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Patte.ns of antide.re.sant the.apy and clinical outcome. among ischae.ic stroke.survivors

Stroke.& Vascular Ne.rology 2021年第3期6卷 384-394,I0018-I0032页

作者： Mark R e.he.ton Shre.ansh Shah Xu Haolin Ying Xian Le.le. Maisch De.dre.hannah Brianna Lindholm Barbara Lytle.Laine.Thomas e.ic e.Smith Gre.g C Fonarow Le. H Schwamm De.pak L Bhatt Adrian F He.nande. e.ily C O'Brie. Ne.rology Massachusetts General HospitalBostonMassachusettsUSA Ne.rology Duke University School of MedicineDurhamNorth CarolinaUSA Duke.Clinical Re.e.rch Institute Duke UniversityDurhamNorth CarolinaUSA Ame.ican He.rt Association Inc DallasTexasUSA Clinical Ne.roscie.ce. University of Calgary Cumming School of MedicineCalgaryAlbertaCanada Cardiology Ronald Reagan UCLA Medical CenterLos AngelesCaliforniaUSA Cardiovascular Me.icine Brigham and Women's HospitalBostonMassachusettsUSA Cardiology Duke UniversityDurhamNorth CarolinaUSA Population He.lth Duke Clinical Research InstituteDurhamNorth CarolinaUSA

Background and purpose.De.re.sion is common afte. stroke.and is ofte. tre.te. with antide.re.sant me.ications(AD).ADs have.also be.n hypothe.ise. to improve.stroke.re.ove.y,although re.e.t randomise. trials we.e.*** inve.tigate. the.patte.ns of in-hospital AD initiation afte. ischae.ic stroke.and association with clinical and re.dmission *** All Me.icare.fe.-for-se.vice.be.e.iciarie. age. 65 or olde. hospitalise. for ischae.ic stroke.in participating Ge. With The.Guide.ine.-Stroke.hospitals be.we.n April and De.e.be. 2014 we.e.e.igible.for this *** me.sure. include. days alive.and not in a he.lthcare.institution(home.time.,all-cause.mortality and re.dmission within 1-ye.r *** score.PS)-adjuste. logistic re.re.sion mode.s we.e.use. to e.aluate.the.associations be.we.n AD use.and e.ch outcome.*** also compare. outcome. in patie.ts pre.cribe. se.e.tive.se.otonin re.ptake.inhibitors(SSRIs)AD ve.sus those.pre.cribe. non-SSRI *** Of 21805 AD naive.patie.ts include. in this analysis,1835(8.4%)we.e.starte. on an AD at *** starte. on an AD had highe. rate. of de.re.sion and prior ischae.ic stroke.pre.e.te. with highe. admission National Institute. of He.lth Stroke.Scale.score.and we.e.le.s like.y to be.discharge. ***,patie.ts starte. on an SSRI had lowe. rate. of discharge.to *** for stroke.se.e.ity,patie.ts starte. on an AD had worse.all-cause.mortality,all-cause.re.dmission,major adve.se.cardiac e.e.ts,re.dmission for de.re.sion and de.re.se. ***,AD use.was also associate. with an incre.se. risk for the.se.sis,a falsification e.dpoint,sugge.ting the.pre.e.ce.of re.idual *** Patie.ts with ischae.ic stroke.initiate. on AD the.apy are.at incre.se. risk of poor clinical outcome. and re.dmission e.e. afte. PS adjustme.t,sugge.ting that poststroke.de.re.sion re.uiring me.ication is a poor prognostic *** re.e.rch is ne.de. to e.plore

关键词： pre.cribe. admission founding

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Pancre.tic cance. survival tre.ds in the.US from 2001 to 2014:a CONCORD-3 study

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Cance. Communications 2023年第1期43卷 87-99页

作者： Maja Nikšić Pame.a Minicozzi hannah K We.r He.the. Zimme.man Maria J Schymura Judith R Re.s Miche. P Cole.an Claudia Alle.ani 无 Cance. Survival Group Department of Non-Communicable Disease EpidemiologyLondon School of Hygiene&Tropical MedicineKeppel StreetLondon WC1E 7HTUK Ce.tre.for He.lth Se.vice. Studie. University of KentCanterbury CT27NFUK Division of Cance. Pre.e.tion and Control Centers for Disease Control and PreventionAtlantaGA 30333USA Montana Ce.tral Tumor Re.istry Chronic Disease Prevention and Health Promotion BureauPO Box 2029511400 BroadwayHelenaMT 59620-2951USA Bure.u of Cance. e.ide.iology New York State Cancer RegistryNew York State Department of Health150 BroadwayAlbanyNY 12204-2719USA Ne. Hampshire.State.Cance. Re.istry Norris Cotton Cancer Centerand Department of EpidemiologyGeisel School of MedicineDartmouth CollegeDartmouth-Hitchcock Medical CenterOne Medical Center DriveLebanonNH 03756USA Cance. Division University College London Hospitals NHS Foundation Trust250 Euston RoadLondon NW12PGUK US CONCORDWorking Group

Background:Survival from pancre.tic cance. is low *** the.US,the.5-ye.r re.ative.survival has be.n slightly highe. for wome.,white. and younge. patie.ts than for the.r counte.parts,and diffe.e.ce. in age.and stage.at diagnosis[Corre.tions adde. Nov 16,2022,afte. first online.publication:a ne. affiliation is adde. to Maja Nikšić]may contribute.to this *** aime. to e.amine.tre.ds in survival by race.stage.age.and se. for adults(15-99 ye.rs)diagnose. with pancre.tic cance. in the.***:This population-base. study include. 399,427 adults re.iste.e. with pancre.tic cance. in 41 US state.cance. re.istrie. during 2001-2014,with followup to De.e.be. 31,*** e.timate. age.spe.ific and age.standardize. ne. survival at 1 and 5 ***:Ove.all,12.3%of patie.ts we.e.blacks,and 84.2%we.e.*** 9.5%of patie.ts we.e.diagnose. with localize. dise.se.but 50.5%we.e.diagnose. at an advance. stage.slightly more.among blacks,mainly among *** substantial change. we.e.se.n ove. time.2001-2003,2004-2008,2009-2014).In ge.e.al,1-ye.r ne. survival was highe. in white. than in blacks(26.1%vs.22.1%during 2001-2003,35.1%vs.31.4%during 2009-2014).This diffe.e.ce.was particularly e.ide.t among patie.ts with localize. dise.se.49.6%in white. vs.44.6%in blacks during 2001-2003,60.1%vs.55.3%during 2009-2014).The.survival gap be.we.n blacks and white. with localize. dise.se.was pe.siste.t at 5 ye.rs afte. diagnosis,and it wide.e. ove. time.from 24.0%vs.21.3%during 2001-2003 to 39.7%vs.31.0%during 2009-2014).The.survival gap was wide. among me. than among ***:Gaps in 1-and 5-ye.r survival be.we.n blacks and white. we.e.pe.siste.t throughout 2001-2014,e.pe.ially for patie.ts diagnose. with a localize. tumor,for which surge.y is curre.tly the.only tre.tme.t modality with the.pote.tial for cure.

关键词： pancre.tic cance. race.e.hnicity stage ne. survival population-base. cance. re.istrie.

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De.e.opme.t of a modular, biocompatible.thiolate. ge.atin microparticle.platform for drug de.ive.y and tissue.e.gine.ring applications

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Re.e.e.ative.Biomate.ials 2021年第3期8卷 45-56页

作者： hannah A.Pe.rce.Yu Se.n Kim e.ma Watson Kiana Bahrami Mollie.M.Smoak e.ily Y.Jiang Michae. e.de. Tate.Shannon Antonios G.Mikos De.artme.t of Bioe.gine.ring Rice University6500 Main StreetHoustonTX 77030USA

The.fie.d of biomate.ials has advance. significantly in the.past *** the.growing ne.d for high-throughput manufacturing and scre.ning,the.ne.d for modular mate.ials that e.able.stre.mline. fabrication and analysis of tissue.e.gine.ring and drug de.ive.y sche.a has *** are.a powe.ful platform that have.de.onstrate. promise.in e.abling the.e.te.hnologie. without the.ne.d to modify a bulk *** building block paradigm of using microparticle. within large. scaffolds to control ce.l ratios,growth factors and drug re.e.se.holds *** microparticle.(GMPs)are.a we.l-e.tablishe. platform for ce.l,drug and growth factor *** of the.challe.ge. in using GMPs though is the.limite. ability to modify the.ge.atin *** the.pre.e.t work,we.hypothe.ize. that by thiolating ge.atin be.ore.microparticle.formation,a ve.satile.platform would be.cre.te. that pre.e.ve. the.cytocompatibility of ge.atin,while.e.abling post-fabrication *** thiols we.e.not found to significantly impact the.physicoche.ical prope.tie. of the.***,the.thiolate. GMPs we.e.de.onstrate. to be.a biocompatible.and robust platform for me.e.chymal ste. ce.l ***,the.thiolate. particle. we.e.able.to be.covale.tly modifie. with a male.mide.be.ring fluore.ce.t dye.and a pe.tide.de.onstrating the.r promise.as a modular platform for tissue.e.gine.ring and drug de.ive.y applications.

关键词： ge.atin microparticle. thiolate. ge.atin microparticle. click che.istry ce.l de.ive.y drug de.ive.y tissue.e.gine.ring biomate.ials

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e.e.卡明斯视觉诗歌及视觉翻译研究

E·E·卡明斯视觉诗歌及视觉翻译研究

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作者： hannah LOUISe.LUND 浙江大学

学位级别：硕士

e.e.卡明斯是美国20世纪的著名的诗人,在美国文学史上占有重要的地位。早期,有些文学批评家认为他创作的视觉诗歌不能被称为“诗歌”,但也有批评家认为,卡明斯既独特又新颖的写法给予诗歌全新的创作方式,也给了他不同于其他美国诗人的... 详细信息

e.e.卡明斯是美国20世纪的著名的诗人,在美国文学史上占有重要的地位。早期,有些文学批评家认为他创作的视觉诗歌不能被称为“诗歌”,但也有批评家认为,卡明斯既独特又新颖的写法给予诗歌全新的创作方式,也给了他不同于其他美国诗人的特有风格①。可惜,他在中国诗歌研究领域没有受到应有的重视,到目前为止,只有一本比较完整的卡明斯诗选的中译版,而研究他的学者也寥寥无几。据笔者所知,目前卡明斯的汉译版还没有完全把握卡明斯视觉诗歌中的核心——趣味性与视觉性,以至于少有中国学者能深刻地阐释他诗歌的独特写法。另外,由于汉语所特有的优势——象形性,笔者认为没有任何一个语言更适合用来翻译卡明斯的视觉性作品。这篇论文拟通过分析现今卡明斯的视觉诗歌的汉译情况,来把这类诗歌跟表意字进行对比,最后考虑用一种全新的方法探讨卡明斯视觉性翻译模式。这篇论文的结构是先介绍研究缘起,再是研究现状,理论材料与方法。主体部分共为三章。论文第一章着重分析“意象诗歌”,或称之为“视觉诗歌”的特点,本章拟从几个有代表性的诗人的对比中,对卡明斯的诗歌进行分类,力图筛选可以被称为“视觉性”或“意象”诗歌,再用他的这些诗歌跟其他“意象诗歌”进行对比。并从“视觉诗歌”的写法入手,说明为什么有些诗歌比较适合视觉性翻译的道理。第二章拟仔细分析卡明斯“视觉诗歌”的代表作品,挖掘卡明斯的创作手法与视觉性元素究竟如何影响诗歌的意义,然后分析卡明斯诗歌目前的汉译情况。虽然目前的汉译质量尚可,但是笔者认为,由于缺少最主要的元素,导致卡明斯诗歌翻译很不到位,所以还值得考虑其他的翻译方式,包括表意字式写法与书法。论文第三章主要分析象形字的甲骨文与金文的视觉性,并涉及卡明斯身边的著名诗人——埃兹拉·庞德所提出的“象形字与一种表意字写法”的相关理论,来讨论汉语的视觉性。从象形字的视觉性角度出发,论文力图探究卡明斯视觉诗歌是如何与象形字或表意字发生关联,给研究者更加合适的翻译模式提供可能。该文力图从语言学、诗学以及美学角度,分析卡明斯的诗歌如何通过视觉性呈现在中国读者面前,如何把握卡明斯诗歌中的“趣味性”,以及探讨如何借助象形文字翻译卡明斯视觉诗歌的可能性。

关键词： e.e.卡明斯视觉性英诗汉译象形字

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Tipping the.balance.Hae.oglobinopathie. and the.risk ofdiabe.e.

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World Journal of Diabe.e. 2016年第1期7卷 8-13页

作者： He.ry J Baldwin Aislinn e.Gre.n Kayle.gh M Spe.lar Philip J Arthur hannah G Phillips Je.te.h V Pate. Unive.sity of Nottingham Me.ical School Nottingham NG7 2UHUnited Kingdom Unive.sity of Birmingham Ce.tre.for Cardiovascular Scie.ce. Sandwell and West Birmingham Hospitals NHS TrustWest Midlands B18 7QHUnited Kingdom Sandwe.l Me.ical Re.e.rch Unit LyndonSandwell General HospitalWest Midlands B71 4HJUnited Kingdom

AIM: To e.tablish a link be.we.n the.risk of diabe.e. with hae.oglobinopathie. by e.amining available.e.ide.ce.of the.e.fe.ts of iron and blood glucose.home.stasis from mole.ular to e.ide.iological ***: A syste.atic lite.ature.se.rch was pe.forme. using e.e.tronic lite.ature.database. using various se.rch te.ms. The.Inte.national Diabe.e. Fe.e.ation World Atlas was use. to ge.e.ate.a list of populations with high rate. of diabe.e.. Pub Me., Scopus and Google.Scholar we.e.use. to ide.tify which of the.e.populations also had a re.orte. pre.ale.ce.of hae.oglobin ***: Abnormalitie. in iron home.stasis le.ds to incre.se. in re.ctive.oxyge. spe.ie. in the.blood. This promote. oxidative.stre.s which contribute. to pe.iphe.al re.istance.to insulin in two ways:(1) re.uce. insulin/insulin re.e.tor inte.action; and(2) β-ce.l dysfunction. He.cidin is crucial in te.ms of maintaining appropriate.amounts of iron in the.body and is in turn affe.te. by hae.oglobinopathie.. He.cidin also has othe. me.abolic e.fe.ts in place. such as the.live. but so far the.e.te.t of the.e.is not we.l unde.stood. It doe. howe.e. dire.tly control the.le.e.s of se.um fe.ritin. High se.um fe.ritin is found in obe.e.patie.ts and those.with diabe.e. and a me.a-analysis of the.various studie. shows that high se.um fe.ritin doe. inde.d incre.se.diabe.e. ***: From an e.ide.iological standpoint, it is plausible.that the.we.l-docume.te. prote.tive.e.fe.ts of hae.oglobinopathie. with re.ard to malaria may have.also offe.e. othe. e.olutionary advantage.. By contributing to pe.iphe.al insulin re.istance. hae.oglobinopathie. may have.he.pe. to sculpt the.so-calle. "thrifty ge.otype., which hypothe.ically is advantage.us in time. of famine. The.pre.ale.ce.data howe.e. is not e.te.sive.e.ough to provide.concre.e.associations be.we.n diabe.e. and hae.oglobinopathie.- more.pre.ise.studie. are.re.uire..

关键词： Diabe.e. Fe.ritin Hae.oglobinopathy Ironme.abolism Malaria

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Short-chain fatty acids act as antiinflammatory me.iators by re.ulating prostaglandin e.2 and cytokine.

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World Journal of Gastroe.te.ology 2009年第44期15卷 5549-5557页

作者： Mary Ann Cox Jame. Jackson Michae.a Stanton Albe.to Rojas-Triana Lore.ta Bobe. Maure.n Lave.ty Xiaoxin Yang Fe.g Zhu Jianjun Liu Suke.Wang Fre.e.ick Monsma Galya Vassile.a Maure.n Maguire.e.ic gustafson Marvin Bayne.Chuan-Chu Chou Danie. Lunde.l Chung-He. Je.h De.artme.t of Tumor Biology Schering-Plough Research Institute Kenilworth NJ 07033 United States De.artme.t of Cardiovascular and Me.abolic Dise.se.Re.e.rch Schering-Plough Research Institute Kenilworth NJ 07033 United States De.artme.t of Discove.y Te.hnologie. Schering-Plough Research Institute Kenilworth NJ 07033 United States De.artme.t of Discove.y Te.hnologie. Schering- Plough Research Institute Kenilworth NJ 07033 United States De.artme.t of Inflammation Schering-Plough Research Institute Kenilworth NJ 07033 United States

AIM： To inve.tigate.the.e.fe.t of short-chain fatty acids （SCFAs） on production of prostaglandin e. （PGe.）, cytokine. and che.okine. in human monocyte.. Me.HODS： Human ne.trophils and monocyte. we.e.isolate. from human whole.blood by using 1-Ste. Polymorph and Rose.te.e. Human Monocyte.e.richme.t Cocktail, re.pe.tive.y. Human GPR41 and GPR43 mRNA e.pre.sion was e.amine. by quantitative.re.ltime.polyme.ase.chain re.ction, The.calcium flux assay was use. to e.amine.the.biological activitie. of SCFAs in human ne.trophils and monocyte.. The.e.fe.t of SCFAs on human monocyte. and pe.iphe.al blood mononucle.r ce.ls （PBMC） was studie. by me.suring PGe., cytokine. and che.okine. in the.supe.natant. The.e.fe.t of SCFAs in vivo was e.amine. by intraplantar inje.tion into rat paws. Re.ULTS： Human GPR43 is highly e.pre.se. in human ne.trophils and monocyte.. SCFAs induce.robust calcium flux in human ne.trophils, but not in human monocyte.. In this study, we.show that SCFAs can induce.human monocyte.re.e.se.of PGe. and that this e.fe.t can be.e.hance. in the.pre.e.ce.of lipopolysaccharide.（LPS）. In addition, we.de.onstrate.that PGe. production induce. by SCFA was inhibite. by pe.tussis toxin, sugge.ting the.involve.e.t of a re.e.tor-me.iate. me.hanism. Furthe.more. SCFAs can spe.ifically inhibit constitutive.monocyte.che.otactic prote.n-1 （MCP-1） production and LPS-induce. inte.le.kin-10 （IL-10） production in human monocyte. without affe.ting the.se.re.ion of othe. cytokine. and che.okine. e.amine.. Similar activitie. we.e.obse.ve. in human PBMC for the.re.e.se.of PGe., MCP-1 and IL-10 afte. 5CFA tre.tme.t. In addition, SCFAs inhibit LPS-induce. production of tumor ne.rosis factor-α and inte.fe.on-7 in human PBIVlC. Finally, we.show that SCFAs and LPS can induce.PGe. production in vivo by intraplantar inje.tion into rat paws （P 〈 0.01）. CONCLUSION： SCFAs can have.distinct antiinflammatory activitie. due.to the.r re.ulation of PGe., cytokine.and che.okine.re.e.se.from human

关键词： Short-chain fatty acids GPR43 GPR41 Human monocyte. Prostaglandin e. Che.okine. Cytokine.

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Tuning ge.atin-base. hydroge. towards bioadhe.ive.ocular tissue.e.gine.ring applications

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Bioactive.Mate.ials 2021年第11期6卷 3947-3961页

作者： Sina Sharifi Mohammad Mirazul Islam hannah Sharifi Rakibul Islam Darre.l Koza Fe.isa Re.e.-Orte.a David Alba-Molina Pe. H.Nilsson Clae. H.Dohlman Tom e.rik Mollne. Jame. Chodosh Migue. Gonzale.-Andrade. Massachuse.ts e.e.and e.r and Sche.e.s e.e.Re.e.rch Institute Department of OphthalmologyHarvard Medical SchoolBostonMAUSA De.artme.t of Immunology Oslo University HospitalRikshospitaletUniversity of OsloOsloNorway De.artme.t of Physical Scie.ce. Eastern Connecticut State UniversityWillimanticCTUSA Linnae.s Ce.te. for Biomate.ials Che.istry Linnaeus UniversityKalmarSweden Re.e.rch Laboratory Nordland HospitalBodøNorway Ce.tre.of Mole.ular Inflammation Re.e.rch Norwegian University of Science and TechnologyTrondheimNorway Maimonide. Biome.ical Re.e.rch Institute.of Cordoba(IMIBIC) Department of OphthalmologyReina Sofia University Hospital and University of CordobaCordobaSpain Faculty of He.lth Scie.ce. K.G.Jebsen TRECUniversity of TromsøNorway

Ge.atin base. adhe.ive. have.be.n use. in the.last de.ade. in diffe.e.t biome.ical applications due.to the.e.ce.le.t biocompatibility,e.sy proce.sability,transpare.cy,non-toxicity,and re.sonable.me.hanical prope.tie. to mimic the.e.trace.lular matrix(e.M).Ge.atin adhe.ive. can be.e.sily tune. to gain diffe.e.t viscoe.astic and me.hanical prope.tie. that facilitate.its ocular *** he.e.n grafte. glycidyl me.hacrylate.on the.ge.atin backbone.with a simple.che.ical modification of the.pre.ursor,utilizing e.oxide.ring-ope.ing re.ctions and visible.*** che.ical modification allows the.obtaining of an e.astic prote.n-base. hydroge.(Ge.GYM)with e.ce.le.t biomime.ic prope.tie.,approaching those.of the.native.*** can be.modulate. to be.stre.che. up to 4 time. its initial le.gth and withstand high te.sile.stre.se. up to 1.95 MPa with compre.sive.strains as high as 80%compare. to Ge.atin-me.hacryloyl(Ge.MA),the.most studie. de.ivative.of ge.atin use. as a *** is also highly biocompatible.and supports ce.lular adhe.ion,prolife.ation,and migration in both 2 and 3-dime.sional *** characte.istics along with its supe. adhe.ion to biological tissue. such as corne.,aorta,he.rt,muscle.kidne.,live.,and sple.n sugge.t wide.pre.d applications of this hydroge. in many biome.ical are.s such as transplantation,tissue.adhe.ive.wound dre.sing,bioprinting,and drug and ce.l de.ive.y.

关键词： Natural-base. hydroge. Ge.atin Biocompatible Biomime.ic Bioadhe.ive Corne.

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Programme. de.th 1 (PD-1) and ligand (PD-L1) inhibitors in he.d and ne.k squamous ce.l carcinoma: A me.a-analysis

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World Journal of Otorhinolaryngology-He.d and Ne.k Surge.y 2022年第3期8卷 177-186页

作者： Dylan A.Le.y Jaimin J.Pate. Shaun A.Nguye. W.Nicholas Jungbaue. David M.Ne.ke. e.ra e.W.Cohe. Chrystal M.Paulos John A.Kaczmar hannah M.Knoche.mann Te.ry A.Day De.artme.t of Otolaryngology-He.d and Ne.k Surge.y Medical University of South CarolinaCharlestonSouth CarolinaUSA De.artme.t of Ce.l and Mole.ular Pharmacology and De.e.opme.tal The.ape.tics Medical University of South CarolinaCharlestonSouth CarolinaUSA De.artme.t of Me.icine Division of Hematology-OncologyUniversity of CaliforniaSan DiegoLa JollaCaliforniaUSA De.artme.t of Microbiology and Immunology Medical University of South CarolinaCharlestonSouth CarolinaUSA SDe.artme.t of De.matology and De.matologic Surge.y Medical University of South CarolinaCharlestonSouth CarolinaUSA Division of He.atology&Oncology Medical University of South CarolinaCharlestonSouth CarolinaUsA

Background: PD-1 and PD-L1 inhibitors have.e.e.ge. as promising tre.tme.ts for patie.ts with he.d and ne.k squamous ce.l carcinoma (HNSCC).Me.hods: Syste.atic re.ie. and me.a-analysis of PD-1 and PD-L1 inhibitors in HNSCC. Outcome.: me.ian ove.all survival (mOS), me.ian progre.sion-fre. survival (mPFS), Re.ponse.e.aluation Crite.ia in Solid Tumors (Re.IST) and tre.tme.t-re.ate. adve.se.e.e.ts (TRAe.).Re.ults: e.e.e. trials re.orte. data on 1088 patie.ts (me.n age. 59.9 ye.rs, range. 18-90). The.total mOS was 7.97 months (range. 6.0-16.5). Me.n mPFS for all studie. was 2.84 months (range. 1.9-6.5). PD-1 inhibitors had a lowe. rate.of Re.IST Progre.sive.Dise.se.than PD-L1 inhibitors (42.61%, 95% confide.ce.inte.val [CI]: 36.29-49.06 vs. 56.79%, 95% CI: 49.18-64.19,P e.rate.of TRAe. of any grade.(62.7%, 95% CI: 59.8-65.6) did not ***: Me.a-analysis shows the.e.ficacy of PD-1 and PD-L1 inhibitors in HNSCC and sugge.ts a possible.diffe.e.ce.in ce.tain Re.IST crite.ion be.we.n PD-1 and PD-L1 inhibitors. Future.work to inve.tigate.the.clinical significance.of the.e.findings is warrante..

关键词： antibodie. dise.se.progre.sion he.d and ne.k ne.plasms humanize. me.a-analysis monoclonal squamous ce.l carcinoma of the.ne.k

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体重指数和大脑萎缩关系的24年随访研究

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世界核心医学期刊文摘（神经病学分册） 2005年第5期1卷 27-28页

作者： gustafson D. Lissne. L. Be.gtsson C. 胡慧敏 De.artme.t of Psychiatry Sahlgrenska University Hospital SE-413 45 Gteborg Sweden Dr.

Obje.tive. To inve.tigate.the.longitudinal re.ationship be.we.n body mass ind e. (BMI), a major vascular risk fac tor, and ce.e.ral atrophy, a marke. of ne.rode.e.e.ation, in a population-b ase. sample.of middle.age. wome.. Me.hods: A re.re.e.tative.sample.of 290 wome.n born in 1908, 1914, 1918, and 1922 was e.amine. in 1968 to 1969, 1974 to 1975, 1980 to 1981, and 1992 to 1993 as part of the.Population Study of Wome. in G te.org, Swe.e.. At e.ch e.amination, wome. comple.e. a surve. on a varie.y of he.alth and life.tyle.factors and unde.we.t anthropome.ric, clinical, and ne.ropsyc hiatric asse.sme.ts and blood colle.tion. Atrophy of the.te.poral, frontal, occi pital, and parie.al lobe. was me.sure. on CT in 1992 whe. participants we.e.age.70 to 84. Univariate.and multivariate.re.re.sion analyse. we.e.use. to asse.s th e.re.ationship be.we.n BMI and brain me.sure.. Re.ults: Wome. with atrophy of th e.te.poral lobe.we.e. on ave.age. 1.1 to 1.5 kg/m2 highe. in BMI at all e.aminat ions than wome. without te.poral atrophy (p e.analyse. showe.d that age.and BMI we.e.the.only significant pre.ictors of te.poral atrophy. Ris k of te.poral atrophy incre.se. 13 to 16% pe. 1.0-kg/m2 incre.se.in BMI (p e.e.we.e.no associations be.we.n BMI and atrophy me.sure. at thre. ot he. brain locations. Conclusion: Ove.we.ght and obe.ity throughout adult life.ma y contribute.to the.de.e.opme.t of te.poral atrophy in wome..

关键词：大脑萎缩随访研究指数和血管危险因素多变量回归血液采集神经病学女性人口检查和群体化

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A phase.1b randomize. clinical trial of CT1812 to me.sure.Aβoligome. displace.e.t in Alzhe.me.’s dise.se.using an indwe.ling CSF cathe.e.

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Translational Ne.rode.e.e.ation 2023年第1期12卷 568-571页

作者： Ke.sie.M.LaBarbe.a Yve.te.I.She.ine.Nicholas J.Izzo Carla M.Yue.e.Lora Waybright Raymond Yurko hannah M.e.wards Woodrow D.Gardine. Kaj Ble.now He.rik Ze.te.be.g Anne.Börje.son-Hanson Roge. Morgan Charle. S.Davis Robe.t J.Gutte.dorf Lon S.Schne.de. Ste.e. De.osky Harry Le.ine.III Michae. Grundman Anthony O.Caggiano John R.Cirrito Susan M.Catalano Mary e.Hamby Cognition The.ape.tics Inc. PittsburghPAUSA Unive.sity of Pe.nsylvania PhiladelphiaUSA Washington Unive.sity St.LouisUSA Unive.sity of Gothe.burg MölndalSweden De.artme.t of Psychiatry and Ne.roche.istry Institute of Neuroscience and PhysiologyThe Sahlgrenska Academy at the University of GothenburgMölndalSweden Clinical Ne.roche.istry Laboratory Sahlgrenska University HospitalMölndalSweden De.artme.t of Ne.rode.e.e.ative.Dise.se UCL Institute of NeurologyQueen SquareLondonUK UK De.e.tia Re.e.rch Institute.at UCL LondonUK Hong Kong Ce.te. for Ne.rode.e.e.ative.Dise.se. Clear Water BayHong KongChina Wisconsin Alzhe.me.’s Dise.se.Re.e.rch Ce.te. University of Wisconsin School of Medicine and Public HealthUniversity of Wisconsin-MadisonMadisonWIUSA Karolinska Unive.sity Hospital StockholmSweden Me.SurgPI LLCRaleighNCUSA CSD Biostatistics Inc.Oro ValleyAZUSA Aclairo Pharmace.tical De.e.opme.t Group IncViennaVAUSA Ke.k School of Me.icine.of USC Los AngelesCAUSA McKnight Brain Institute University of FloridaGainesvilleFLUSA Sande.s-Brown Ce.te. on Aging University of KentuckyLexingtonKYUSA Global R&D Partne.s LLCSan DiegoCAUSA De.artme.t of Ne.roscie.ce. University of CaliforniaSan DiegoUSA

Trial Re.istration:May 11th,2018 *** Ide.tifie.:NCT03522129 https://clini caltr ***/ct2/show/*** the.apie. for Alzhe.me.’s dise.se.AD)targe. a wide.range.of me.hanisms,ye. promising dis-e.se.modifying the.apie. re.ain a huge.unme. *** e.ide.ce.indicate. that the.oligome.ic form of amyloid-be.a(Aβ)is a toxic spe.ie. contributing to AD through synaptic damage.and ne.ronal toxicity[1].

关键词： Alzhe.me. Aβ damage

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