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Additional comments on extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis

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World Journal of Stem Cells 2024年第7期16卷 739-741页

作者： hang pei Yi Zhang Chao Wang Bang-Jian He The First School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Orthopaedics Anji County Hospital of Chinese MedicineAnji 313300Zhejiang ProvinceChina Department of Orthopedics The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina

Recently,we read an article published by the Yang et *** results of this study indicated that engineered exosomes loaded with microRNA-29a(miR-29a)alleviate knee inflammation and maintain extracellular matrix stability in Sprague Dawley *** study’s results provide useful information for treating knee osteoarthritis(KOA).This letter,shares our perspectives on treating KOA using engineered exosomes for miR-29a.

关键词： Exosomes Intra-articular injection Mesenchymal stem cells MicroRNA-29a Osteoarthritis

Additional comments on foot reflexology treatment for sensorineural hearing loss in infant

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World Journal of Clinical Cases 2024年第30期12卷 6407-6409页

作者： Yi Zhang hang pei Bang-Jian He The First School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina Department of Orthopedics The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310006Zhejiang ProvinceChina

Currently,treatment options for infant sensorineural hearing loss(SNHL)are *** article describes a novel case of SNHL in an infant successfully treated with foot reflexology,along with observed brain activity changes before and after treatment,as indicated by functional magnetic resonance ***,this commentary discusses the case and our viewpoints regarding foot reflexology for treating SNHL.

关键词： Foot reflexology treatment Sensorineural hearing loss Infant Comment

A Coordinate-Free Approach to the Design of Generalized Griffis-Duffy Platforms

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 95-103页

作者： Chengwei Shen Xu pei Lubin hang Jingjun Yu College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityHangzhou 311300China School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China School of Mechanical and Automotive Engineering Shanghai University of Engineering ScienceShanghai 201620China

Architectural singularity belongs to the Type II singularity,in which a parallel manipulator(PM)gains one or more degrees of freedom and becomes *** remaining permanently in a singularity are beneficial for linearto-rotary motion ***-Duffy(GD)platform is a mobile structure admitting a Bricard *** this paper,we present a coordinate-free approach to the design of generalized GD platforms,which consists in determining the shape and attachment of both the moving platform and the fixed *** generalized GD platform is treated as a combination of six coaxial single-loop mechanisms under the same *** to the inversion,hidden in the geometric structure of these single-loop mechanisms,the mapping from a line to a circle establishes the geometric transformation between the fixed base and the moving platform based on the center of inversion,and describes the shape and attachment of the generalized GD ***,the center of inversion not only identifies the location of rotation axis,but also affects the shape of the platform mechanism.A graphical construction of generalized GD platforms using inversion,proposed in the paper,provides geometrically feasible solutions of the manipulator design for the requirement of the location of rotation axis.

关键词： Generalized Griffis-Duffy platforms Self-motion Inversion Coordinate-free determination Manipulator design

Active digital spoof plasmonics

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National Science Review 2020年第2期7卷 261-269页

作者： Hao Chi Zhang Tie Jun Cui Yu Luo Jingjing Zhang Jie Xu pei hang He Le Peng Zhang State Key Laboratory of Millimeter Waves Southeast University The Photonics Institute and Centre for Optoelectronics and Biophotonics School of Electrical and Electronic Engineering Nanyang Technological University

Digital coding and digital modulation are the foundation of modern information science. The combination of digital technology with metamaterials provides a powerful scheme for spatial and temporal controls of electromagnetic waves. Such a technique, however, has thus far been limited to the control of free-space light. Its application to plasmonics to shape subwavelength fields still remains elusive. Here, we report the design and experimental realization of a tunable conformal plasmonic metasurface, which is capable of digitally coding and modulating designer surface plasmons at the deep-subwavelength scale. Based on dynamical switching between two discrete dispersion states in a controlled manner, we achieve digital modulations of both amplitude and phase of surface waves with nearly 100% modulation depth on a single device. Our study not only introduces a new approach for active dispersion engineering, but also constitutes an important step towards the realization of subwavelength integrated plasmonic circuits.

关键词： digital coding digital modulation plasmonics digital metamaterials

A plasmonic route for the integrated wireless communication of subdiffraction-limited signals

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Light(Science & Applications) 2020年第1期9卷 930-938页

作者： Hao Chi Zhang Le Peng Zhang pei hang He Jie Xu Cheng Qian Francisco J.Garcia-Vidal Tie Jun Cui State Key Laboratory of Millimeter Waves Southeast University210096 NanjingChina Departamento de Fisica Teorica de la Materia Condensada and Condensed Matter Physics Center(IFIMAC) Universidad Autonoma de MadridMadridSpain Donostia International Physics Center(DIPC) Donostia/San SebastianSpain

Perfect lenses,superlenses and time-reversal mirrors can support and spatially separate evanescent waves,which is the basis for detecting subwavelength information in the far ***,the inherent limitations of these methods have prevented the development of systems to dynamically distinguish subdiffraction-limited *** the physical merits of spoof surface plasmon polaritons(SPPs),we demonstrate that subdiffraction-limited signals can be transmitted on planar integrated SPP channels with low loss,low channel interference,and high gain and can be radiated with a very low environmental ***,we show how deep subdiffraction-limited signals that are spatially coupled can be distinguished after line-of-sight wireless *** a visualized demonstration,we realize the high-quality wireless communication of two movies on subwavelength channels over the line of sight in real time using our plasmonic scheme,showing significant advantages over the conventional methods.

关键词： communication spatially diffraction

Integrated spoof plasmonic circuits

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Science Bulletin 2019年第12期64卷 843-855页

作者： Jingjing Zhang Hao-Chi Zhang Xin-Xin Gao Le-Peng Zhang Ling-Yun Niu pei-hang He Tie-Jun Cui State Key Laboratory of Millimeter Waves Southeast University

Using a metamaterial consisting of metals with subwavelength surface patterning, one can mimic surface plasmon polaritons(SPPs) and achieve surface waves with subwavelength confinement at microwave and terahertz frequencies, thus bringing most of the advantages associated with the optical SPPs to lower frequencies. Due to the properties of strong field confinement and high local field intensity, spoof SPPs have demonstrated the improved performance for data transmission and device miniaturization in an intensively integrated environment. The distinctive abilities, such as suppression of transmission loss and bending loss, and increase of signal integrity, make spoof SPPs a promising candidate for future generation of electronic circuits and electromagnetic systems. This article reviews the progress in spoof SPPs with a special focus on their applications in circuits from transmission lines to passive and active devices in microwave and terahertz regimes. The integration of versatile spoof SPP devices on a single platform,which is compatible with established electronic circuits, is also discussed.

关键词： Spoof surface plasmons Metamaterial Electromagnetic system Integrated circuits

Preparation of TiO_(2) Nano-Flower Coating on Ti Substrates with Good Physical Sterilization Effect and Biocompatibility

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Acta Metallurgica Sinica(English Letters) 2024年第9期37卷 1581-1589页

作者： Ruoyu Di Yonghua Sun Runhua Yao Sen pei Xiaohong Yao Ruiqiang hang Shanxi Key Laboratory of Biomedical Metal Materials College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan030024China College of Safety and Emergency Management Engineering Taiyuan University of TechnologyTaiyuan030024China

We report a facile solution method to form titanium oxide(TiO_(2))nano-flower structure on the titanium(Ti)substrates for realizing good physical sterilization and *** first prepare TiO_(2) nanotubes(NT)with a diameter of about 80-100 nm and a length of about 5μm on Ti substrates by anodization,which is utilized as ***,we employ immersion treatment in different concentrations of phosphoric acid solution at 75℃ for 5 h to realize the transformation from TiO_(2) NT to TiO_(2) nano-flower *** addition,we studied the effects of phosphoric acid concentration(1 wt%,2.5 wt%,5 wt% and 10 wt%)on the TiO_(2) nano-flower structure,and the antibacterial properties and biocompatibility of the TiO_(2) nano-flower *** results show that TiO_(2) nano-flower structure become larger and thicker with the increase in the phosphoric acid concentration,and the thickness of the coating can reach 6.88μ***,the TiO_(2) nano-flower structure shows good physical sterilization effect,especially for the TiO_(2) nano-flower structure formed in 10 wt%H^(3)PO_(4) solution,the antibacterial rate can reach 95%.In addition,the TiO_(2) nano-flower structure have no toxicity to the osteoblasts and support cell growth.

关键词： Anodization Biocompatibility Physical sterilization TiO_(2)nano-flower

A single nucleotide polymorphism in the IL1RL1 gene is associated with Behcet's disease in a Chinese Han population

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International Journal of Ophthalmology(English edition) 2021年第9期14卷 1315-1320页

作者： Xin-Shu Liu Zi-Yan Wu Si Chen Chan Zhao Fei Gao Ming-hang pei Shan-Shan Jia Yong-Zhe Li pei-Zeng Yang Mei-Fen Zhang Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Rheumatology and Clinical Immunology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeKey Laboratory of Rheumatology and Clinical ImmunologyMinistry of EducationBeijing 100730China Department of Clinical Laboratory Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China Department of Clinical Laboratory Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100730China The First Affiliated Hospital of Chongqing Medical University Chongqing Key Laboratory of Ophthalmology and Chongqing Eye InstituteChongqing 400016China

AIM:To explore the association of single nucleotide polymorphisms(SNPs)in the IL33/IL1RL1 gene region with the susceptibility to Behcet’s disease(BD)in a Chinese Han ***:A total of eight SNPs in the candidate gene region(rs11792633,rs7025417,rs10975519 and rs1048274 in IL33;rs2310220,rs12712142,rs13424006 and rs3821204 in IL1RL1)were genotyped in783 BD patients and 701 healthy controls by the Sequenom Mass Array i PLEX ***:A statistically significant association was observed between IL1RL1 rs12712142 and BD *** frequency of IL1RL1 rs12712142 variant allele A was significantly lower in BD patients than that in controls(OR=0.8,95%CI:0.69-0.94,Pc=0.039);the genotype distribution(Pc=0.043)and additive and dominant genetic model analyses(OR=0.8,95%CI:0.69-0.94,Pc=0.040 and OR=0.72,95%CI:0.58-0.88,Pc=0.011)also indicated a strong association between rs12712142 and BD ***:This is the first study to reveal the association between IL1RL1 rs12712142 variant allele A and the decreased risk of BD in the Chinese Han population,indicating a protective role of IL1RL1 in the pathogenesis of BD.

关键词： Behcet’s disease single nucleotide polymorphism Chinese Han population IL33 IL1RL1

Spatially selective p-type doping for constructing lateral WS_(2) p-n homojunction via low-energy nitrogen ion implantation

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Light(Science & Applications) 2024年第6期13卷 1159-1169页

作者： Yufan Kang Yongfeng pei Dong He hang Xu Mingjun Ma Jialu Yan Changzhong Jiang Wenqing Li Xiangheng Xiao School of Physics and Technology Key Lab of Artificial Micro-and Nano-Structures of Ministry of EducationWuhan UniversityWuhanChina

The construction of lateral p-n junctions is very important and challenging in two-dimensional(2D)semiconductor manufacturing *** researches have demonstrated that vertical p-n junction can be prepared simply by vertical stacking of 2D ***,interface pollution and large area scalability are challenges that are difficult to overcome with vertical stacking *** 2D lateral p-n homojunction is an effective strategy to address these *** selective p-type doping of 2D semiconductors is expected to construct lateral p-n *** this work,we have developed a low-energy ion implantation system that reduces the implanted energy to 300 ***-energy implantation can form a shallow implantation depth,which is more suitable for modulating the electrical and optical properties of 2D ***,we utilize low-energy ion implantation to directly dope nitrogen ions into few-layer WS_(2) and successfully realize a precise regulation for WS_(2) with its conductivity type transforming from n-type to bipolar or even p-type ***,the universality of this method is demonstrated by extending it to other 2D semiconductors,including WSe_(2),SnS_(2) and MoS_(2).Based on this method,a lateral WS_(2) p-n homojunction is fabricated,which exhibits significant rectification characteristics.A photodetector based on p-n junction with photovoltaic effect is also prepared,and the open circuit voltage can reach to 0.39 *** work provides an effective way for controllable doping of 2D semiconductors.

关键词： implantation doping Spatial