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Magnetic Resonance Letters 2022年第2期2卷 61-68,I0002页

作者： Alexandra born Morkos A.Henen Parker J.Nichols beat Vogeli University of Colorado Anschutz Medical Campus Department of Biochemistry and Molecular Genetics12801 East 17th AvenueAuroraCO80045USA Faculty of Pharmacy Mansoura UniversityMansoura35516Egypt

Residual dipolar couplings(RDCs)are powerful nuclear magnetic resonance(NMR)probes for the structure calculation of ***,an alignment tensor that defines the orientation of the entire molecule relative to the magnetic field is determined either before refinement of individual bond vectors or simultaneously with this *** single-domain proteins this approach works well since all bond vectors can be described within the same coordinate frame,which is given by the alignment ***,novel approaches are sought after for systems where no universal alignment tensor can be ***,we present an approach that can be applied to two-domain proteins that enables the calculation of multiple states within each domain as well as with respect to the relative positions of the two domains.

关键词： RDC Residual dipolar coupling Two-domain protein Multi-state structure

Timing of surgical repair of bile duct injuries after laparoscopic cholecystectomy: A systematic review

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World Journal of Hepatology 2022年第2期14卷 442-455页

作者： Patryk Kambakamba Sinead Cremen beat Möckli Michael Linecker Department of HPb and Transplant Surgery St.Vincent’s University Hospital DublinDublin d04 T6F4Ireland Department of Surgery Cantonal Hospital GlarusGlarus 8750Switzerland Department of Visceral and Transplantation Surgery University of Geneva HospitalsGeneva 1205Switzerland Department of Surgery and Transplantation University Medical Center Schleswig HolsteinKiel 24105Germany

bACKGROUND The surgical management of bile duct injuries(bDIs)after laparoscopic cholecystectomy(LC)is challenging and the optimal timing of surgery remains *** primary aim of this study was to systematically evaluate the evidence behind the timing of bDI repair after LC in the *** To assess timing of surgical repair of bDI and postoperative *** The MEDLINE,EMbASE,and The Cochrane Library databases were systematically screened up to August *** of bias was assessed via the Newcastle Ottawa *** primary outcomes of this review included the timing of bDI repair and postoperative *** A total of 439 abstracts were screened,and 24 studies were included with 15609 patients included in this *** the 5229 bDIs reported,4934(94%)were classified as major *** of bile duct repair was immediate(14%,n=705),early(28%,n=1367),delayed(28%,n=1367),or late(26%,n=1286).Standardization of definition for timing of repair was remarkably poor among *** for immediate repair ranged from24 h to>12 wk after LC)and late repair(>6 wk after LC)showed a broad *** The lack of standardization among studies precludes any conclusive recommendation on optimal timing of bDI repair after *** finding indicates an urgent need for a standardized reporting system of bDI repair.

关键词： bile duct injury Major bile duct injury Laparoscopic cholecystectomy Surgical repair Immediate repair Early repair Delayed repair Late repair biliary reconstruction Standardization of bile duct injury repair reporting

The Matthew Effect in Running:An Analysis of Elite Endurance Athletes Over 23 Years

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Journal of Science in Sport and Exercise 2023年第3期5卷 236-243页

作者： Mabliny Thuany beat Knechtle Kevin Kipchumba Lee Hill Thayse Natacha Gomes Centre of Research EducationInnovation and Intervention in Sport(CIFI2D)Faculty of SportUniversity of Porto4200-450 PortoPortugal Medbase Street Gallen Am Vadianplatz Vadianstrasse 269001 Street GallenGallenSwitzerland Kenyatta University NairobiKenya Division of Gastroenterology&Nutrition Department of PediatricsMcMaster UniversityHamiltonCanada Department of Physical Education Federal University of Sergipe(UFS)São CristóvãoSergipe 49100-000Brazil

Purpose The purpose of this study was to investigate the frequency of countries represented in the TOP20 long-distance elite runners ranking during 1997-2020,taking into account the countries’Human Development Index(HDI),and to verify if the Matthew effect can be observed regarding countries’representativeness in the raking alongside the *** The sample comprised 1852 professional runner athletes,ranked in the Senior World TOP20 half-marathon(403 female and 487 male)and marathon(480 female and 482 male)races,between the years *** about the countries’HDI was included,and categorized as“low HDI”,“medium HDI”,“high HDI”,and“very-high HDI”.Athletes were categorized according to their ranking positions(1st-3rd;4th-10th;>10th),and the number of athletes per country/year was summed and categorized as“total number of athletes 1997-2000”;“total number of athletes 2001-2010”;and“total number of athletes 2011-2020”.The Chi-square test and Spearman correlation were used to verify potential associations and relationships between *** Most of the athletes were from countries with medium HDI,followed by low HDI and very-high ***-square test results showed significant differences among females(χ^(2)=15.52;P=0.017)and males(χ^(2)=9.03;P=0.014),in half-marathon and marathon,*** significant association was verified between HDI and the total number of athletes,but the association was found for the number of athletes alongside the years(1997-2000 to 2001-2010:r=0.60;Pby those with low HDI and very-high *** Matthew effect was observed,but a generalization of the results should not be done.

关键词： Endurance High-elite athletes Human development index

Is there stability in the performance of elite half-marathoners?

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Sports Medicine and Health Science 2022年第2期4卷 101-104页

作者： Mabliny Thuany beat Knechtle Pantelis Theodoros Nikolaidis Thayse Natacha Gomes Faculty of Sports University of PortoPortoPortugal Institute of Primary Care University of ZurichZurichSwitzerland School of Health and Caring Sciences University of West AtticaAthensGreece Department of Physical Education Federal University of SergipeSao CristovaoBrazil

The purpose of this study was to investigate the performance stability of elite half-marathoners of both *** study was composed of 24 elite athletes(12 female and 12 male),ranked among the Senior World TOP20 halfmarathoners,who completed a half-marathon race for at least three consecutive *** was tested using autocorrelations and Kappa *** revealed a significant association,but a decrease in correlation among the years in both *** overall weighted kappa showed lower stability in performance for both sexes(K=0.191 and K=-0.245)than for *** findings suggest that both female and male elite halfmarathoners showed low stability in performance during three *** that,athletes with a better performance tended to present the highest performance *** is recommended that coaches track the developmental trajectories of the athletes to comprised the changes in performance across the years,as to provide environmental characteristics that can influence performance.

关键词： Tracking Endurance Running Elite athletes

The Relationship between Training Volume and bMI in the Expression of Running Performance in Runners: A Mediation Model

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Journal of Science in Sport and Exercise 2023年第2期5卷 142-148页

作者： Mabliny Thuany Lee Hill JoséRamón Alvero‑Cruz beat Knechtle Thayse Natacha Gomes CIFI²D Faculty of SportUniversity of PortoPortoPortugal Division of Gastroenterology and Nutrition Department of PediatricsMcMaster UniversityHamiltonON L8N 3Z5Canada Dpto de Fisiología Humana HistologíaAnatomia Patológica y Educación Física y DeportivaUniversidad de MálagaMálagaSpain Medbase St.Gallen Am Vadianplatz Vadianstrasse 269001 St.GallenSwitzerland Department of Physical Education Federal University of SergipeSão CristóvãoSEBrazil

Purpose The relationships between anthropometric and training variables with running performance were previously ***,it is possible that through the moderating role of anthropometric variables,the magnitude of the relationship between training and performance may be *** purpose of this study was to estimate the mediation role of body mass index(bMI)in the relationship between training volume and running performance among non-professional runners,taking into account sex and age *** The sample comprised 1151 non-professional road runners(61.8%male),aged 18–72 *** about sex,age,body mass(kg),body height(cm),running pace,motivation for running,training volume and frequency were obtained through an online *** into account athletes’age,they were split into two age categories:“until 34 years”(adult runners)and“≥35 years”(master athletes).A mediation analysis was computed in Macro Process(SPSS 26),considering sex and age *** was the mediating variable,while training volume/week was used as independ-ent variable,and running pace was considered as dependent *** For both sexes and age categories,a significant association between training volume on running pace was observed[male adult:β=-0.67;95%CI(-1.04 to-0.53);male master:β=-0.241;95%CI(-0.44 to-0.26);female adult:-0.83;95%CI(-1.25 to-0.41);female master:-0.76;95%CI(-1.09 to-0.44)],as well the association between training volume and bMI;and running bMI and running *** for female adult runners,a mediation effect of bMI was *** The present study showed that bMI mediated the association between training volume and running pace in non-professional runners of different sexes and age *** the other hand,a small influence of training volume on the expression of bMI was found.

关键词： body mass index Running Mediation model

Liver transplantation for malignant liver tumors

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iLIVER 2022年第1期1卷 3-11页

作者： Richard X.Sousa Da Silva beat Muellhaupt Philipp Dutkowski Pierre-Alain Clavien Department of Surgery and Transplantation Swiss Hepato-Pancreato-Biliary(HPB)and Transplant CenterUniversity Hospital ZurichRaemistrasse 1008091 ZurichSwitzerland Wyss Zurich ETH ZurichUniversity of ZurichWeinbergstrasse 358006 ZurichSwitzerland Department of Gastroenterology and Hepatology University Hospital ZurichRaemistrasse 1008091 ZurichSwitzerland

Liver transplantation is a highly effective treatment not only for acute or chronic liver failure but also for primary liver cancer such as hepatocellular carcinoma,perihilar cholangiocarcinoma,intrahepatic cholangiocarcinoma,and metastatic tumors such as from neuroendocrine or colorectal liver *** success strongly relies on strict adherence to stringent selection criteria,which lead to excellent outcomes,while previously regarded as contraindication for liver *** impressive results are,however,mostly achieved with a combination of pretreatment strategies and convincing control of the tumor growth prior to transplantation,as well as minimizing long-term *** this emergence of oncologic liver transplantation,we expect an increasing need of grafts,and therefore included in this report strategies to improve the number of available grafts by maximizing liver utilization *** machine liver perfusion approaches may play in this respect an important role.

关键词： Liver transplantation Selection criteria Malignant tumor Machine perfusion Tumor recurrence

Combined non-alcoholic fatty liver disease and type 2 diabetes in severely obese patients-medium term effects of sleeve gastrectomy versus Roux-en-Y-gastric bypass on disease markers

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Hepatobiliary Surgery and Nutrition 2022年第6期11卷 795-807页

作者： Franck billmann Sherehan El Shishtawi Tom bruckner Mostafa ElSheikh beat Peter Muller-Stich Adrian billeter Department of Surgery University Hospital of HeidelbergHeidelbergGermany Institut für Medizinische biometrie und Informatik Universität HeidelbergHeidelbergGermany Department of General Surgery El-Gharbia GovenorateTantaEl gash St.Medical CampusThe Faculty of MedicineTantaEgypt

background:We aimed to evaluate the medium-term efficacy of sleeve gastrectomy(SG)***-en-Y gastric bypass(RYGb)on remission of non-alcoholic fatty liver disease(NAFLD)in patients with type 2 diabetes mellitus(T2DM).Methods:We identified severely obese patients[body mass index(bMI)>35 kg/m^(2)]with NAFLD(as defined by the Longitudinal Assessment of bariatric Surgery Study)and T2DM(as defined by the American Association of Clinical Endocrinologists and the American College of Endocrinology)who underwent SG or RYGb in a single university surgical *** cohorts were match-paired and data were analysed after at least 3 years of follow *** key outcomes measured were:(I)the improvement of liver function tests and NAFLD markers;(II)glycemic control and insulin ***:Ninety-six patients were investigated;44(45.8%)were *** mean pre-operative bMI was 45.2 kg/m2 in the SG and 42.0 kg/m^(2) in the RYGb *** and RYGb both significantly reduced serum liver enzyme *** markers resolved 2 years after SG in all *** contrast,only 78%and 80%of patients achieved remission of NAFLD 2 and 3 years after RYbG *** procedures resulted in comparable rates of remission of ***:bariatric surgery with SG may be preferable to RYGb for obese patients with NAFLD and T2DM based on the rates of remission of markers of these ***,our results need to be confirmed in prospective *** the metabolic effects of specific bariatric surgical procedures may facilitate the development of a personalised approach to weight-loss surgery.

关键词： bariatric surgery morbid obesity complications non-alcoholic fatty liver disease(NAFLD) type 2 diabetes mellitus(T2DM) gastric bypass sleeve gastrectomy(SG) transaminases

Robotic pancreaticoduodenectomy after the learning curve-a new hope

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 489-491页

作者： Philip C.Müller beat P.Müller-Stich Thilo Hackert Felix Nickel Swiss HPb and Transplantation Center Department of Surgery and TransplantationUniversity Hospital ZurichZurichSwitzerland Department of General Visceral and Transplantation SurgeryHeidelberg University HospitalHeidelbergGermany

First,we would like to congratulate Liu et *** their successful multicenter study including 1,032 patients undergoing robotic pancreaticoduodenectomy(RPD)and 1,154 open pancreaticoduodenectomy(OPD)in seven high volume centers in China over an 8 year period(1).To ensure the best possible outcomes of both techniques,RPD was performed by five surgeons from three centers after overcoming the individual learning curve that was defined as having performed>40 *** the other hand,OPD was performed by 9 surgeons from 6 centers after reaching the individual learning curve,defined as an experience of>60 OPD.

关键词： centers learning after

The effect of sex and performance level on pacing in cross-country skiers:Vasaloppet 2004-2017

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Journal of Sport and Health Science 2018年第4期7卷 453-458页

作者： pantelis theodoros nikolaidis elias villiger beat knechtle exercise physiology laboratory Nikaia 18450 Greece institute of primary care university of zurichZurich 9000Switzerland medbase st.gallen am vadianplatz St.Gallen 9001 Switzerland

background: Pacing, defined as percentage changes of speed between successive splits, has been extensively studied in running and cycling endurance sports; however, less information about the trends in change of speed during cross-country(XC) ski racing is available. Therefore, the aim of the present study was to examine the effect of performance(quartiles of race time(Q), with Q1 the fastest and Q4 the slowest) level on pacing in the Vasaloppet ski race, the largest XC skiing race in the ***: For this purpose, we analyzed female(n = 19,465) and male(n = 164,454) finishers in the Vasaloppet ski race from 2004 to 2017 using a one-way(2 sexes) analysis of variance with repeated measures to examine percentage changes of speed between 2 successive splits. Overall,the race consisted of 8 ***: The race speeds of Q1, Q2, Q3, and Q4 were 13.6 § 1.8, 10.6 § 0.5, 9.2 § 0.3, and 8.1 § 0.4 km/h, respectively, among females and16.7 § 1.7, 13.1 § 0.7, 10.9 § 0.6, and 8.9 § 0.7 km/h, respectively, among males. The overall pacing strategy of finishers was variable. A small sex ￡ split interaction on speed was observed(h2= 0.016, p between sexes ranging from 14.9%(Split 7) to27.0%(Split 1) and larger changes in speed between 2 successive splits being shown for females(p between splits, was shown for females(h2= 0.149, p by going faster at times during the race.

关键词：滑雪表演速度变化完成时间水相互作用运动员上海大学