition period promoted the differentiated metabolic rate of folate and fatty *** revealed the polygenicity of biological adaptation traits and the pleiotropy of adaptive genes,indicating that complex recent polygenic adaptations,genetic interactions,and genotype–phenotype correlations have contributed to the genetic architecture of comple

关键词： demographic history biological adaptation polygenicity and pleiotropy metabolic fitness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：