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Clinical Outcome after Laminectomy without Fusion for Cervical Spondylotic Myelopathy

Open Journal of Modern Neurosurgery 2015年第2期5卷 41-48页

作者： Kerstin Woernle Serge Marbacher Abdussalam Khamis hans landolt Javier Fandino Department of Neurosurgery Kantonsspital Aarau Aarau Switzerland

Dorsal decompression in patients, presenting with cervical spondylotic myelopathy with no signs of instability, is a standard surgical option. Laminectomy or laminoplasty is applied to reduce the pressure on the myelon. The aim of this study was to evaluate the clinical outcome in a consecutive series of patients. This retrospective study included a total of 65 patients who underwent laminectomy or laminoplasty at a single or more levels, without fusion for cervical spondylotic myelopathy, during an 8-year period (2000-2007). The clinical data evaluation included pre- and postoperative patient history and neurological and surgical variables. The radiological assessment included MRI, CT, and plain anterior-posterior, lateral, and lateral flexion-extension X-rays. The mean follow-up time was 15 months. Improvement of gait disturbance was documented in 74% of the patients concerned. Radicular pain in the upper limbs (UL) and lower limbs (LL) improved in 87% and 50% of the patients, respectively. Sensory deficits improved in the UL and LL in 76% and 54%, respectively. Motor deficits improved in the UL and LL in 70% and 56% of the patients, respectively. Clinical deterioration after surgery was documented in one patient. Based on our results, laminectomy without fusion can be advocated as a safe and effective surgical strategy to treat cervical spondylotic myelopathy in patients without preoperative instability. In these patients, the occurrence of post-procedural clinical deterioration and instability was low, and overall improvement of neurological deficits and amelioration of radicular pain can be expected in a significant number of patients.

关键词： Cervical Myelopathy Cervical Spine Laminectomy Outcome Surgical Technique

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Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology

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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： Daniel Adam Felix Langerscheidt hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

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Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al Kabbani Christoph Köhler hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

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Removing trace oxygen to obtain truly intrinsic transport in organic semiconductors

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Science China Materials 2024年第5期67卷 1668-1669页

作者： hans Kleemann Dresden Integrated Center for Applied Physics and Photonic Materials Technische UniversitätDresdenGermany

Organic semiconductor is an emerging generation semiconductor material,which has a broad application prospect in the field of flexible and large-area *** now,tens of thousands of organic semiconductor molecules with diverse functions have been developed through elaborate molecular *** molecules are often classified into n-type and ptype,depending on whether the prevalent charge carriers are electrons or holes[1].

关键词： transport intrinsic moving

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Chitin synthesis inhibitors： old molecules and new developments

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Insect Science 2013年第2期20卷 121-138页

作者： hans Merzendorfer Department of Biology/Chemistry University of Osnabruck 49069 OsnabrEick Germany

Chitin is the most abundant natural aminopolysaccharide and serves as a structural component of extracellular matrices. It is found in fungal septa, spores, and cell walls, and in arthropod cuticles and peritrophic matrices, squid pens, mollusk shells, nematode egg shells, and some protozoan cyst walls. As prokaryotes, plants and vertebrates including humans do not produce chitin, its synthesis is considered as an attractive target site for fungicides, insecticides, and acaricides. Although no chitin synthesis inhibitor has been developed into a therapeutic drug to treat fungal infections in humans, a larger number of compounds have been successfully launched worldwide to combat arthropod pests in agriculture and forestry. This review summarizes the latest advances on the mode of action of chitin synthesis inhibitors with a special focus on those molecules that act on a postcatalytic step of chitin synthesis.

关键词： acaricide benzoylurea chitin synthesis inhibitor cuticle etoxazole,insecticide

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THE GENERALIZED(NONLINEAR)POISSON PROBLEM:A DUAL VARIATIONAL APPROACH

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Acta Mechanica Sinica 1994年第3期10卷 227-236页

作者： hans Bufler Institute for Mechanics Stuttgart UniversityD-70550 StuttgartGermany

A series of problems in mechanics and physics are governed by the ordinary Poisson equation which demands linearity,isotropy,and material homo- *** this paper a generalization with respect to nonlinearity,anisotropy,and inhomogeneity is *** from the canonical basic equations in the primal and dual formulation respectively we derive systematically the corresponding generalized variational principles;under certain conditions they can be extended to so called complementary extremum principles allowing for global *** simplicity a restriction to two dimensional problems is made,including twice-connected domains.

关键词： Generalized Poisson problem dual and complementary variational principles

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Morphological properties and residual strain along the small intestine in rats

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World Journal of Gastroenterology 2002年第2期8卷 312-317页

作者： hans Gregersen Biomechanics Lab Centre for Sensory-Motor InteractionAalborg University and Department of surgery AAalborg HospitalDenmark

AIM: Residual stress and strain are important for gastrointestinal function and relate to the geometric configuration, the loading conditions and the zero-stress state of the gastrointestinal tract. The purpose of this project is to provide morphometric data and residual strains for the rat small intestine ( n =11). METHODS: To approach the no-load state, the intestine was surgically excised, transferred to an organ bath and cut transversely into short ring-shaped segments. Each ring was cut radially for obtaining the zero-stress state. The residual stress can be characterised by an opening angle. The strain difference between the zero-stress state and the no-load state is called residual strain. RESULTS: Large morphometric variations were found along the small intestine. The wall thickness was highest in the proximal duodenum and decreased in distal direction along the axis of the small intestine (P<0.001). The circumferential length of the inner and outer surfaces decreased rapidly along the length of duodenum by 30-50% (P<0.001). The wall area and lumen area showed a similar pattern (P<0.001). In zero-stress state the rings always opened up after making the cut. The experiments resulted in larger inner circumferential length and smaller outer circumferential length when compared to the no-load state. The wall thickness and wall area did not differ between the no-load and zero-stress state. The opening angle and tangent rotation angle increased along the length of the duodenum and had its highest value 30% down the intestine. Further down the intestine it decreased again (P<0.001). The serosal residual strain was tensile with the highest value close to the ligament of Treitz (P<0.001). The mucosal residual strain was compressive in all segments of the small intestine with average values between -0.25 and -0.4 and with the lowest values close to the ligament of Treitz (P<0.001). CONCLUSION: Axial variation in morphometric properties and residual s

关键词： Animals In Vitro Intestine, Small histology Male Rats Rats, Sprague-Dawley Research Support, Non-U.S. Gov't Stress, Mechanical

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The Dichotomy Between Traces on d-sets Г in R^n and the Density of D(R^n\Г) in Function Spaces

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Acta Mathematica Sinica,English Series 2008年第4期24卷 539-554页

作者： hans TRIEBEL Mathematisches Institut Fakultt fr Mathematik und InformatikFriedrich-Schiller-Universitt JenaD-07737 JenaGermany

A space Apq^s （R^n） with A ： B or A = F and s ∈R, 0 〈 p, q 〈 ∞ either has a trace in Lp（Г）, where Г is a compact d-set in R^n with 0 〈 d 〈 n, or D（R^n／Г） is dense in it. Related dichotomy numbers are ... 详细信息

A space Apq^s （R^n） with A ： B or A = F and s ∈R, 0 〈 p, q 〈 ∞ either has a trace in Lp（Г）, where Г is a compact d-set in R^n with 0 〈 d 〈 n, or D（R^n／Г） is dense in it. Related dichotomy numbers are introduced and calculated.

关键词： function spaces d-sets fractals traces

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Collaborative Assessments in Computer Science Education: A Survey

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Tsinghua Science and Technology 2019年第4期24卷 435-445页

作者： hans Yuan Paul Cao the Computer Science & Engineering Department University of CaliforniaSan Diego

As computer science enrollments continue to surge, assessments that involve student collaboration may play a more critical role in improving student learning. We provide a review on some of the most commonly adopted collaborative assessments in computer science, including pair programming, collaborative exams, and group projects. Existing research on these assessment formats is categorized and compared. We also discuss potential future research topics on the aforementioned collaborative assessment formats.

关键词： assessment collaboration pair programming collaborative exam group project

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DYNAMIC MODEL AND SIMULATION OF THE PLATELETS'ROLE IN BLOOD COAGULATION

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Acta Mechanica Sinica 2002年第4期18卷 420-428页

作者：许传青曾衍钧 hans Grgersen Biomechanics Research Center Beijing Polytechnic Univ.Beijing 100022China Armed Forced InstituteBeijing 100072China Biomechanics Research Center Beijing Polytechnic Univ.Beijing 100022China Center for Sensory-Motor Interaction Aalborg UniversityDenmark

In order to confirm which process is the most important in the blood coagulation cascade,a dynamic model on the function of platelets in blood coagulation is presented based on biochemical *** on qualitative analysis and mathematical simulation,a series of conclusions about the influence of the activation rate of factor VIII and factor IX on the generation of thrombin(IIa)are *** is evident that the pro-coagulation stimulus must exceed a threshold value to initiate the coagulation *** value is related to the binding constant d_2 of the platelet. The stability of the equilibrium value is also related to the pro-coagulation stimulus. This article also evaluates the influence of the stimulus strength and the activated rate parameter of platelets on *** proportion of platelets activated at any given time is designated *** each c,we obtain a maximum concentration of *** is evident that when the level of factor IX is below 1% of the normal level,the rate of thrombin generation reduces dramatically,resulting in severe bleeding tendency.

关键词： dynamic system numerical simulation biochemical process blood coagulation waterfall mechanism

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