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Complete kinetic model for esterification reaction of lauric acid with glycerol to synthesize glycerol monolaurate

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Chinese Journal of Chemical Engineering 2024年第6期70卷 211-221页

作者： han-Qiao hu Yue Zhang Ming Fan Yong Cai Guang-Wen Chu Liang-Liang Zhang Research Center of the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Petrochemical Research Institute China National Petroleum CorporationBeijing 102206China

Glycerol monolaurate(GML)is a widely used industrial chemical with excellent emulsification and antibacterial *** direct esterification of glycerol with lauric acid is the main method to synthesize *** this work,the kinetic process of direct esterification was systematically studied using p-toluenesulfonic acid as catalyst.A complete kinetic model of consecutive esterification reaction has been established,and the kinetic equation of acid catalysis was *** isomerization reactions of GML and glycerol dilaurate were *** was found that the reaction was an equilibrium reaction and the reaction rate was faster than the esterification *** kinetic equations of the consecutive esterification reaction were obtained by experiments as k1=(276+92261Xcat)exp(-37720/RT)and k2=(80+4413Xcat)exp(-32240/RT).The kinetic results are beneficial to the optimization of operating conditions and reactor design in GML production process.

关键词： Glycerol monolaurate p-Toluenesulfonic acid Esterification Kinetics Mass transfer

Advances in the study of mitophagy in osteoarthritis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第3期25卷 197-211页

作者： Hong CAO Xuchang ZHOU Bowen XU han hu Jianming GUO Miao WANG Nan LI Jun ZOU Department of Sport Rehabilitation Shanghai University of SportShanghai 200438China National Key Laboratory of Immunity and Inflammation Naval Medical UniversityShanghai 200433China School of Sport Medicine and Rehabilitation Beijing Sport UniversityBeijing 100084China

Osteoarthritis(OA),characterized by cartilage degeneration,synovial inflammation,and subchondral bone remodeling,is among the most common musculoskeletal disorders globally in people over 60 years of *** initiation and progression of OA involves the abnormal metabolism of chondrocytes as an important pathogenic *** degeneration features mitochondrial dysfunction as one of the important causative factors of abnormal chondrocyte ***,maintaining mitochondrial homeostasis is an important strategy to mitigate *** is a vital process for autophagosomes to target,engulf,and remove damaged and dysfunctional mitochondria,thereby maintaining mitochondrial *** studies have revealed a strong association between mitophagy and OA,suggesting that the regulation of mitophagy may be a novel therapeutic direction for *** reviewing the literature on mitophagy and OA published in recent years,this paper elaborates the potential mechanism of mitophagy regulating OA,thus providing a theoretical basis for studies related to mitophagy to develop new treatment options for OA.

关键词： Mitophagy Osteoarthritis Chondrocyte Mitochondria Apoptosis

Advances in the study of protein folding and endoplasmic reticulum-associated degradation in mammal cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第3期25卷 212-232页

作者： Hong CAO Xuchang ZHOU Bowen XU han hu Jianming GUO Yuwei MA Miao WANG Nan LI Jun ZOU Department of Sport Rehabilitation Shanghai University of SportShanghai 200438China National Key Laboratory of Immunity and Inflammation Naval Medical UniversityShanghai 200433China

The endoplasmic reticulum is a key site for protein production and quality *** than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic ***,during protein folding,unfolded and/or misfolded proteins are prone to occur,which may lead to endoplasmic reticulum *** can monitor the quality of the proteins produced by endoplasmic reticulum quality control(ERQC)and endoplasmic reticulum-associated degradation(ERAD),which maintain endoplasmic reticulum protein homeostasis by degrading abnormally folded *** underlying mechanisms of protein folding and ERAD in mammals have not yet been fully ***,this paper reviews the process and function of protein folding and ERAD in mammalian cells,in order to help clinicians better understand the mechanism of ERAD and to provide a scientific reference for the treatment of diseases caused by abnormal ERAD.

关键词： Endoplasmic reticulum-associated degradation(ERAD) Protein folding Ubiquitination Retrotranslocation

General anesthetic agents induce neurotoxicity through oligodendrocytes in the developing brain

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Zoological Research 2024年第3期45卷 691-703页

作者： Wen-Xin hang Yan-Chang Yang Yu-han hu Fu-Quan Fang Lang Wang Xing-hua Qian Patrick M.McQuillan hui Xiong Jian-hang Leng Zhi-Yong hu Department of Anesthesiology First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310003China Department of Cell Biology Yale UniversityNew HavenCT 06520USA Department of Neurology of the First Affiliated Hospital Interdisciplinary Institute of Neuroscience and TechnologySchool of Brain Science and Brain MedicineZhejiang University School of MedicineHangzhouZhejiang 310027China Department of Anesthesiology Jiaxing Maternity and Childcare Health HospitalJiaxingZhejiang 314009China Department of Anesthesiology Penn State Hershey Medical CentrePenn State College of MedicineHersheyPA 17033USA Department of Central Laboratory Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang 310006China

General anesthetic agents can impact brain function through interactions with neurons and their effects on glial *** perform essential roles in the central nervous system,including myelin sheath formation,axonal metabolism,and neuroplasticity *** are particularly vulnerable to the effects of general anesthetic agents resulting in impaired proliferation,differentiation,and *** are increasingly interested in the effects of general anesthetic agents on *** agents not only act on the surface receptors of oligodendrocytes to elicit neuroinflammation through modulation of signaling pathways,but also disrupt metabolic processes and alter the expression of genes involved in oligodendrocyte development and *** this review,we summarize the effects of general anesthetic agents on *** anticipate that future research will continue to explore these effects and develop strategies to decrease the incidence of adverse reactions associated with the use of general anesthetic agents.

关键词： Oligodendrocytes General anesthetic agents Neurotoxicity Central nervous system Perioperative neurocognitive disorders

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面向方面情感分析的多通道增强图卷积网络

电子与信息学报 2024年第3期46卷 1022-1032页

作者：韩虎范雅婷徐学锋兰州交通大学电子与信息工程学院兰州730070

传统的基于单通道的特征提取方式,仅使用单一的依赖关系捕获特征,忽略单词间的语义相似性与依赖关系类型信息。尽管基于图卷积网络进行方面情感分析的方法已经取得一定成效,但始终难以同时聚合节点的语义信息和句法结构特征,在整个迭代... 详细信息

传统的基于单通道的特征提取方式,仅使用单一的依赖关系捕获特征,忽略单词间的语义相似性与依赖关系类型信息。尽管基于图卷积网络进行方面情感分析的方法已经取得一定成效,但始终难以同时聚合节点的语义信息和句法结构特征,在整个迭代训练过程中最初的语义特征会逐渐遗失,影响句子最终的情感分类效果。由于缺乏先验知识会导致模型对相关情感词的误解,因此需要引入外部知识来丰富文本信息。目前,如何利用图神经网络(GNN)融合句法和语义特征的方式仍值得深入研究。针对上述问题,该文提出一种多通道增强图卷积网络模型。首先,通过对情感知识和依赖类型增强的句法图进行图卷积操作,得到基于语法的两种表示,与经过多头注意力和图卷积学习到的语义表示进行融合,使多通道的特征能够互补学习。实验结果表明,在5个公开数据集上,准确率和宏F1值优于基准模型。由此可见,依赖类型和情感知识均对增强句法图有重要影响,表明融合语义信息与句法结构的有效性。

关键词：方面情感分析图卷积网络情感知识依赖关系嵌入多头注意力

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散杂居情景下文化适应的地理因素分析——基于豫北社亲文化的研究

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热带地理 2024年第4期44卷 733-745页

作者：聂桂博胡涵艾少伟河南大学黄河文明与可持续发展研究中心/黄河文明省部共建协同创新中心河南开封475001 广东理工学院电气与电子工程学院广东肇庆526100

文化适应研究需要同时考虑人和地2个方面的因素,关注“地理因素”的分析是一个重要的研究方向。为了分析黄河流域中下游地区散杂居情景下社亲文化的产生原因及地理因素在文化适应过程中的作用,以豫北地区的社亲文化为案例,采用文献法、... 详细信息

文化适应研究需要同时考虑人和地2个方面的因素,关注“地理因素”的分析是一个重要的研究方向。为了分析黄河流域中下游地区散杂居情景下社亲文化的产生原因及地理因素在文化适应过程中的作用,以豫北地区的社亲文化为案例,采用文献法、参与观察与半结构访谈等研究方法,对2组文化适应案例进行分析。研究发现:1)豫北不同群体间的社亲文化是在特定的散杂居地理情景下形成的。豫北地区特殊的地理环境、地理区位是社亲村落之间交流的前提,而特定距离范围内的祈雨仪式路线和共同的信仰是维系社亲联系、延续社亲文化的纽带。2)社亲双方在发展过程中基本遵循“分离、碰撞、汇融、延续”的文化适应过程,在维护基层团结、实现社会稳定的过程中,“整合策略”在这种特有的文化适应形式中发挥了重要作用。3)在文化适应的不同阶段,不同的地理要素所发挥的作用不同。对于社亲双方而言,空间距离和文化距离都需在特定范围内才能维系社亲文化。4)在散杂居情景下,同一文化群体与不同村落群体的交流中均采取“整合策略”实现了较好的文化适应效果,拓展了文化适应在特定情景下的适用范围。

关键词：地理要素文化适应整合假设社亲文化豫北地区

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多模态学习的研究进展与趋势:跨学科的透视

黑龙江高教研究 2024年第6期42卷 148-154页

作者：胡翰林冯瑞西南大学重庆400715

多模态学习注重信息的多样存在形式以及多种感知通道对认知与学习过程的积极影响,在智能技术助力教与学的时代具有重要价值,系统性地梳理多模态学习相关研究是其进一步理论与实践研究的关键。首先,从不同多模态学习的来源出发进行概念辨... 详细信息

多模态学习注重信息的多样存在形式以及多种感知通道对认知与学习过程的积极影响,在智能技术助力教与学的时代具有重要价值,系统性地梳理多模态学习相关研究是其进一步理论与实践研究的关键。首先,从不同多模态学习的来源出发进行概念辨析,并提出多模态学习的概念内涵;其次,从三个学科视角分析多模态学习的研究进展,即计算机科学视角的多模态数据表示、融合、对齐以及应用等研究,认知心理学视角的信息加工、学习注意以及数据采集等研究,教育学视角的多模态学习环境、学习分析以及学习效果等研究。最后,提出多模态学习的研究趋势,即推进多模态学习跨学科融合研究、优化多模态数据中的异质性、强化多模态学习的教育实践指导、解决多模态数据分析的伦理问题,为进一步多模态学习的理论与实践研究提供参考。

关键词：多模态多模态学习多模态数据跨学科研究

地方立法视阈下农村集体经济组织法律概念的界定

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陕西理工大学学报（社会科学版） 2024年第1期42卷 1-8页

作者：胡瀚陕西理工大学经济管理与法学学院陕西汉中723000 华中科技大学法学院湖北武汉430074

在农村集体经济组织法律概念的界定问题上,关于农村集体经济组织及其相关事项的地方立法采取了概括式、列举式和概括列举式三种表达模式。地方立法遵循明确本质属性、立足历史实践、突出典型特征等逻辑进路,在很大程度上保证和增强了事... 详细信息

在农村集体经济组织法律概念的界定问题上,关于农村集体经济组织及其相关事项的地方立法采取了概括式、列举式和概括列举式三种表达模式。地方立法遵循明确本质属性、立足历史实践、突出典型特征等逻辑进路,在很大程度上保证和增强了事实与规范的相对称,使农村集体经济组织的“名实关系”达成了相对“统一”。目前正在制定的《农村集体经济组织法》在界定农村集体经济组织法律概念时,应当吸收地方立法经验,兼容并蓄,择善而从,同时还应当处理好其与宪法规范的关系,实现与特别法人定位的有效衔接,正视农村集体经济组织的分化问题,重视农村集体经济组织与其他经济合作组织的区别,以确保法律概念界定的科学性和适用范围的准确性。

关键词：《农村集体经济组织法》农村集体经济组织地方立法法律概念

Tislelizumab in previously treated,locally advanced unresectable/metastatic microsatellite instability-high/mismatch repair-deficient solid tumors

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Chinese Journal of Cancer Research 2024年第3期36卷 257-269页

作者： Jian Li Ye Xu Aimin Zang Yunong Gao Quanli Gao Yanqiao Zhang Dong Wang Jianming Xu Ying Yuan Haiping Jiang Jieer Ying Chunmei Shi Yanhong Deng Jing Wang Tianshu Liu Yi huang Xiaoping Qian Yueyin Pan Ying Cheng Sheng hu Jin Wang Mengyue Shi Ke Wang han hu Lin Shen State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Medical Oncology Affiliated Hospital of Hebei UniversityBaoding 071000China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of GynecologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Immunotherapy Henan Cancer HospitalZhengzhou 450001China Department of Gastrointestinal Oncology Affiliated Cancer Hospital of Harbin Medical UniversityHarbin 150086China Department of Gastrointestinal Oncology Chongqing University Cancer HospitalChongqing 400030China Department of Gastrointestinal Oncology the Fifth Medical CenterChinese PLA General HospitalBeijing 100048China Department of Medical Oncology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Medical Oncology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Medical Oncology Cancer Hospital of the University of Chinese Academy of SciencesHangzhou 310022China Department of Medical Oncology Fujian Medical University Union HospitalFuzhou 350001China Department of Oncology the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China Department of Medical Oncology Hunan Cancer HospitalChangsha 410013China Department of Medical Oncology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Immunotherapy Hubei Cancer HospitalWuhan 430079China Department of Medical Oncology the Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Medical Oncology Anhui Provincial HospitalHefei 230001China Department of Medical Oncology Jilin Cancer Hospital

Objective:The open-label,phase II RATIONALE-209 study evaluated tislelizumab(anti-programmed cell death protein 1 antibody)as a tissue-agnostic monotherapy for microsatellite instability-high(MSI-H)/mismatch repair-deficient(dMMR)***:Adults with previously treated,locally advanced unresectable or metastatic MSI-H/dMMR solid tumors were *** received tislelizumab 200 mg intravenously every 3 *** response rate(ORR;primary endpoint),duration of response(DoR),and progression-free survival(PFS)were assessed by independent review committee(Response Evaluation Criteria in Solid Tumors v1.1).Results:Eighty patients were enrolled and treated;75(93.8%)patients had measurable disease at *** had metastatic disease and received at least one prior therapy for advanced/metastatic disease(n=79;98.8%).At primary analysis(data cutoff July 8,2021;median follow-up 15.2 months),overall ORR[46.7%;95%confidence interval(95%CI),35.1−58.6;one-sided P<0.0001]and ORR across tumor-specific subgroups[colorectal(n=46):39.1%(95%CI,25.1–54.6);gastric/gastroesophageal junction(n=9):55.6%(95%CI,21.2−86.3);others(n=20):60.0%(95%CI,36.1−80.9)]were significantly greater with tislelizumab vs.a prespecified historical control ORR of 10%;five(6.7%)patients had complete *** DoR,PFS,and overall survival were not reached with long-term follow-up(data cutoff December 5,2022;median follow-up 28.9 months).Tislelizumab was well tolerated with no unexpected safety ***-related adverse events(TRAEs)of grade≥3 occurred in 53.8%of patients;7.5%of patients discontinued treatment due to ***:Tislelizumab demonstrated a significant ORR improvement in patients with previously treated,locally advanced unresectable or metastatic MSI-H/dMMR tumors and was generally well tolerated.

关键词： Biomarkers DNA mismatch repair immune checkpoint inhibitors microsatellite instability phase II clinical trials programmed cell death 1 receptor