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How to manage isolated tension non-surgical pneumoperitonium during bronchoscopy?A case report

World Journal of Clinical Cases 2022年第34期10卷 12717-12725页

作者： Yang-Jin Baima Dan-Dan Shi Xing-Ya Shi Li Yang Yun-Tao Zhang Ba-Sang Xiao he-Yan Wang hang-yong he Department of Pulmonary Medicine Lhasa People’s HospitalLhasa 850013Tibet Autonomous RegionChina Department of Critical Care Medicine The Sixth Hospital of GuiyangSchool of Basic MedicineGuizhou University of Traditional Chinese MedicineGuiyang 550002Guizhou ProvinceChina Department of Respiratory and Critical Care Medicine Beijing Institute of Respiratory MedicineBeijing Key Laboratory of Respiratory and Pulmonary CirculationBeijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China

BACKGROUND Tension pneumoperitonium is a rare complication during bronchoscopy that can cause acute respiratory and hemodynamic failure,with fatal *** pneumoperitonium during bronchoscopy usually results from ruptures of the abdominal viscera that need surgical ***-surgical pneumoperitoneum(NSP)refers to some pneumoperitoneum that could be relieved without surgery and only by conservative ***,the clinical experience of managing tension pneumoperitonium during bronchoscopy is limited and *** SUMMARY A 51-year-old female was admitted to our hospital for cough with bloody sputum of seven *** the 8th day of her admission,a bronchoscopy was arranged for bronchial-alveolar lavage to detect possible pathogens in the lower respiratory tract,as oxygen was delivered via a 12 F nasopharyngeal cannula,approximately 5-6 cm from the tip of the catheter,with a flow rate of 5-10 L/*** four minutes of bronchoscopy,the patient suddenly vomited 20 mL of water,followed by severe abdominal pain,while physical examination revealed obvious abdominal distension,as well as hardness and tenderness of the whole abdomen,which was considered pneumoperitonium,and the bronchoscopy was terminated immediately.A computer tomography scan indicated isolated tension pneumoperitonium,and abdominal decompression was performed with a drainage tube,after which her symptoms were relieved.A multidisciplinary expert consultation discussed her situation and a laparotomy was suggested,but finally refused by her *** had no signs of peritonitis and was finally discharged 5 d after bronchoscopy with a good *** The possibility of tension pneumoperitonium during bronchoscopy should be guarded against,and given its serious clinical consequences,cardiopulmonary instability should be treated *** strategies could be adopted according to whether it is complicated with pneumothorax or pneumomediastinum,and the presence of p

关键词： Pneumoperitonium Tension Isolated Non-surgical Bronchoscopy Case report

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Th17 cells are involved in mouse chronic obstructive pulmonary disease complicated with invasive pulmonary aspergillosis

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Chinese Medical Journal 2021年第5期134卷 555-563页

作者： Wan-Ru Geng hang-yong he Qing Zhang Zhao-Hui Tong Department of Respiratory and Critical Care Medicine Beijing Institute of Respiratory MedicineBeijing Chao-Yang HospitalCapital Medical UniversityBeijing 100020China Department of Respiratory Medicine Affiliated Hospital of Inner Mongolia University for the NationalitiesTongliaoInner Mongolia 028000China Department of Respiratory and Critical Care Medicine The Second Hospital of Jilin UniversityChangchunJilin 130041China

Background:The incidence of chronic obstructive pulmonary disease(COPD)complicated with invasive pulmonary aspergillosis(IPA)has increased in the last two *** mechanism underpinning susceptibility to and high mortality of COPD complicated with IPA is unclear,and the role of T helper cells 17(Th17 cells)in the compound disease remains ***,this study aimed to assess the function of Th17 cells in COPD combined with ***:COPD,IPA,and COPD+IPA mouse models were established in male wild type C57/BL6 *** amounts of Th17 cells and retinoic acid-related orphan receptorsγt(RORyt)were tested by flow ***,serum interleukin(IL)-17 and *** were detected by enzyme-linked immunosorbent assay(ELISA)in the control,COPD,IPA and COPD+IPA *** addition,COPD+IPA was induced in IL-17 knockout(KO)mice,for determining the role of Th17 cells in COPD+***:Compared with the COPD group,the COPD+IPA group showed higher amounts of blood RORyt([35.09±16.12]%vs.[17.92±4.91]%,P=0.02)and serum IL-17(17.96±9.59 pg/mL vs.8.05±4.44 pg/mL,P=0.02),but blood([5.18±1.09]%vs.[4.15±0.87]%,P=0.28)and lung levels of Th17 cells(1.98±0.83]%vs.[2.03±0.98]%,P=0.91),lung levels of RORyt([9.58±6.93]%vs.[9.63±5.98]%,P=0.49)and serum IL-23(51.55±27.82 pg/mL us.68.70±15.20 pg/mL,P=0.15)showed no significant *** with the IPA group,the COPD+IPA group displayed lower amounts of blood([5.18±1.09]%vs.[9.21±3.56]%,P=0.01)and lung Th17 cells([1.98±0.83]%vs.[6.29±1.11]%,P=0.01)and serum IL-23(51.55±27.82 pg/mL vs.154.90±64.60 pg/mL,P=0.01)and IL-17(17.96±9.59 pg/mL uUs.39.81±2.37 pg/mL,P=0.02),while comparable blood([35.09±16.12]%Vs.[29.86±15.42]%,P=0.25)and lung levels of RORγt(9.58±6.93]%VUS,[15.10±2.95]%,P=0.18)were found in these two ***,Aspergillus load in IL-17 KO COPD+IPA mice was almost 2 times that of COPD+IPA mice(1,851,687.69±944,480.43"vs.892,958.10±686,808.80,t=2.32,P=0.02).Conclusion:These findings indicate that Th17 cells

关键词： T helper cells 17 Chronic obstructive pulmonary disease(COPD) Invasive pulmonary aspergillosis(IPA)

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Should we initiate vasopressors earlier in patients with septic shock: A mini systemic review

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World Journal of Critical Care Medicine 2023年第4期12卷 204-216页

作者： hang-Xiang Zhou Chun-Fu Yang he-Yan Wang Yin Teng hang-yong he Department of Critical Care Medicine Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Critical Care Medicine The Sixth Hospital of GuiyangGuiyang 550002Guizhou ProvinceChina Department of Respiratory Medicine The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang 550002Guizhou ProvinceChina School of Basic Medicine Guizhou University of Traditional Chinese MedicineGuiyang 550002Guizhou ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina Department of Respiratory and Critical Care Medicine Beijing Chao-Yang HospitalBeijing 100020China Beijing Institute of Respiratory Medicine Beijing Chao-Yang HospitalBeijing 100020China Beijing Key Laboratory of Respiratory and Pulmonary Circulation Beijing Chao-Yang HospitalBeijing 100020China

Septic shock treatment remains a major challenge for intensive care units,despite the recent prominent advances in both management and *** serve as a cornerstone of septic shock therapy,but there is still controversy over the timing of ***,it remains unclear whether vasopressors should be used early in the course of ***,we provide a systematic review of the literature on the timing of vasopressor *** was systematically identified through PubMed,Embase and Cochrane searching according to PRISMA *** studies met the eligibility criteria and were included in the *** pathophysiological basis for early vasopressor use was classified,with the exploration on indications for the early administration of mono-vasopressors or their combination with vasopressin or *** found that mortality was 28.1%-47.7%in the early vasopressors group,and 33.6%-54.5%in the control *** also investigated the issue of vasopressor ***,we acknowledged the subsequent challenge of administration of high-dose norepinephrine via peripheral veins with early vasopressor *** on the literature review,we propose a possible protocol for the early initiation of vasopressors in septic shock resuscitation.

关键词： Septic shock Resuscitation Vasopressor Norepinephrine Vasopressin Timing

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3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

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Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying Hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong Li Yuewei Chen Nian Liu Jing he Jue Shi Zihe Hu Yanyan Zhou Zhijian Xie yong he State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

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Stability and Stabilization of Sampled-Data Based LFC for Power Systems:A Data-Driven Method

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 291-293页

作者： Yu-Long Fan Chuan-Ke Zhang yong he the School of Automation China University of Geosciences the Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems the Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education IEEE

Dear Editor,This letter is concerned with stability analysis and stabilization design for sampled-data based load frequency control(LFC) systems via a data-driven method. By describing the dynamic behavior of LFC systems based on a data-based representation, a stability criterion is derived to obtain the admissible maximum sampling interval(MSI) for a given controller and a design condition of the PI-type controller is further developed to meet the required MSI. Finally, the effectiveness of the proposed methods is verified by a case study.

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Positive effect of Mo on mechanical properties of a Ni-42W-10Co-x Mo medium heavy alloy

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China Foundry 2025年

作者： Guo-xin Cao Jian-xin Dong yong-sheng he he Jiang Fang Hao Zhi-hua Nie Teng-fei Ma Bao-quan Fu School of Materials Science and Engineering University of Science and Technology Beijing Xi'an Superalloy Technology Co. Ltd. School of Materials Science and Engineering Beijing Institute of Technology Key Laboratory of Air-driven Equipment Technology of Zhejiang Province Quzhou University

In this study,a novel Ni-W-Co-Mo medium heavy alloy (MHA) was designed to improve its mechanical strength via Mo *** the Ni-42W-10Co-xM o alloy series,where x represents the weight percent of Mo and varies between 0,1,2,5,and 10,the microstructure transitions from a dendritic structure to a hypoeutectic structure as the Mo content increases from 0 to 5wt.%.Moreover,as the Mo content increases from 0to 10wt.%,the distribution of theμ-phase shifts from being individually dispersed to forming aggregates,and its volume fraction rises from 0.5%to 7.9%.Notably,theμ-phase evolves into an eutectic microstructure,which helps in minimizing the segregation of *** change is accompanied by a substantial enhancement in mechanical properties;specifically,the compressive yield strength at room temperature increases from 350 MPa to 646 MPa,indicating a significant 85%***,the microhardness increases from 230 HV to 304 *** dynamics simulations further reveal that the strengthening mechanism of Ni-42W-10Co-xM o alloys is Mo-induced solid solution strengthening and precipitation strengthening.

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Protective effects of total triterpenoids of Prunella Vulgaris L.(TTP) against carbon tetrachloride—induced acute liver injury in rats

Protective effects of total triterpenoids of Prunella Vulgar...

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全国第十二届生化与分子药理学学术会议

作者： Shengpeng Zhang,Jun Li,Cheng hang,Jiali Xie,yong he College of Pharmacy,Anhui Medical University Key Laboratory of Natural Product Bioactivity of Anhui Province Three—level Laboratory of Scientific Research of Traditional Chinese Medicine of State Administration of Traditional Chinese Medicine of People’s Republic of China"Pharmacology of Traditional Chinese Medicine", hefei,Anhui 230032,China

OBJECTIVE:To investigate the hepatoprotective effect of total triterpenoids of Prunella vulgaris L.(TTP)(on ***:Sixty rats were randomly divided into six groups as follows:control group,CC

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High-entropy intermetallics:from alloy design to structural and functional properties

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Rare Metals 2022年第6期41卷 1989-2001页

作者： hang Wang Quan-Feng he yong Yang Department of Mechanical Engineering City University of Hong KongHong Kong 999077China Department of Materials Science and Engineering.City University of Hong Kong Hong Kong 999077China Department of Advanced Design and System Engineering.City University of Hong Kong Hong Kong 999077China

Conventional intermetallics are strong but ***,multi-principal element intermetallics,also termed as high-entropy intermetallics(heIs)in the recent high-entropy alloy literature,are strong but malleable,some of which even show appreciable ductility and fracture toughness at room *** this article,we provide a focused review on the recent researches on heIs,from the fundamentals,such as the concept of heIs,the formation rules to the structural and functional properties of *** results hitherto reported clearly show that the heIs with distinct properties could be a promising material for future structural and functional applications.

关键词： Internetallics High-entropy alloys Phase formation Mechanical properties Functional properies

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Properties of the phase diagram from the Nambu-Jona-Lasino model with a scalar-vector interaction

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Nuclear Science and Techniques 2024年第10期35卷 168-179页

作者： yong-hang Yang he Liu Peng-Cheng Chu Science School Qingdao University of TechnologyQingdao 266520China The Research Center of Theoretical Physics Qingdao University of TechnologyQingdao 266033China

We investigated the properties of the phase diagram of high-order susceptibilities,speed of sound,and polytropic index based on an extended Nambu-Jona-Lasinio model with an eight-quark scalar-vector ***-monotonic behavior was observed in all these quantities around the phase transition boundary,which also revealed the properties of the critical ***,this study indicated that the chiral phase transition boundary and critical point could vary depending on the scalarvector coupling constant G_(SV).At finite densities and temperatures,the negative G_(SV)term exhibited attractive interactions,which enhanced the critical point temperature and reduced the chemical *** G_(SV)term also affected the properties of the high-order susceptibilities,speed of sound,and polytropic index near the critical *** non-monotonic(peak or dip)structures of these quantities shifted to a low baryon chemical potential(and high temperature)with a negative G_(SV).G_(SV)also changed the amplitude and range of the nonmonotonic ***,the scalar-vector interaction was useful for locating the phase boundary and critical point in QCD phase diagram by comparing the experimental *** study of the non-monotonic behavior of high-order susceptibilities,speed of sound,and polytropic index is of great interest,and further observations related to high-order susceptibilities,speed of sound,and polytropic index being found and applied to the search for critical points in heavy-ion collisions and the study of compact stars are eagerly awaited.

关键词： QCD phase diagram High-order susceptibilities Speed of sound Polytropic index NJL model

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Epigenetics in the modern era of crop improvements

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Science China Life Sciences 2025年

作者： Yan Xue Xiaofeng Cao Xiangsong Chen Xian Deng Xingwang Deng yong Ding Aiwu Dong Chengguo Duan Xiaofeng Fang Lei Gong Zhizhong Gong Xiaofeng Gu Chongsheng he hang he Shengbo he Xinjian he Yan he Yuehui he Guifang Jia Danhua Jiang Jianjun Jiang Jinsheng Lai Zhaobo Lang Chenlong Li Qing Li Xingwang Li Bao Liu Bing Liu Xiao Luo Yijun Qi Weiqiang Qian Guodong Ren Qingxin Song Xianwei Song Zhixi Tian Jiawei Wang Yuan Wang Liang Wu Zhe Wu Rui Xia Jun Xiao Lin Xu Zhengyi Xu Wenhao Yan Hongchun Yang Jixian Zhai Yijing Zhang Yusheng Zhao Xuehua Zhong Daoxiu Zhou Ming Zhou Yue Zhou Bo Zhu Jiankang Zhu Qikun Liu College of Life Sciences Institute of Life Science and Green Development Hebei University Biotechnology Research Institute Chinese Academy of Agricultural Sciences College of Biology Hunan Key Laboratory of Plant Functional Genomics and Developmental Regulation Hunan Engineering and Technology Research Center of Hybrid Rapeseed Hunan University Institute of Advanced Agricultural Sciences School of Advanced Agricultural Sciences Peking University State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural University National Institute of Biological Sciences Key Laboratory of Seed Innovation Institute of Genetics and Developmental Biology Chinese Academy of Sciences School of Advanced Agricultural Sciences Peking-Tsinghua Center for Life Sciences Peking University Synthetic and Functional Biomolecules Center Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education College of Chemistry and Molecular Engineering Peking University Key Laboratory of Seed Innovation State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences State Key Laboratory of Wheat Improvement Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences in Weifang State Key Laboratory of Crop Stress Adaptation and Improvement School of Life Sciences Henan University State Key Laboratory of Maize Bio-breeding National Maize Improvement Center Department of Plant Genetics and Breeding China Agricultural University Frontiers Science Center for Molecular Design Breeding China Agricultural University Center for Crop Functional Genomics and Molecular Breeding China Agricultural University Sanya Institute of China Agricultural University Hainan Yazhou Bay Seed Laboratory Institute of Advan

Epigenetic mechanisms are integral to plant growth, development, and adaptation to environmental stimuli. Over the past two decades,our comprehension of these complex regulatory processes has expanded remarkably, producing a substantial body of knowledge on both locus-specific mechanisms and genome-wide regulatory patterns. Studies initially grounded in the model plant Arabidopsis have been broadened to encompass a diverse array of crop species, revealing the multifaceted roles of epigenetics in physiological and agronomic traits. With recent technological advancements, epigenetic regulations at the single-cell level and at the large-scale population level are emerging as new focuses. This review offers an in-depth synthesis of the diverse epigenetic regulations, detailing the catalytic machinery and regulatory functions. It delves into the intricate interplay among various epigenetic elements and their collective influence on the modulation of crop traits. Furthermore, it examines recent breakthroughs in technologies for epigenetic modifications and their integration into strategies for crop improvement. The review underscores the transformative potential of epigenetic strategies in bolstering crop performance, advocating for the development of efficient tools to fully exploit the agricultural benefits of epigenetic insights.

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