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Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology

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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： Daniel Adam Felix Langerscheidt hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al Kabbani Christoph Köhler hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Chitin synthesis inhibitors： old molecules and new developments

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Insect Science 2013年第2期20卷 121-138页

作者： hans Merzendorfer Department of Biology/Chemistry University of Osnabruck 49069 OsnabrEick Germany

Chitin is the most abundant natural aminopolysaccharide and serves as a structural component of extracellular matrices. It is found in fungal septa, spores, and cell walls, and in arthropod cuticles and peritrophic matrices, squid pens, mollusk shells, nematode egg shells, and some protozoan cyst walls. As prokaryotes, plants and vertebrates including humans do not produce chitin, its synthesis is considered as an attractive target site for fungicides, insecticides, and acaricides. Although no chitin synthesis inhibitor has been developed into a therapeutic drug to treat fungal infections in humans, a larger number of compounds have been successfully launched worldwide to combat arthropod pests in agriculture and forestry. This review summarizes the latest advances on the mode of action of chitin synthesis inhibitors with a special focus on those molecules that act on a postcatalytic step of chitin synthesis.

关键词： acaricide benzoylurea chitin synthesis inhibitor cuticle etoxazole,insecticide

THE GENERALIZED(NONLINEAR)POISSON PROBLEM:A DUAL VARIATIONAL APPROACH

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Acta Mechanica Sinica 1994年第3期10卷 227-236页

作者： hans Bufler Institute for Mechanics Stuttgart UniversityD-70550 StuttgartGermany

A series of problems in mechanics and physics are governed by the ordinary Poisson equation which demands linearity,isotropy,and material homo- *** this paper a generalization with respect to nonlinearity,anisotropy,and inhomogeneity is *** from the canonical basic equations in the primal and dual formulation respectively we derive systematically the corresponding generalized variational principles;under certain conditions they can be extended to so called complementary extremum principles allowing for global *** simplicity a restriction to two dimensional problems is made,including twice-connected domains.

关键词： Generalized Poisson problem dual and complementary variational principles

The Dichotomy Between Traces on d-sets Г in R^n and the Density of D(R^n\Г) in Function Spaces

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Acta Mathematica Sinica,English Series 2008年第4期24卷 539-554页

作者： hans TRIEBEL Mathematisches Institut Fakultt fr Mathematik und InformatikFriedrich-Schiller-Universitt JenaD-07737 JenaGermany

A space Apq^s （R^n） with A ： B or A = F and s ∈R, 0 〈 p, q 〈 ∞ either has a trace in Lp（Г）, where Г is a compact d-set in R^n with 0 〈 d 〈 n, or D（R^n／Г） is dense in it. Related dichotomy numbers are ... 详细信息

A space Apq^s （R^n） with A ： B or A = F and s ∈R, 0 〈 p, q 〈 ∞ either has a trace in Lp（Г）, where Г is a compact d-set in R^n with 0 〈 d 〈 n, or D（R^n／Г） is dense in it. Related dichotomy numbers are introduced and calculated.

关键词： function spaces d-sets fractals traces

Collaborative Assessments in Computer Science Education: A Survey

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Tsinghua Science and Technology 2019年第4期24卷 435-445页

作者： hans Yuan Paul Cao the Computer Science & Engineering Department University of CaliforniaSan Diego

As computer science enrollments continue to surge, assessments that involve student collaboration may play a more critical role in improving student learning. We provide a review on some of the most commonly adopted collaborative assessments in computer science, including pair programming, collaborative exams, and group projects. Existing research on these assessment formats is categorized and compared. We also discuss potential future research topics on the aforementioned collaborative assessment formats.

关键词： assessment collaboration pair programming collaborative exam group project

DYNAMIC MODEL AND SIMULATION OF THE PLATELETS'ROLE IN BLOOD COAGULATION

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Acta Mechanica Sinica 2002年第4期18卷 420-428页

作者：许传青曾衍钧 hans Grgersen Biomechanics Research Center Beijing Polytechnic Univ.Beijing 100022China Armed Forced InstituteBeijing 100072China Biomechanics Research Center Beijing Polytechnic Univ.Beijing 100022China Center for Sensory-Motor Interaction Aalborg UniversityDenmark

In order to confirm which process is the most important in the blood coagulation cascade,a dynamic model on the function of platelets in blood coagulation is presented based on biochemical *** on qualitative analysis and mathematical simulation,a series of conclusions about the influence of the activation rate of factor VIII and factor IX on the generation of thrombin(IIa)are *** is evident that the pro-coagulation stimulus must exceed a threshold value to initiate the coagulation *** value is related to the binding constant d_2 of the platelet. The stability of the equilibrium value is also related to the pro-coagulation stimulus. This article also evaluates the influence of the stimulus strength and the activated rate parameter of platelets on *** proportion of platelets activated at any given time is designated *** each c,we obtain a maximum concentration of *** is evident that when the level of factor IX is below 1% of the normal level,the rate of thrombin generation reduces dramatically,resulting in severe bleeding tendency.

关键词： dynamic system numerical simulation biochemical process blood coagulation waterfall mechanism

Putting Faces to Names： Snapshots of Two Committee Meetings, 95 Years Apart, Emphasize Continuous International Cooperation in the Atmospheric Sciences

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Advances in Atmospheric Sciences 2017年第5期34卷 571-575页

作者： hans VOLKERT Deutsches Zentrum für Luft- und Raumfahrt lnstitut für Physik der Atmosphare 82234 Oberpfaffenhofen Germany

*** Spectacular advances have been made in the atmospheric sciences on a global level during a period of one hundred years or more,which is arguably most evident through"the quiet revolution of numerical weather predi... 详细信息

关键词： Co work Putting Faces to Names:Snapshots of Two Committee Meetings,95 Years Apart,Emphasize Continuous International Cooperation in the Atmospheric Sciences

N*-Program at COSY-Jülich

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Chinese Physics C 2009年第12期33卷 1102-1104页

作者： hans Strher Institut fr Kernphysik and Jlich Center for Hadron Physics Forschungszentrum Jülich 52425 Jlich Germany

The paper gives a brief introduction into the COSY-facility, the currently used detector systems （ANKE, TOF and WASA） and the targets （cluster jet, pellet and ABS）, and it presents some recent results, which were ... 详细信息

关键词： handron-induced reactions nucleon and hyperon resonances