Utilizing biodegradable alloys as guided bone regeneration(GBR)membrane:Feasibility and challenges

作     者：Kai Chen Li Zhao Jie Sun Xuenan Gu Chenyang Huang Haoran Su Yubo Fan 陈凯;赵莉;孙洁;顾雪楠;黄晨阳;苏皓然;樊瑜波

作者机构：Key Laboratory of Biomechanics and Mechanobiology(Beihang University)Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Beijing Advanced Innovation Center for Materials Genome EngineeringInstitute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China Department of StomatologyThe Fifth Medical CenterChinese PLA General HospitalBeijing 100036China 

出 版 物：《Science China Materials》 (中国科学（材料科学（英文版）)

年 卷 期：2022年第65卷第10期

页      面：2627-2646页

核心收录：

学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0702[理学-物理学] 

基　　金：supported by the National Key R&D Program of China(2018YFC1106600) the National Natural Science Foundation of China(52071008,and U20A20390) Beijing Natural Science Foundation(2192027) 

主　　题：biodegradable alloy guided bone regeneration biocompatibility mechanical property osteogenic performance 

摘      要：Guided bone regeneration(GBR)is a therapeutic procedure used to enhance alveolar bone volume before dental *** non-absorbable membranes(i.e.,titanium membranes)typically require a second surgery to remove,whereas absorbable membranes(i.e.,collagen membranes)will fail when put over extensive bone lesions due to their low mechanical *** GBR membrane that has been sought is still being *** metals(BMs),particularly Mg and Zn,have recently been postulated as promising barrier membrane ***,the goal of this research is to evaluate the mechanical and biological feasibility of using BMs as GBR *** shows that BMs have a wide range of potential applications as GBR membranes,owing to their benign biocompatibility,sufficient mechanical support,tunable degradation rate,good osteogenic capabilities,broad-spectrum antibacterial behavior,and improved wound healing *** rapid degradation rate,hydrogen evolution impact,and stress corrosion cracking behavior all pose obstacles to the use of Mg-based membranes,which can be improved by surface modifications,heat treatment,alloying,*** to its acceptable degradation rate and lack of gas production,Zn appears to be a better candidate for usage as a GBR *** general,advances in the development of BMs have paved the door for BMs to be used as GBR membranes in oral clinical trials.